ライフサイエンスコーパス: conventional dendritic cell

1 impaired for viral entry in comparison with conventional dendritic cells.

2 immune cells was limited to a subset of CD8+ conventional dendritic cells.

3 okines and chemokines by bone marrow-derived conventional dendritic cells.

4 issue distribution that differs from that of conventional dendritic cells.

5 guishes them from other cell types including conventional dendritic cells.

6 lacked circulating B cells and possessed few conventional dendritic cells.

7 dritic cells in vivo and IL-23 and IL-36a in conventional dendritic cells.

8 ic cells in vivo and IL-23 and IL-36alpha in conventional dendritic cells.

9 A9(+) macrophages and S100(hi)HLA(lo) type 2 conventional dendritic cells.

10 s-presented Ag by depleting cross-presenting conventional dendritic cells.

11 persistent TLR4-mediated activation of lung conventional dendritic cells.

12 CD169-mediated retroviral capture activated conventional dendritic cells 1 (cDC1s) and promoted cyto

13 es ZBTB46, a transcription factor specifying conventional dendritic cells(16-20).

14 ived dendritic cells and langerin-expressing conventional dendritic cells 2 (cDC2).

15 Colon gamma/delta T cells in mice that lack conventional dendritic cells 2 produced increased amount

16 al gating confirmed increased frequencies of conventional dendritic cells (3.1% versus 2.1%; P = 0.02

17 ours after local allergen challenge, whereas conventional dendritic cells accumulated after several d

18 lly dichotomous, and pure cultures of type 2 conventional dendritic cells acquire these states (terme

19 tion with Th2 polarization in the absence of conventional dendritic cell activation.

20 able for their ability to differentiate into conventional dendritic cells after appropriate stimulati

21 phages and cluster of differentiation 11b(+) conventional dendritic cells after myocardial infarction

22 a consistently sparse population of resident conventional dendritic cells, among the last cells to in

23 frequencies of plasmacytoid dendritic cells, conventional dendritic cells and B lineage cells but an

24 was due to type I IFN-dependent depletion of conventional dendritic cells and could be reproduced by

25 transcription factor that is shared between conventional dendritic cells and ILC3s, and identify a c

26 es and co-localization of cytotoxic T cells, conventional dendritic cells and inflammatory fibroblast

27 nd activation of immune cells, in particular conventional dendritic cells and Langerhans cells, accou

28 in a paracrine manner, incited activation of conventional dendritic cells and lymphocytes in Cre(LysM

29 tly and inhibited TLR-mediated activation of conventional dendritic cells and macrophages.

30 on their role in the modulation of CD11b(+) conventional dendritic cells and monocyte-derived dendri

31 opharyngeal CCL13 levels locally produced by conventional dendritic cells and monocytes, along with c

32 iated with a reduction of pulmonary CD11b(+) conventional dendritic cells and regulation of CD4(+) T-

33 enerate pDCs, MPs were polarized to generate conventional dendritic cells and the kinetics of pDC gen

34 fy a potential role for activated monocytes, conventional dendritic cells, and CD21(+)/CD23(-) B cell

35 ignificant increases in activated monocytes, conventional dendritic cells, and CD21(+)/CD23(-) B cell

36 ial lymphocytes, lamina propria lymphocytes, conventional dendritic cells, and enterocytes.

37 the development of NK cells and CD8alpha(+) conventional dendritic cells, and is also involved in ma

38 lopmentally and phenotypically distinct from conventional dendritic cells, and its expression is impr

39 ected in South African children's monocytes, conventional dendritic cells, and plasmacytoid dendritic

40 rinsic MHC-II expression but rather required conventional dendritic cells as well as MHC-II expressio

41 molecules produced mainly by macrophages and conventional dendritic cells, as well as type I interfer

42 l types of professional APC exist, including conventional dendritic cells, B cells and macrophages, a

43 0 is transiently expressed on the surface of conventional dendritic cells, but is constitutively expr

44 Stimulation of conventional dendritic cells by IL-25 promoted proximal

45 Targeting Ags to conventional dendritic cells can enhance Ag-specific imm

46 associated with an increase in the number of conventional dendritic cells, CD11b(+) and CD103(+) dend

47 s) promote the expansion of subsets of CD1c+ conventional dendritic cells (CD1c+ DCs), but the molecu

48 suppressor cells while also impairing type I conventional dendritic cell, CD8+ T-cell, and NK cell fu

49 odes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains po

50 Here, we used two conventional dendritic cell (cDC) depletion systems to i

51 ins phenotypically and functionally distinct conventional dendritic cell (cDC) subpopulations, termed

52 atients, identifying specific macrophage and conventional dendritic cell (cDC) subsets as key mediato

53 onstrated that the heart contained two major conventional dendritic cell (cDC) subsets, CD103(+) and

54 plasmacytoid dendritic cells (pDCs) and two conventional dendritic cell (cDC) subsets, cDC1 and cDC2

55 Development and function of conventional dendritic cell (cDC) subsets, cDC1 and cDC2

56 ing pDC to a professional antigen-presenting conventional dendritic cell (cDC) that lacks IFN-I-secre

57 ATRC-101 increased the relative abundance of conventional dendritic cell (cDC) type 1 cells in the bl

58 at in situ reprogramming of tumor cells into conventional dendritic cell (cDC)-like cells using viral

59 Whether conventional dendritic cells (cDC) acquire subset identi

60 Conventional dendritic cells (cDC) and macrophages exhib

61 function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs

62 Conventional dendritic cells (cDC) are antigen-presentin

63 Conventional dendritic cells (cDC) are key activators of

64 Conventional dendritic cells (cDC) are necessary and suf

65 Conventional dendritic cells (cDC) are professional anti

66 Conventional dendritic cells (cDC) control adaptive immu

67 xpansion and activation of type 1 and type 2 conventional dendritic cells (cDC) in the dural meninges

68 small percentage of CD103(neg) and CD103(+) conventional dendritic cells (cDC) in the intestinal lam

69 APCs, antagonizes inflammation by affecting conventional dendritic cells (cDC), inducing IL-10, and

70 nscriptional changes in resident CD1C+/CD1A+ conventional dendritic cells (cDC)2 following challenge.

71 Type 1 conventional dendritic cells (cDC1) can support T cell r

72 ntracellular processing route used by type I conventional dendritic cells (cDC1) for cross-presentati

73 promote CD8(+) T cell clustering with type 1 conventional dendritic cells (cDC1) in the T cell zone b

74 terleukin (IL)-12 by tissue-resident XCR1(+) conventional dendritic cells (cDC1) promoted ILC1 produc

75 show that the human chemokines bound type 1 conventional dendritic cells (cDC1), and that immunizati

76 esponses by reducing the abundance of type 1 conventional dendritic cells (cDC1), but the mechanism r

77 nd activation by enhancing the maturation of conventional dendritic cells (cDC1), ultimately resultin

78 ional antigen-presenting cells termed type-1 conventional dendritic cells (cDC1).

79 Further characterization of mregDCs versus conventional dendritic cells (cDC1/cDC2) highlights thei

80 my between IRF8(+) type 1 and IRF4(+) type 2 conventional dendritic cells (cDC1s and cDC2s, respectiv

81 Type I conventional dendritic cells (cDC1s) are an essential Ag

82 Batf3-dependent type 1 conventional dendritic cells (cDC1s) are important in in

83 Type 1 CD8alpha(+) conventional dendritic cells (cDC1s) are required for CD

84 reatitis (ptPDAC), antigen-presenting type I conventional dendritic cells (cDC1s) are specifically ac

85 Type 1 conventional dendritic cells (cDC1s) are typically thoug

86 Type 1 conventional dendritic cells (cDC1s) are unique in their

87 of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to under

88 Although type 1 conventional dendritic cells (cDC1s) were dispensable fo

89 lled MHC-II tumour antigen-presenting type 1 conventional dendritic cells (cDC1s), leading to low num

90 nanoparticles (AC-NPs) and migratory type 1 conventional dendritic cells (cDC1s), named Antigen Capt

91 Here, we report that type 1 conventional dendritic cells (cDC1s), which are defined

92 presentation of exogenous antigens by type 1 conventional dendritic cells (cDC1s).

93 ng to eliminate cross-presentation by type 1 conventional dendritic cells (cDC1s).

94 Type 2 conventional dendritic cells (cDC2s) are central orchest

95 Type 2 conventional dendritic cells (cDC2s) are functionally an

96 e doubling of the number of activated type 2 conventional dendritic cells (cDC2s) in draining lymph n

97 miasis induced expansion of pulmonary type-2 conventional dendritic cells (cDC2s) in human and murine

98 , one of the most important alkylphenols, on conventional dendritic cells (cDCs) and adaptive T-cell

99 immune receptors often induce activation of conventional dendritic cells (cDCs) and enhance antigen

100 ls of BAFF; other myeloid subsets, including conventional dendritic cells (cDCs) and monocyte (MO) su

101 ses against blood-borne pathogens, including conventional dendritic cells (cDCs) and MZ B cells.

102 Surprisingly, both conventional dendritic cells (cDCs) and plasmacytoid DCs

103 high-level expression of type 1 IFNs by both conventional dendritic cells (cDCs) and plasmacytoid den

104 Conventional dendritic cells (cDCs) are arguably the mos

105 Antigen-presenting conventional dendritic cells (cDCs) are broadly divided

106 Conventional dendritic cells (cDCs) are comprised of two

107 Conventional dendritic cells (cDCs) are critical APCs fo

108 Conventional dendritic cells (cDCs) are critical for pro

109 Macrophages and conventional dendritic cells (cDCs) are distributed thro

110 Conventional dendritic cells (cDCs) are important antige

111 Conventional dendritic cells (cDCs) are potent antigen-p

112 Conventional dendritic cells (cDCs) are sentinel cells t

113 Conventional dendritic cells (cDCs) are sentinels of the

114 Rather, we identified conventional dendritic cells (cDCs) as a source of hepci

115 Conventional dendritic cells (cDCs) can integrate multip

116 Conventional dendritic cells (cDCs) consist of two major

117 Lung-resident conventional dendritic cells (cDCs) coordinate immune re

118 antigen presentation molecule expression on conventional dendritic cells (cDCs) early after infectio

119 Skin conventional dendritic cells (cDCs) exist as two distinc

120 In humans, conventional dendritic cells (cDCs) exist as two unique

121 immature, a small population of CD11c(high) conventional dendritic cells (cDCs) exists that expresse

122 the generation of CD103(+)CD11c(hi)MHCII(hi) conventional dendritic cells (cDCs) from Flt3L-mobilized

123 The existence of conventional dendritic cells (cDCs) has not yet been dem

124 We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis ind

125 I IFN-driven upregulation of FcepsilonRI on conventional dendritic cells (cDCs) in the lung.

126 , DT treatment altered the representation of conventional dendritic cells (cDCs) in the skin-draining

127 Conventional dendritic cells (cDCs) include functionally

128 Maturation of conventional dendritic cells (cDCs) is crucial for maint

129 n, we found that the number and frequency of conventional dendritic cells (cDCs) is dependent on micr

130 TLR-stimulated cross-presentation by conventional dendritic cells (cDCs) is important in host

131 Conventional dendritic cells (cDCs) play an essential ro

132 r, it is unclear whether specific subsets of conventional dendritic cells (cDCs) promote the differen

133 9G2(+) NK cells stabilized and then enhanced conventional dendritic cells (cDCs) recovery after infec

134 t of plasmacytoid dendritic cells (pDCs) and conventional dendritic cells (cDCs) requires the ligand

135 In contrast to conventional dendritic cells (cDCs) that are constantly

136 ified the medLNs with an increased number of conventional dendritic cells (cDCs) that mediate enhance

137 unexpectedly induces IL-1beta production in conventional dendritic cells (cDCs) via a STAT3-dependen

138 Here we show that IL-21 induced apoptosis of conventional dendritic cells (cDCs) via STAT3 and Bim, a

139 Two subsets of conventional dendritic cells (cDCs) with distinct cell s

140 hat localized proximal to IL-1beta-producing conventional dendritic cells (cDCs) within SLT.

141 required for the development of CD8alpha(+) conventional dendritic cells (cDCs), but the basis for t

142 plasmacytoid dendritic cells (pDCs) and two conventional dendritic cells (cDCs), ccl35+ cDCs and cnn

143 Conventional dendritic cells (cDCs), cDC1 and cDC2, act

144 We found that conventional dendritic cells (cDCs), defined in mice via

145 ore, NK cell transfer augments activation of conventional dendritic cells (cDCs), Foxp3(-)CD4(+) T ce

146 The THSCs--two types of conventional dendritic cells (cDCs), plasmacytoid dendri

147 numbers of Batf3- and Irf8-dependent CD103+ conventional dendritic cells (cDCs), providing new oppor

148 In conventional dendritic cells (cDCs), Src is involved in

149 likely the inability to sufficiently engage conventional dendritic cells (cDCs), the antigen-present

150 Two conventional dendritic cells (cDCs), the CD8alpha(+)Sirp

151 In conventional dendritic cells (cDCs), the TLR4 ligand bac

152 of SLOs, neighboring pre-dendritic cells and conventional dendritic cells (cDCs).

153 response is associated with the presence of conventional dendritic cells (cDCs).

154 ogocytic acquisition of these molecules from conventional dendritic cells (cDCs).

155 gnize antigens presented by tumor-associated conventional dendritic cells (cDCs).

156 demonstrate that the impairment lies within conventional dendritic cells (cDCs).

157 lung cancer are differences in infiltrating conventional dendritic cells (cDCs).

158 infection is the cGAS-STING pathway, whereas conventional dendritic cells (DC) exploit endosomal reco

159 n vitro and in vivo responses of mouse IKDC, conventional dendritic cells (DC), and natural killer (N

160 Type 1 conventional dendritic cells (DC1s) showed a mLN-specifi

161 asmacytoid dendritic cells (pDCs) and type 2 conventional dendritic cells (DC2s) stimulated with Delt

162 CD141 and CD161 monocytes, absence of CD11c1 conventional dendritic cells (DCs) and CD11c1/CD1231 pla

163 strongly upregulated on splenic CD8alpha(+) conventional dendritic cells (DCs) and plasmacytoid DCs

164 Conventional dendritic cells (DCs) are key APCs for T ce

165 -12 h of antigen administration, followed by conventional dendritic cells (DCs) at 12-24 h, then fina

166 More particularly, CD301b(+) type 2 conventional dendritic cells (DCs) in neonatal skin were

167 Conventional dendritic cells (DCs) in particular exist a

168 nced by costimulatory molecules expressed on conventional dendritic cells (DCs) in regional lymph nod

169 However, how conventional dendritic cells (DCs) orchestrate this adap

170 )34.5 is required to block the maturation of conventional dendritic cells (DCs) that initiate adaptiv

171 acid-related orphan receptor yt(+) cells and conventional dendritic cells (DCs) using germline and co

172 y deficiency affects antigen presentation in conventional dendritic cells (DCs) without impacting the

173 ranasal vaccination, neutrophils, monocytes, conventional dendritic cells (DCs), and monocyte-derived

174 recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in TH2 pol

175 , we assessed the deletion of ADAM17 in mice conventional dendritic cells (DeltaDC) and employed a co

176 where myeloid cells, such as macrophages and conventional dendritic cells, detect infections with her

177 d B and plasmacytoid dendritic cell, but not conventional dendritic cell development.

178 Conventional dendritic cells driven by the transcription

179 with Ebola virus under the same conditions, conventional dendritic cells expressed viral proteins wh

180 y well-organized T and B areas enmeshed with conventional dendritic cells, follicular dendritic cells

181 Reduced numbers of anti-viral type I conventional dendritic cells in asthma are associated wi

182 CII, XCR1, and other markers associated with conventional dendritic cells in mice.

183 ly to the MHC II self-peptidome presented by conventional dendritic cells in vivo.

184 s autoantigens presented by class II MHCs on conventional dendritic cells, including self-peptides th

185 A-aPC inhibited the inflammatory response of conventional dendritic cells independent of EPCR and sup

186 CD103(+) and CD11b(+) conventional dendritic cells interacted directly with TH

187 ted, including plasmacytoid dendritic cells, conventional dendritic cells, macrophages, and T cells,

188 asmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to ga

189 t blockade of IL-25 signaling in either lung conventional dendritic cells or in T cells resulted in s

190 or necrosis factor in macrophages and type 2 conventional dendritic cells partially through the neuro

191 main role as IFN-a-producing cells to a more conventional dendritic cell phenotype.

192 that mononuclear phagocytes such as CD11c(+) conventional dendritic cells play an important role in t

193 These data suggest that CXCR5-expressing conventional dendritic cells play an important role in t

194 itional and nonclassical monocytes and CD1c+ conventional dendritic cells preferentially migrate from

195 vity induced when these cells cocluster with conventional dendritic cells presenting Ag to naive Th c

196 c alpha1 subunit in alveolar macrophages and conventional dendritic cells produced less IL-13 and CCL

197 e used to determine whether CXCR5-expressing conventional dendritic cells propagate prions toward FDC

198 This led to type 1 conventional dendritic cell recruitment and synergized w

199 on, there was also a significant decrease in conventional dendritic cells recruitment to the lungs of

200 n this study that murine bone marrow-derived conventional dendritic cells responded to GBS by secreti

201 SuHx nonclassical monocytes and MCT conventional dendritic cells showed particularly strong

202 Although conventional dendritic cell subsets have received much a

203 o the chemokine XCL1, is highly expressed in conventional dendritic cells subtype 1 (cDC1s) and cruci

204 -induced cell death in plasmacytoid, but not conventional, dendritic cells, suggesting a context-depe

205 e with an expansion in the numbers of type-2 conventional dendritic cells, T effector cells, T follic

206 ammation, describing a GM-CSF-dependent lung conventional dendritic cell-T-cell-neutrophil axis that

207 in the specific absence of CXCR5-expressing conventional dendritic cells the early accumulation of p

208 es demonstrate the age-dependent function of conventional dendritic cells, their role in determining

209 s (MDPs) map with nonclassical monocytes and conventional dendritic cells; these localize to a subset

210 s promote the maturation and traffic of lung conventional dendritic cells to draining mediastinal lym

211 This suggests that prions exploit conventional dendritic cells to facilitate their initial

212 dsRNA by viral NS1 explains the inability of conventional dendritic cells to produce IFN-I on infecti

213 ted with enhanced influx of CD11b-expressing conventional dendritic cells to the lungs in response to

214 In addition, there are more conventional dendritic cell type 1 (cDC1) cells and fewe

215 alyzing Batf3(-/-) mice lacking the CD103(+) conventional dendritic cell type 1 (cDC1) subpopulation

216 Spleen conventional dendritic cells type 1 (cDC1) take up apopt

217 is deficit is preceded by poor activation of conventional dendritic cells type 2 (cDC2) due to reduce

218 l19 by a subpopulation of CD205(+)/CD172a(+) conventional dendritic cells type 2 and upregulation of

219 is Tfh-dominant response, whereas priming by conventional dendritic cells was dispensable.

220 etion of bone marrow-derived macrophages and conventional dendritic cells was equally inhibited by IN

221 We show in this article that lung-resident conventional dendritic cells were direct targets of IL-2

222 Macrophages, plasmacytoid, and conventional dendritic cells were each implicated based

223 We showed that conventional dendritic cells were the major sources of e

224 We created mice in which mobile conventional dendritic cells were unable to migrate towa

225 Numbers of type I conventional dendritic cells, which cross prime CD8(+) T

226 ot in Tmem176b-/- MHCII + CD11c high CD11b + conventional dendritic cells within the graft.