ライフサイエンスコーパス: contractility

1 dynamics can be manipulated to alter muscle contractility.

2 retch-sensitive proteins, up-regulating cell contractility.

3 to regulate actin cytoskeletal dynamics and contractility.

4 tem cells (NSCs) by suppressing cytoskeletal contractility.

5 ts were independent of changes in actomyosin contractility.

6 ic channel that regulates cell migration and contractility.

7 dback mechanism that regulates smooth muscle contractility.

8 ship can be shifted by inhibiting actomyosin contractility.

9 proliferation, but by myosin II-driven cell contractility.

10 Rac1/Rho-mediated regulation of cytoskeletal contractility.

11 gh Ca(v)1.2 and, consequently, cardiomyocyte contractility.

12 a high density of cardiomyocytes for optimal contractility.

13 e (SERCA), which plays a lead role in muscle contractility.

14 e next probed effects on human cardiomyocyte contractility.

15 divisions with ectopic activation of apical contractility.

16 in advanced heart failure impair myocardial contractility.

17 oliferation, migration, differentiation, and contractility.

18 (1)-ARs, leading to increased heart rate and contractility.

19 cytoskeletal gene expression, and actomyosin contractility.

20 tween the secretion machinery and actomyosin contractility.

21 acellular calcium regulation as a readout of contractility.

22 tomyosin dysfunction and cell membrane hyper-contractility.

23 , where they in turn limit RhoA activity and contractility.

24 ith the polarity protein Par3 and actomyosin contractility.

25 nes play a key role in modulating myocardial contractility.

26 um signaling pathways to coordinate cellular contractility.

27 ze cell behaviours by controlling actomyosin contractility.

28 ms of drug-induced effects on cardiac muscle contractility.

29 ls inhibited calcification and enhanced cell contractility.

30 beating rate and significant enhancement of contractility.

31 because of a decrease in myosin II-mediated contractility.

32 ft ventricular hypertrophy and cardiac hyper-contractility.

33 nificantly prolonged due to impaired colonic contractility.

34 ding protein-C (cMyBP-C) accelerates cardiac contractility.

35 er is required for the regulation of cardiac contractility.

36 at potentially involve differential cortical contractility.

37 of the effects of MO on fetal cardiomyocyte contractility.

38 n of extracellular matrix proteins, and cell contractility.

39 hypertrophy is a compensation for decreased contractility.

40 tive regulator of RHO-1/Rho and spermathecal contractility.

41 rization/turnover defects, thereby affecting contractility.

42 ate actin cytoskeleton assembly and cellular contractility.

43 multaneous measurements of 5-HT overflow and contractility.

44 -specific inhibition on calcium kinetics and contractility.

45 D and can detect induced changes in load and contractility.

46 cardiac nerve plexus to enhance ventricular contractility.

47 sarcomere protein misalignment and impaired contractility.

48 oA and its cytoskeletal effectors to inhibit contractility.

49 ng e.g. motility, differentiation and muscle contractility.

50 R that both triggers arrhythmias and impairs contractility.

51 n shown to cause acute reductions in cardiac contractility.

52 TRPM4 that KCTD5 promotes cell migration and contractility.

53 dP/dt(Max)) indicated changes in ventricular contractility.

54 receptor (RyR2), critically regulate cardiac contractility.

55 intain the shape independent from actomyosin contractility.

56 via cytoskeletal remodelling and actomyosin contractility(1-3).

57 II cadherin, Cadherin2, patterns actomyosin contractility along tissue boundaries to control zipperi

58 In vitro studies suggest that contractility also depends on the geometrical organizati

59 This increased contractility also impaired movement of basal progenitor

60 rturbations in vivo, we show that actomyosin contractility and actin polymerization together push on

61 structures, leading to increased actomyosin contractility and amoeboid migration.

62 During heart formation, for example, contractility and blood flow generate biomechanical cues

63 1 channels in regulation of arterial myocyte contractility and blood pressure.

64 parks in SMCs and the regulation of vascular contractility and blood pressure.

65 Consistent with reduced contractility and calcium (Ca(2+)) currents, the cytosol

66 bsequent in vitro analyses addressed cardiac contractility and calcium handling in isolated tissues a

67 as activation of Rho enhances acto-myosin II contractility and cell retraction.

68 this study shows that a balance between cell contractility and cell-cell adhesion is crucial for prom

69 aglandins (PGs) play key roles in myometrial contractility and cervical ripening.

70 multiple pulses overcomes the saturation of contractility and confirms this experimentally.

71 y the cell-cycle oscillator through cortical contractility and cytoplasmic flows.

72 ts have slow muscle relaxation, compromising contractility and daily life activities.

73 diminution of the VSMC layer with attenuated contractility and decreased systemic as well as right ve

74 died the role of GPRC5B in the regulation of contractility and dedifferentiation in human and murine

75 are often characterized by altered cellular contractility and deformability, lending them the flexib

76 tion-contraction coupling, impairing myocyte contractility and delaying relaxation, along with altere

77 ynamic measurement revealed improved cardiac contractility and diastolic relaxation in treated mice c

78 oupled receptors are important regulators of contractility and differentiation in vascular smooth mus

79 l vacuolization along with decreased myocyte contractility and disrupted Ca(2+) cycling.

80 na1 in zebrafish resulted in reduced cardiac contractility and early lethality.

81 ur model, utilizing heterogeneous cell-layer contractility and elastic moduli values based on experim

82 uate aortic root widening and improve aortic contractility and elasticity in MFS mice.

83 dothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.

84 sferase CREBBP/EP300 is a major regulator of contractility and extracellular matrix production via co

85 ion inhibitory factor (MIF) in inhibiting PC contractility and facilitating neutrophil transmigration

86 lysophosphatidic acid-induced RhoA-mediated contractility and force generation by controlling lysoph

87 (2+) spark signaling, and thus regulation of contractility and function, in lower urinary tract SMCs.

88 ity is critical for regulation of actomyosin contractility and lumen opening.

89 xicity effects on human muscle regeneration, contractility and metabolic function in ALS.

90 ell-cell interaction networks showed that CM contractility and metabolism are the most prominent aspe

91 ion, translation, and signaling), organ (eg, contractility and metabolism), and whole-body (eg, physi

92 tive cortical processes including actomyosin contractility and microtubule sliding.

93 e through signal interference between apical contractility and mitosis.

94 d vimentin overexpressions did not alter BSM contractility and MLC(20) phosphorylation in strips isol

95 e, we identify MASTL as an activator of cell contractility and MRTF-A/SRF (myocardin-related transcri

96 tween cellular-level Rho GTPase activity and contractility and multicellular-level junctional forces.

97 s of culture and stained for markers of both contractility and myofibroblastic activation.

98 Heart muscle contractility and performance are controlled by posttran

99 nhibition of TLR4 or MD2 diminishes vascular contractility and reduces oxidative stress in the aorta

100 of cardiac function as well as cardiomyocyte contractility and reduction in adverse ventricular remod

101 tion in hearts from diabetic mice, improving contractility and relaxation while restoring coronary pe

102 Nitroxyl donors have been shown to affect contractility and relaxation, but the mechanistic basis

103 olic function but impaired beta(1)AR-induced contractility and relaxation.

104 Currently, the effect of boron on cardiac contractility and remodeling is unknown.

105 n cardiomyocytes have major implications for contractility and rhythm, but compared to HFrEF, very li

106 h both TPM1 and VCL variants display reduced contractility and sarcomeres that are less organized.

107 load-independent marker of left ventricular contractility and should be not used to track contractil

108 ported that clenbuterol-induced increases in contractility and skeletal muscle hypertrophy were lost

109 hat common assumptions of uniformity in cell contractility and stiffness break down in postconfluence

110 SHP platform capable of assessing myocardial contractility and suggests that metabolic parameters alo

111 cale-invariant relationship between spheroid contractility and the surrounding matrix deformations.

112 TRPV4 may also directly regulate detrusor contractility and the urothelial barrier function.

113 nisms by which SLN modulates SERCA-dependent contractility and thermogenesis remain unclear.

114 junctions, helping maintain balanced apical contractility and tissue integrity.

115 cularization of the retinal TS increased its contractility and tone and raised the intravascular pres

116 activation impairs RhoA activity, actomyosin contractility and viscoelasticity, eliciting mitotic fai

117 itochondrial and metabolic processes, muscle contractility) and reduced expression of pacemaker gene

118 lower SR Ca(2+) load and depressed cellular contractility) and SERCA2a downregulation in ventricular

119 t collagen remodeling, reduced smooth muscle contractility, and dysfunctional mechanosensing or mecha

120 l properties, like substrate stiffness, cell contractility, and forces generated by adjacent cells.

121 ion of individual elastic lamellae, lost SMC contractility, and GAG production within an intra-lamell

122 e for MASTL as a regulator of cell adhesion, contractility, and MRTF-A/SRF activity.

123 senting 16 motors, reduced force generation, contractility, and the total connectivity of filament ne

124 cellular junctions in response to actomyosin contractility, and this mechanosensitivity requires Abl-

125 e, that effects of compromised smooth muscle contractility are more important in terms of dysfunction

126 of mitochondrial dynamics on skeletal muscle contractility are poorly understood.

127 sults suggest that Rho/ROCK and actinomyosin contractility are regulated by AMP/ATP levels independen

128 The exact mechanisms that lead to this contractility are unknown, although some models posit th

129 signals spatially define regions of cortical contractility are unresolved.

130 elease and its influences on skeletal muscle contractility are widely used as experimental tools to s

131 4 days) had no significant effect on cardiac contractility as measured by ejection fraction.

132 he sensor was able to monitor a reduction in contractility as well as an increase in 5-HT overflow as

133 hree- or fourfold increase in all metrics of contractility, as well as myocardial energy production a

134 Using homology modeling and binding and contractility assays with recombinant KBTBD13, Kbtbd13-k

135 scle relaxation, muscle fiber- and sarcomere-contractility assays, low-angle x-ray diffraction, and s

136 analyzed using a combination of muscle fiber contractility assessments, RNA sequencing, and undirecte

137 otinic acid receptor agonists impair cardiac contractility associated with a decline in cardiac energ

138 nhibition of JNK2 may improve diminished BSM contractility associated with obstructive bladder diseas

139 output of active RhoA to control actomyosin contractility at epithelial junctions and during cell di

140 hemocyte migration by controlling actomyosin contractility at the cell rear, whereas its role in phag

141 results identify 14-3-3 binding to PLN as a contractility-augmenting mechanism.

142 es, we found that DeltaK210 not only reduces contractility but also causes cellular hypertrophy and i

143 htly controlled by high levels of actomyosin contractility, but how it is coupled to other cytoskelet

144 X conformation, which enhanced cardiomyocyte contractility, but impaired relaxation and evoked hypert

145 ted hydrogen peroxide decreases spermathecal contractility by inhibition of RHO-1, which depends on a

146 onstrated that mitotic entry reverses apical contractility by interfering with medioapical RhoA signa

147 We observed that MO impaired cardiomyocyte contractility by reducing peak shortening and shortening

148 oles in controlling cardiac gene expression, contractility, Ca(2+)-handling, electrophysiological fun

149 ssociated with cardiac maturation, including contractility, calcium handling, metabolism, and hypertr

150 Effects of non-cardiac drugs on cardiac contractility can lead to serious adverse events.

151 ocal biochemical signaling that affects cell contractility, cell adhesion, and/or cell polarity but i

152 tubule organizing center triggers actomyosin contractility controlled by RhoA and its exchange factor

153 such as external stiffness and related cell contractility, controlled LAMTOR targeting to the cell p

154 with stable heart failure, left ventricular contractility could be accentuated without an increase i

155 inement-induced activation of RhoA/myosin-II contractility, coupled with LINC complex-dependent nucle

156 neous measurements of calcium transients and contractility demonstrated that VASH1 depletion speeds k

157 impacts the feedback and subsequently induce contractility-dependent alterations in the properties of

158 ype that promoted endothelial sprouting in a contractility-dependent manner.

159 vated by mechanical stretch in an actomyosin contractility-dependent manner.

160 stingly, carvedilol enhanced skeletal muscle contractility despite a lack of effect on skeletal muscl

161 Other cells responded with increased contractility despite unchanged Ca(2+) release.

162 roteins and organelles, myosins can generate contractility, directly regulate actin assembly to ensur

163 logical inhibition of ROCK-driven actomyosin contractility does not impact the maintenance of tissue

164 Cell proliferation and actomyosin contractility dominate tissue architectures in monolayer

165 .3 +/- 929.5 vs. 492.7 +/- 308.1; myocardial contractility, dP/dt(max) : 2748.9 +/- 1514.9 vs. 763.7

166 Actomyosin cortical contractility drives many cell shape changes including c

167 al regulator, activating cortical actomyosin contractility during cytokinesis and other events.

168 ble for regulating multicellularity and cell contractility during sprouting.

169 Increased cardiac contractility during the fight-or-flight response is cau

170 increased baseline RhoA activity and pulsed contractility during zygote polarization.

171 ng performance/respiration and cardiomyocyte contractility dynamics in mahi-mahi (Coryphaena hippurus

172 Lack of Kindlin3 causes high microglial contractility, dysregulation of ERK signaling, excessive

173 yzing drug-treated hiPSC-CMs, confirming the contractility effects of compounds that directly activat

174 cle myosin II, inhibition of skeletal muscle contractility ex vivo, and slowing of in vitro actin-sli

175 Additionally, ex vivo contractility experiments showed that loss of Ca(2+) spa

176 en coupled with an index of left ventricular contractility for studying the ventricular-arterial coup

177 them shut and to prevent myosin II-dependent contractility from tearing cadherin adhesive contacts ap

178 While actomyosin contractility has been implicated in regulating nuclear

179 ll, our results do not support the increased contractility hypothesis.

180 action (cFTOE), cardiac output (CO), cardiac contractility (iCON) and systemic vascular resistances (

181 the in-vivo cardiac pyruvate metabolism and contractility in a porcine model of chronic pulmonary in

182 regulation of Ca(2+)-signaling activity and contractility in bladder and urethral smooth muscle cell

183 t mechanisms may be responsible for impaired contractility in CA, with an amyloid burden effect in tr

184 sed changes in sarcomere function to augment contractility in cardiac muscle.

185 ontractility and should be not used to track contractility in critically ill patients.

186 ere protein misalignment as well as impaired contractility in DCM TnT-R173W iPSC-CMs.

187 Oral Study of Myosin Activation to Increase Contractility in Heart Failure).

188 is sufficient to lower stiffness and improve contractility in HF.

189 the signaling pathways regulating actomyosin contractility in live adult animals.

190 dy points to an essential role of actomyosin contractility in maintaining the integrity of the nucleu

191 culture medium, we prolong the small airway contractility in mouse PCLS for up to two weeks.

192 artery diameter and increased uterine artery contractility in normoxic mice, providing evidence that

193 modulating adipogenesis, HA production, and contractility in orbital fibroblasts.

194 morphology and function and improves cardiac contractility in rats with heart failure, suggesting tha

195 tory contractions may contribute to enhanced contractility in response to inotropic stimuli.

196 e in actin retrograde flow rate and cellular contractility in S2 and S2R+ cells, respectively.

197 acts with SERCA and differentially regulates contractility in skeletal and atrial muscle.

198 Actomyosin-based contractility in smooth muscle and nonmuscle cells is re

199 t2 to control local F-actin organization and contractility in this subcellular region and promote tra

200 senchymal differentiation, and myofibroblast contractility, in which NUAK1 or NUAK2 silencing enhance

201 ked improvements in both global and regional contractility, increased muscle mass and reduced scar si

202 Mb (100 ug/mL) reduced the vascular contractility induced by phenylephrine (PE), and caused

203 perties of individual cells (polarizability; contractility) influence the emerging collective motion

204 keletal relaxation that occurs when cortical contractility is down-regulated at the junctions between

205 Cardiac contractility is enhanced by phosphorylation of myosin l

206 Cortical contractility is further found to limit the cells motili

207 ch are sensitive to blebbistatin, suggesting contractility is increased.

208 Any direct inhibition of UBSM contractility is likely to be from non-specific effects

209 gonists, and thus adrenergic augmentation of contractility is markedly impaired in isolated cardiomyo

210 and actomyosin, ensuring that cell membrane contractility is tightly controlled to execute proper da

211 While positive regulation of contractility is well characterized, counterbalancing ne

212 between heart rate and left ventricular (LV) contractility known as the force-frequency relationship

213 Loss of contractility leading to stasis of blood flow following

214 ourse of the aging process, fibroblasts lose contractility, leading to reduced connective-tissue stif

215 ly inhibits calcium influx and smooth muscle contractility, leading to voiding dysfunction.

216 ding axis promotes furrow formation at lower contractility levels.

217 recognized as a key regulator of myocardial contractility, little is known about its mechanism of ac

218 This benign increase in contractility may benefit patients admitted for acute de

219 w that local fibre organization and cellular contractility mediate this process and that the aberrant

220 Our results indicate that cell contractility mediates integrin signaling via inside-out

221 deformations are regulated by RhoA-mediated contractility, membrane trafficking, and adhesion recept

222 Thus, human cardiomyocyte contractility model could accurately facilitate informed

223 develop an adult human primary cardiomyocyte contractility model that has the potential to provide a

224 Spatiotemporal patterning of contractility modulates pressure-driven strain for regio

225 Prior studies of cardiac contractility modulation (CCM) employed a 3-lead Optimiz

226 by repair factor overexpression and also by contractility modulators in clinical trials.

227 and cardiovascular disease, including heart contractility, myocyte hypertrophy, arterial stiffness,

228 in light-chain kinase-mediated myofibroblast contractility, myofibroblast migration, myofibroblast co

229 agnitude of matrix deformations to the total contractility of arbitrarily sized spheroids.

230 ology for the first time to characterize the contractility of cardiac cells in response to Blebbistat

231 stinct mouse lines, we found that increasing contractility of differentiated cells resulted in non-ce

232 show that dynamic (D) hydrogels increase the contractility of human endothelial colony-forming cells

233 The maximum contractility of human heart failure myocardial slices a

234 ective forces of tumor spheroids reflect the contractility of individual cells for up to 1 hr after s

235 we followed changes in Ca(2+) signaling and contractility of individual cells under sustained applic

236 fering with extrinsic forces by reducing the contractility of interphasic blastomeres or disrupting t

237 ized tissue assembly, electrophysiology, and contractility of neonatal rat ventricular cardiomyocytes

238 NMJ), end-plate structure of NMJs and muscle contractility of semitendinosus muscles.

239 ) affects 1 in 500 people and leads to hyper-contractility of the heart.

240 bismus was compensated mainly by significant contractility of the lateral more than the medial compar

241 Contractility of the nonmuscle and smooth muscle cells t

242 Contractility of the rectus and superior oblique (SO) ex

243 eparation for delivery, the excitability and contractility of the uterine smooth muscle layer, the my

244 demonstrate that EC-derived MIF decreases PC contractility on 2-dimensional silicone substrates via r

245 but were not necessary for initiating apical contractility or adherens junction assembly.

246 ut did not demonstrate an improvement in the contractility or an improved relaxation of the left vent

247 is that myosin HCM mutations increase muscle contractility, or causes a gain in function; instead, it

248 calcium signaling, modulation of actomyosin contractility, or mitosis.

249 relatively low-throughput, indirectly assess contractility, or only assess well-aligned sarcomeres fo

250 lower ventricular efficiency ( P<0.0001) and contractility ( P<0.0001) in patients with heart failure

251 Increases in contractility (P < 0.05) and coronary blood flow (P < 0.

252 ion based on cluster analysis of a set of 12 contractility parameters.

253 allenges in assessing drug effect on cardiac contractility point to the fundamental translational val

254 MyBP-C modulates muscle contractility, presumably through its N terminus extendi

255 nvolves ratcheting behavior whereby periodic contractility produces transient changes in cell-cell co

256 noceptor on skeletal muscle proteostasis and contractility properties in neurogenic myopathy in mice.

257 ments in skeletal muscle autophagic flux and contractility properties in neurogenic myopathy, without

258 tion on the skeletal muscle proteostasis and contractility properties in neurogenic myopathy.

259 sed skeletal muscle cross-sectional area and contractility properties.

260 ds for performing mechanical measurements of contractility, ranging from single cell techniques to mu

261 l mydriasis is due to reduced iris sphincter contractility rather than its absence.

262 21 TLOs contained FRC-like cells with higher contractility, regulatory, and anti-inflammatory propert

263 mere function, and cell biology, we assessed contractility, relaxation, and cardiomyocyte morphology

264 ed with Palm, T2DM hearts exhibited improved contractility/relaxation compared to WT, accompanied by

265 upon RLC, in the regulation of cardiomyocyte contractility remains poorly understood.

266 Accordingly, mild inhibition of actomyosin contractility rescued fibroblast polarization even on th

267 blood flow-we find that inducing actomyosin contractility rescues cardiomyocyte delamination and is

268 itors as inotropic therapies for maintaining contractility reserve after hypertrophic stress.

269 onal defects, including reduced or abolished contractility, respectively.

270 idly decreases upon inhibition of actomyosin contractility (specifically, of myosin ATPase, Rho kinas

271 In vitro contractility studies determined a decreased basal detru

272 ic interactions of cell cycle and actomyosin contractility systems synchronize nuclear cleavages, gen

273 en implicated as regulators of smooth muscle contractility, though they display different sensitiviti

274 indicate that MO impairs fetal cardiomyocyte contractility through altered intracellular Ca(2+) handl

275 e attributed to the modulation of actomyosin contractility through changes in RhoA and septin signali

276 e compact layer and drives those with higher contractility to delaminate and seed the trabecular laye

277 and acts synergistically with RhoA/myosin-II contractility to further augment blebbing in confinement

278 demonstrate a high sensitivity of lymphatic contractility to K(ATP) channel activators through activ

279 Pp1 further restricts actomyosin contractility to the cluster periphery rather than at in

280 es from expanded hiPSC-CMs showed comparable contractility to those from unexpanded hiPSC-CMs, demons

281 Hierarchical clustering of contractility transient parameters, coupled with princip

282 ia also inhibited CA4P-mediated actinomyosin contractility, VE-cadherin junction disruption and perme

283 YK-461) myosin molecules or indirectly alter contractility (verapamil and propranolol).

284 tionally, [Na(+)](o) modulates cardiomyocyte contractility via a sodium-calcium exchanger (NCX) media

285 ctin receptors (AdipoRs) decrease myometrial contractility via AMPK to promote uterine quiescence in

286 GCK-1 and CCM-3 regulate cortical actomyosin contractility via negative feedback.

287 erived neurotrophic factor (BDNF), on airway contractility [ via increased airway smooth muscle (ASM)

288 teract to regulate keratocyte activation and contractility, we cultured primary rabbit corneal kerato

289 Using optogenetic control of actomyosin contractility, we find that epithelial junctions show el

290 Development and baseline contractility were analyzed by video-optical recording.

291 fibers of differing metabolic activities and contractility, which become remodeled in response to chr

292 ons highlight the crucial role of actomyosin contractility, which is required to trigger the instabil

293 al is associated with a defect in actomyosin contractility, which results from inappropriate RhoA act

294 e of carvedilol to stimulate skeletal muscle contractility while avoiding the adverse effects with be

295 cle cells promoted calcification and reduced contractility, while inhibition of HDAC9 in human aortic

296 Surprisingly, inhibiting cellular contractility with blebbistatin did not affect the exten

297 cs via statistical mechanics, allowed better contractility with coarse graining, though connectivity

298 fication of all major drug classes affecting contractility with detection sensitivities higher than i

299 n the subcellular distribution of actomyosin contractility, with pMLC localized at the tips of thin c

300 is a highly sensitive tool to evaluate cell contractility within a soft extracellular matrix (ECM) e

301 e, and density depending on patterns of cell contractility within them.