ライフサイエンスコーパス: corneum

1 of poor drug penetration across the stratum corneum.

2 y the heterogeneous structure of the stratum corneum.

3 uctures could be elucidated in human stratum corneum.

4 ar to be free to act only within the stratum corneum.

5 se approximately 50% of the lipid in stratum corneum.

6 , an integral lipid component of the stratum corneum.

7 ound to a thiol-rich band within the stratum corneum.

8 lete absence of a granular layer and stratum corneum.

9 e 5-fold thickening of the Abca12-/- stratum corneum.

10 m granulosum, and a non-keratinizing stratum corneum.

11 rupted, producing a poorly developed stratum corneum.

12 stages: spinous, granular layer, and stratum corneum.

13 se agents on the lipid matrix of the stratum corneum.

14 ch microabscesses formed beneath the stratum corneum.

15 nd in the intercellular space of the stratum corneum.

16 l moisturizing factors (NMFs) in the stratum corneum.

17 f abundant lipase activity in asebia stratum corneum.

18 that previously recorded from intact stratum corneum.

19 differentiation and enriched in the stratum corneum.

20 overy of the barrier function of the stratum corneum.

21 that can rival the volume of the dry stratum corneum.

22 arrier of cornified cell layers, the stratum corneum.

23 filaggrin-processing products in the stratum corneum.

24 corneum was 85% lower than in normal stratum corneum.

25 ly disrupt the lipid bilayers of the stratum corneum.

26 layers of the epidermis, beneath the stratum corneum.

27 tration efficacy of the nanogel into stratum corneum.

28 effectively permeate through intact stratum corneum.

29 corneocytes in the outer layer, the stratum corneum.

30 ustain 0.6N that is enough to pierce stratum corneum.

31 create microscopic pores across the stratum corneum.

32 ccumulation of lipid droplets in the stratum corneum.

33 ter way to deliver siRNAs across the stratum corneum.

34 tributed into, or on the top of, the stratum corneum.

35 lts in increased water loss from the stratum corneum.

36 the intracellular components of the stratum corneum.

37 n grafting experiments confirmed the stratum corneum abnormalities and normal BrdU uptake.

38 ventions with partial removal of the stratum corneum after curettage and microdermabrasion and simila

39 imated saturation doses in the upper stratum corneum allows one to distinguish between diffusion-limi

40 Such barrier function of the stratum corneum also hampers the use of common adjuvants used to

41 After minimal injury to the stratum corneum alterations in the calcium concentration in the

42 ween a macroscopic sample of porcine stratum corneum and an adherent deformable elastomer substrate.

43 rome, which causes detachment of the stratum corneum and chronic inflammation.

44 effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/upper derm

45 ow permeability of siRNA through the stratum corneum and epidermis has significantly limited its use

46 While the makeup of healthy stratum corneum and epidermis is generally understood, the mobil

47 in permeation barrier imposed by the stratum corneum and facilitate transcutaneous delivery of nanopa

48 as been shown to efficiently disrupt stratum corneum and facilitate transcutaneous drug delivery, but

49 munostaining was associated with the stratum corneum and fluorescein isothiocyanate-labeled oligonucl

50 logical analysis showing an impaired stratum corneum and higher cellular infiltration after papain ap

51 th SRB and RBHE penetrate beyond the stratum corneum and into the viable epidermis only in discrete r

52 ry of encapsulated molecules via the stratum corneum and mammary ducts in a formulation-dependent bas

53 significantly more dye via both the stratum corneum and mammary ducts, while the 80% and 70% water f

54 Mutant mice exhibit fragile stratum corneum and perinatal death due to dehydration.

55 the physical barrier function of the stratum corneum and provide innate cutaneous host defense.

56 anionic molecules must penetrate the stratum corneum and reach the living epidermis and dermis.

57 ornified envelope) is present in the stratum corneum and retains the ability to form covalent inhibit

58 erved deficit in the adhesion of the stratum corneum and the severely compromised epidermal barrier f

59 oneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delive

60 ies in both skin barrier structures (stratum corneum and tight junctions), a robust T(H)2 response to

61 system that can permeate through the stratum corneum and viable epidermis and efficiently deposit the

62 ccumulation of lipid droplets in the stratum corneum, and a water barrier defect.

63 intercellular lipid lamellae in the stratum corneum, and aberrant keratinocyte differentiation.

64 ("cisternae") present throughout the stratum corneum, and at 24 h these cisternae substantially incre

65 ssion, microjet penetration into the stratum corneum, and impact of microjet on the stratum corneum a

66 ctivity, prevented detachment of the stratum corneum, and improved the barrier function of the epider

67 mal changes, primarily involving the stratum corneum, and increased epidermal thickness were mainly p

68 gh the external barrier of the skin, stratum corneum, and secure exposure to the viable skin layers.

69 anges of the surrounding tissue, the stratum corneum; and information storage is possible in both.

70 rneum, and impact of microjet on the stratum corneum are considered.

71 is in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated.

72 he polymer matrix, breach the skin's stratum corneum barrier and dissolve upon contact with skin inte

73 eolytic cascade that is required for stratum corneum barrier functionality.

74 o their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achi

75 he skin is highly constrained by the stratum corneum barrier layer(1).

76 work, that deliver the precursors of stratum corneum barrier lipids to the extracellular compartment.

77 e and shown to penetrate through the stratum corneum barrier when topically applied to mouse skin.

78 w that on breakdown of the epidermal stratum corneum barrier, type 2 and type 17 inflammatory respons

79 differentiation to form an effective stratum corneum barrier.

80 mouse skin on breakdown of epidermal stratum corneum barrier.

81 nction is compromised because of the stratum corneum becoming spontaneously detached in the newborn m

82 rease in the free thiol layer in the stratum corneum, but not in the nucleated epidermis.

83 er and thinning of the epidermis and stratum corneum by 50%.

84 diffusivities of these compounds in stratum corneum by factors ranging from 250 to over 2000.

85 d to the extracellular spaces of the stratum corneum by the secretion of lamellar bodies.

86 Disruption of the stratum corneum, by acetone application on the skin of hairless

87 Physical disruption of the stratum corneum can improve the efficiency of delivery.

88 glands, since increased hydration in stratum corneum causes it to become softer.

89 tum corneum swelling, and identifies stratum corneum cell layers that swell less.

90 Both the number of stratum corneum cell layers was reduced and the processing of th

91 caused striking malformations of the stratum corneum, characterized by dysmorphic and pleomorphic cor

92 In the normal epidermis, the stratum corneum chymotryptic enzyme (SCCE) thought to play a cen

93 mes are potential substrates for the stratum corneum chymotryptic enzyme (SCCE), protein extracts fro

94 ptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein 7) were

95 es permeability barrier homeostasis, stratum corneum cohesion, wound healing, and epidermal innate im

96 Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of molecular sp

97 Stratum corneum comprises corneocytes, derived from outer stratu

98 t allergy, nickel sensitization, and stratum corneum defects.

99 rin) and prevented cytokine-mediated stratum corneum degradation.

100 d, following penetration through the stratum corneum, depleted thiols in the viable epidermis.

101 ornified envelope morphogenesis, and stratum corneum desquamation.

102 peptidases that are associated with stratum corneum detachment was either low or undetectable, but t

103 ovides free amino acids in the outer stratum corneum, did not account for the relative humidity depen

104 ed that a well-tolerated regimen for stratum corneum disruption before vaccine patch application resu

105 d immunity and that the magnitude of stratum corneum disruption correlates with the immune response.

106 These rhythms persist during stratum corneum disruption with and without CS application.

107 -effects is related to the degree of stratum corneum disruption.

108 uamation by cleaving proteins of the stratum corneum (e.g., corneodesmosin and plakoglobin).

109 Injury to the stratum corneum elicits an epidermal hyperproliferative response

110 d in culture media and extracts from stratum corneum, epidermis and dermis after 24h, and the results

111 Even though stratum corneum exhibits structural features across multiple len

112 oncept is probed using excised human stratum corneum exposed to aqueous solutions of radiolabeled sod

113 the in vivo swelling behavior of the stratum corneum: exposure to water for 4 or 24 h results in a 3-

114 The stratum corneum extracellular matrix (ECM) is enriched in lipids

115 epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesi

116 that psoriasin, purified from human stratum corneum extracts, selectively kills Escherichia coli by

117 epidermal thickness, contributes to stratum corneum formation and may eliminate pre-malignant cells.

118 ole in epidermal differentiation and stratum corneum formation in utero.

119 -specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier

120 is required for epidermal turnover, stratum corneum formation, and removal of ultraviolet-damaged pr

121 g filaggrin, a protein essential for stratum corneum formation, these data point to an innate epiderm

122 /-) mice with striking impairment of stratum corneum formation.

123 ferentiation protein expression, and stratum corneum formation.

124 Serum antibody reactive with human stratum corneum found in patients with psoriatic arthritis was s

125 rin were quantified in tape-stripped stratum corneum from 31 atopic dermatitis patients and urocanic

126 bers of bacteria which penetrate the stratum corneum from everyday activities.

127 nocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, th

128 orneum neutralization alone provokes stratum corneum functional abnormalities, including aberrant per

129 ecretion of lamellar bodies into the stratum corneum, glucosylceramides are metabolized to ceramides,

130 e outer layer of mammalian skin, the stratum corneum, has been previously investigated by multiple bi

131 n-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of ros

132 lar metabolites, which contribute to stratum corneum hydration and pH.

133 sessed here whether sebum influences stratum corneum hydration or permeability barrier function in as

134 riglycerides) did not restore normal stratum corneum hydration to asebia skin, topical glycerol, the

135 triglyceride in sebaceous glands for stratum corneum hydration was demonstrated further by (i) the ab

136 ysis in sebaceous glands, normalized stratum corneum hydration, and the glycerol content of asebia st

137 , inflammation, and decreased (>50%) stratum corneum hydration, associated with a reduction in sebace

138 lity barrier homeostasis and reduced stratum corneum hydration, we hypothesized here that epidermal d

139 d glycerol is a major contributor to stratum corneum hydration.

140 and uncharged, partition into human stratum corneum immersed in aqueous solutions to an extent compa

141 risscross the cornified cells of the stratum corneum imparting structural integrity, and defects in f

142 ed glycerol content in epidermis and stratum corneum in AQP3-knockout mice, and correction of the phe

143 water loss, increased overt loss of stratum corneum in inflammatory lesions, and impaired stratum co

144 have been shown to permeabilize the stratum corneum in vivo and facilitate the transport of macromol

145 ontrast to BMV, restores compromised stratum corneum integrity and barrier function.

146 ty barrier homeostasis and decreased stratum corneum integrity/cohesion, as well as the mechanisms re

147 us permeability barrier function and stratum corneum integrity/cohesion, as well as the responsible m

148 permeability barrier homeostasis and stratum corneum integrity/cohesion, but these approaches all int

149 ties in both barrier homeostasis and stratum corneum integrity/cohesion.

150 bitors with the superbase normalized stratum corneum integrity/cohesion.

151 Three modes of bubble-stratum corneum interactions including shock wave emission, micr

152 ure leads to extensive disruption of stratum corneum intercellular lipid lamellae.

153 ptive effect of overhydration on the stratum corneum intercellular space, identifies large and numero

154 ong signal at the stratum granulosum/stratum corneum interface.

155 Keratinization of the stratum corneum involves a highly choreographed sequence of even

156 fter tape-stripping, indicating that stratum corneum is a major source of UVA-induced oxidative stres

157 The study suggests the stratum corneum is a more chaotic structure than previously envi

158 ding of the mechanical properties of stratum corneum is based on the assumption that its thickness an

159 The stratum corneum is composed of protein-enriched corneocytes embe

160 een the follicle and the surrounding stratum corneum is involved.

161 pic brick-and-mortar geometry of the stratum corneum is obtained using the commercial finite element

162 The barrier function of the stratum corneum is provided by patterned lipid lamellae localize

163 The permeabilization of the stratum corneum is transient and its barrier function recovers.

164 The skin barrier (stratum corneum) is a major factor for determining the nature of

165 the viable epidermis, underlying the stratum corneum, is included as a potentially important contribu

166 e activity at the stratum granulosum-stratum corneum junction and a modest decrease in both involucri

167 expression at the stratum granulosum/stratum corneum junction.

168 of terminal differentiation markers (stratum corneum, K10, and loricrin).

169 The stratum corneum layer and Ki67 in keratinocytes of the epidermis

170 he lack of restoration of functional stratum corneum layers observed after BM treatment.

171 ion of the lacunar spaces within the stratum corneum leading to the formation of transient channels.

172 tural analyses demonstrated abnormal stratum corneum lipid architecture in AD and IV HEEs, independen

173 ion of the lacunar spaces within the stratum corneum lipid bilayers but no changes in the organizatio

174 tions of cavitation bubbles with the stratum corneum lipid bilayers.

175 ely drive both the generation of the stratum corneum lipid-enriched extracellular matrix and the tran

176 l dermal absorption models treat the stratum corneum lipids as a homogenous medium through which solu

177 lar distribution patterns within the stratum corneum lipids as observed in experimental data.

178 udies demonstrate unequivocally that stratum corneum neutralization alone provokes stratum corneum fu

179 To study the consequences of stratum corneum neutralization, independent of hydration, we app

180 The PCA content in the stratum corneum of AD(-)PA(+) subjects was significantly reduced

181 es in skin properties and CCBAs from stratum corneum of healthy human subjects, providing a means to

182 ort and distribution of water of the stratum corneum of infants and compare it to those of adults.

183 he results suggest that although the stratum corneum of infants may appear intact shortly after birth

184 dingly, the lipid composition of the stratum corneum of Irf6(-/-) skin was abnormal, culminating in a

185 The stratum corneum of lesional but also clinically unaffected skin

186 both interfollicular and follicular stratum corneum of lesional KP, which correlated ultrastructural

187 tratum basale, stratum spinosum, and stratum corneum of lesions from the transgenic mice using PALM m

188 mised chelation of the metals in the stratum corneum of patients with atopic dermatitis.

189 r protein-to-lipid ratios within the stratum corneum of RHS indicated reduced lipid amounts after 30

190 phylococcus aureus spreads under the stratum corneum of skin by elaboration of exfoliative toxin, whi

191 notable topographical changes in the stratum corneum of skin permeated with CYnLIP that were absent i

192 is a major structural protein in the stratum corneum of the epidermis.

193 by their poor permeation across the stratum corneum of the skin and low penetration into the skin's

194 the transport barriers posed by the stratum corneum of the skin and the biofilm.

195 ions made between the keratin of the stratum corneum of the skin and the glass surface.

196 pact of the complex structure of the stratum corneum on transdermal penetration is not yet fully desc

197 interactions between the gel and the stratum corneum or, more specifically, its protein and lipid str

198 hat it shrunk the corneocytes in the stratum corneum (p<0.001) and the imaging of the skin hair folli

199 ntegrity and barrier function of the stratum corneum, particularly during times of skin inflammation.

200 l penetration, but minimally altered stratum corneum penetration as compared to the control solution.

201 down, attributed to the elevation of stratum corneum pH.

202 The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which

203 or in the protein components of the stratum corneum produce scaly or ichthyotic skin with abnormal b

204 In the stratum corneum proteases degrade the inhibitor, freeing the RNa

205 downregulation of tight junction and stratum corneum proteins in the skin of patients with severe ACD

206 downregulation of tight junction and stratum corneum proteins, even in the absence of clinical sympto

207 correlated with the denaturation of stratum corneum proteins, making it feasible to use protein conf

208 ns multiple conserved genes encoding stratum-corneum proteins.

209 rs of these specialized cells in the stratum corneum provide a tough and resilient framework for the

210 Since stratum corneum (SC) acidification in adults is required for nor

211 l endogenous pathway responsible for stratum corneum (SC) acidification.

212 ths) are linked instead to defective stratum corneum (SC) acidity.

213 Neutralization of stratum corneum (SC) adversely impacts key epidermal functions,

214 d by their low absorption across the stratum corneum (SC) and into viable cells of skin.

215 s often dependent upon breaching the stratum corneum (SC) and targeting cells within defined layers o

216 Stratum corneum (SC) and viable epidermal thickness measured wit

217 ts has been proposed on the basis of stratum corneum (SC) architecture, proliferation kinetics, melan

218 long periodicity phase (LPP) in the stratum corneum (SC) are studied using bilayer-slab-bilayer (san

219 mality was associated with decreased stratum corneum (SC) ceramide content and impaired lamellar body

220 At birth, human stratum corneum (SC) displays a near-neutral surface pH, which d

221 we assessed epidermal structure and stratum corneum (SC) function in a previously genotyped human lo

222 ed the mechanisms by which PS alters stratum corneum (SC) function.

223 rter aquaporin-3 (AQP3) have reduced stratum corneum (SC) hydration and skin elasticity, and impaired

224 Although stratum corneum (SC) hydration has been primarily of concern to

225 al permeability barrier function and stratum corneum (SC) integrity were abnormal, but barrier recove

226 nonlamellar phase separation in the stratum corneum (SC) interstices, explaining the barrier abnorma

227 The stratum corneum (SC) is an effective permeability barrier.

228 ty and spatial distribution of human stratum corneum (SC) lipids from samples collected in vivo.

229 in (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) component

230 The reduced pH of the stratum corneum (SC) of darkly pigmented skin could account for

231 ant lacunae of unprocessed lipids in stratum corneum (SC) of FAK(K5 KO) mice and delayed barrier reco

232 een altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis and thei

233 ecently that short-term increases in stratum corneum (SC) pH are accompanied by minor alterations in

234 At birth, neonatal stratum corneum (SC) pH is close to neutral but acidifies with m

235 es in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and S

236 ive, but the barrier of skin's outer stratum corneum (SC) prevents delivery of most drugs.

237 rmalities were not evident, and both stratum corneum (SC) skin hydration and surface pH were normal.

238 We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU

239 ture the skin, can bypass the skin's stratum corneum (SC) to enter the skin microcirculation and achi

240 's outermost and rate limiting layer stratum corneum (SC), and increase its permeability.

241 utermost layer of the epidermis, the stratum corneum (SC), are not understood.

242 l details of epidermis, specifically stratum corneum (SC), during sonophoresis are beyond the resolut

243 In neonatal rat stratum corneum (SC), pH declines from pH 6.8 at birth to adult

244 termost region of the epidermis, the stratum corneum (SC), provides an essential barrier to water los

245 s fifth stripping ("outer" vs. "mid"-stratum corneum (SC), respectively) from nine normal adult forea

246 epidermal skin layers, including the stratum corneum (SC), stratum granulosum (SG), stratum basale (S

247 Intercellular lipids of the stratum corneum (SC), the outer layer of the epidermis, form a b

248 on the outermost layer of skin, the stratum corneum (SC), using polarization transfer solid-state NM

249 f epidermal ontogenesis is to form a stratum corneum (SC), which is required for post-natal permeabil

250 0-5.5) over 5-6 days in neonatal rat stratum corneum (SC).

251 h the skin, specifically through the stratum corneum (SC).

252 utermost layer of the epidermis, the stratum corneum (SC).

253 ng from serine proteases (SP) in the stratum corneum (SC).

254 eous functions largely reside in the stratum corneum (SC).

255 bnormally-compacted outer epidermis [stratum corneum (SC)], while electron microscopy revealed defici

256 ost skin barrier (referred to as the stratum corneum, SC) and subsequent catalytic generation of O2 b

257 rcellular lipid matrix of the skin's stratum corneum serves to protect the body against desiccation a

258 The stratum corneum showed parakeratotsis.

259 the secreted lamellar bodies at the stratum corneum-stratum granulosum boundary.

260 nical effects of these events on the stratum corneum structure, the relationship between the number o

261 ng permeability barrier homeostasis, stratum corneum surface pH, and water-holding capacity, and resp

262 e acquired every 1.7 microm from the stratum corneum surface to the first viable layer (stratum granu

263 structures, defines the magnitude of stratum corneum swelling, and identifies stratum corneum cell la

264 oduce the protective, semi-permeable stratum corneum that permits terrestrial life.

265 ally reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominant at sho

266 onding to a depth of 2-3 mum, of the stratum corneum (the outermost, 15-20 mum skin layer).

267 allow S. aureus to spread under the stratum corneum, the main barrier of the skin, explaining how, a

268 ffectively deliver siRNA through the stratum corneum, the major challenge is that this approach is pa

269 Stratum corneum, the outermost layer of skin, allows transport o

270 We study the drying of stratum corneum, the skin's outermost layer and an essential bar

271 oids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that likely und

272 n inflammatory lesions, and impaired stratum corneum thickening after phorbol ester treatment.

273 (filaggrin and loricrin), increased stratum corneum thickness, and significantly reduced T-cell infi

274 s in a 3- or 4-fold expansion of the stratum corneum thickness, respectively.

275 arger values consistently for infant stratum corneum throughout the first year of life and showed gre

276 reacts with amino acids in the outer stratum corneum to form a mixture of high molecular weight pigme

277 Both exposure of stratum corneum to neutral pH buffers and blockade of acidificat

278 cholesterol sulfate signal along the stratum corneum toward the migrating epithelial tongue.

279 ality associated with an increase in stratum corneum tryptic enzyme (SCTE) in the epidermis.

280 lot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and stratum

281 Located in the stratum corneum, urocanic acid is a major epidermal chromophore

282 r effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microderma

283 , and the glycerol content of asebia stratum corneum was 85% lower than in normal stratum corneum.

284 The interaction of water with the stratum corneum was assessed by measuring capacitance, transepid

285 e skin barrier was defective and the stratum corneum was detached through desmosomal cleavage.

286 In the current study, the stratum corneum was disrupted using an electrocardiogram prep pa

287 e content of both asebia and control stratum corneum was low, consistent with high rates of triglycer

288 indicating that the structure of the stratum corneum was not a major factor.

289 AQP3-knockout mice have reduced stratum corneum water content and elasticity compared with wild-

290 in the extracellular matrix of skin stratum corneum, were analyzed by X-ray diffraction methods.

291 Unlike stratum corneum where lipids are organized under a precisely ord

292 limited solute diffusion through the stratum corneum, where the lipid structure is represented by a l

293 al epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and

294 iation and the formation of a mature stratum corneum, which is essential for the skin to prevent alle

295 ation is the barrier function of the stratum corneum, which must be overcome either by abrasive metho

296 of ultra long-chain ceramides in the stratum corneum, which play a key role in maintaining the permea

297 aled hyperkeratosis and a disordered stratum corneum with an accumulation of neutral lipid droplets;

298 a pathogen that is restricted to the stratum corneum, with little or no tissue reaction.

299 kin barrier function and a defective stratum corneum, with SerpinB2(-/-) mice showing increased trans

300 n water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular