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1 IU/kg pump prime, and 10,000 KIU/kg per hour continuous infusion).
2 ng for 10 minutes, followed by 0.5 mg/kg/min continuous infusion).
3 concurrent fluorouracil (200 mg/m(2) per day continuous infusion).
4 assigned to intravenous exenatide or placebo continuous infusion.
5 in 3 days and persisted throughout 7 days of continuous infusion.
6 700, 850, and 1,000 mg/m(2)/d for 4 days via continuous infusion.
7 ected daily but causes severe bone loss with continuous infusion.
8 with FU/LV; FU was administered by bolus or continuous infusion.
9 cause undesirable side effects and require a continuous infusion.
10 No DLT occurred with 24-hour continuous infusion.
11 d two-compartment (biexponential) model with continuous infusion.
12 nge of 2-7 mmol/kg either as a bolus or as a continuous infusion.
13 administered through intrathecal boluses or continuous infusion.
14 efore resuscitation, and 1.5 mL.kg-1.hr-1 by continuous infusion.
15 ay courses of 2-CDA (8.9 mg/m(2)/d) given by continuous infusion.
16 n with paclitaxel, administered as a 96-hour continuous infusion.
17 zodiazepines and opioids, via both bolus and continuous infusion.
18 g i.v. bolus injections, as well as by 5-day continuous infusions.
19 nd prefer to administer these medications as continuous infusions.
20 termittent sedative dosing prior to starting continuous infusions.
22 caine (n = 7) bolus (1.5 mg/kg), followed by continuous infusion (100 mg/h for patients >70 kg or 70
23 itial bolus (4 mg/m(2)) and subsequent 4-day continuous infusion (12.5, 15.0, 17.5, or 20.0 mg/m(2)/w
25 or (3) loading dose (200 mg/kg) followed by continuous infusion (300 mg/kg per day) until discharge.
29 l 400 mg/m(2), followed by 2400 mg/m(2) 46-h continuous infusion), administered every 2 weeks for a t
31 by means of either a bolus every 12 hours or continuous infusion and at either a low dose (equivalent
32 the same amount of antibody administered by continuous infusion and by split administrations, compar
33 o 10 mg/kg, FU 600 to 800 mg/m(2) (120 hours continuous infusion), and hydroxyurea from 500 to 1,000
35 (2) by either a 1-hour infusion (Arm A) or a continuous infusion (Arm B) for 3, 5, or 7 days before a
37 udy groups received morphine (boluses and/or continuous infusion) as rescue medication on the guidanc
38 xed-onium chlorofumarate 24a following a 1 h continuous infusion at 10-20 microg/kg/min (95-100% bloc
40 domly assigned to receive levosimendan (in a continuous infusion at a dose of 0.025 to 0.2 mug per ki
42 ver a 10-minute period; this was followed by continuous infusion at a rate of 1 mug/kg/h until imagin
44 ur O6-BG infusion at 120 mg/m2 followed by a continuous infusion at an initial dose of 30 mg/m2/d for
45 aline when given as an intravenous bolus and continuous infusion attenuates water content of small bo
46 val after a regimen combining rituximab with continuous-infusion chemotherapy followed by allogeneic
47 m(2) daily and fluorouracil (FU) 400 mg/m(2) continuous infusion (CI) daily for the final 10 days of
49 unorubicin 90 mg/m(2) per day for 3 days and continuous-infusion cytarabine 100 mg/m(2) per day for 7
50 s 4 to 6), and cytarabine 1.5 g/m(2) IV as a continuous infusion daily for 3 or 4 days (days 4 to 7).
51 g regimen consisted of cisplatin (25 mg/m(2) continuous infusion daily for 4 days), fludarabine (30 m
52 ction included cytarabine 1.5 g/m(2) by 24-h continuous infusion daily on days 1-4 (3 days in patient
53 mg/m(2)), day 0; 5-FU (1,000 mg/m(2)/d), by continuous infusion days 0 to 2; and VCR (1.5 mg/m(2)),
55 monthly, and high-dose pulses of in-patient continuous infusion decrescendo IL-2 (54 MIU/m(2)) over
58 was to define the maximum-tolerated dose of continuous-infusion doxorubicin administered with standa
60 al-beam radiation with concurrent fixed-dose continuous-infusion doxorubicin followed by surgical res
65 gimen by adding fludarabine to dose-adjusted continuous-infusion etoposide, prednisone, vincristine,
66 Paclitaxel was administered as a 120-hour continuous infusion every 3 weeks during the course of r
67 el feature, UCN-01 is administered as a 72-h continuous infusion every 4 weeks (in second and subsequ
69 dition of weekly oxaliplatin to preoperative continuous infusion fluorouracil (FU) and external-beam
70 terial floxuridine combined with intravenous continuous-infusion fluorouracil (chemotherapy arm, 53 p
71 e-to-one ratio to epirubicin, cisplatin, and continuous-infusion fluorouracil (ECF), irinotecan plus
72 oxicity and possibly enhanced activity makes continuous-infusion fluorouracil (FU) an attractive alte
73 included cisplatin 20 mg/m(2) for 4 days and continuous-infusion fluorouracil 1,000 mg/m(2)/d for 4 d
74 reated with blinatumomab in cycles of 4-week continuous infusion followed by a 2-week treatment-free
75 ered on cardiopulmonary bypass followed by a continuous infusion for >/=12 hours and </=5 days after
77 120 mg/m2 of O6-BG over 1 hour followed by a continuous infusion for 2 days at escalating doses presu
78 inistering the antagonists as a subcutaneous continuous infusion for 2 weeks compared to a single bol
79 ients received 1.5 g/m(2) per day cytarabine continuous infusion for 3 days and laromustine 600 mg/m(
80 nder the curve of 6.5, followed by TOPO as a continuous infusion for 3 days; the starting dose of TOP
81 d 11 h), and bleomycin (25 units per day, by continuous infusion for 5 days on days 10-14; two cycles
82 ight patients received cladribine 12 mg/m(2) continuous infusion for 5 days with melphalan 180 mg/m(2
83 mg/m2, weekly; arm E, 5-FU 750 mg/m2/d IV by continuous infusion for 5 days, then 750 mg/m2 weekly, a
84 9-AC 35 microg/m(2)/h was administered by continuous infusion for 72 hours every 2 weeks via ambul
85 patients at a dose of 0.1 mg/kg as a 24-hour continuous infusion for a total of 7 days each cycle.
87 infusion) or ciclosporin (2 mg/kg per day by continuous infusion for up to 7 days, followed by twice-
88 was performed every 8 hrs in lumens without continuous infusions for the duration of catheter placem
90 stases were treated with weekly oxaliplatin, continuous infusion FU 200 mg/m2 intravenously, and RT.
91 , the addition of oxaliplatin to intravenous continuous infusion FU and RT for patients with locally
93 15) was developed to compare the efficacy of continuous-infusion FU (CIFU) plus levamisole to FU/LV p
94 25 g of human serum albumin every 8 hrs with continuous infusion furosemide, or dual placebo, targete
97 ents with pneumonia who received extended or continuous infusion had lower mortality than those recei
99 of 200 mg/day in four divided doses or as a continuous infusion in a dose of 240 mg/day (10 mg/hr) f
100 s, and arginine butyrate was administered by continuous infusion in an intrapatient dose escalation,
102 administration of beta-lactam antibiotics by continuous infusion in critically ill patients with seve
103 ed ara-C doses of 1 to 2 gm/m(2)/d, given by continuous infusion in IA, and over 2 to 4 hours in FA a
104 armacokinetics of a 96-hour intravenous (IV) continuous infusion in patients with advanced cancer.
105 h-dose (100 U/kg bolus followed by age-based continuous infusion in randomized children) vs low-dose
106 e., approximately EC(95)]) administered as a continuous infusion in vitro provides virtually complete
108 stered through either intrathecal boluses or continuous infusion induced a dose-dependent downregulat
109 ively, were given sedation or analgesia as a continuous infusion, intermittent doses, or both (p<0.00
110 and 194 eligible patients were randomized to continuous infusion intravenous IL-2 (9 million units/m(
112 hat received intravenous bolus followed by a continuous infusion, lung water content was significantl
113 linical data suggest that administration via continuous infusion may result in enhanced antitumor act
114 detection dynamic range is described, and a "continuous infusion" mode to provide a low sample consum
115 ulmonary arterial hypertension (PAH) require continuous infusions, multiple inhalations, or oral admi
117 tumors, (2) evaluate the safety of extending continuous-infusion O6-BG at the optimal dose with intra
119 sing a conventional dosing of 16 g/2 g/24 hr continuous infusion, obese patients were more likely tha
120 ficantly greater risk of nephrotoxicity than continuous infusion (odds ratio = 8.204; p </= 0.001).
122 d either to 3 mg/kg Bbeta15-42 followed by a continuous infusion of 1 mg/kg/hr for 5 hours (pFX06; n
124 njection of 2 nmol ghrelin was followed by a continuous infusion of 12 nmol ghrelin via a primed 200-
125 400 mg/m(2) intravenously on day 1 and then continuous infusion of 2,400 mg/m(2) over the next 46 ho
126 e randomly allocated 1:1 either to receive a continuous infusion of 200 mg of hydrocortisone for 5 da
130 mg/mL per min per day for 4 days, etoposide continuous infusion of 338 mg/m(2) per day for 4 days, a
132 s (control), or injured animals treated with continuous infusion of 7-nitroindazole, a specific neuro
133 Ten men and eight women received a primed-continuous infusion of [1,1,2,3,3-(2)H(5)]glycerol and c
134 of age) were studied during 8.5 h of primed continuous infusion of [1,2-(1)(3)C]leucine with intermi
135 infusion of [1,1,2,3,3-(2)H(5)]glycerol and continuous infusion of [1-(13)C]palmitate to measure gly
137 nts with Parkinson's disease, long-acting or continuous infusion of a dopaminergic drug reduces the r
138 aising intragastric pH on the first day as a continuous infusion of a histamine-2-receptor antagonist
139 and LHA from groups of male rats treated by continuous infusion of aCSF or lactate into the caudal f
142 hBNP-054 or vehicle in 6 dogs that received continuous infusion of ANG II to induce hypertension.
144 at 6 months of age, followed 1 week later by continuous infusion of angiotensin II (1 microg/kg per m
145 one site of mouse aorta (elastase model) or continuous infusion of angiotensin II in hyperlipidemic
147 kg of anti-rat NPCT antibody was followed by continuous infusion of anti-NPCT (16 mug per hour) via a
149 viding neural progenitor cells using a 7-day continuous infusion of Ara-C prior to rSham or rmTBI.
150 d melphalan regimen consisted of carboplatin continuous infusion of area under the plasma concentrati
151 ponse of lymphocytes in leukemic patients to continuous infusion of blinatumomab helps to better unde
152 all patients of a phase 2 study responded to continuous infusion of blinatumomab in a strikingly simi
153 s lower among patients receiving extended or continuous infusion of carbapenems or piperacillin/tazob
154 randomized studies suggests that extended or continuous infusion of carbapenems or piperacillin/tazob
156 (97.4%) in the intervention group started a continuous infusion of cisatracurium (median duration of
157 sure [PEEP] of >=8 cm of water) to a 48-hour continuous infusion of cisatracurium with concomitant de
158 induction chemotherapy including 4 cycles of continuous infusion of combinations of dexamethasone, vi
159 ntravenously to male adult rats, followed by continuous infusion of curcumin (0.24 micromol/day) for
160 nts received 7 + 3 induction chemotherapy of continuous infusion of cytarabine (100 mg/m(2) per day o
162 2,100 mg/m2/d on days 1 and 2, and a 72-hour continuous infusion of doxorubicin 75 mg/m2 and vincrist
166 d) or intermittent air (IA; control) and (2) continuous infusion of either 50% dextrose or saline (co
168 randomly allocated at H6 to receive a 42-hr continuous infusion of either hydrocortisone at 200 mg/d
169 e randomly assigned 77 patients to receive a continuous infusion of esmolol titrated to maintain hear
170 nderwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks.
172 betes treatment involves daily injections or continuous infusion of exogenous insulin aimed at regula
179 oncentrate complex (hPCC; 2.5 mL/kg, n = 2), continuous infusion of hPCC (1.0 mL/h, n = 1) or continu
180 inuous infusion of hPCC (1.0 mL/h, n = 1) or continuous infusion of human recombinant factor VIIa (1
182 creases in lung and brain water content with continuous infusion of hypertonic saline may have therap
183 GFR was measured simultaneously using a continuous infusion of I-iothalamate and external radioa
187 Isoproterenol testing was performed with continuous infusion of isoproterenol (45 mug/min) for 3
188 Desensitization was then induced by a 2-hour continuous infusion of isoproterenol, and venodilatation
192 n +/- SEM age: 27 +/- 1 y) received a primed continuous infusion of l-[ring-2H5]-phenylalanine, l-[ri
193 ol intravenously as boluses before and after continuous infusion of L748337 (a specific beta3 antagon
197 estigate the effect of an acute injection or continuous infusion of LPS on experimentally induced hyp
199 with an ED(50) of 1.2 mg/kg/day for a 14-day continuous infusion of MP, and a maximum inhibitory effe
200 7) We suggest that patients receiving a continuous infusion of neuromuscular-blocking agent rece
201 neuromuscular blockade in patients receiving continuous infusion of neuromuscular-blocking agents.
202 od, fetuses were given a bolus followed by a continuous infusion of Nomega-nitro-L-arginine methyl es
203 A total of 190 C57BL/6J mice received a continuous infusion of norepinephrine or vasopressin via
204 this hypothesis, rats were made tolerant by continuous infusion of NTG for 3 days (10 microgram kg(-
206 connected to osmotic pumps that delivered a continuous infusion of patients' or control cerebrospina
208 he kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligon
210 electively stimulated VEGFR-1 and VEGFR-2 by continuous infusion of receptor-specific ligands or sele
211 after subtotal nephrectomy, rats received a continuous infusion of recombinant HGF, neutralization o
212 after subtotal nephrectomy, rats received a continuous infusion of recombinant HGF, neutralization o
213 bres were placed in ventral forearm skin for continuous infusion of Ringer solution or 20 mM l-NAME.
217 ith a subcutaneous minipump that delivered a continuous infusion of secreted products from the model
218 tion interruption (defined as cessation of a continuous infusion of sedation agent) were identified.
219 echanically ventilated patients prescribed a continuous infusion of sedative medication while in the
220 th dextran sulphate sodium (DSS) followed by continuous infusion of soy lipid-based PN solution throu
221 p (n = 91) received a weight-based bolus and continuous infusion of T4 according to the organ procure
223 aneous implantation of a morphine pellet and continuous infusion of the delta-opioid receptor antagon
224 cardiotoxicity can be prevented in adults by continuous infusion of the drug, but mechanisms of cardi
226 16 open-chest dogs: 8 controls and 8 given a continuous infusion of the GPI tirofiban, starting 45 mi
227 In mice where hyperalgesia subsided after continuous infusion of the highest morphine dose (i.e.,
228 n experimental cancer medicine study by 1-wk continuous infusion of the small-molecule inhibitor AMD3
229 ature osmotic pumps, we now demonstrate that continuous infusion of these cytokines for 7 days had a
231 Pulmonary hypertension was produced by the continuous infusion of U46619, a thromboxane A2 mimetic.
233 l; group 2, vancomycin twice daily; group 3, continuous infusion of vancomycin; and group 4, linezoli
234 In addition, six sham animals (not injured, continuous infusion of vehicle) were used to obtain refe
235 c oxide synthase group was administered with continuous infusion of ZK 234238 started 1 hr postinjury
236 h sessions, participants received bolus plus continuous infusions of 2-FA, were scanned for 1 h after
237 ein turnover were determined by using primed continuous infusions of [(2)H(5)]phenylalanine and [1-(1
238 inhibitor may be an alternative to high-dose continuous infusions of a histamine-2-receptor antagonis
239 d 2002, 222 patients were treated with 4-day continuous infusions of fluorouracil (1,000 mg/m2/d) and
240 ted at rest and after exercise during primed continuous infusions of l-[ring-(2)H5]phenylalanine and
243 f patients with delirium (CAM-ICU+) received continuous infusions of midazolam (59% vs. 32%, p < .05)
244 el and eyelid closure for patients receiving continuous infusions of neuromuscular-blocking agents.
245 en the analyses were adjusted for the use of continuous infusions of opioids and/or sedatives and ven
248 oprotection, and biomechanics under acute or continuous infusions of the apelinergic agonists ELA or
250 ach on day 1 plus fluorouracil 750 mg/m(2)/d continuous infusion on days 1 to 5 every 3 weeks (DCF) o
251 ) on day 1 plus fluorouracil 1,000 mg/m(2)/d continuous infusion on days 1 to 5 every 4 weeks (CF).
252 , and 3), cytarabine (100 mg/m(2) per day by continuous infusion on days 1-7), and GO (6 mg/m(2) on d
253 ne reduced 25% plus interleukin-2 by 24-hour continuous infusion (on days 5 to 8, 17 to 20, and 26 to
254 ified, the schedule was changed to a 24-hour continuous infusion once weekly (starting dose, 300 mg/m
255 m(2) bolus followed by 2,400 mg/m(2) 46-hour continuous infusion, once every 2 weeks) or gemcitabine
256 A second group of rats were treated with continuous infusion only for 48 hrs of either 7.5% hyper
257 y was administered by bolus as compared with continuous infusion or at a high dose as compared with a
261 every 21 days, ifosfamide 9 g/m2 over 3 days continuous infusion, or ifosfamide 3 g/m2 per day in 3 h
262 , patients can be treated with higher doses, continuous infusions, or the addition of a thiazide diur
263 /m(2) in combination with mesna 5000 mg/m(2) continuous infusion over 24 h, days 1 and 2; one dose of
264 cated that the higher dose of 10 mg given as continuous infusion over 24 hours had the most favorable
266 (2), LV 400 mg/m(2), and FU 1,400 mg/m(2) by continuous infusion over 48 hours, with the same FUDR do
269 nts, median z score = -0.70 SD, P =.006; for continuous-infusion patients, median z score = -0.765, P
271 he authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) t
272 odilatation has been shown to decline during continuous infusion, possibly suggestive of an internali
275 use of either intermittent bolus sedation or continuous infusion sedation targeting specific titratio
276 using either intermittent bolus sedation or continuous infusion sedation with daily interruptions or
278 that it provides long-term cardioprotection; continuous infusions should be eliminated from pediatric
279 g intravenous bolus along with a 10 mg/kg/hr continuous infusion starting just before reperfusion and
280 nine (O6-BG) administered intravenously as a continuous infusion that suppresses O6-alkylguanine-DNA
283 the clinical evidence base for prolonged or continuous infusion therapy is insufficiently strong to
285 agent such as alteplase is an alternative to continuous-infusion thrombolytic regimens and minimizes
286 diation (fluorouracil 225 mg/m(2) per day by continuous infusion throughout radiotherapy, and 45.0 Gy
287 or to placebo (n = 283), all administered as continuous infusions titrated according to hemodynamic p
288 hypothesis, IFN-gamma was administered as a continuous infusion to Fancc-/- and wild-type (WT) mice
289 human clinical trials comparing prolonged or continuous infusion to intermittent injection have faile
290 rmittent bolus administration or propofol by continuous infusion to maintain a Ramsay score of 2-3.
291 uscular blockers, which were administered as continuous infusions to 146 (7%) of these neonates.
293 double-blind, randomized controlled trial of continuous infusion versus intermittent bolus dosing of
294 by intermittent intraperitoneal injection or continuous infusion via an implanted infusion pump.
295 When compared with intermittent infusion, continuous infusion was associated with a reduction in a
296 njury from the intraparenchymal catheter and continuous infusion was confined primarily to a narrow z
298 is phase I study of relapsed/refractory NHL, continuous infusion with CD19-targeted immunotherapy bli
299 ase II dose of G3139 is 7 mg/kg/d as a 7-day continuous infusion, with cyclophosphamide 500 mg/m2/d a
300 (112 mug/d; n = 2) dosing of blinatumomab by continuous infusion, with dexamethasone prophylaxis, in