ライフサイエンスコーパス: contractile ring

1 f recruiting other proteins to stabilize the contractile ring.

2 bers outside the plasma membrane, not by the contractile ring.

3 uently captured by the ingressing polar body contractile ring.

4 yosin-V (Myo51) that are also present in the contractile ring.

5 to cytoplasmic puncta, actin cables, and the contractile ring.

6 idual filaments throughout the cell, and the contractile ring.

7 join these nodes, which condense to form the contractile ring.

8 at protein layer, generated by an actomyosin contractile ring.

9 the nodes pull nodes together into a single contractile ring.

10 stress fibers and the cytokinetic actomyosin contractile ring.

11 lane and allow efficient constriction of the contractile ring.

12 cleavage can continue in the absence of the contractile ring.

13 mbly and constriction of an actomyosin-based contractile ring.

14 s is mediated by a cortical actomyosin-based contractile ring.

15 dles of linear antiparallel filaments in the contractile ring.

16 polarizing actin cables, and the cytokinetic contractile ring.

17 e actin filaments to condense nodes into the contractile ring.

18 y Dia3 strongly localized at the cytokinetic contractile ring.

19 venting DNA breaks or constrictions from the contractile ring.

20 generation of actin filaments that form the contractile ring.

21 s pulls the nodes together to form a compact contractile ring.

22 embly and contraction of an actomyosin-based contractile ring.

23 PIP2 promote cytokinesis in the absence of a contractile ring.

24 divides by assembling actin filaments into a contractile ring.

25 s accomplished by constriction of a cortical contractile ring.

26 proteins that condense into the cytokinetic contractile ring.

27 eavage furrow formed by the actomyosin-based contractile ring.

28 uired for localization and activation of the contractile ring.

29 ngly with other F-actin networks such as the contractile ring.

30 lymerize actin filaments for the cytokinetic contractile ring.

31 first phase relies on the assembly of a wide contractile ring.

32 ature into the precursors of the cytokinetic contractile ring.

33 d is required for myosin enrichment into the contractile ring.

34 was reported to arrest with an unconstricted contractile ring.

35 ed models of the dynamics of the cytokinetic contractile ring.

36 supergroups lack myosin II of the actomyosin contractile ring.

37 t the cell cycle and are constituents of the contractile ring.

38 ins in the functional units of a cytokinetic contractile ring.

39 suggest act as inhibitors of F-actin at the contractile ring.

40 o, which allows cells to assemble functional contractile rings.

41 ved dynamin-related proteins that form outer contractile rings.

42 reas decreasing actin favors formin-mediated contractile rings.

43 ols remodeling of the hexagonal network into contractile rings.

44 to understand how these proteins function at contractile rings.

45 quired for appropriate constriction of these contractile rings.

46 many eukaryotes requires an actomyosin-based contractile ring [1].

47 sition and triggers the assembly of a medial contractile ring [5, 9-11].

48 alizes to and assists in the assembly of the contractile ring, a conserved eukaryotic actomyosin stru

49 Here, we identified alpha-actinin Ain1, a contractile ring ABP, as another Fim1 competitor.

50 Therefore, the combination of contractile ring ABPs Ain1 and Cdc8 is capable of inhibi

51 proteins that contribute to the cytokinetic contractile ring accumulate during interphase in nodes-p

52 In contrast to cells that use a contractile ring, actin was not concentrated in the furr

53 The contractile ring also contains a potential filament cros

54 have revealed that cytokinesis in cells with contractile rings (amoebas, fungi, and animals) depends

55 nisms that position the furrow, assemble the contractile ring, anchor the ring to the plasma membrane

56 ow invagination requires an actomyosin-based contractile ring and addition of new membrane.

57 sis requires cooperative interaction between contractile ring and central spindle components, but how

58 Forces from the actomyosin contractile ring and cortex do contribute to the cell sh

59 calization of Hof1p from septin rings to the contractile ring and for Hof1p-triggered contractile rin

60 ut not NMII-A (MYH9), is localized in the MK contractile ring and implicated in mitosis/endomitosis t

61 determines myosin II localization to the MK contractile ring and is responsible for the specific rol

62 protein, Nod1, colocalizes with Gef2 in the contractile ring and its precursor cortical nodes.

63 ast, cytokinesis nodes are precursors of the contractile ring and mark the future cleavage site.

64 und that p27 and citron-K colocalized at the contractile ring and mid-body during telophase and cytok

65 In contrast, the contractile ring and midbody required for cytokinesis, t

66 e for actin patches but is important for the contractile ring and possibly actin cables.

67 ain protein, add structural integrity to the contractile ring and prevent it from fragmenting during

68 obe formation is driven by constriction of a contractile ring and requires the RhoGEF ECT-2, a RhoA a

69 unexpected signaling interaction between the contractile ring and the adjacent cells.

70 ngly, Cyk3p localizes both to the actomyosin contractile ring and the division septum, promoting ring

71 al protein whose localization depends on the contractile ring and the secretory pathway.

72 uator, guide the assembly of the acto-myosin contractile ring and ultimately ensure complete separati

73 ut it is not known how SpTm localizes to the contractile ring and whether SpTm plays a direct role in

74 and Myo52p (class V myosins that function at contractile rings and actin cables, respectively).

75 longation of actin filaments for cytokinetic contractile rings and other cellular structures.

76 icle cells, resulted in over-constriction of contractile rings and ring canals.

77 e developed a method to measure the sizes of contractile rings and ring canals.

78 of non-muscle actomyosin structures, such as contractile rings and stress fibers, are poorly understo

79 uss the model's implication for mechanics of contractile rings and stress fibers.

80 sufficient to induce assembly of functional contractile rings and that cell rounding facilitates fur

81 ein that organizes and stabilizes actomyosin contractile rings and was previously thought to function

82 is critical for normal F-actin levels in the contractile ring, and acute inhibition of CYK-1 after fu

83 ells, Dia1 and Dia2 were mislocalized to the contractile ring, and cells exhibited increased cytokine

84 ications between the central spindle and the contractile ring are critical for the spatial and tempor

85 ontrol the formation and constriction of the contractile ring are incompletely understood.

86 nisms by which myosin II is recruited to the contractile ring are not fully understood.

87 ngs reveal how components of the cytokinetic contractile ring are reemployed during interphase to cre

88 at nodes, protein assembly precursors to the contractile ring, are discrete structural units with sto

89 esulting in decreased cell height and larger contractile ring area in cellularization similar to that

90 They are released from the contractile ring as it disassembles and then associate w

91 Contractile rings assemble normally in blt1 cells, but t

92 Unlike mitotic contractile rings, polar body contractile rings assemble over one spindle pole so that

93 ion of the cytokinesis furrow, such that the contractile ring assembles in an equatorial zone between

94 The actomyosin contractile ring assembles through the condensation of a

95 cdc12 truncations were severely defective in contractile ring assembly and constriction, although cor

96 ne triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction.

97 The GTPase RhoA promotes contractile ring assembly and furrow ingression during c

98 , with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest c

99 asses normal cell-cycle controls and induces contractile ring assembly and sometimes even ring contra

100 e, we report that the myosin-V Myo51 affects contractile ring assembly and stability during fission y

101 dlin oligomerization during anaphase induces contractile ring assembly at the membrane.

102 ese evolutionarily diverse formins can drive contractile ring assembly by a generally similar mechani

103 animal cell cytokinesis, the spindle directs contractile ring assembly by activating RhoA in a narrow

104 , in which the deletion of Fim1p rescues the contractile ring assembly defects caused by mutation of

105 refore, SpTm makes multiple contributions to contractile ring assembly during and after actin polymer

106 for both endocytic actin patch kinetics and contractile ring assembly during cytokinesis.

107 To investigate the mechanism of contractile ring assembly in animal cells, we directly c

108 g actomyosin interactions, which facilitates contractile ring assembly in the fission yeast system.

109 on of formin Cdc12 is required for efficient contractile ring assembly in vivo.The fission yeast cyto

110 the fission yeast Schizosaccharomyces pombe, contractile ring assembly initiates at the onset of mito

111 nd concentrating the factors responsible for contractile ring assembly, whereas KIF4A is required for

112 n a three-dimensional computational model of contractile ring assembly, with semiflexible actin filam

113 egulated to ensure spatiotemporal control of contractile ring assembly.

114 umerous factors to the equatorial region for contractile ring assembly.

115 GAP domain, ultimately promoting actomyosin contractile ring assembly.

116 torial cortex in spermatocytes, critical for contractile ring assembly.

117 es important steps and molecular players for contractile ring assembly.

118 gle tropomyosin isoform SpTm is required for contractile ring assembly.

119 m the Plo1 kinase to control a final step in contractile ring assembly.

120 s that may explain the role of this motor in contractile ring assembly.

121 els have emerged to explain the mechanism of contractile-ring assembly during cytokinesis in the fiss

122 ntractile-ring closure, but does not inhibit contractile-ring assembly, localization of a chromosomal

123 Mid1 specifies the division site and induces contractile-ring assembly.

124 ablished role in formation of the actomyosin contractile ring at mitotic exit, through the local acti

125 eins that play key roles in anchorage of the contractile ring at the cell equator during cytokinesis

126 ich triggers assembly of an actomyosin-based contractile ring at the equatorial cortex.

127 heet-like equatorial band into a ribbon-like contractile ring at the furrow tip.

128 ity is required to condense the nodes into a contractile ring, based on slower or absent node condens

129 o not have a constriction, arguing against a contractile ring-based nuclear expulsion mechanism.

130 le so that the spindle must move through the contractile ring before cytokinesis.

131 The failure to properly position the contractile ring between the segregated chromosomes can

132 and amoebas depends on the constriction of a contractile ring built from a common set of conserved pr

133 rces for cytokinesis are not produced by the contractile ring but are driven by the assembly of cell

134 can assemble nodes and actin filaments into contractile rings but complete assembly later than norma

135 yosin, is the major source of tension in the contractile ring, but how Myo2 is anchored and regulated

136 coalescence of components on one side of the contractile ring, but is insensitive to a 10-fold reduct

137 ns of Rng3p can concentrate independently in contractile rings, but only full-length Rng3p supports c

138 12p, and other proteins, and condense into a contractile ring by movements that depend on actin and m

139 indle and overlying membrane out through the contractile ring center.

140 reveal a novel role for Aim44p in regulating contractile ring closure through effects on Hof1p.

141 the contractile ring and for Hof1p-triggered contractile ring closure, rescues the cytokinesis defect

142 oth septins and type II myosins and promotes contractile ring closure.

143 Deletion of AIM44 results in defects in contractile ring closure.

144 -II is required throughout cytokinesis until contractile ring closure.

145 Deletion of MDM10 inhibits contractile-ring closure, but does not inhibit contracti

146 Sticky (Sti), the Drosophila ortholog of the contractile ring component Citron kinase (CIT-K), intera

147 As an early, abundant contractile ring component with multiple binding partner

148 ecting and regulating a molecular network of contractile ring components and microtubule-associated p

149 h-avidity membrane binding, stabilization of contractile ring components at the medial cortex, and th

150 al organization of Schizosaccharomyces pombe contractile ring components relative to the plasma membr

151 nesis failure due to disruption of two other contractile ring components, the Rho effectors diaphanou

152 Contractile rings constrict to a greater degree, resulti

153 These slowly assembled contractile rings constricted at a normal rate but with

154 vitro motility rate, which ensures effective contractile ring constriction and function.

155 ac activity was proposed to be inhibitory to contractile ring constriction and thus specifically inac

156 nship between centralspindlin and the CPC in contractile ring constriction during cytokinesis.

157 ns in parallel with RhoA activation to drive contractile ring constriction during cytokinesis.

158 ng vertebrate cytokinesis it is thought that contractile ring constriction is driven by nonmuscle myo

159 of germline cyst formation demonstrates that contractile ring constriction proceeds to a defined end

160 pport the canonical "purse-string" model for contractile ring constriction, but also suggest that the

161 n is only required during assembly and early contractile ring constriction.

162 laments and to exert tension on actin during contractile ring constriction.

163 tion at this site promotes the initiation of contractile ring constriction.

164 that these calcium transients could trigger contractile ring constriction.

165 the cleavage furrow relatively evenly during contractile-ring constriction, but the rim of the cleava

166 During cytokinesis, although the contractile ring constricts more rapidly in the pkd2 mut

167 The contractile ring contains three filament systems: actin,

168 litated by the constriction of an actomyosin contractile ring (CR) [1].

169 uring cytokinesis, closure of the actomyosin contractile ring (CR) is coupled to the formation of a m

170 and constricting an actin- and myosin-based contractile ring (CR) that is physically linked to the p

171 We find that Clp1/Flp1 is tethered at the contractile ring (CR) through its association with anill

172 the components and spatial regulation of the contractile ring (CR), the precise ultrastructure of act

173 mbly and constriction of an actomyosin-based contractile ring (CR).

174 CPC activity for proper accumulation at the contractile ring (CR).

175 a late cytokinesis failure associated with a contractile ring defect.

176 Gef2 localization to cortical nodes and the contractile ring depends on its last 145 residues, and t

177 the ARP2/3 complex does not localize in the contractile ring, depletion of the ARP2 subunit or treat

178 -based midbody or from the outside in by the contractile ring-derived midbody ring, it is assumed tha

179 Contractile rings disassemble as they constrict.

180 activity to block cytokinesis progress after contractile ring disassembly.

181 echanistic understanding of how the parasite contractile ring drives cell division.

182 During cytokinesis, an actomyosin contractile ring drives the separation of the two daught

183 phase specify the location of the actomyosin contractile ring during cytokinesis, but the detailed me

184 conserved force-generating components of the contractile ring during cytokinesis.

185 specifically in assembly of the actin-based contractile ring during cytokinesis.

186 ion of formin activity and the mechanisms of contractile ring dynamics and assembly.

187 understanding of the molecular mechanisms of contractile ring dynamics in the model organism Schizosa

188 ch is necessary for proper RhoA activity and contractile ring dynamics.

189 g recruitment of a critical component of the contractile ring, filamentous actin (F-actin).

190 FtsZ, a cytoskeletal GTPase, forms a contractile ring for cell division in bacteria and chlor

191 In all organisms that use a contractile ring for cell division, the process of cytok

192 eatment with ARP2/3 complex inhibitor delays contractile ring formation and constriction.

193 c bundling by SpAin1 is important for proper contractile ring formation and constriction.

194 II (Myo2p) and tropomyosin are essential for contractile ring formation and cytokinesis in fission ye

195 directional cortical transport contribute to contractile ring formation during cytokinesis.

196 p is required for both the normal process of contractile ring formation from precursor nodes and an a

197 Contractile ring formation has been well characterized i

198 owever, whether and how the SIN functions in contractile ring formation has remained unclear.

199 limited G-actin and to assemble F-actin for contractile ring formation in dividing cells.

200 We propose that lobe contractile ring formation is locally inhibited by the P

201 Contractile ring formation is mediated by RhoA activatio

202 Furthermore, their careful analysis of contractile ring formation may help bridge two existing

203 the search-capture-pull and release model of contractile ring formation predicted that nodes clump wh

204 ndlin activates ECT-2 to promote cytokinetic contractile ring formation, we show that the ECT-2 regul

205 mbly at the division site is predominant for contractile ring formation.

206 lethal with mutations that cause defects in contractile ring formation.

207 gulators of division-plane specification and contractile-ring formation during cytokinesis, but how t

208 provide strong support for the SCPR model of contractile-ring formation in cytokinesis.

209 the small GTPase RhoA is a key regulator of contractile-ring formation.

210 Unlike mitosis, where an actomyosin contractile ring forms between the sets of segregating c

211 sets of segregating chromosomes, the meiotic contractile ring forms on the cortex adjacent to one spi

212 mutant cells at late stages of division, the contractile ring frequently detaches from the cortex and

213 ay be two parallel mechanisms to prevent the contractile rings from being completely closed, physical

214 quirement for cleavage furrow maturation and contractile ring function during cytokinesis.

215 e rings, but only full-length Rng3p supports contractile ring function in vivo.

216 e cell wall with the plasma membrane and for contractile ring function, as proposed for the equivalen

217 mal Myo2p in vitro motility rates and normal contractile ring function.

218 l map provides a framework for understanding contractile ring function.

219 In addition, Gef2 also regulates contractile-ring function late in cytokinesis and may ne

220 ring cytokinesis, constriction of a cortical contractile ring generates a furrow that partitions one

221 The fission yeast contractile ring has been proposed to assemble by Search

222 The functions of the actin-myosin-based contractile ring in cytokinesis remain to be elucidated.

223 expansion and concatenation also formed the contractile ring in dividing cells.

224 cortical nodes that generate the cytokinetic contractile ring in fission yeast.

225 ate in the formation and constriction of the contractile ring in fission yeast.

226 lin-like protein mid1p helps to position the contractile ring in the cell middle.

227 We conclude that orderly assembly of the contractile ring in wild-type cells depends on Mid1p to

228 We discovered that contractile rings in cps1-191 cells constrict slowly and

229 of a membrane-tethered version of FtsZ into contractile rings in lipid tubules, in vitro dynamic pat

230 of loop formation and constriction of tilted contractile rings in live cells, and tracking of network

231 ls the organization of cytokinesis nodes and contractile rings in live fission yeast cells.

232 organizing the structural components of the contractile ring including filamentous actin (F-actin),

233 essential role in recruiting proteins to the contractile ring, including Pxl1 and Fic1.

234 report evidence of an as yet unknown type of contractile ring-independent cytokinesis that we termed

235 However, also contractile ring-independent forms of cell division are

236 s that contain all maternal DNA, because the contractile ring ingressed past the spindle midpoint.

237 cofilins condensed nodes, precursors of the contractile ring, into clumps rather than rings.

238 The contractile ring is a complex molecular apparatus which

239 Assembly of a cytokinetic contractile ring is a form of cell polarization in which

240 The actomyosin contractile ring is a network of cross-linked actin fila

241 Cell division facilitated by a contractile ring is an almost universal feature across a

242 How the constriction of a contractile ring is arrested and how an arrested contrac

243 eavage-furrow tip adjacent to the actomyosin contractile ring is believed to be the predominant site

244 The contractile ring is essential for cytokinesis in most fu

245 ted from the furrow region, where the myosin contractile ring is subsequently formed.

246 ractile ring is arrested and how an arrested contractile ring is transformed into a ring canal is unk

247 The contractile-ring localization of Nod1 and Gef2 also depe

248 where the Nod1/Gef2 complex plays a role in contractile-ring maintenance and affects the septation i

249 ime-lapse imaging of C. elegans meiosis, the contractile ring moved downward along the length of the

250 ing Aip1 are viable and assemble cytokinetic contractile rings normally, but rings in these Deltaaip1

251 Cells with only Myo2 assemble contractile rings normally.

252 Chemical disruption of the contractile ring of actin and myosin immediately vegetal

253 Animals and fungi assemble a contractile ring of actin filaments and the motor protei

254 myosin-II (Myo2) to assemble and constrict a contractile ring of actin filaments.

255 intercellular bridges, are derived from the contractile rings of incomplete cytokinesis (IC) in most

256 Contractile rings play critical roles in a number of bio

257 Unlike mitotic contractile rings, polar body contractile rings assemble

258 ivisions and driven by the constriction of a contractile ring positioned and controlled solely by the

259 e the assembly of the actin filaments into a contractile ring positioned between the daughter nuclei

260 Here, we show that the contractile ring possesses an intrinsic symmetry-breakin

261 ing in vitro reconstitution of fission yeast contractile ring precursor nodes containing formins and

262 in nodes that accumulate myosin-II and other contractile ring proteins during mitosis.

263 formation to anaphase onset by concentrating contractile ring proteins on the equatorial cortex in a

264 strands containing actin filaments and other contractile ring proteins.

265 nesis in animal cells is that the actomyosin contractile ring provides the primary force to divide th

266 Without Blt1p, contractile rings recruited and retained less Sid2p/Mob1

267 tion with myosin light chain 2 (MLC2) in the contractile ring region of mitotic cells during cytokine

268 factor Gef2p, and kinesin Klp8p emerge from contractile ring remnants.

269 chosen, the local assembly of the actomyosin contractile ring remodels the plasma membrane.

270 itosis, cytoskeletal actin forms part of the contractile ring, rendering a round shape to podocytes.

271 luding filopodia used for cell migration and contractile rings required for cell division.

272 As does Rgf3, Art1 concentrates to the contractile ring starting at early anaphase and spreads

273 tubulin-like FtsZ protein polymerizes into a contractile ring structure required for cytokinesis in m

274 ust process impervious to discontinuities in contractile ring structure.

275 ans, ring channels are a specialized form of contractile ring that are maintained at a constant diame

276 Myosin II is an essential component of the contractile ring that divides the cell during cytokinesi

277 cytokinesis commonly relies on an actomyosin contractile ring that drives equatorial furrowing and se

278 s is driven by constriction of an actomyosin contractile ring that is controlled by Rho-family small

279 karyotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction a

280 ll division by constriction of an actomyosin contractile ring that separates the two daughter cells.

281 ha-Actinin ain1 deletion cells form a normal contractile ring through nodes in the absence of the spo

282 around the cell equator and assembled into a contractile ring through stochastic motions, after a mes

283 t regulatory logics for the anchorage of the contractile ring through the anillin/Mid1 family protein

284 alizes with Myo1p, the type II myosin of the contractile ring, throughout most of the cell cycle.

285 a growing shell, a cell-cycle engine, and a contractile ring to enforce cytokinesis.

286 to be required for segmentation, acting as a contractile ring to establish daughter cell boundaries.

287 uce force to assemble and then constrict the contractile ring to form a cleavage furrow.

288 n nodes from early interphase through to the contractile ring until cell separation.

289 vivo formation of actin cables or the actin contractile ring were identified.

290 is general node organization persists in the contractile ring where nodes move bidirectionally during

291 the type 2 node markers incorporate into the contractile ring, whereas type 1 nodes with Cdr1p and Cd

292 The contractile ring, which is predicted to provide only a t

293 s of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting

294 sulting in a net pulling of the nodes into a contractile ring, while cross-linking interactions help

295 s requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remai

296 s in the spatial cues that dictate where the contractile ring will form.

297 Although both proteins localize to the contractile ring, with Cdc15 preceding Imp2, only cdc15

298 proteins control assembly of the cytokinetic contractile ring, yet it remains unclear how those prote

299 In Escherichia coli, a contractile ring (Z-ring) is formed at midcell before cy

300 ofilaments, which forms the scaffold for the contractile ring (Z-ring) to achieve bacterial cell divi