ライフサイエンスコーパス: core domain

1 structs consisting of the predicted CASV GP2 core domain.

2 ed by a flexible linker and an alpha-helical core domain.

3 for its intrinsically disordered N-terminal core domain.

4 the sequence and structure divergence of the core domain.

5 in accessorizes the ubiquitous Rossmann-fold core domain.

6 cket between loop L1 and sheet S3 of the p53 core domain.

7 in dynamics at opposite ends of the troponin core domain.

8 are known to function through the catalytic core domain.

9 egulation of activity by TFIIF and the TFIIB core domain.

10 r on the N-terminal domain and W(113) in the core domain.

11 C-terminal domains that flank the catalytic core domain.

12 for a high-resolution model of the complete core domain.

13 flexible N terminus followed by a structured core domain.

14 the 600-bp fragment encoding the entire p53 core domain.

15 tudies of a soluble variant of the catalytic core domain.

16 re domain and a smaller domain that caps the core domain.

17 e-induced closure of the cap domain over the core domain.

18 teracts with a linker region adjacent to the core domain.

19 se of UbcH10 by the APC, specified by the E2 core domain.

20 ull-length construct lacking only the kinase core domain.

21 ter of three methionine residues in the Fes1 core domain.

22 IN C-terminal domain (CTD) and the catalytic core domain.

23 bed DNA- and protein-binding surfaces of the core domain.

24 ation with xanthine bound to residues in the core domain.

25 o the C-terminal segment of Rev1's catalytic core domain.

26 ome measurement instruments to measure these core domains.

27 ure of its supernumerary ensemble around the core domains.

28 erized by interactions between two catalytic core domains.

29 ls, suggesting interplay between the cap and core domains.

30 an form a four-helix bundle with other SNARE core domains.

31 er, due to relative movement of the gate and core domains.

32 g of the DNA duplex relative to the helicase core domains.

33 ther, these data highlight the plasticity of core domain 1 conformation and illustrate the relationsh

34 ding domain (ZBD), a 1B domain, and helicase core domains 1A and 2A.

35 mis protein 4, also known as WAP 4-disulfide core domain-2 or Wfdc2) as the most upregulated gene in

36 The pentameric core domain, a doughnut-like structure with a central po

37 :DNA complex that includes an entire central core domain, a ssDNA GCAGT substrate, and two magnesium

38 or through segregation within the allantoic core domain (ACD) through reduction of cell adhesion and

39 ntains a pool of cells, called the Allantoic Core Domain (ACD), critical for allantoic elongation to

40 The small nuclear ribonucleoprotein (snRNP) core domain, acting as an assembly nucleus for the matur

41 itioning of the general acid/base within the core domain active site is coordinated with substrate-in

42 glucose 6-phosphate (G6P) using Asp8 of the core domain active site to mediate phosphoryl transfer f

43 where the Asp10 side chain is located in the core domain active site.

44 ossess a classical alpha/beta-hydrolase fold core domain additionally equipped with a cap domain.

45 combinant enzymes, and showed that the first core domain affects overall catalytic activity.

46 on of appropriate dynamic flexibility to the core domain allowed the inclusion of multiple conformati

47 re a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression pa

48 The core domain amides of ECAK and TNAK in the open and clos

49 demonstrated that deletion of either the PL2 core domain (amino acids [aa] 47 to 180) or the immediat

50 FEN-1 consists of a nuclease core domain and a C-terminal extension.

51 ing enzyme UBE2K has a 150-residue catalytic core domain and a C-terminal ubiquitin-associated (UBA)

52 ructure of dematin includes a loosely folded core domain and a compact headpiece domain that was orig

53 NhaA is made up of two distinct domains: a core domain and a dimerization domain.

54 orming enzyme that encompasses a well-folded core domain and a disordered C-terminal tail (CTT).

55 UapA is formed from two domains, a core domain and a gate domain, similar to the previously

56 red in an open active site cleft between the core domain and a lid subdomain.

57 cid phosphatase, consisting of an alpha/beta core domain and a smaller domain that caps the core doma

58 strates strong conservation of a beta-barrel core domain and an alpha-helix, from which emanate sever

59 Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal t

60 u153 and 154 on the first alpha-helix of the core domain and Arg19 on first alpha-helix of the N-term

61 able than the wild-type protein, distort its core domain and as a result reduce the ability of the pr

62 ur model, the junction between the catalytic core domain and C-terminal domain adopts a helix-loop-he

63 explore its consequences, beginning with the core domain and extending to the full-length p53 mutant

64 derivative comprising the C-terminal protein core domain and for AnxA2 residing in a heterotetrameric

65 Here, we studied the histone H2B core domain and found that phosphorylation of H2B serine

66 he ability of MDM2 acidic domain to bind p53 core domain and induce p53 misfolding are also suppresse

67 e active state and comprise a beta-propeller core domain and intrinsically disordered N- and C-termin

68 ich connects an N-peptide motif to the SNARE core domain and is thought to participate in the binding

69 hat nidoviruses contain a conserved helicase core domain and key amino acid sites affecting helicase

70 tations that impair p53 usually occur in the core domain and negate the p53 sequence-specific DNA bin

71 Its core domain and tetramerization domain are linked and fl

72 ulate Snf7 activation at both its N-terminal core domain and the C-terminus alpha6 helix through two

73 of IN via interactions between the catalytic core domain and the CTD and that understanding the inter

74 o the head, where it contacts both the motor core domain and the neck domain, forming an inhibited co

75 in has two F-actin binding sites, one in the core domain and the other in the headpiece domain.

76 ed by two negatively charged residues on the core domain and three positively charged ones on the N t

77 s stabilize interhelical interactions in the core domain and thus assist the formation of functional

78 Escherichia coli SurA has a core domain and two peptidylprolyl isomerase (PPIase) do

79 E. coli SurA comprises a core domain and two peptidylprolyl isomerase domains (P1

80 ormed by the highly flexible N-terminal TSC1 core domains and a barbed "tail" makes up the TSC1 coile

81 a dimer the monomer of which consists of two core domains and a flexible protruding alphacap.

82 gnated as the LID, GMP-binding (GMP-BD), and CORE domains and is in an open configuration that is nuc

83 tivity always requires the conserved Type IA core domains and the same catalytic residue used in DNA

84 hat can interact with their respective SNARE core domains and thereby affect the kinetics of SNARE co

85 terminal region of Bud6 into a Bni1-binding "core" domain and a G-actin binding "flank" domain.

86 N-terminal extension in addition to its ABC "core" domain and transports substrates in the form of gl

87 P binding sites are located primarily in the core domain, and OMP binding results in conformational c

88 ment in defining the overall topology of the core domain, and suggest that interhelical motions in P2

89 conformational changes on binding to the p53 core domain, and support the hypothesis that sequence-de

90 e full-length Rev1 protein and its catalytic core domain are similar in their ability to support BER

91 spacer region of RNAse H1, while the P54nrb core domains are required for association with RNase H1.

92 nnecting the lid to the alpha/beta-hydrolase core domain, as a determinant in the oligomeric state an

93 the apical junction is independent of Drosha core domains, as observed in a second structure in the p

94 The helix is stabilized by a core domain assembled from four beta strands donated by

95 ructure and kinetics of the cardiac troponin core domain associated with the Ca(2+)-dependent regulat

96 main structural domains of the HAstV CP: the core domain at 2.60-A resolution and the spike domain at

97 present a crystal structure of the U4 snRNP core domain at 3.6 A resolution, detailing how the Sm si

98 vely regulated by phosphorylation in its ABC core domain at residues Ser-908 and Thr-911.

99 al arm residues, causing displacement of the core domain away from the monolayer.

100 Here we show that after oxidation, the core domain binds to part of the N terminus, thus restra

101 The p53 core domain binds to response elements (REs) that contai

102 the mutant p53-MDM2 complex, the mutant p53 core domain binds to the MDM2 acidic domain with signifi

103 we describe the crystal structure of the p53 core domain bound to a naturally occurring RE located at

104 of the Cronobacter sakazakii RecQ catalytic core domain bound to duplex DNA with a 3' single-strande

105 ding at the dimer interface of the catalytic core domain but at the same time markedly impair HIV-1 r

106 hereas oncogenic iASPP also binds to the p53 core domain but inhibits p53-dependent apoptosis.

107 these suppressors are located in the movable core domain, but also in the core-dimerization interface

108 Two alpha-helices C-terminal to the core domain, but unique to hPus1, extend along the back

109 uires both the suppressor and ligand-binding core domains, but has no effect on InsP3 binding to the

110 ed at similar rates and kinetics to isolated core domains, but there was some induced aggregation of

111 A moiety of Francisella LPS is linked to the core domain by a single 2-keto-3-deoxy-D-manno-octuloson

112 present high-resolution structures of their core domains (cABC, cHSP27), each in complex with a segm

113 ause of evolutionarily restrictive catalytic core domain-carboxy-terminal domain linker regions.

114 held in a structural framework comprising a core domain catalyzing the oxidation of amines with an a

115 A weak interaction with the catalytic core domain (CCD) and a strong interaction with the C-te

116 tegrase predominantly involves the catalytic core domain (CCD) and the C-terminal domain (CTD) of the

117 971 fragments against the HIV-1 IN catalytic core domain (CCD) followed by a fragment expansion appro

118 ent IN inhibitor 11j within the IN catalytic core domain (CCD) is described as well as its binding mo

119 The x-ray crystal structure of the catalytic core domain (CCD) of IN in complex with the IN binding d

120 By dissecting the catalytic core domain (CCD) of IN into short structural fragments,

121 ains: the N-terminal domain (NTD), catalytic core domain (CCD), and C-terminal domain (CTD).

122 a structural homology model of the catalytic core domain (CCD).

123 three-dimensional structure of its catalytic core domain (CCD).

124 gical functions but share a common catalytic core domain composed of six membrane-spanning segments.

125 hree basic residues within Helix 1 of the E2 core domain, confirmed by transthiolation kinetics.

126 Monomers are organized into "head" and "core" domains connected by a flexible "linker".

127 tate with similar rate constants to those of core domain, consistent with a unimolecular initiation t

128 rom its RNA binding domain, wraps around the core domain consisting of the seven Sm proteins and fina

129 ucceeded in crystallising the human U4 snRNP core domain containing seven Sm proteins and a truncated

130 even when sound is consciously valued as the core domain content.

131 A) that can transfer Hg(2+) to the catalytic core domain (Core) for reduction to Hg(0).

132 ian NF, only constructs with intact head and core domains could form filaments with L-NFL.

133 in the amino-terminal (Cys-2 and Cys-12) and core domains (Cys-95) of RGS4 is important for protein s

134 d studies on the recombinant MMP-2 catalytic core domain demonstrated that anacardic acid directly in

135 Mutations in the p53 DNA-binding core domain destabilize the structure and reduce DNA-bin

136 shown that ALLINIs bind at the IN catalytic core domain dimer interface and bridge two interacting s

137 le-nucleotide variants (nsSNVs) of the hGMPK CORE domain distant from the nucleotide-binding site of

138 With these criteria we identify a core domain (domain A) of small subunit rRNA.

139 y the LPS composition, e.g., the lipid A and core domains, during proliferation within epithelial cel

140 rmational change at the region past the cSH2 core domain encompassing Tyr-771 and Tyr-783 to facilita

141 e orientation of troponin-T and the troponin core domain established troponin polarity.

142 of catalysis in which betaG1P binding to the core domain facilitates recruitment of the general acid/

143 main organization, consisting of a catalytic core domain flanked by amino- and carboxy-terminal domai

144 cture comprising an anti-parallel beta-sheet core domain followed by a C-terminal helix that packs on

145 Core domain formation is a prerequisite for re-import in

146 While two core domains from both dimers of the p53 tetramer intera

147 ively screened the activity of the catalytic core domains from subfamily 4 (GH5_4) and closely relate

148 oia were able to be explained exclusively by core domain-general alterations we would not observe dif

149 t of visual experiences in VOT feed in to a "core" domain-general representation of visual aesthetic

150 While the core domain harbors the nuclease activity, the C-termina

151 yme mechanisms, but to date the IN catalytic core domain has proven resistant to such an analysis.

152 Structures of all helical elements of the core domain have been recently reported, providing the b

153 We find that the two core domains have a preferred relative orientation in th

154 x protein Mss116p indicate that the helicase core domains have modular functions that enable a novel

155 To identify the "core domains" (i.e., patient outcomes, health-related co

156 id and beta-car connection of peripheral and core domains, (iii) stabilization of the iron-sulfur pro

157 Here we describe the structure of the E2 core domain in complex with an antigen-binding fragment

158 propose the fibrillar arrangement of the NSs core domain in crystals reveals the molecular basis of a

159 It contains a helicase core domain in its C terminus and a potential KH domain

160 on of a pseudoknot (PK) in the conserved RNA core domain in the ribonucleoprotein human telomerase is

161 that CoA is bound to different parts of the core domain in these two enzymes and approaches the acti

162 ituted in vitro, and showed that the two RNA core domains in both systems can reconstitute activity i

163 Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting i

164 monstrated that two isolated p53 DNA-binding core domains interact with one half-site of the p53 DNA

165 nance spectroscopy to study the longin-SNARE core domain interaction for VAMP7.

166 ng interactions that stabilize either a core-core domain interface or N-terminal domain intermolecula

167 by blocking the ion conduction pore, and the core domain is a functional enzyme that uses NADPH as a

168 ns, revealing for the first time that the CP core domain is antigenic.

169 In particular, the stability of the core domain is linked to the conformation of its C-termi

170 een sequence and structure divergence of the core domain is shown to be monotonic and independent of

171 ing that hydration water dynamics around the core domain is significantly reduced after fiber formati

172 ase structure, illustrating that the MHETase core domain is similar to PETase, capped by a lid domain

173 stal structures imply that a single helicase core domain is sufficient for DNA unwinding activity, bi

174 iron(III)] derivatives showed that the TFIIB core domain is surprisingly positioned away from Pol II,

175 is capable of rapid translocation, while the core domain is unable to slide and instead hops along DN

176 iate measurement instruments to assess these core domains is an important next step toward developing

177 al configuration, in which each of the SNARE core domains is individually rooted in the membrane bila

178 pon a conformational change in which the two core domains join to form a 'closed state' with an ATPas

179 Interestingly, the trypanosome template core domain lacks the ubiquitous pseudoknot found in all

180 ines are acetylated in histone tails and the core domain/lateral surface of histone octamers.

181 d the headpiece domain to associate with the core domain, leading us to the mechanism for cAMP-depend

182 headgroups during interaction, and that the core domain lies directly against the lipid headgroups,

183 d-binding sites) and allosteric (location of CORE domain-located nsSNVs) standpoint.

184 One patient with AML who had a p53 core domain mutation showed a reduction of blast percent

185 s unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal

186 between these domains and the transmembrane core domain nearly eliminated Ca(2+)-dependent desensiti

187 ions within Pezizomycotina TERs revealed two core domains nearly identical in secondary structure to

188 spite substantial sequence homology in their core domains, nTop1 and mitochondrial Top1B exhibit dram

189 This core domain of 120 amino acids (aa) is flanked in all FG

190 d show that the Wnt lipid is shielded by the core domain of a subclass of glypicans defined by the Da

191 The NTD-core domain of Aedes aegypti Nbr adopts a HEAT-like repe

192 eils the structural features of the homology core domain of all 10 human FHF isoforms.

193 he Golgi in association with vesicles, and a core domain of Bassoon is sufficient to facilitate forma

194 rminal sequences indicate that the Alba-type core domain of both Rpp20 and Rpp25 contains most of the

195 Both proteins bind to the core domain of CHMP4B, which has a strong propensity to

196 ted translation and show that the functional core domain of eIF4G plus an adjacent probable RNA-bindi

197 human single nucleotide polymorphism in the core domain of FGF12 (P149Q), we identified a surface pr

198 We identified a core domain of FSP27, amino acids 120-220, that interact

199 The non-core domain of Gpi8 following the caspase-like domain in

200 Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recen

201 We report three structures of the catalytic core domain of hPus1 from two crystal forms, at 1.8A res

202 Designed sensor comprising the IP(3)-binding core domain of IP(3)-receptor fused between complementar

203 a higher abundance of Q in the alpha-helical core domain of keratins, neighboring residues and steric

204 The SA-binding core domain of NPR4 refolded with SA adopts an alpha-hel

205 f p53 by changing a single amino acid in the core domain of p53 (N268R), which abolishes binding of S

206 rigin on the mechanism of aggregation of the core domain of p53 (p53C) using light scattering, intrin

207 or suppressors, ASPP1 and ASPP2, bind to the core domain of p53 and stimulate transcription of apopto

208 ASPP2 primarily binds to the core domain of p53, whereas iASPP predominantly interact

209 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53.

210 ysates can "seed" aggregation of the central core domain of recombinant WT p53, corroborating the pri

211 We identified a stable core domain of RVFV NSs (residues 83-248), and solved it

212 Here we show that the conserved catalytic core domain of SIRT1 has very low catalytic activity tow

213 A core domain of six helices harbours two sodium ions, and

214 First, the HD-PTP Bro1 domain binds the core domain of STAM2.

215 ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and

216 The results demonstrate that the core domain of SurA endows its generic chaperone ability

217 Hence, peptides that mimic the active core domain of TGFbeta1 may be promising candidates for

218 e cationic nanoparticles and the hydrophobic core domain of the anionic central cylindrical nanostruc

219 induces structural changes in the catalytic core domain of the enzyme.

220 model of a pseudoknot found in the conserved core domain of the human telomerase (hTR) by varying bot

221 of the acetylation of lysine 117 within the core domain of the murine p53 protein, which is required

222 We suggest that RPT is the amyloid core domain of the Pmel17 filaments so critical for mela

223 mediated by the conserved C-terminal annexin core domain of the protein and requires the presence of

224 The core domain of the protein consists of an extended singl

225 each small nuclear RNA (snRNA), to form the core domain of the respective snRNP particle.

226 mer with the C-terminal domain and catalytic core domain of the second monomer as well as direct inte

227 We have identified a core domain of the yeast SF3a complex required for compl

228 observations suggest that the transmembrane core domain of TRPV1, but not the intracellular domains,

229 erminal beta-barrel domain and the catalytic core domain of tTG.

230 of the AdMLP TATA sequence (TATAAAAG) by the core domain of yeast TBP allow quantitation of the roles

231 d 3 in an outward-open state reveal that the Core domains of Bor1 have rotated inwards to achieve an

232 tes were observed within the AMP binding and core domains of both AK homologs.

233 icipants completed three tasks that assessed core domains of cognitive functions: response inhibition

234 Here, we report the crystal structure of the core domains of NP (NPcore) encoded by Sin Nombre virus

235 The DNA sequences in the core domains of rice Cen4, Cen5 and Cen8 showed elevated

236 etiological double dissociation between two core domains of social perception (judgments of identity

237 We observed that the core domains of the 2 truncated isoforms are much less s

238 igh-resolution crystal structures of the p53 core domains of the cancer-related proteins, the rescued

239 e hydroxyl group and residues of the cap and core domains of the protein, thereby providing exquisite

240 The core domains of vav2 bound to the intracellular domains

241 titative analysis on a unique dataset of 154 core-domain-only and cap-domain-only structures, basic p

242 not ATP or ADP) release P1 from the protein core (domains P3P4P5) and increase its mobility.

243 erial transcription factor suggests that the core domain performs nucleosome-independent activities,

244 riori consensus criteria to be designated as core domains: physical function, cognition, mental healt

245 tes from actin and binds in part to TnC; the core domain pivots significantly; the N-lobe of TnC bind

246 in which interactions between the catalytic core domains play a prominent role.

247 In this format, the IN catalytic core domain produced a K(i) of 15.2 nm while competing f

248 proteinase [SLPI], 0.6-fold; WAP 4-disulfide core domain protein [WFDC2], 0.5-fold; haptoglobin [HP],

249 ay structure of the drug-resistant catalytic core domain protein, which provides means for rational d

250 d on both the HIV-1 IN and RNase H catalytic core domains provided new structural insights for the fu

251 The sequence truncations in the p53 core domain raise key questions related to their physico

252 meric p53, and the proper folding of the p53 core domain, rather than the presence of the N- or C-ter

253 mily, show that the downward pivoting of the Core domains relative to the Gate domains may access an

254 on the orientations of the PH and catalytic core domains relative to the lipid membranes.

255 t with DNA within the complex, the other two core domains remain available for binding another DNA si

256 with amidation-based shell cross-linking the core domain remained accessible.

257 he N and C terminus of the catalytic otubain core domain, respectively.

258 The tetramerization helix is linked to a core domain responsible for RNA binding activity by a fl

259 icking, suggesting that stabilization of the core domain restores function by sustaining structural d

260 2-A resolution crystal structure of the Bud6 core domain reveals an elongated dimeric rod with a uniq

261 main mediates fast sliding of p53, while the core domain samples DNA by frequent dissociation and rea

262 l an "open" conformation whereby the cap and core domains separate and visualize the striking conform

263 iscovered universal "hand-shaped" polymerase core domain shared by DNA polymerases and telomerases, o

264 equires a surprisingly large rotation of the core domain, some 20 degrees against the dimerization in

265 idues to the N-terminal end of the DENV RdRp core domain stabilizes DENV1-4 proteins and improves the

266 e and tyrosine binding sites within the AP-1 core domain such that binding of a cargo signal to one s

267 th E1a and G729R E1a with the E2o lipoyl and core domains suggested that correct positioning of the C

268 alysis or to the structural integrity of the core domain, suggesting that it may play a role in media

269 Our functional study of trypanosome TR core domains suggests that the functional requirement of

270 The structures show that the core domain supplies the phosphoryl binding site, cataly

271 h IncA functions are encoded in a structured core domain that encompasses SLD1 and part of SLD2.

272 AP-1 induces a conformational change in its core domain that greatly enhances its interaction with A

273 er is contained in a conserved 33-amino acid core domain that has the same membrane topology as the f

274 erase RNAs contain a catalytically essential core domain that includes the template and a pseudoknot

275 CtBP contains a central NAD(H) binding core domain that is homologous to D2 hydroxy acid dehydr

276 we identified a conserved surface on the FHF core domain that mediates channel binding in vitro and i

277 try of TR comprising two distinct structural core domains that can assemble in trans with TERT and re

278 SNAREs generally consist of one or two core domains that can form a four-helix bundle with othe

279 m in which alternating access is provided by Core domains that carry substrates across a membrane.

280 is study generated a consensus-based list of core domains that should be assessed in all clinical res

281 mediating role of conserved residues in the core domain, the accompanying conformational changes (in

282 The troponin core domain, the C-terminal third of TnI, and tropomyosi

283 domains (LID and NMP) close over the larger CORE domain; the reverse (opening) motion limits the rat

284 region stably associates with the catalytic core domain to form a SIRT1 holoenzyme.

285 mer the extended C terminus destabilizes the core domain to produce highly extended yet stable confor

286 the addition of TFIIF repositions the TFIIB core domain to the Pol II wall domain.

287 ly representing parts of TnT or the troponin core domain, to promote tropomyosin movement on actin to

288 hed the basic kinetics of aggregation of its core domain, using the mutant Y220C that has a mutation-

289 this system to select mutations in catalytic core domain V (DV) that partially rescue retrohoming at

290 ior of the Ca(2+)-saturated cardiac troponin core domain was mapped in detail at 10 degrees C, using

291 The highly conserved Anx core domain was sufficient to mediate these effects, whe

292 While the ring-shaped core domain was surprisingly congruent between the two s

293 al studies have only been conducted with the core domain where the terminal tails have been truncated

294 lines carrying mutations in the first PNPase core domain, which does not harbor the catalytic site.

295 we found that ARF interacted with the topo I core domain, which encompasses most of the catalytic and

296 er, mutation of conserved amino acids in the core domain, which may be involved in a salt bridge, abo

297 roviruses are most significantly enriched in core domains with accessible chromatin, and bear recogni

298 However, core domains with the same cap type share greater simila

299 nd M. tuberculosis share a common structural core domain, with extensive, apparently disordered, N- a

300 the hydrophobic region of AAP2 and conserved core domains within AAPN creates a gain-of-function AAP2