ライフサイエンスコーパス: cord

1 DBL-1-expressing cells in the ventral nerve cord.

2 rain through the central canal of the spinal cord.

3 geminal nucleus and all levels of the spinal cord.

4 tatory synapses throughout the lumbar spinal cord.

5 targets to improve self-repair of the spinal cord.

6 ion site of completely transected rat spinal cord.

7 ligand in the brain compared with the spinal cord.

8 and their synaptic trafficking in the spinal cord.

9 bition between motoneurons within the spinal cord.

10 x that ligate the severed ends of the spinal cord.

11 tion and demyelination occur together in the cord.

12 rmine S1 CST termination patterns within the cord.

13 ls across the transverse plane of the spinal cord.

14 ose activity patterns resemble intact spinal cord.

15 downstream of Npr1(+) neurons in the spinal cord.

16 , hmx1, and hmx4 are not expressed in spinal cord.

17 influence the signals that enter the spinal cord.

18 activity is found in the lumbosacral spinal cord.

19 biting AMPA and NMDA receptors in the spinal cord.

20 te matter of the motor cortex and the spinal cord.

21 ory stimuli are represented along the spinal cord.

22 entry zone (DREZ) to extend into the spinal cord.

23 rior peripheral nerves from the dorsal nerve cord.

24 naptic and postsynaptic NMDARs in the spinal cord.

25 nesis profiles of V3 INs in the mouse spinal cord.

26 ng LJA5 neurons through the brain and spinal cord.

27 optic nerve, corpus callosum, and the spinal cord.

28 glia (DRG) and the dorsal horn of the spinal cord.

29 ar organ and the central canal of the spinal cord.

30 cs (or overtones) emanating from their vocal cords.

31 pigmentosa (RP; 85.94%), cone-rod dystrophy (CORD; 10.94%), and Leber congenital amaurosis (LCA; 3.12

32 valuate tissue samples from the C2-C6 spinal cord 3 days after a C3/C4 hemi-crush injury (C3Hc).

33 recessive RP (23.4%) and autosomal recessive CORD (9.9%) in the Japanese population.

34 e sclerosis (MS), knowledge about how spinal cord abnormalities translate into clinical manifestation

35 time, continuous objective measure of spinal cord activation in response to therapy via recorded evok

36 examine pain relief and the extent of spinal cord activation with ECAP-controlled closed-loop versus

37 smission of voluntary commands to the spinal cord after damage (e.g., after stroke or spinal cord inj

38 The spinal cord also expresses all dopamine receptors; however, how

39 ng from the graft into the denervated spinal cord also triggered local host neuronal network response

40 the cerebral cortex or the hindbrain/spinal cord and assemble them with human skeletal muscle sphero

41 o undergo 7 T imaging of the cervical spinal cord and brain as well as conventional 3 T brain acquisi

42 % alpha-tubulin acetylation for mouse spinal cord and brain homogenate tissue, respectively, as measu

43 white matter lesion fractions in the spinal cord and brain of the 9-Hole Peg Test and cortical thick

44 the colon and central nervous system (spinal cord and brain) that underlies the gut-brain axis, is vi

45 Cord and breastmilk to maternal plasma ratios were 1.279

46 pathetic preganglionic neurons in the spinal cord and central targets of primary sensory afferents (n

47 its immune-cell infiltration into the spinal cord and completely abrogates immune responses to myelin

48 n in the midbrain-hindbrain boundary, spinal cord and dorsal root ganglia.

49 common progenitor cell for posterior spinal cord and muscle enables the formation of functional neur

50 nstrate that GBF1 is present in mouse spinal cord and muscle tissues and is particularly abundant in

51 on of neuronal pathways in the brain, spinal cord and neuromuscular system of cats, rats and zebrafis

52 n severe and predominantly affect the spinal cord and optic nerve.

53 lusion Gadolinium was retained in the spinal cord and peripheral nerves in rats exposed to multiple a

54 alpha2delta-1-GluN1 complexes in the spinal cord and the level of alpha2delta-1-bound GluN1 proteins

55 antitumor response.See related commentary by Cordes and Metallo, p.

56 lar dystrophy, nine with cone-rod dystrophy (CORD), and three with retinitis pigmentosa.

57 ne levels in the rodent brainstem and spinal cord, and a significantly shorter life-span of the mice.

58 pain signals from the meninges to the spinal cord, and if so, to what extent and through which classe

59 triggers the release of Wnt5a in the spinal cord, and inhibition of spinal Wnt5a signaling attenuate

60 ystem (CNS), consisting of the brain, spinal cord, and retina, superintends to the acquisition, integ

61 encephalon, mesencephalon, hindbrain, spinal cord, and retina.

62 emonstrate that CS projections to the spinal cord are eliminated in an activity-dependent manner.

63 this perspective, but studies for the spinal cord are lacking.

64 Neurons within the spinal cord are sensitive to environmental relations and can br

65 ial, and away from the ventrolateral, spinal cord as the frequency of fictive locomotion increases.

66 y review the application of brain and spinal cord atrophy in clinical practice in the management of M

67 quantified by estimation of brain and spinal cord atrophy with MRI.

68 linear regression model, independently from cord atrophy.

69 he existence of the BBB and the blood-spinal cord barrier have been terrible and threatening challeng

70 ibited AQP4 localization to the blood-spinal cord barrier, ablated CNS edema, and led to accelerated

71 ted with Fenton BW z-score and the umbilical cord blood (CB) lipidome.

72 ed a single infusion of autologous umbilical cord blood and, as part of their clinical outcome measur

73 Cord blood cadmium was analyzed as detectable or undetec

74 OXA(+) CD34(+) progenitors, as well as human cord blood CD34(+) cells, give rise to NK cells that exh

75 he offspring of mothers with T1D had reduced cord blood CD4(+) T-cell responses to proinsulin and ins

76 Cord blood DNA from singletons was measured using the Me

77 Umbilical cord blood DNA methylation was evaluated using the Illum

78 iated with altered prenatal GCs in newborn's cord blood DNA.

79 et production, and for the improved usage of cord blood for transplantation research and therapy.

80 ison, antitoxin IgG and NAb were measured in cord blood from 50 mothers unrelated to study infants.

81 ing outcomes: newborn weight, adiposity, and cord blood glucose, insulin, lipids, and leptin.

82 ng the dominant-negative ETS1 p27 isoform in cord blood hematopoietic progenitor cells, we show that

83 istent with CPI203-mediated reprogramming of cord blood hematopoietic stem and progenitor cells.

84 bitor CPI203 enhanced the expansion of human cord blood HSCs without losing cell viability in vitro.

85 metals in infants, the observed increases in cord blood lead and cadmium require further exploration.

86 ernal lead and with significant increases in cord blood lead and cadmium.

87 00, 16,800, 28,000 IU) vs. placebo, neonatal cord blood lead levels were 8.5% (95% CI: - 3.5, 22), 16

88 We examined cord blood micronutrient biomarkers in relation to anten

89 ith motor improvement, after human umbilical cord blood mononuclear cell (hUCBC) infusion.

90 ood mononuclear cells and neonatal umbilical cord blood mononuclear cells were collected and cryopres

91 ose-associated methylation signatures in the cord blood of the infant appeared to be attenuated by th

92 Cord blood regulatory T-cell populations were measured a

93 118-239 maternal blood specimens and 100-201 cord blood samples analyzed.

94 chain reaction in leukocytes extracted from cord blood shortly after birth.

95 smatched anti-CD19 CAR-NK cells derived from cord blood to 11 patients with relapsed or refractory CD

96 Spinal cord blood vessels of CMH-treated mice showed reduced ex

97 e bone marrow, adipose tissue, and umbilical cord blood without altering their ex vivo characteristic

98 t were measured in maternal blood, umbilical cord blood, and placental tissue when available.

99 Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples

100 uring each trimester of pregnancy and in the cord blood, providing unambiguous assurance of drug expo

101 hairpin RNA knockdown of CLC/Gal-10 in human cord blood-derived CD34(+) progenitor cells impairs eosi

102 1A (LSD1) induces a rapid expansion of human cord blood-derived CD34+ cells and promotes in vitro pro

103 ine bone marrow-derived mast cells and human cord blood-derived mast cells.

104 of B cells in vitro In this study, we used a cord blood-humanized mouse model to compare the phenotyp

105 llergy-promoting IL-4Ralpha mutation; and hu cord blood-reconstituted immunodeficient, hu cytokine-se

106 In infants born >=34 weeks gestational age, cord-blood IgG geometric mean concentrations (GMC) were

107 ulation pharmacokinetics in maternal plasma, cord, breastmilk and infant plasma of DolPHIN-1 particip

108 by projections from the brain to the spinal cord, but the neural substrates for top-down sensory con

109 sory input is modulated in the dorsal spinal cord by a network of excitatory and inhibitory interneur

110 hrough distinct pathways in different spinal cord cell types and further implicate the importance of

111 Swelling of the brain or spinal cord (CNS edema) affects millions of people every year.

112 e diagnostic algorithm is to rule out spinal cord compression before evaluating other causes of myelo

113 The spinal cord corticospinal tracts lesion volume fraction remaine

114 However, correlation with spinal cord cross-sectional area-a predictor of disability-is p

115 on from neuronal tissue lysates after spinal cord crush injury of mice.

116 nal images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotempo

117 vents immune-cell infiltration in the spinal cord, decreases integrin expression in antigen-specific

118 Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the r

119 of excitatory synapses in the lumbar spinal cord, detailing synaptic diversity that is dependent on

120 However, Hmx functions in spinal cord development have not been analyzed.

121 be used to model and manipulate seminiferous cord development, including induction of focal dysgenesi

122 n of Cos2, likely acting through binding the CORD domain of Ci, or PKA, revealing separate inhibitory

123 onal area of the cervical and upper thoracic cord (down to T3 level) was calculated with the active-s

124 sion of programmed-death-ligand-1) in spinal cord-draining lymph nodes and decreases the number of T

125 PI16 expression in neurons or glia in spinal cord, DRG, and nerve.

126 reactive microglia frequently contact spinal cord endothelial cells.

127 inhibiting Hsp90 specifically in the spinal cord enhanced the antinociceptive effects of morphine in

128 crobial gene expression by the mycobacterial cord factor that may contribute to mycobacterial persist

129 ir glycerol, glucose, and trehalose esters ("cord factor") form the main part of the mycomembrane.

130 The MM intervention increased cord ferritin (mean: +12.4%; 95% CI: 1.3, 24.6%), 25(OH)

131 ociceptive circuits in the developing spinal cord, following injuries during the neonatal period.SIGN

132 y-stage serotonergic neurons into the spinal cord for cardiovascular functional recovery after spinal

133 protecting mitochondria and hence the spinal cord from secondary injury.

134 Here, analysis of umbilical cords from humans and other mammals identified different

135 yma changes after injury of the adult spinal cord, functionally resembling the immature active-stem c

136 that sensorimotor circuits within the spinal cord generate backward locomotion and adjust it to task

137 reactivate from quiescence and ventral nerve cord glia expand their membranes.

138 ing axons to penetrate the inhibitory spinal cord glial scar.

139 ector induced pig model of high-grade spinal cord glioma and may potentially be used in preclinical t

140 report the production of a high-grade spinal cord glioma model in pigs using lentiviral gene transfer

141 rs of EDSS score in PMS were cervical spinal cord GM CSA and brain GM volume (R(2) = 0.44).

142 gression analysis identified cervical spinal cord GM CSA and T2 lesion volume as independent predicto

143 Cervical spinal cord GM lesions may subsequently cause GM atrophy, which

144 esterol synthesis, was reduced in the spinal cord GM of ALS patients.

145 s is adversely affected in the in the spinal cord gray matter (GM), and if so, whether it is because

146 uclei, anterior olfactory nuclei, and spinal cord gray matter.

147 Lesion fractions within the spinal cord grey and white matter were related to the lesion fr

148 e Peg Test and cortical thickness and spinal cord grey matter cross-sectional area of the Timed 25-Fo

149 ctical tool for clinical quantitative spinal cord imaging.

150 ated signaling spreads to the DRG and spinal cord in females, but remains localized to the sciatic ne

151 gle session of TESS over the cervical spinal cord in individuals with incomplete chronic cervical SCI

152 e locomotion when bath-applied in the spinal cord in vitro.

153 nd for the first time identify extracellular cords in this species.

154 ys of protection in heart, brain, and spinal cord injuries.

155 8) years) with subacute (ie, 1 month) spinal cord injury (25 patients with neuropathic pain, 19 pain-

156 to spinal motor neurons from ischemic spinal cord injury (ISCI).

157 ds for Neurological Classification of Spinal Cord Injury (ISNCSCI), examination.

158 C) grafts can integrate into sites of spinal cord injury (SCI) and generate neuronal relays across le

159 Spinal cord injury (SCI) is a common cause of disability, which

160 le injury, but the Acomys response to spinal cord injury (SCI) is unknown.

161 long after SCI.SIGNIFICANCE STATEMENT Spinal cord injury (SCI) significantly disrupts immunity, thus

162 In spinal cord injury (SCI), the initial damage leads to a rapidly

163 llion individuals in the US live with spinal cord injury (SCI).

164 s recovery of function in humans with spinal cord injury (SCI).

165 al to reestablish motor control after spinal-cord injury (SCI).

166 es functional recovery in humans with spinal cord injury (SCI).

167 ficits and long-term disability after spinal cord injury (SCI).

168 Spinal cord injury in mammals is thought to trigger scar format

169 alamic tract function-at 1 month post-spinal cord injury is associated with the emergence and mainten

170 and functional recovery in vivo in a spinal cord injury model through a unique mechanism of anti-inf

171 Inhibition of calmodulin in a rat spinal cord injury model with the licensed drug trifluoperazine

172 Spinal cord injury remains a scientific and therapeutic challen

173 mplete cervical, thoracic, and lumbar spinal cord injury were randomly assigned to 10 sessions of exe

174 thout exercise in 13 individuals with spinal cord injury with similar characteristics.

175 s and restore forelimb function after spinal cord injury(1); however, the molecular mechanisms that u

176 d after damage (e.g., after stroke or spinal cord injury), possibly assisting recovery of function.

177 plete recovery of neonatal mice after spinal cord injury, and suggest strategies that could be used t

178 ients with impaired voiding following spinal cord injury, patients undergoing nonurologic surgeries,

179 llar ataxia, Alzheimer's disease, and spinal cord injury, respectively.

180 As rats are used extensively to model spinal cord injury, we asked if the S1 CST response is conserve

181 n and functional repair in vivo after spinal cord injury.

182 r and extensor muscles after cervical spinal cord injury.

183 nt degrees of paralysis and levels of spinal cord injury.

184 mpetent axons after sciatic nerve and spinal cord injury.

185 diovascular functional recovery after spinal cord injury.

186 her ED peptide has similar effects in spinal cord injury.

187 cell precursors that migrate from the spinal cord into the intestine.

188 circuitry.SIGNIFICANCE STATEMENT The spinal cord is a critical hub for processing somatosensory inpu

189 w itch signals are encoded within the spinal cord is not fully understood.

190 e interconnected across the brain and spinal cord is unclear.

191 by a neural network, situated in the spinal cord, known as the locomotor central pattern generator (

192 en-presenting cells (APCs) within the spinal cord leptomeninges in experimental autoimmune encephalom

193 Despite the prevalence of cervical spinal cord lesions and atrophy, brain pathology seems more str

194 sex, younger age, and the presence of spinal cord lesions as independent factors that increase the 5-

195 These findings show that spinal cord lesions involve both grey and white matter from the

196 osis showed a greater predominance of spinal cord lesions nearer the outer subpial surface compared t

197 reated with peptidase inhibitors into spinal cord lesions of adult mice, and found that both types of

198 Cervical spinal cord lesions were mapped voxel-wise as a function of dis

199 naptic and postsynaptic NMDARs at the spinal cord level and that presynaptic NMDARs play a prominent

200 ling in nociceptive modulation at the spinal cord level.

201 hesis attenuates nerve injury-induced spinal cord microglia activation and pain hypersensitivity.

202 Spinal cord microglia contribute to nerve injury-induced neurop

203 talk is necessary for eliciting this spinal cord microglia phenotype and also for conferring optimal

204 it is possible to consistently elicit spinal cord microglia via systemic delivery of inflammogens to

205 or nerve injury-induced activation of spinal cord microglia, but the responsible endogenous TLR2 agon

206 resident macrophages of the brain and spinal cord, microglia are crucial for the phagocytosis of infe

207 er, by quantitative immunostaining of spinal cord MNs, we found corresponding protein level changes f

208 Conclusion Cervical spinal cord MRI involvement has a central role in explaining di

209 aluated three-dimensional T1-weighted spinal cord MRI scans in seropositive participants with NMOSDs

210 In the zebrafish spinal cord, neural progenitors form stereotypic patterns despi

211 3-kinase activation, brain and ventral nerve cord neuroblasts reactivate from quiescence and ventral

212 rome c activities, leading to reduced spinal cord neuronal cell apoptosis and smaller lesion area tha

213 ents degeneration of cultured primary spinal cord neurons derived from SMA mice.

214 cate this finding in primary cultured spinal cord neurons, spinal cord slice, and Xenopus laevis oocy

215 estoring locomotion in mice following spinal cord neurostimulation.

216 ancing focal lesions in the brain and spinal cord observed on MRI.

217 ogy in the developing mouse brain and spinal cord of both sexes.

218 Ectopic CSF-cNs in the spinal cord of C57Bl/6N mice emerge during whole period devoted

219 he ectopic position of CSF-cNs in the spinal cord of C57Bl/6N mice.

220 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neuro

221 mass tagged proteomic analysis of the spinal cord of Ppt1(-/-)and control mice at these timepoints re

222 , immunohistochemical analyses of the spinal cords of treated animals showed significantly lower ROS,

223 Diseases of the spinal cord often have devastating consequences and imaging stu

224 In the developing spinal cord, Onecut transcription factors control the diversifi

225 ot cause loss of motor neurons in the spinal cord or denervation at the neuromuscular junction.

226 ular junction, peripheral nerves, the spinal cord or the brain and discuss the autoimmune mechanisms

227 Flexible bronchoscopy revealed vocal cord paralysis in paramedian position, potentially due t

228 Bilateral vocal cord paralysis is a rare but potentially fatal complicat

229 o monitor intraspinal pressure (ISP), spinal cord perfusion pressure (SCPP), tissue metabolism and in

230 dren slightly attenuated after adjusting for cord plasma creatinine (P = 0.05).

231 dihydrofolate reductase (DHFR) genotype and cord plasma creatinine.

232 pothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile f

233 Spinal cord pMN progenitors sequentially produce motor neurons

234 tracts along the brain, brainstem and spinal cord portions to explain physical disability in multiple

235 Trpa1 disruption in a mouse brainstem-spinal cord preparation impedes the amplitude augmentation of t

236 ity of various frequencies in upright spinal cords prepared from male and female neonatal mice.

237 strated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and

238 ural neurons in the developing ventral nerve cord produces defasciculated axon bundles that do not re

239 brainstem (r = 0.45, P < 0.0001) and spinal cord (r = 0.57, P < 0.0001) corticospinal tracts.

240 olleagues demonstrated that zebrafish spinal cord radial glia differentiate into cells that are simil

241 We conclude that seminiferous cord reformation during the MPW results in development o

242 mice have long-range projections into spinal cord regions harboring Mc4r-expressing V2a interneurons,

243 ve distinct spatial preference in the spinal cord regions where motor and sensory tracts run.

244 or interventions to improve brain and spinal cord remyelination, paving the way for the translation o

245 mechanisms contributing to successful spinal cord repair in adult zebrafish are, however, currently u

246 es into the role of mechanosensing in spinal cord repair.

247 of the dorsal root ganglia (DRG) and spinal cord response, not observed at the nerve injection site.

248 ZIKV infection in the mouse brain and spinal cord resulting in massive neurodegeneration of infected

249 e identified M. kansasii forms extracellular cords, resulting in acute infection and rapid larval dea

250 weeks of delivery, with matched maternal and cord samples at delivery.

251 Spinal cord (SC) contributions to the slower components are rar

252 uron dysfunction in vivo by comparing spinal cord (SC) transcriptomes reported from TDP-43 and SOD1 A

253 es, after cystometry c-Fos neurons in spinal cord segments L5-S2 were concentrated in the sacral para

254 Our patient presented with delayed cord separation, failure to thrive, and sepsis.

255 lts showed a significant association between cord serum interleukin-7 at birth and the trajectories o

256 assium-stimulated acute slices of the lumbar cord showed that oxytocin-neurophysin-immunoreactivity w

257 primary cultured spinal cord neurons, spinal cord slice, and Xenopus laevis oocytes expressing recomb

258 with two-photon microscopy in ex vivo spinal cord slices from CX3CR1-GFP mice complemented with confo

259 Located within red pulp cords, splenic red pulp macrophages (RPMs) are constantl

260 Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden

261 h upper-limb amputation that epidural spinal cord stimulation (SCS), a common clinical technique to t

262 d-loop versus fixed-output, open-loop spinal cord stimulation for the treatment of chronic back and l

263 A novel spinal cord stimulation system provides the first in vivo, real

264 relief up to 12 months than open-loop spinal cord stimulation.

265 The terminal ileum and thoracic spinal cord (T(11)) were sampled for evaluating ileitis at days

266 taneous electrical stimulation of the spinal cord (TESS) promotes functional recovery in humans with

267 taneous electrical stimulation of the spinal cord (TESS) promotes recovery of function in humans with

268 In the spinal cord, the central canal forms through a poorly understoo

269 t, adult zebrafish are able to repair spinal cord tissue and restore motor function after complete sp

270 ping of the spatiotemporal changes of spinal cord tissue stiffness in regenerating adult zebrafish an

271 g regeneration after transection, the spinal cord tissues displayed a significant increase of the res

272 s in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands on MNs

273 upregulation on postmortem human ALS spinal cord tissues.

274 descending pathways to hindbrain and spinal cord to activate muscle and generate movement.

275 wo-photon Ca(2+) imaging of the mouse spinal cord to establish that NK1R and the gastrin-releasing pe

276 eurons (MNs) in the C. elegans ventral nerve cord to select and maintain their unique terminal identi

277 layers of M1 that send output to the spinal cord to support movement, imagined movements evoked resp

278 redirected disease pathology from the spinal cord to the brain.

279 Cord total folate and maternal supplement intake during

280 progenitors (RN-NSCs) into a complete spinal cord transection lesion site in adult female rats.

281 restore motor function after complete spinal cord transection owing to a complex cellular response th

282 y (n = 64, 21.9%) including brain and spinal cord trauma.

283 st of interaction between race/ethnicity and cord UMFA concentrations was significant (P = 0.007).

284 al investigations on the sources and role of cord UMFA in children's neurodevelopmental outcomes and

285 Higher concentrations of cord UMFA, but not 5-methyl THF or total folate, were as

286 second trimester were associated with higher cord UMFA.

287 We show NK1R mRNA expression in human spinal cord, underscoring the translational relevance of our fi

288 The Drosophila ventral nerve cord (VNC) receives and processes descending signals fro

289 and abdominal neuromeres, the ventral nerve cord (VNC), to provide an anatomical description of this

290 Similarly, myelination in the spinal cord was disorganized after exposure at 2 dpf but not 1

291 al white matter tract of the cervical spinal cord, we found that both lesioned dorsal and intact late

292 MT images of the cervical spinal cord were collected parallel to the intervertebral disks

293 Labeling throughout the brainstem and spinal cord were very similar for the two antibodies and was el

294 or 19 weeks of age, and their lumbar spinal cords were processed for histo- and immunohistochemistry

295 MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6

296 om the striatum, locus coeruleus, and spinal cord, where multiple peptidases metabolize enkephalin.

297 eral projections of CS neurons in the spinal cord, while other studies demonstrate that CS projection

298 eous delivery throughout the cervical spinal cord white and gray matter and brain motor centers.

299 oglia activation were observed in the spinal cord white matter of 7-month-old Hri(-/-) mice as compar

300 terneuron (IN) diversity empowers the spinal cord with the computation flexibility required to perfor