ライフサイエンスコーパス: corneal stroma

1 ccupied the anterior to middle layers of the corneal stroma.

2 d haze due to neutrophil infiltration to the corneal stroma.

3 ulminating in dissolution of the collagenous corneal stroma.

4 oxylation of collagen that is present in the corneal stroma.

5 aracterized by leukocyte emigration into the corneal stroma.

6 EGFP inflammatory cells through the anterior corneal stroma.

7 otrusion of the anterior chamber with a thin corneal stroma.

8 cilitates corneal invasion, and degrades the corneal stroma.

9 ting inflammatory cell migration through the corneal stroma.

10 ) infiltration and neovascularization in the corneal stroma.

11 T revealed increased reflectivity within the corneal stroma.

12 ient way to deliver and express genes in the corneal stroma.

13 ellular architecture and distribution in the corneal stroma.

14 ed immunoinflammatory response to HSV in the corneal stroma.

15 nce of deposits as bright lesions within the corneal stroma.

16 cans (PGs) in the periphery and center of KC corneal stroma.

17 ements on fibrils isolated from adult bovine corneal stroma.

18 tly higher relative to the RI in the younger corneal stroma.

19 This method can be used to engineer a new corneal stroma.

20 duced mononuclear cell infiltration into the corneal stroma.

21 ents of extracellular KSPG in the vertebrate corneal stroma.

22 BM-derived cell subsets reside in the normal corneal stroma.

23 eosinophils, but not of neutrophils, to the corneal stroma.

24 ncided with neutrophil infiltration into the corneal stroma.

25 al in the establishment of a properly formed corneal stroma.

26 aped granular opacities are deposited in the corneal stroma.

27 rm Onchocerca volvulus are injected into the corneal stroma.

28 nd stroma, and of MMP-3/stromelysin-1, in DR corneal stroma.

29 progressive disease that thins and scars the corneal stroma.

30 nflammatory cells from limbal vessels to the corneal stroma.

31 ogic lesions were confined to the peripheral corneal stroma.

32 l opacity, and modest disorganization in the corneal stroma.

33 use it to drive a foreign gene expression in corneal stroma.

34 ite antigens were injected directly into the corneal stroma.

35 broblasts of all types, including those from corneal stroma.

36 mbrane, and the interfibrillar matrix of the corneal stroma.

37 l and mononuclear cell infiltration into the corneal stroma.

38 iniscent of the organization of normal fetal corneal stroma.

39 those seen in normal developing and healing corneal stroma.

40 erior banded layer, which is adhesive to the corneal stroma.

41 ornea and are secreted by keratocytes in the corneal stroma.

42 and biochemically similar to that in healing corneal stroma.

43 ilar or less intense in PE compared with the corneal stroma.

44 howed a decrease in IL-1beta and MMP9 in the corneal stroma.

45 and slightly more intense compared with the corneal stroma.

46 zed by progressive protein deposition in the corneal stroma.

47 d expression of MAGP1 throughout the central corneal stroma.

48 tan sulfate, a unique molecular component of corneal stroma.

49 fluences myofibroblast transformation in the corneal stroma.

50 ility properties necessary for replacing the corneal stroma.

51 ght fascicles, advancing straight toward the corneal stroma.

52 t also functions to restore integrity of the corneal stroma.

53 d vessel endothelial cells that occur in the corneal stroma.

54 th an intact cornea penetrates well into the corneal stroma.

55 owever, showed variable penetration into the corneal stroma.

56 in adults, deposits are found posteriorly in corneal stroma.

57 te phenotype and the regeneration of damaged corneal stroma.

58 scopy were used to assess HCEC attachment to corneal stroma.

59 model in which conidia are injected into the corneal stroma.

60 flammation in which LPS is injected into the corneal stroma.

61 ds and in the structural organization of the corneal stroma.

62 t with delayed neutrophil recruitment to the corneal stroma.

63 nce for a predominance of neutrophils in the corneal stroma.

64 e significantly lower than in normal control corneal stromas.

65 in the pericentral and central region of the corneal stroma (200-300 cells/mm(2)).

66 l ocular morphogenesis characterized by thin corneal stroma, absence of corneal endothelium, fusion o

67 f AQP1 in active extrusion of fluid from the corneal stroma across the corneal endothelium.

68 and peripheral corneal epithelium and in the corneal stroma adjacent to the limbal blood vessels.

69 Neutrophil emigration into corneal stroma after epithelial abrasion occurs in two w

70 ns in neutrophil (PMN) migration through the corneal stroma after epithelial scrape injury.

71 before corneal infection and was also in the corneal stroma after infection.

72 diation led to damage of collagen fibrils in corneal stroma and a loss of their regular arrangement.

73 However, they have a thinner corneal stroma and a narrower cornea-iris angle of the a

74 Pax6 is transiently expressed in developing corneal stroma and a subset of limbal and corneal stroma

75 RB penetrated approximately 100 mum into the corneal stroma and absorbed >90% of the incident green l

76 ncontrolled growth of Fusarium hyphae in the corneal stroma and anterior chamber, and eventually resu

77 In the first wave, MCs migrated to the corneal stroma and became distributed throughout the cor

78 by inadvertent perforation of the posterior corneal stroma and Descemet membrane (DM).

79 s (2.3%) showed focal adhesions of DM to the corneal stroma and developed isolated tears during strip

80 the tear film toward bacteria in the central corneal stroma and early neutrophil migration from the l

81 phil and F4/80(+) cell infiltration into the corneal stroma and elevated corneal haze, which is an in

82 ult heterozygotes had defects in the central corneal stroma and endothelium and anterior polar catara

83 the corneal epithelial cells, but not in the corneal stroma and endothelium nor in other ocular tissu

84 essed at high levels, but also to the to the corneal stroma and endothelium, where the protein is det

85 ient of the hydrogen-bicarbonate ion pair in corneal stroma and epithelium is calculated from the obs

86 rmal corneas confirmed its expression in the corneal stroma and epithelium.

87 emet membrane, allowing aqueous to enter the corneal stroma and epithelium.

88 a3 collagens were expressed in normal rabbit corneal stroma and in keratocytes cultured in serum-free

89 type XII collagen is present in the ECMs of corneal stroma and in the sclera, as well as in the corn

90 aureus induced neutrophil recruitment to the corneal stroma and increased corneal thickness and haze

91 e that induce neutrophil infiltration to the corneal stroma and loss of corneal clarity.

92 Ten cadaveric porcine eyes with exposed corneal stroma and plastic test spheres underwent unifor

93 Keratocytes isolated from rabbit corneal stroma and plated in a serum-free medium were tr

94 ratopathy with a fluid interface between the corneal stroma and previous laser-assisted in situ kerat

95 cterized by neutrophil infiltration into the corneal stroma and the development of corneal haze.

96 ely by extracellular collagen fibrils in the corneal stroma and the highly concentrated crystallin pr

97 st for specification of corneal endothelium, corneal stroma and the sclera.

98 ed depositions of matrix proteins within the corneal stroma and the stroma-to-stroma interface, which

99 production and cellular infiltration to the corneal stroma and unimpaired bacterial growth.

100 anti-VEGF antibodies were implanted into the corneal stroma and were used to determine the requiremen

101 stnatal days (Ps) in wild-type C57BL/6 mouse corneal stromas and after injury.

102 cules within mammalian collagen fibrils from corneal stromas and that this region becomes masked as c

103 ne production, neutrophil recruitment to the corneal stroma, and bacterial clearance than C57BL/6 mic

104 al epithelium, nerve axons were evaluated in corneal stroma, and capacity of manipulated eyes to supp

105 , leukocytes and platelets rapidly enter the corneal stroma, and CCR6(+) IL-17(+) gammadelta T cells

106 Keratocytes, isolated from rabbit corneal stroma, and cultured in a serum-free medium, pre

107 escens induced neutrophil recruitment to the corneal stroma, and increased corneal thickness and haze

108 ness of corneal neovessels, loss of axons in corneal stroma, and loss of ability of I/CB after kerato

109 s purified from isolated corneal epithelium, corneal stroma, and primary cultures of both epithelial

110 hemokines, recruitment of neutrophils to the corneal stroma, and subsequent bacterial killing and tis

111 es, leading to neutrophil recruitment to the corneal stroma, and that TLR2 mediates O. volvulus/Wolba

112 involve the anterior to middle layers of the corneal stroma, and the disease is primarily a keratitis

113 partments of the rodent eye (ocular surface, corneal stroma, anterior chamber, subconjunctival space,

114 he demarcation between treated and untreated corneal stroma appeared as a region where normal keratoc

115 Keratan sulfate proteoglycans (KSPGs) in the corneal stroma are believed to influence collagen fibril

116 ective tissues of other organs and embryonic corneal stroma as a glycoprotein.

117 up there was a reduced number of PMNs in the corneal stroma at 3 and 7 days of follow-up.

118 corneal epithelial layer and portions of the corneal stroma at 9 hours PI, and polymorphonuclear (PMN

119 vulus) induces eosinophil recruitment to the corneal stroma at the time of maximum corneal opacificat

120 corneal edema was present, typically in the corneal stroma at the time of netarsudil initiation.

121 Apoptosis was detected in the corneal stroma at various time points using an in situ t

122 Neovascularization of the corneal stroma began on day 3 and was sustained through

123 h as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics.

124 of PE's extracellular matrix was similar to corneal stroma but with some variability in staining int

125 ased cross-linking reactions dominate in the corneal stroma, but other possible reaction schemes are

126 Keratocytes isolated from rabbit corneal stroma by collagenase digestion were plated in s

127 rs to regulate neutrophil recruitment to the corneal stroma by enhancing TLR2 expression and OvAg-ind

128 ion through the dense collagenous ECM of the corneal stroma by generating chemotactic PGP during infl

129 Invasion of the corneal stroma by neutrophils and eosinophils and subseq

130 all time points tested, infiltration of the corneal stroma by P. aeruginosa revealed a high degree o

131 t of EGFP-positive inflammatory cells in the corneal stroma can be detected in vivo by 6 hours after

132 study sought identification of cells in the corneal stroma capable of assuming a keratocyte phenotyp

133 uated 1-year safety and efficacy outcomes of corneal stroma cell therapy.

134 Cultured human corneal stroma cells and whole human corneas received UV

135 After corneal wounding, the remaining corneal stroma cells are phenotypically fibroblasts and

136 Corneal stroma cells cultured at 500 cells/mm2 were trea

137 noviral construct could be used to transfect corneal stroma cells effectively in vivo and to determin

138 Collagenase-isolated corneal stroma cells obtained from newborn and adult mic

139 allowed visualization of EGFP expression in corneal stroma cells, to accurately assess cellular arch

140 of IL-1, IL-6, IL-8, and TNF alpha in human corneal stroma cells.

141 n average, throughout the whole depth of the corneal stroma, collagen fibrils in mimecan-null mice, u

142 produced significantly less CXCL1/KC in the corneal stroma compared with C57BL/6 mice consistent wit

143 Fibroblasts in the corneal stroma, conjunctiva, and sclera labeled similarl

144 n sulfate-containing proteoglycans of bovine corneal stroma contain three unique core proteins design

145 xyproline content indicated that the central corneal stroma contained significantly more collagen per

146 The normal murine corneal stroma contains a significant number of CD45(+)

147 Corneal stroma contains an extracellular matrix of ortho

148 Normal murine corneal stroma contains heterogeneous cell populations i

149 and ciliary body) and cranial neural crest (corneal stroma, corneal endothelium and anterior iris).

150 y of 1 microm to cut a spiral pattern in the corneal stroma creating precise lamellar flaps for LASIK

151 sed the entry of topical riboflavin into the corneal stroma despite the presence of a previously inta

152 During normal corneal stroma development and healing, changes in mRNA

153 pectively, and neutrophil recruitment to the corneal stroma, development of corneal haze, and chemoki

154 sion function of preparations indicated that corneal stromas dialysed against 154 mM NaCl had usable

155 njection of air or collagenase into the deep corneal stroma did not result in a reproducible separati

156 of autologous ADASc and decellularized human corneal stroma did not show complications at 1 year of f

157 acellular matrix in vitro resembling primary corneal stroma during embryonic development.

158 e the inflammatory cells that migrate to the corneal stroma during endotoxin-induced keratitis and to

159 sive corneal isolate of P. aeruginosa in the corneal stroma during infection of ex vivo and in vivo r

160 increase the oxygen concentration within the corneal stroma during the A-CXL process.

161 tion of collagen reorganization in the avian corneal stroma during the latter stages of embryogenesis

162 stallins are lost from resident cells of the corneal stroma during wound repair, and this is associat

163 erful tool for enhanced visualization of the corneal stroma environment and cellular biology.

164 Keratocytes in the corneal stroma express keratan sulfate-containing proteo

165 Corneal stroma extracellular matrix (ECM) glycosaminogly

166 6, and induction of lymphangiogenesis in the corneal stroma facilitating sustained presentation of an

167 human foreskin fibroblasts (HFFs), and human corneal stroma fibroblasts (HCFs).

168 blasts (RAB9) and primary cultures of rabbit corneal stroma fibroblasts (NRCF) were grown to confluen

169 g tissue-specific promoter constructs to the corneal stroma for gene expression.

170 Wholemounts of paraformaldehyde-fixed corneal stroma from normal mice at 5 to 16 weeks of age

171 Regeneration of corneal stroma has always been a challenge due to its so

172 Collagen fibrils in the corneal stroma have been recognised to have a high degre

173 ages and polarization anisotropy profiles of corneal stroma heated in the 35-80 degrees C range are a

174 dure that delivers radio-frequency energy to corneal stroma in a circular fashion to steepen the corn

175 D11b monocyte-specific antigen appear in the corneal stroma in high numbers by 24 hours after epithel

176 nvestigate the fibrillar architecture of the corneal stroma in mice homozygous for a null mutation in

177 The corneal stroma in persons undergoing penetrating keratop

178 eovascularization process that occurs in the corneal stroma in response to HSV infection.

179 s facilitated the attachment of HCECs to the corneal stroma in the human anterior segment model with

180 the influx of monocytes-macrophages into the corneal stroma in the rabbit.

181 anscripts were also detected in the anterior corneal stroma, in the ciliary muscle, beneath the anter

182 or T-cells and NK cells were absent from the corneal stroma, indicating that all the cells identified

183 156S and recombinant murine VEGF-D) into the corneal stroma induce not only LA but also robust HA cha

184 We discovered that antigens delivered to corneal stroma induced enhanced, rather than suppressed,

185 ryonic day (E)9, then penetrate the anterior corneal stroma, invade the epithelium, and branch over t

186 ithelial scrape injury, PMN migration in the corneal stroma involves close contact between keratocyte

187 No recognizable corneal endothelium, corneal stroma, iris stroma, or anterior chamber was fou

188 of extracellular matrix architecture in the corneal stroma is associated with abundant type VI colla

189 The transparency of the corneal stroma is critically dependent on the hydration

190 such as neutrophils and eosinophils into the corneal stroma is initiated from peripheral (limbal) ves

191 In addition, the layering of the corneal stroma is poorly formed or absent.

192 Incisional or ablation injury to the corneal stroma is repaired by deposition of a fibrotic t

193 The RI in the older corneal stroma is slightly higher relative to the RI in

194 one marrow-derived fibroblastic cells of the corneal stroma is strongly correlated with the failure o

195 Within the corneal stroma, keratocytes communicate through gap junc

196 ssion patterns of adult and postnatal day-10 corneal stroma, keratocytes, fibroblasts, and myofibrobl

197 received decellularized donor 120-mum-thick corneal stroma lamina alone (n = 5).

198 atitis is an immunopathologic disease in the corneal stroma leading to scarring, opacity, and blindne

199 a large number of macrophages infiltrate the corneal stroma, limbus, and lacrimal glands of diseased

200 nubs of whorled collagen extending from the corneal stroma, lined in some instances, by Descemet mem

201 This study unravels the nerve influence on corneal stroma metabolism.

202 We propose that loss of beta-actin in the corneal stroma might be a triggering factor in the devel

203 the ability of FIB to bind noncovalently to corneal stroma molecules, Coll-I, decorin, dermatan sulf

204 ession of ANGPTL7 protein was located in the corneal stroma, near the limbus, and throughout the scle

205 Furthermore, corneal stroma neovascularization and meibomian gland de

206 Further studies are warranted in the corneal stroma-nerve interactions.

207 -9 stimulated neutrophil recruitment to the corneal stroma of C57BL/6 mice, but not TLR2(-/-) or -9(

208 ogenous cytokines, we injected OvAg into the corneal stroma of C57BL/6, IL-1 receptor 1(-/-) (IL-1R1(

209 e to impaired KC and MIP-2 production in the corneal stroma of CXCR2(-/-) mice, which was similar to

210 lus adult worms (OvAg) was injected into the corneal stroma of each animal.

211 on of a lumican expression minigene into the corneal stroma of Lum-/- mice.

212 marked contrast, neutrophil migration to the corneal stroma of MyD88(-/-) mice challenged with Pam(3)

213 adult stem cell recellularization within the corneal stroma of patients with advanced keratoconus.

214 show that beta-actin is downregulated in the corneal stroma of patients with KC, which may be related

215 SP present in the corneal stroma of the eyes with severe HSK lesions coloc

216 -smooth muscle actin (a-SMA) in the superior corneal stroma of the keratectomy-only group (indicative

217 In the present study, the corneal stroma of the mouse was examined to provide some

218 No staining was observed in the corneal stroma or in the choroid.

219 lassic NK cells migrated into the limbus and corneal stroma, peaking at 24 hours with an eightfold in

220 on through limbal vessels into the avascular corneal stroma, peaking within 12 to 18 hours after woun

221 cellular and molecular effects on the human corneal stroma post CXL, and promises to establish optim

222 fferentiation, such as the thickening of the corneal stroma, proceed relatively slowly.

223 Keratocytes of the corneal stroma produce a specialized extracellular matri

224 Keratocytes of the corneal stroma produce a transparent extracellular matri

225 Keratocytes of the corneal stroma produce transparent extracellular matrix

226 iform scanning excimer laser ablation of the corneal stroma produces a significant central steepening

227 the direction favoring stemness, whereas the corneal stroma promotes differentiation.

228 and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid ti

229 -2, KC, and MIP-1 alpha was localized to the corneal stroma, rather than to the epithelium, which was

230 implex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause of blindness.

231 e response to infection, and in the infected corneal stroma represents an elementary defense mechanis

232 es and dissociates interstitial water in the corneal stroma, resulting in ROS production in the absen

233 larization-maintaining backscattering in the corneal stroma secondary to CXL.

234 Keratocytes of the corneal stroma secrete a unique population of proteoglyc

235 as a combined defect in DM and the posterior corneal stroma seemed to consistently elicit a typical c

236 broblasts or other cell types present in the corneal stroma show no significant expression of VEGF mR

237 Collagen XII is a regulator of corneal stroma structure and function.

238 These enhanced immune responses in corneal stroma suggest new approaches to medical interve

239 gth ultraviolet light (UVA; RFUVA) increases corneal stroma tensile strength significantly.

240 ly less (P < 0.0001) GAG accumulation in the corneal stroma than dogs with a later onset of treatment

241 Regions within the corneal stroma that lack collagen autofluorescence coinc

242 d population of PAX6-positive cells in adult corneal stroma that maintain the potential to assume a k

243 that it is the basis for the formation of a corneal stroma that must be transparent to visible light

244 howed eosinophilic deposits in subepithelial corneal stroma that stained negative for Congo-red.

245 ort variant form of type XII collagen, human corneal stroma, the BM zone, and the sclera contain the

246 orm of type XII collagen was detected in the corneal stroma, the sclera, and the stroma in the rudime

247 r viral persistence and dissemination to the corneal stroma, the site of inflammation.

248 event attachment of the lens and iris to the corneal stroma, therefore permitting the normal formatio

249 ied cholesterol and cholesterol ester in the corneal stroma; this is believed to be due to an imbalan

250 Implantation was performed in the corneal stroma through a femtosecond-assisted 9.5-mm dia

251 ine anterior chamber including ciliary body, corneal stroma, TM and corneal nerves using the adeno-as

252 on resident bone marrow-derived cells in the corneal stroma to produce CXC chemokines, leading to neu

253 Progression of the virus from the corneal stroma to the retina during acute infection was

254 During wound healing, keratocytes in the corneal stroma transdifferentiate into fibroblasts and m

255 In the corneal stroma, type XII collagen may be organized along

256 DSCs), with few regulatory T cells, into the corneal stroma under erosion sites.

257 Slit2 in preventing nerves from entering the corneal stroma until the proper time (i.e., they serve a

258 e ablation threshold for the collagen in the corneal stroma was determined to be 30 mJ/cm2.

259 in vitro three-dimensional (3-D) model of a corneal stroma was developed by using primary human corn

260 scent signal from the collagen fibers of the corneal stroma was evident in the TPAF channel.

261 al microscopy, neutrophil recruitment to the corneal stroma was quantified by immunohistochemistry, a

262 itment of neutrophils and eosinophils to the corneal stroma was significantly impaired in FcgammaR(-/

263 Prolonged virus expression in the corneal stroma was suggested to cause bystander activati

264 which mediate neutrophil recruitment to the corneal stroma, was elevated in the corneal epithelium a

265 of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inf

266 mediators of granulocyte recruitment to the corneal stroma, we determined the relative contribution

267 Imaging deeper into the corneal stroma, we show that crawling macrophages and ra

268 ation of leukocyte migration into and out of corneal stroma, we showed reentry of extravasated leukoc

269 crophage inflammatory protein (MIP)-2 in the corneal stroma were also significantly elevated after ex

270 The depth distributions of RF in the corneal stroma were calculated using a group of linear e

271 es of 84 patients with disorders of anterior corneal stroma were correlated to clinical outcome param

272 ages, PMN and fibroblasts) and mBD3 (PMN) in corneal stroma were identified by dual label immunostain

273 orneal fibroblasts and human KC cells in the corneal stroma were isolated, cultured, and stimulated w

274 After corneal stromas were digested with proteinase K, aliquot

275 microscopy showed patches along the denuded corneal stroma where there was a partial or complete los

276 the PE stroma was similar or weaker than the corneal stroma, whereas collagen III staining was focal

277 ce scar was significantly higher than normal corneal stroma, whereas concentrations of DeltaUA-beta-1

278 eas can lead to blinding inflammation in the corneal stroma, which is referred to clinically as herpe

279 a pronounced cellular infiltration into the corneal stroma, which was TLR3- and TRIF-dependent.

280 e to altered autofluorescence signals of the corneal stroma, which were confirmed by conventional his

281 15 mm/s), phase gratings were created in the corneal stroma, which were shown to be pure RI changes r

282 ce were immunized s.c. and injected into the corneal stroma with Ags from the parasitic helminth Onch

283 g spatial expression patterns throughout the corneal stroma with differential temporal expression.

284 development, particularly the formation of a corneal stroma with the appropriate number of fibroblast

285 stals were mostly localized in the posterior corneal stroma with the depth of crystal deposition show

286 uggests that it is a direct extension of the corneal stroma with variable locations that may displace

287 epithelialised and de-endothelialised bovine corneal stromas with a hydration of 3.2 equilibrated at

288 1 hours after injection of adeno-EGFP in the corneal stroma, with a duration of approximately 3 weeks

289 with peak accumulation of neutrophils in the corneal stroma within 12 hours.

290 without sheets of decellularized donor human corneal stroma within the stroma of patients with advanc

291 gnetic source and attachment of cells to the corneal stroma without affecting cell viability or light

292 n frozen sections of 5- to 6-month-old mouse corneal stromas without the need for any unmasking techn