ライフサイエンスコーパス: corneal endothelium

1 of fluid from the corneal stroma across the corneal endothelium.

2 sed to examine the expression of CLCA in the corneal endothelium.

3 iferative mechanism in developing and mature corneal endothelium.

4 y across the apical membrane of the cultured corneal endothelium.

5 r segment inflammation adversely affects the corneal endothelium.

6 netics of p27kip1 expression in neonatal rat corneal endothelium.

7 nonviral method for delivering genes to the corneal endothelium.

8 mation that accompanies the formation of the corneal endothelium.

9 t to the lens epithelium differentiated into corneal endothelium.

10 he anterior chamber is promptly covered with corneal endothelium.

11 cultures, and whether VIP is produced by the corneal endothelium.

12 id not detect OVOL2 expression in the normal corneal endothelium.

13 ed to stimulate concomitant proliferation of corneal endothelium.

14 creasing cAMP, decreases permeability of the corneal endothelium.

15 robust tdTomato expression in the angle and corneal endothelium.

16 esulted in increased Ovol2 expression in the corneal endothelium.

17 bal, and conjunctival epithelium, as well as corneal endothelium.

18 ded on RAFT to construct a tissue-engineered corneal endothelium.

19 ameral injections have no adverse effects on corneal endothelium.

20 short and long-term effects of FLACS on the corneal endothelium.

21 technique that is the least traumatic to the corneal endothelium.

22 apoptosis in the Col8a2(Q455K/Q455K) mutant corneal endothelium.

23 croscopic images of the alizarin red-stained corneal endothelium.

24 response element-driven antioxidants in FECD corneal endothelium.

25 ylation of Akt and p38, respectively, in the corneal endothelium.

26 GF-2 and facilitated its nuclear location in corneal endothelium.

27 in the anterior chamber (AC) or attached to corneal endothelium.

28 ent deleterious effects on the health of the corneal endothelium.

29 Prx proteins were identified in human corneal endothelium.

30 , p21WAF1/Cip1, and p27Kip1 are expressed in corneal endothelium.

31 olysis or by inducing apoptosis of the donor corneal endothelium.

32 the expression and function of JAM-A in the corneal endothelium.

33 proteins JAM-C, CAR, and AF-6 in the rabbit corneal endothelium.

34 expression was found to be restricted to the corneal endothelium.

35 , that have potentially toxic effects on the corneal endothelium.

36 binding of heparin binding growth factors to corneal endothelium.

37 ibute to the HCO(3)(-) transport in cultured corneal endothelium.

38 asurements in all patients: (1) near central corneal endothelium; (2) in mid-AC; and (3) in AC angle.

39 ied in serial analysis of gene expression of corneal endothelium, a finding confirmed by immunohistoc

40 Human corneal endothelium, a neural crest-derived tissue, has

41 m presence of the implant did not affect the corneal endothelium adversely.

42 however, that growth factors released by the corneal endothelium also could modulate lens functions (

43 e mice resulted in efficient transduction of corneal endothelium and an increase in aqueous concentra

44 The presence of both implants was affecting corneal endothelium and anterior chamber angle in both e

45 y) and cranial neural crest (corneal stroma, corneal endothelium and anterior iris).

46 , oxygen tension was 24 +/- 5 mm Hg near the corneal endothelium and decreased to 17 +/- 8 mm Hg near

47 90G>C leads to increased KS sulfation in the corneal endothelium and DM, with no change of KS sulfati

48 The corneal endothelium and epithelium from 21 human corneas

49 section provides higher survival of both the corneal endothelium and graft, but lower visual acuity.

50 A expression in tight junctions of the human corneal endothelium and human RPE.

51 a wound closure model of the cultured rabbit corneal endothelium and in cultures treated with experim

52 By contrast, ocular tissues, such as the corneal endothelium and iris/ciliary body, are imperviou

53 rophy (FCD) is a progressive disorder of the corneal endothelium and is pathologically defined by the

54 rophy (FCD) is a hereditary dystrophy of the corneal endothelium and is responsible for majority of t

55 (FECD) is a common, familial disease of the corneal endothelium and is the leading indication for co

56 dystrophy (FCD) is a genetic disorder of the corneal endothelium and is the most common cause of corn

57 lliam Bourne, MD, summarizes his work on the corneal endothelium and its importance to corneal transp

58 ctopic expression of epithelial genes in the corneal endothelium and keratocytes, including the basem

59 nstrated to be beneficial for protecting the corneal endothelium and lowering the risk of complicatio

60 e presence of a Na+-K+-2Cl- cotransporter in corneal endothelium and of its possible involvement in v

61 sular and zonular integrity, and protect the corneal endothelium and other anterior segment structure

62 Expression of Qa-2 in the corneal endothelium and other substructures lining the a

63 ey investigate JAM-A expression in the human corneal endothelium and retinal pigment epithelium (RPE)

64 structures lining the anterior chamber: the corneal endothelium and stroma, iris stroma, and trabecu

65 y reported that JAM-A is expressed in rabbit corneal endothelium and that antibody to JAM-A produces

66 AF-6 are expressed in tight junctions of the corneal endothelium and that JAM-A has a major role in m

67 However, 2 days after surgery, the corneal endothelium and the anterior chamber formed adja

68 misexpression disrupts the integrity of the corneal endothelium and the expression of extracellular

69 e adenovirus-mediated gene transfer to donor corneal endothelium and to delineate the kinetics of mar

70 ior surface of rejected grafts was devoid of corneal endothelium and was covered incompletely with bo

71 xpression of markers indicative of the human corneal endothelium, and can be tissue-engineered onto t

72 uveoscleral outflow pathway and in the iris, corneal endothelium, and ciliary nonpigmented epithelium

73 as observed in ciliary muscle, iris, sclera, corneal endothelium, and ciliary nonpigmented epithelium

74 ns epithelium, immature trabecular meshwork, corneal endothelium, and corneal epithelium, whereas NT-

75 r detailed imaging of the transplanted human corneal endothelium, and enabled non-invasive observatio

76 nsferring a gene encoding soluble TNFR-Ig to corneal endothelium, and ex vivo production of a biologi

77 Expression of JAM-A was observed in human corneal endothelium, and its distribution correlated wit

78 is present in both fresh and cultured bovine corneal endothelium, and the expression is apparently hi

79 r fibrosis tissue did not originate from the corneal endothelium, and they maintained fibroblastic ph

80 PDGF-A is also present in the corneal endothelium anterior to the lens epithelium in e

81 cadherin expression and the formation of the corneal endothelium are regulated by signals from the le

82 stmortem studies showed no difference in the corneal endothelium between PPC and CCC eyes.

83 Corneal endothelium bound the antibody for all three TGF

84 denovirus receptor) was also observed in the corneal endothelium, but their distribution was diffuse

85 mmunolabeling was detected in normal control corneal endothelium, but was absent in corneal endotheli

86 TNF-alpha-induced barrier dysfunction in the corneal endothelium can be suppressed by inhibitors of p

87 der certain pathophysiologic conditions, the corneal endothelium can produce an abnormal posterior co

88 Corneal endothelium (CE) is a monolayer of mitochondria-

89 l cellular pattern during development of the corneal endothelium (CE), a monolayer of neural crest-de

90 Nevertheless, long-term corneal endothelium cell density and crystalline lens cl

91 changes in number, density, and shape of the corneal endothelium cells in 128 eyes of 64 patients div

92 rent pattern of diabetic retinopathy (DR) on corneal endothelium cells in type 2 diabetes mellitus pa

93 F-alpha breaks down the barrier integrity of corneal endothelium, concomitant with the disruption of

94 The corneal endothelium, considered a nonrenewing population

95 owever, aqueous humor (AH), which bathes the corneal endothelium, contains a 12-kDa protein which inh

96 equired in neural crest for specification of corneal endothelium, corneal stroma and the sclera.

97 No recognizable corneal endothelium, corneal stroma, iris stroma, or ant

98 endothelial-mesenchymal transition in a rat corneal endothelium cryo-injury model and significantly

99 e is the standard treatment for irreversible corneal endothelium decompensation by replacing the malf

100 dophakic eyes appears relatively safe to the corneal endothelium, demonstrating a small and nonsignif

101 ser-assisted cataract surgery (FLACS) affect corneal endothelium during cataract surgery.

102 Our data suggest that formation of a corneal endothelium during early ocular morphogenesis is

103 y offer equal or increased protection of the corneal endothelium during surgery compared with viscoel

104 Our finding of a novel phenotype of corneal endothelium emphasizes the morphologic diversity

105 nists that increased intracellular Ca(2+) in corneal endothelium, enhanced HCO(3)(-) permeability by

106 It is unknown why human corneal endothelium exhibits limited capacity to divide

107 re corneal lenticules after the removal of a corneal endothelium for DMEK transplantation.

108 les, such as TGF-beta, which may protect the corneal endothelium from NK cell-mediated damage.

109 act inhibition and promoted proliferation in corneal endothelium from older donors.

110 The authors hypothesize that corneal endothelium from older individuals divide in sit

111 be an important modulator for protecting the corneal endothelium from unbridled NK cell-mediated inju

112 d RAFT transplantation successfully restored corneal endothelium function, drawing the thickness of e

113 acterized by thin corneal stroma, absence of corneal endothelium, fusion of cornea to lens (a Peters'

114 The cells of the corneal endothelium had TRF lengths ranging from 11.0 to

115 The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet li

116 Gene transfer to the corneal endothelium has potential for the prevention or

117 ct baseline CT, which is consistent with the corneal endothelium having a substantial functional rese

118 Expression of JAM-A in human corneal endothelium, human RPE tissue, and cultured ARPE

119 We also found a novel phenotype of corneal endothelium in 4 normal eyes of 2 subjects, whic

120 ine in aqueous humor could help maintain the corneal endothelium in a G1-phase-arrested state in vivo

121 As such, this cytokine may maintain the corneal endothelium in a G1-phase-arrested state in vivo

122 as observed in the tight junctions of rabbit corneal endothelium in a localization pattern identical

123 uman aqueous humor, promotes the survival of corneal endothelium in corneal organ cultures, and wheth

124 The presence of VIP in the corneal endothelium in fresh human donor and bovine eyes

125 following: (1) secondary involvement of the corneal endothelium in Fuchs dystrophy; (2) separate hyd

126 Corneal endothelium in humans does not divide to any sig

127 ntrol corneal endothelium, but was absent in corneal endothelium in patients with endothelialization

128 ble deposits called guttae develop under the corneal endothelium in patients with FCD.

129 These changes in the corneal endothelium in patients with PCG should be consi

130 OL4A3, which is ectopically expressed by the corneal endothelium in PPCD.

131 The possible roles of corneal endothelium in promoting immune privilege of cor

132 iated state and suppressing apoptosis in the corneal endothelium in situ.

133 ession and localization of the three CKIs in corneal endothelium in situ.

134 show that long-term AAV9 transduction of the corneal endothelium in the nonhuman primate is safe and

135 tive proliferative capacity exhibited by the corneal endothelium in these two species may be caused b

136 gated whether PAF can affect the function of corneal endothelium in vitro.

137 Corneal endothelium in vivo is arrested in G1, the phase

138 Ki67, suggesting that, as in humans, rabbit corneal endothelium in vivo is arrested in G1-phase upst

139 and maintenance of mitotic inhibition of the corneal endothelium in vivo.

140 In vivo, gene transfer was evident in corneal endothelium, iris anterior surface, and trabecul

141 nded from 1 week to more than 5 weeks in the corneal endothelium, iris, and trabecular meshwork of nu

142 D), in which an epithelial transition of the corneal endothelium is associated with abnormal endothel

143 Fluid transport by the corneal endothelium is dependent on the presence of HCO(

144 Although the corneal endothelium is highly susceptible to Fas-induced

145 l, especially when the functional reserve of corneal endothelium is low.

146 us methods of tube-shunt implantation on the corneal endothelium is needed.

147 The results of our study indicate that the corneal endothelium is subjected to stress in patients w

148 The corneal endothelium is the most important single layer i

149 r chamber showed distributed localization in corneal endothelium, lens epithelium, and TM and did not

150 ons of rBV resulted in GFP expression in the corneal endothelium, lens, RPE, and retina.

151 PIOL's positional stability (distance to the corneal endothelium [M1] and the natural lens [M2]) as w

152 lation of AQP1 expression and/or function in corneal endothelium may reduce corneal swelling and opac

153 lated with fibroblast growth factor-2 and/or corneal endothelium modulation factor, they synthesize a

154 A confluent bovine corneal endothelium monolayer was used as the control.

155 The permeabilities of the RPE and bovine corneal endothelium monolayers to fluorescein (20 microg

156 tial to selectively identify a region of the corneal endothelium most affected by densely packed gutt

157 Staining patterns of the corneal endothelium most closely corresponded to those o

158 Apoptosis was also not induced in human corneal endothelium, mouse corneal epithelium, or iris/c

159 tudy, the authors rephotographed the central corneal endothelium of 52 normal subjects with the same

160 roliferating subpopulation of cells from the corneal endothelium of adult normal and FECD donors that

161 scles, periocular mesenchymal-like cells and corneal endothelium of early zebrafish embryos.

162 The corneal endothelium of rabbits stained positively for cy

163 evidence of ectopic expression of COL4A3 in corneal endothelium of the proband of the original PPCD3

164 noclonal antibodies were localized in rabbit corneal endothelium only: cyclins D, E, A, and B1; prote

165 However, effects on corneal endothelium or ciliary epithelium are a potentia

166 pathway and did not show any activity in the corneal endothelium or other cells posterior to the scle

167 escriptive-analytical cross-sectional study, corneal endothelium parameters including endothelial cel

168 prevented endothelial cell loss, and rescued corneal endothelium pumping function in adult Col8a2 mut

169 a lesser extent, the trabecular meshwork and corneal endothelium--revealed positive fluorescence stai

170 results following the repair are acceptable, corneal endothelium seems to be subjected to severe dama

171 The corneal endothelium showed polymegethism and cells conta

172 The corneal endothelium shows features consistent with HIV-r

173 In corneal endothelium, SLC4A11 displays robust Na(+)-coupl

174 lls of the corneal and limbal epithelium and corneal endothelium stained positively for protein kinas

175 corneal tissue in vivo demonstrated that the corneal endothelium stains with anti-type I collagen ant

176 We assessed features of the corneal endothelium that are known to be associated with

177 cross cell membranes, including those in the corneal endothelium that contribute to the fluid transpo

178 ssay revealed very few dead cells in ex vivo corneal endothelium that overexpressed E2F2.

179 D) is a degenerative genetic disorder of the corneal endothelium that represents one of the most comm

180 t rejection, and this is in contact with the corneal endothelium, this has the potential to restrict

181 cannot penetrate Descemet's membrane and the corneal endothelium to enter the anterior chamber (AC).

182 After exposure of the corneal endothelium to I/A, the corneas were prepared to

183 Rabbit corneal endothelium tolerated exposure to 6.8 M PROH, an

184 was measured by Goldmann tonometry, AHF and corneal endothelium transfer coefficient (ka) by fluorop

185 Therefore we ask whether SLC4A11 in corneal endothelium transports borate (B[OH](4)(-)), bic

186 ssion of N-cadherin and the formation of the corneal endothelium until E15.

187 aqueous humor stimulates FGF-2 synthesis in corneal endothelium via PI3-kinase and p38.

188 Using specular microscopy, the corneal endothelium was assessed for features of aging (

189 role of CKIs in inhibiting proliferation in corneal endothelium was examined by first determining th

190 rmeability across the apical membrane of the corneal endothelium was examined.

191 morphology, maturation, and function of the corneal endothelium was examined.

192 after cryotreatment, whereas FGF-2 in normal corneal endothelium was localized at the plasma membrane

193 f polymorphonuclear leukocytes (PMNs) to the corneal endothelium was observed after freezing, and IL-

194 The images of the corneal endothelium was obtained by specular microscopy

195 The corneal endothelium was poorly visualized but no endothe

196 When corneal endothelium was stained with anti-FGF-2 antibody

197 Changes in density of the corneal endothelium were quantified by specular microsco

198 The posterior stroma and corneal endothelium were unaffected.

199 embrane, a thick basement membrane under the corneal endothelium, where it forms a hexagonal lattice

200 A were localized in the cytoplasm of rabbit corneal endothelium, whereas cyclins B1 and p34cdc2 were

201 The absence of MHC class I Ags on the corneal endothelium, which lines the anterior chamber of

202 rated the colocalization of E2F2 and EGFP in corneal endothelium with a transfection efficiency of 10

203 FCD) is an autosomal dominant disease of the corneal endothelium with variable penetrance and express

204 EnC) has provided a source of transplantable corneal endothelium, with a significant potential to cha