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1 f cross-species overlap in cancer-associated copy number aberrations.
2 profiles revealed numerous recurrent genomic copy number aberrations.
3 y modeling transformations of the genome via copy number aberrations.
4 ng of 232 LCINS showed 3 subtypes defined by copy number aberrations.
5 on as determined by somatic mutations and/or copy number aberrations.
6 mmune infiltration, high MYC expression, and copy number aberrations.
7 essential in tumor cells with high levels of copy number aberrations.
8 ion, expansive 3D growth, and high burden of copy number aberrations.
9         We also observe biases in chromosome copy number aberrations.
10 ferentially methylated regions and detecting copy number aberrations.
11 er genes are targeted by regional chromosome copy number aberrations.
12 led similar frequencies of recurrent genomic copy number aberrations.
13  few driver point mutations but abundant DNA copy number aberrations.
14 predominantly nonsilent mutations, and fewer copy number aberrations.
15 ng the statistical significance of recurrent copy number aberrations.
16 troduced for identifying common regions with copy number aberrations.
17 o distinguish between recurrent and sporadic copy number aberrations.
18 s, mutational profiles, gene expression, and copy-number aberrations.
19 omas had a significantly higher frequency of copy number aberrations (67%) than other subgroups (P =
20 .0 array-based genomic profiling of acquired copy number aberrations (aCNA) and copy neutral LOH (cnL
21 genesis of CLL as recurrent acquired genomic copy number aberrations (aCNA) and recurrent gene mutati
22 m 255 patients with CLL for acquired genomic copy number aberrations (aCNAs) with the use of ultra-hi
23                                              Copy number aberrations affected a mean of only 0.5% of
24                                We identified copy number aberrations affecting important tumor suppre
25                                              Copy number aberrations alter multiple adjacent genomic
26                 Significantly higher somatic copy number aberration and allelic imbalance burdens are
27               Cancer cells often exhibit DNA copy number aberrations and can vary widely in their plo
28                                      Genomic copy number aberrations and corresponding transcriptiona
29 also extend SubMARine to work with subclonal copy number aberrations and define equivalence constrain
30 nitiating cells have uncovered multiple gene copy number aberrations and have yielded new insight int
31 edominant UV mutational signature, increased copy number aberrations and increased mutant TP53 select
32  We validate our GBM cohort, finding similar copy number aberrations and mutated genes based on codin
33 g, which is limited in its ability to detect copy number aberrations and other genomic changes beyond
34 relationships of protein expression with DNA copy number aberrations and signatures of post-transcrip
35  variations, small insertions and deletions, copy number aberrations and structural variations in bot
36 on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the
37 igned to detect driver mutations, chromosome copy number aberrations, and mutation signatures.
38  novel biomarkers based on gene expressions, copy number aberrations, and mutations predictive of dru
39 omatic mutations (up to 50 bases in length), copy number aberrations, and structural rearrangements i
40 rrently mutated with coding point mutations, copy number aberrations, and their associations with pat
41  tumours were characterised by an absence of copy-number aberrations apart from LOH chromosome 16q, t
42 dual evolution, showing that the majority of copy number aberrations are acquired at the earliest sta
43 edian of 68.9% of point mutations and 83% of copy number aberrations are shared between different his
44                                     Although copy-number aberrations are known to contribute to the d
45 ic landscape of mCRC reveals a number of DNA copy number aberrations associated with response to drug
46                                              Copy number aberrations at these loci may define metasta
47                                          DNA copy number aberration--both inherited and sporadic--is
48                                         High copy number aberration burden is associated with worse p
49 ion of either single-nucleotide variation or copy number aberration, but not ideally for both.
50                             Detection of DNA copy number aberrations by shallow whole-genome sequenci
51 el approach for finding regions of recurrent copy number aberrations, called CNAnova, from Affymetrix
52                                The number of copy number aberration changes and biallelic inactivatio
53 CLLs by combining whole-exome sequencing and copy number aberration (CNA) analysis, which showed an a
54 epertoire associated with higher chromosomal copy number aberration (CNA) burden.
55                                          DNA copy number aberration (CNA) is a hallmark of genomic ab
56                  By comparing the cells' DNA copy number aberration (CNA) landscapes with those of th
57 a necessitates untangling the effects of the Copy Number Aberration (CNA) occurrence rates and the se
58                  We initially determined the copy number aberration (CNA) profiles of 74 patients wit
59 nd MYD88(L265P) mutation and the genome-wide copy number aberration (CNA) profiles of individual vitr
60 ntify potential driver genes on the basis of copy number aberration (CNA) regions of cancer genomes,
61 of metastasis, and to define multichromosome copy number aberration (CNA) signatures that can be used
62 es in 2,433 primary breast tumours that have copy number aberration (CNA), gene expression and long-t
63 se approach to identify the most significant copy number aberrations (CNA) and identified regions of
64                                          DNA copy number aberrations (CNA) are frequently observed in
65 s, we performed a genome-wide search for DNA copy number aberrations (CNA) in a panel of 33 tumors en
66                                              Copy-number aberration (CNA) analysis identified recurre
67 erived from breast tumours devoid of somatic copy-number aberrations (CNA-devoid) are consistently pr
68 volves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches.
69                Driver mutations, chromosomal copy number aberrations (CNAs) and aberrant DNA methylat
70 Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin remodeling,
71                                          DNA copy number aberrations (CNAs) and gene expression (GE)
72  (n = 29), for which genome-wide chromosomal copy number aberrations (CNAs) and mutational profiles f
73 ithm to simultaneously infer allele-specific copy number aberrations (CNAs) and reconstruct spatial t
74                                        These copy number aberrations (CNAs) can be detected at high r
75                                              Copy number aberrations (CNAs) have been commonly used t
76                                      Somatic copy number aberrations (CNAs) have been implicated in t
77 ymorphism (SNP) arrays allows measurement of copy number aberrations (CNAs) in cancer at more than on
78                           Studying recurrent copy number aberrations (CNAs) in human cancers would en
79 netic abnormalities, including the high-risk copy number aberrations (CNAs) of +1q21 and 17p(-).
80 -derived from real data-that contain somatic copy number aberrations (CNAs) of various lengths and fr
81 anding the biological and clinical impact of copy number aberrations (CNAs) on the development of pre
82 cleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expr
83                                              Copy number aberrations (CNAs) were established from 135
84  humans by comparing all D. rerio genes with copy number aberrations (CNAs) with a cohort of 75 publi
85 bled high resolution evolutionary studies of copy number aberrations (CNAs) within tumors.
86        The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of th
87 evelopment of numerous methods for detecting copy number aberrations (CNAs), a key driver of genetic
88 ic driver single nucleotide variants (SNVs), copy number aberrations (CNAs), and structural variants
89  analyzed single nucleotide variants (SNVs), copy number aberrations (CNAs), and subclonal architectu
90                                              Copy number aberrations (CNAs), which are pathogenic cop
91                                              Copy number aberrations (CNAs), which delete or amplify
92 detect single nucleotide variants (SNVs) and copy number aberrations (CNAs), while MutSigCV (SNVs) an
93 fferences: copy number variations (CNVs) and copy number aberrations (CNAs).
94 tations in bona fide drivers (TP53BP1, BLM), copy number aberrations (CNAs; 1qGain, 17pLOH), and doub
95 med to assess the prognostic significance of copy-number aberrations (CNAs) and copy-neutral loss of
96                                              Copy-number aberrations (CNAs) and whole-genome duplicat
97                                              Copy-number aberrations (CNAs) are genetic alterations t
98 s becoming common, yet most methods to infer copy-number aberrations (CNAs) from this data analyze in
99 ve from chemorefractory disease, we examined copy-number aberrations (CNAs) in circulating tumor cell
100 s limited their use to the analysis of large copy-number aberrations (CNAs) in individual cells.
101      We identified extensive allele-specific copy-number aberrations (CNAs) in these samples, includi
102 le nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs).
103                       MBCs showed unique DNA copy number aberrations compared with common breast canc
104  integrated the multi-omics datasets such as copy number aberration, DNA methylation, gene and microR
105 ype, or G-CIMP tumors, have distinct genomic copy number aberrations, DNA methylation patterns, and (
106 roups of meningioma by combining DNA somatic copy-number aberrations, DNA somatic point mutations, DN
107 ofiles to identify relationships between DNA copy number aberrations, gene expression alterations, an
108 q24 and a total number of independent genome copy number aberrations >7 are associated with reduced s
109 profiling remains difficult because true DNA copy-number aberrations have to be discriminated from WG
110 t cancer-specific survival (METABRIC cohort [copy number aberration]: hazard ratio [HR] 1.50, 95% CI
111 umor samples, we define regions of recurrent copy number aberration in breast cancer.
112 to investigate the prevalence of chromosomal copy number aberrations in 256 products of conception (P
113 eletions of 360 cancer genes and genome-wide copy number aberrations in 413 and 170 ILBC samples, res
114 ll variants were present in 94% of cases and copy number aberrations in at least one gene in 58% of c
115 We studied 282 females with SBC, focusing on copy number aberrations in cancer-free breast tissue (un
116 sistent with previous studies, such as large copy number aberrations in chromosome 8 and complex rear
117 enomic hybridization to identify and compare copy number aberrations in five mouse models of breast c
118 gested a breakpoint principle for intragenic copy number aberrations in fusion partners.
119  to increased genome instability and genomic copy number aberrations in genes implicated in EGFR TKI
120 at molecular subtypes are linked to specific copy number aberrations in genes such as mutant KRAS and
121                                              Copy number aberrations in primary tumors and matched me
122  that triple-negative breast cancers acquire copy number aberrations in short punctuated bursts in th
123 e (76 versus 27%; P = 0.001) and type of DNA copy number aberrations in TCV compared with cPTC.
124 allows quantitative detection and mapping of copy number aberrations in tumors and subsequent associa
125           We determined relative chromosomal copy-number aberrations in 44 ependymomas using comparat
126  arrays, we conducted an analysis of somatic copy-number aberrations in 486 gastrointestinal adenocar
127 overy of differentially amplified or deleted copy-number aberrations in a case group of cancer compar
128 verely retarded patients, were found to have copy-number aberrations in addition to the 5p deletion.
129 asis by identifying genes with more frequent copy-number aberrations in BM-LUAD compared to 503 prima
130 many breast cancer genes as well as sporadic copy-number aberrations in non-cancer cells.
131 progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on
132 fDNA enrichment is inversely associated with copy number aberration-inferred tumor fractions.
133 me is represented by an integer vector and a copy number aberration is an event that either increases
134                                              Copy number aberration leading to SPAG5 gain or amplific
135                Here we introduce Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC),
136 ifferent molecular events, including somatic copy number aberration, may be a common characteristic o
137  clinicopathological relevance of SPAG5 gene copy number aberrations, mRNA transcript expression, and
138 comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obt
139                                          DNA copy number aberrations of 349 patients are determined.
140  syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to vari
141 ney cancer, is often associated with genomic copy number aberrations on chromosomes 3p and 5q.
142  reveal acquisition of somatic mutations and copy number aberrations over time.
143 current single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependy
144 of cases, whereas in most cases, large-scale copy number aberrations prevail(2,3).
145  University Hospital to identify genome-wide copy number aberrations, putative driver genes, deregula
146 olution across the genome to map genomic DNA copy number aberrations quantitatively from 14 FTC onto
147 ion sites were enriched in recurrent somatic copy-number aberration regions from multiple cancer type
148                                  Analysis of copy number aberrations revealed genomic changes charact
149 sed by a large number of somatic chromosomal copy number aberrations (SCNA) that frequently affect on
150                                      Somatic copy number aberrations SCNAS: are frequent in cancer ge
151 visualization of complex patterns of somatic copy number aberrations (SCNAs) and structural variants
152 omatic structural variants (SVs) and somatic copy number aberrations (SCNAs) is critical to study the
153 rmal melanocytic proliferations that exhibit copy number aberrations should undergo careful clinical
154 eomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions
155  without chronic sun-induced damage) for DNA copy number aberrations specific to melanoma subtypes wh
156 some breaks, inversions, deletions and micro copy number aberrations, specifically in BRCA1-deficient
157 cleotide variants, insertions and deletions, copy-number aberrations, structural variants and gene fu
158 that contain the 17q23 amplicon, a recurrent copy number aberration that defines about 9% of all prim
159 ssion and analysed the associations of SPAG5 copy number aberrations, transcript expression, and prot
160                   In this study, we analyzed copy number aberrations using Affymetrix SNP 6.0 arrays
161 6 esophageal adenocarcinoma was analyzed for copy number aberrations using Affymetrix SNP 6.0 arrays.
162                                           No copy number aberrations were associated with survival.
163             Frequency differences of somatic copy number aberrations were not significant after corre
164        All tumors showed a high frequency of copy number aberrations with recurrent gains on 3q, 6p,

 
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