ライフサイエンスコーパス: corneal dystrophy

1 sty (1255 eyes [94.4%] for Fuchs endothelial corneal dystrophy).

2 represented (68.5%) among those with lattice corneal dystrophy.

3 n the development of this autosomal dominant corneal dystrophy.

4 n the development of this autosomal dominant corneal dystrophy.

5 first time the molecular basis of Meesmann's corneal dystrophy.

6 ge, four-generation family with Thiel-Behnke corneal dystrophy.

7 minant forms, Reis-Bucklers and Thiel-Behnke corneal dystrophy.

8 nd ulcer compared with those with hereditary corneal dystrophy.

9 ystrophy and some cases of Fuchs endothelial corneal dystrophy.

10 al anterior corneal involvement suspected of corneal dystrophy.

11 c improvement or regression of GCD2/Avellino corneal dystrophy.

12 keratectomy (PTK) in a patient with macular corneal dystrophy.

13 RNA in the treatment of an autosomal genetic corneal dystrophy.

14 e agent for TGFBIp-associated amyloidosis in corneal dystrophy.

15 factor beta-induced protein (TGFBIp)-linked corneal dystrophy.

16 eliminating endothelial rejection in macular corneal dystrophy.

17 patients undergoing DSAEK surgery for Fuchs corneal dystrophy.

18 delineate the pathogenic mechanisms of human corneal dystrophy.

19 s undergoing eye care for reasons other than corneal dystrophy.

20 olutionized our fundamental understanding of corneal dystrophies.

21 present a current review of the genetics of corneal dystrophies.

22 are responsible for four autosomal dominant corneal dystrophies.

23 ad a profound effect on our understanding of corneal dystrophies.

24 eration of the stromal matrix in the macular corneal dystrophies.

25 that they be categorized as CHST6-associated corneal dystrophies.

26 development of gene silencing therapies for corneal dystrophies.

27 IRIS Registry and primarily associated with corneal dystrophies.

28 rocessing that results in amyloidogenesis in corneal dystrophies.

29 FBI) gene cause clinically distinct types of corneal dystrophies.

30 tations give rise to phenotypically distinct corneal dystrophies.

31 may be indicated for patients with advanced corneal dystrophies.

32 strophy 1 (CHED1) and posterior polymorphous corneal dystrophy 1 (PPCD1) are autosomal-dominant corne

33 c keratitis (33.70%), diabetes (31.59%), and corneal dystrophy (14.28%).

34 gies for primary DMEK were Fuchs endothelial corneal dystrophy (32.5%), pseudophakic bullous keratopa

35 The mean age of those with macular corneal dystrophy (47.3 years) was 15 years younger than

36 Corneal dystrophies (64.66%) were the most common cause

37 vious transplant (39%), or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a G

38 ears, undergoing DSAEK for Fuchs endothelial corneal dystrophy (94% of eyes) or pseudophakic or aphak

39 K, performed primarily for Fuchs endothelial corneal dystrophy (96% of the cohort).

40 Endothelial and anterior corneal dystrophies accounted for most of the reported d

41 Avellino corneal dystrophy (ACD) is an autosomal dominant disorde

42 stologically evident exacerbation of macular corneal dystrophy after PTK and emphasizes the relevance

43 of mutations, such as those that cause some corneal dystrophies and Alexander disease, than previous

44 It works well in the treatment of anterior corneal dystrophies and degenerations, but we are learni

45 type-phenotype correlations in TGFBI-related corneal dystrophies and highlight the importance of stru

46 Patients with decreased vision due to Fuchs corneal dystrophy and cataract can present with a number

47 n the corneal epithelium of mice resulted in corneal dystrophy and clouding that was apparent in newb

48 have extended the pedigree of Franceschetti corneal dystrophy and elaborated its natural history on

49 It also suggests a novel genetic locus for corneal dystrophy and enamel hypomineralization without

50 Individuals with corneal dystrophy and no prior surgical treatment were m

51 he psychological well-being of patients with corneal dystrophy and suggest that integrating mental he

52 microphthalmia-anophthalmia-coloboma (MAC), corneal dystrophies, and Axenfeld-Rieger syndrome (ARS).

53 luding myotonic dystrophy, Fuchs endothelial corneal dystrophy, and C9orf72-ALS/FTD.

54 Corneal dystrophies are a genetically heterogeneous grou

55 Corneal dystrophies are a group of rare eye diseases tha

56 Corneal dystrophies are a group of rare, inherited disor

57 New genes and mutations responsible for corneal dystrophies are being discovered at an accelerat

58 Corneal dystrophies are broadly defined as inherited dis

59 symptoms of different epithelial and stromal corneal dystrophies are not specific; therefore, it is v

60 Given that both PMED and macular corneal dystrophy are associated with promoter and codin

61 In addition, we used TGFBI corneal dystrophies as a model of autosomal dominant dis

62 t at understanding the molecular genetics of corneal dystrophies as genetics is increasingly importan

63 , especially for eyes with Fuchs endothelial corneal dystrophy as the indication for primary DMEK wit

64 structures of R124H, R555W, and the lattice corneal dystrophy-associated A546T.

65 rovide a test-bed for therapies not only for corneal dystrophies but also for other keratinopathies c

66 genetic interaction between genes that cause corneal dystrophies can modulate the expressivity of the

67 chyonychia congenita and Messmann epithelial corneal dystrophy-causing missense mutations have been d

68 Francois-Neetens fleck corneal dystrophy (CFD) is a rare, autosomal dominant co

69 l dystrophy (CHED) is a heritable, bilateral corneal dystrophy characterized by corneal opacification

70 ystrophy (CFD) is a rare, autosomal dominant corneal dystrophy characterized by numerous small white

71 The 2015 International Classification of Corneal Dystrophies classifies corneal dystrophies into

72 Fuchs' endothelial corneal dystrophy corneas were categorized as mild, mode

73 pathophysiology of human congenital stromal corneal dystrophy (CSCD).

74 The study included 45 patients with corneal dystrophy (excluding Fuchs endothelial dystrophy

75 loss is due to the cataract versus the Fuchs corneal dystrophy (FCD) before determining the best surg

76 Fuchs corneal dystrophy (FCD) is a degenerative genetic disord

77 Fuchs corneal dystrophy (FCD) is a genetic disorder of the cor

78 Fuchs corneal dystrophy (FCD) is a hereditary dystrophy of the

79 Fuchs's corneal dystrophy (FCD) is a leading cause of corneal tr

80 Fuchs corneal dystrophy (FCD) is a progressive corneal disease

81 Fuchs corneal dystrophy (FCD) is a progressive disorder of the

82 Fuchs corneal dystrophy (FCD) is an autosomal dominant disease

83 nse to oxidative stress in Fuchs endothelial corneal dystrophy (FECD) and normal corneal endothelial

84 compared susceptibility of Fuchs endothelial corneal dystrophy (FECD) and normal corneal endothelial

85 e development of advanced Fuchs' endothelial corneal dystrophy (FECD) and on central corneal thicknes

86 membrane (DM) in advanced Fuchs endothelial corneal dystrophy (FECD) and to image such changes by sl

87 e pathogenic mechanisms of Fuchs endothelial corneal dystrophy (FECD) could contribute to developing

88 risk to the development of Fuchs endothelial corneal dystrophy (FECD) in Eurasian populations.

89 Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothel

90 Fuchs' endothelial corneal dystrophy (FECD) is a common sight-threatening c

91 Fuchs endothelial corneal dystrophy (FECD) is a common, familial disease o

92 Fuchs endothelial corneal dystrophy (FECD) is a heterogeneous, genetically

93 Fuchs Endothelial Corneal Dystrophy (FECD) is a highly prevalent late-onse

94 Fuchs endothelial corneal dystrophy (FECD) is a leading cause of corneal e

95 Fuchs endothelial corneal dystrophy (FECD) is a leading indication for cor

96 Fuchs endothelial corneal dystrophy (FECD) is a progressive, blinding dise

97 Fuchs Endothelial Corneal Dystrophy (FECD) is an age-related disorder that

98 Fuchs endothelial corneal dystrophy (FECD) is an inherited degenerative di

99 Fuchs' endothelial corneal dystrophy (FECD) is an RNA-mediated disease caus

100 Fuchs endothelial corneal dystrophy (FECD) is the leading indication for E

101 Importance: Fuchs endothelial corneal dystrophy (FECD) is the most common indication f

102 Total of 664 eyes with Fuchs endothelial corneal dystrophy (FECD) scheduled for primary DMEK.

103 overall cohort, 29.8% of Fuchs' endothelial corneal dystrophy (FECD) subgroup, and 27.4% of the bull

104 ients with comorbid KC and Fuchs endothelial corneal dystrophy (FECD) underwent uncomplicated Desceme

105 agy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two alpha2 collagen VIII

106 consecutive patients with Fuchs endothelial corneal dystrophy (FECD) who underwent DMEK or triple-DM

107 Patients with Fuchs endothelial corneal dystrophy (FECD) with Scheimpflug examinations b

108 In Fuchs endothelial corneal dystrophy (FECD), an accelerated loss and dysfun

109 In Fuchs endothelial corneal dystrophy (FECD), mitochondrial and oxidative st

110 elial dysfunction, include Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal

111 d the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal dis

112 gene leads to early-onset Fuchs' endothelial corneal dystrophy (FECD), which progressively impairs vi

113 to 4 years after DMEK for Fuchs endothelial corneal dystrophy (FECD).

114 othelial cells in advanced Fuchs endothelial corneal dystrophy (FECD).

115 owed by graft failure and Fuchs' endothelial corneal dystrophy (FECD).

116 in the disease course of Fuchs' endothelial corneal dystrophy (FECD).

117 nerative disorders such as Fuchs endothelial corneal dystrophy (FECD).

118 er a range of severity of Fuchs' endothelial corneal dystrophy (FECD).

119 al dysfunction in advanced Fuchs endothelial corneal dystrophy (FECD).

120 les in the pathogenesis of Fuchs Endothelial Corneal Dystrophy (FECD).

121 underwent DMEK mainly for Fuchs endothelial corneal dystrophy (FECD; 85.3%) or bullous keratopathy (

122 to 8 years after DMEK for Fuchs endothelial corneal dystrophy (FECD; n = 314), bullous keratopathy (

123 K for various indications (Fuchs endothelial corneal dystrophy [FECD]: n = 111; bullous keratopathy [

124 -old woman presented with Fuchs' endothelial corneal dystrophy for DMEK.

125 eceived two or more diagnoses of any type of corneal dystrophy, for an overall corneal dystrophy prev

126 24H and R555W, both associated with granular corneal dystrophy (GCD) characterized by the early-onset

127 Granular corneal dystrophy (GCD) is an autosomal dominant heredit

128 tpatients clinically diagnosed with granular corneal dystrophy (GCD) prior to phototherapeutic kerate

129 ML) techniques for the diagnosis of granular corneal dystrophy (GCD), a rare inherited condition char

130 In patients suspected of corneal dystrophy, genetic testing plays an important ro

131 Individuals with corneal dystrophy had significantly higher prevalence of

132 Our data indicate that corneal dystrophies have a significant impact on an indi

133 No gene therapies for corneal dystrophies have been able to progress into pati

134 nsforming growth factor, beta-induced linked corneal dystrophies have recently been correlated to the

135 Genes causing autosomal, nonsyndromic corneal dystrophy have been mapped to human chromosomes

136 elopments in the surgical treatment of Fuchs corneal dystrophy have greatly enhanced our ability to r

137 in (TGFBIp) are linked to the development of corneal dystrophies in which abnormal protein deposition

138 This is the first description of Avellino corneal dystrophy in the Balkans and in Serbia.

139 The clinical finding of the granular-lattice corneal dystrophy in which deposits are located in the B

140 Exclusion criteria included known corneal dystrophies, infectious keratitis, complicated s

141 sification of Corneal Dystrophies classifies corneal dystrophies into four classes: epithelial and su

142 ation, refractive surgery, corneal edema, or corneal dystrophy, IOP and CCT readings were available f

143 Fuchs endothelial corneal dystrophy is a heterogenous disease with multifa

144 Macular corneal dystrophy is a rare inherited disease of the cor

145 responsible for amyloid deposits in lattice corneal dystrophy (LCD) have not been delineated.

146 g loss, whereas the ocular features comprise corneal dystrophy, lenticonus, dot-and-fleck retinopathy

147 ons are discovered every day for many of the corneal dystrophies located on the BIGH3 gene.

148 atellite markers closely linked to the known corneal dystrophy loci, we excluded linkage between the

149 Altogether, cataract, glaucoma, corneal dystrophies, MAC, ASD, and ARS panels tested 239

150 emonstrated blue deposits typical of macular corneal dystrophy, mainly in the stroma but also in the

151 Whereas some corneal dystrophies may result in few or mild symptoms a

152 uman corneas and corneas affected by macular corneal dystrophies (MCD) types I and II were examined b

153 tron x-ray diffraction patterns from macular corneal dystrophy (MCD) corneas contain an unusual refle

154 Autosomal recessive macular corneal dystrophy (MCD) is a heterogeneous disorder lead

155 Meesmann's corneal dystrophy (MCD) is an autosomal dominant disorde

156 approach as the gene responsible for macular corneal dystrophy (MCD).

157 revealed characteristic features of macular corneal dystrophy (MCD).

158 Macular corneal dystrophy (MCD; MIM 217800) is an autosomal rece

159 Meesmann epithelial corneal dystrophy (MECD) is a rare autosomal dominant di

160 tive of a severe form of Meesmann Epithelial Corneal Dystrophy (MECD), when complexed with silicon-st

161 indications for DMEK were Fuchs endothelial corneal dystrophy (n = 28) and bullous keratopathy (n =

162 genetic sites are discovered for the various corneal dystrophies, new information will arise, allowin

163 Corneal dystrophy of the anterior basement membrane is a

164 we have identified another locus (CDB2) for corneal dystrophy of the anterior basement membrane/Bowm

165 ecurrent corneal erosions was diagnosed with corneal dystrophy of the Bowman layer after a clinical e

166 This report presents corneal dystrophy of the Bowman layer as a rare phenotyp

167 This study presents data on the impact of corneal dystrophies on quality of life compared to a hea

168 001 to 2009 were searched for a recording of corneal dystrophy on a claim submitted by an ophthalmolo

169 ectious keratitis, non-infectious keratitis, corneal dystrophy or degeneration, and corneal neoplasm.

170 ty, the psychological burden associated with corneal dystrophy persists across populations.

171 promoter region cause posterior polymorphous corneal dystrophy (PPCD) 1 by inducing an ectopic expres

172 eal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD) and congenital hereditary endot

173 tage of patients with posterior polymorphous corneal dystrophy (PPCD) confirms this previously report

174 Posterior polymorphous corneal dystrophy (PPCD) is a very rare disorder charact

175 oinsufficiency causes posterior polymorphous corneal dystrophy (PPCD), in a cohort of late-onset FCD

176 n humans is linked to posterior polymorphous corneal dystrophy (PPCD), in which an epithelial transit

177 Posterior polymorphous corneal dystrophy (PPCD, also known as PPMD) is a rare d

178 th punctiform and polychromatic pre-Descemet corneal dystrophy (PPPCD).

179 ny type of corneal dystrophy, for an overall corneal dystrophy prevalence rate of 897 per million (10

180 e, within and between the different types of corneal dystrophies, raise questions that warrant furthe

181 Compared to the control group, patients with corneal dystrophies reported a significantly worse overa

182 lusion, our novel mouse model of TGFBI-R124C corneal dystrophy reproduces features of the human disea

183 ulation, these data provide an indication of corneal dystrophy's prevalence within insured subjects a

184 Schnyder's crystalline corneal dystrophy (SCCD) is an autosomal dominant eye di

185 Schnyder crystalline corneal dystrophy (SCCD; MIM 121800) is a rare autosomal

186 The present review of Schnyder corneal dystrophy (SCD) corrects the misconceptions in t

187 Schnyder corneal dystrophy (SCD) is a rare autosomal dominant con

188 Schnyder corneal dystrophy (SCD) is an autosomal dominant disorde

189 Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opac

190 ant UBIAD1 variants associated with Schnyder corneal dystrophy (SCD), a human disorder characterized

191 s, a history of herpetic keratitis, Avellino corneal dystrophy, significant cataract, and uncontrolle

192 is a potential therapeutic for treatment of corneal dystrophies, such as KC.

193 IGH3 (TGFbeta1) gene responsible for several corneal dystrophies, there has been an explosion of new

194 in, has various roles in human diseases from corneal dystrophies to cancer.

195 mutation of TGFBI gene which causes Granular Corneal Dystrophy Type 2 (GCD2/Avellino CD).

196 R124C mutation in TGFBI that causes lattice corneal dystrophy type1 (LCD1) and generated novel trans

197 omechanical properties of eyes with granular corneal dystrophy undergoing PTK, in an effort to preven

198 A 65-year-old woman with lattice corneal dystrophy underwent uncomplicated DALK, during w

199 ssociated with an autosomal dominant lattice corneal dystrophies variant.

200 Fuchs' endothelial corneal dystrophy was classified clinically into early-s

201 A corneal dystrophy was diagnosed and penetrating keratopl

202 Fuchs endothelial corneal dystrophy was the fourth most common indication

203 st of the reported dystrophies, and granular corneal dystrophy was the least common, being reported i

204 Thirteen different corneal dystrophies were included; genetic testing confi

205 , sex, and race variations among the various corneal dystrophies were observed.

206 dysfunction resulting from Fuchs endothelial corneal dystrophy were enrolled in 6 corneal centers in

207 nalyzed; 15 eyes with primary DMEK for Fuchs corneal dystrophy were included as control group.

208 Additionally, corneal dystrophies which have never been linked to any

209 lopment of alternative, novel treatments for corneal dystrophies, which may substantially improve the

210 The endothelial (posterior) corneal dystrophies, which result from primary endotheli

211 D1) are responsible for Schnyder crystalline corneal dystrophy, which is a genetic disease that cause

212 main is linked to the development of lattice corneal dystrophy with amyloid deposits in the superfici

213 tion of the quality of life in patients with corneal dystrophy with visual acuity, higher order aberr

214 ng keratoplasty for the treatment of macular corneal dystrophy without endothelial involvement were i

215 lasty surgery is a viable option for macular corneal dystrophy without endothelial involvement.

216 participants with EHR data, 2,393 (0.6%) had corneal dystrophy without prior surgery; they were predo

217 Corneal dystrophy without prior surgical treatment is si