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1                    In Mode 3A, keratinocytes cornified and flaked off to free skin appendages (feathe
2                 The eye surface, lacking the cornified barrier of skin, provides an excellent model.
3  fragility or an abnormal cornified envelope/cornified-bound lipid envelope scaffold, a defect that c
4 ither the cornified envelope or the adjacent cornified-bound lipid envelope, i.e., a corneocyte scaff
5                                The epidermal cornified cell envelope (CE) is a complex protein-lipid
6                                          The cornified cell envelope (CE) is a specialized structure
7 ied as a likely constituent of the insoluble cornified cell envelope (CE) of stratified squamous epit
8  ester linkages to undefined proteins of the cornified cell envelope (CE).
9 al compelling lines of evidence point to the cornified cell envelope and structural components of the
10 inocytes, where they serve as a scaffold for cornified cell envelope assembly.
11           The major protein component of the cornified cell envelope barrier structure of the epiderm
12 l involucrin biotinylation and the increased cornified cell envelope formation provided evidence that
13 keratinocyte transglutaminase activities and cornified cell envelope formation.
14 isclose novel insights into perturbations of cornified cell envelope formation.
15 akin may not relate to the physiology of the cornified cell envelope in epidermal keratinocytes but m
16  1) enzyme is involved in the formation of a cornified cell envelope in terminally differentiating ep
17 e, which is critical for the assembly of the cornified cell envelope in terminally differentiating ke
18 periplakin have been shown to be part of the cornified cell envelope in terminally differentiating st
19  a previously characterized component of the cornified cell envelope of stratified epithelia, where i
20 R) proteins are structural components of the cornified cell envelope of stratified squamous epithelia
21 ne-rich (SPR) proteins are components of the cornified cell envelope of stratified squamous epithelia
22  cross-bridging reinforcement protein of the cornified cell envelope of the inner root sheath cells b
23                             Mutations in the cornified cell envelope protein loricrin have been repor
24         Loricrin is a major component of the cornified cell envelope, a highly insoluble structure co
25                                          The cornified cell envelope, a lipoprotein layer that assemb
26 ing keratin filaments, as a component of the cornified cell envelope, and as a source of natural mois
27 uctural proteins and in the formation of the cornified cell envelope, thereby contributing to rigid s
28 plakin, which is known as a precursor of the cornified cell envelope.
29 ns become sequentially incorporated into the cornified cell envelope.
30 cytes, but did not detect the protein in the cornified cell envelope.
31 ified as a putative precursor protein of the cornified cell envelope.
32 l differentiation and incorporation into the cornified cell envelope.
33 tin filaments, intercellular lipids, and the cornified cell envelope.
34 ross-linked to form a major component of the cornified cell envelope.
35 fferentiation of keratinocytes that form the cornified cell layer.
36 well-developed basal, spinous, granular, and cornified cell layers providing an excellent model to st
37 nsults by creating an impermeable barrier of cornified cell layers, the stratum corneum.
38  suggest a mechanism for the coordination of cornified cell structure by permanent covalent attachmen
39 optotic biochemical machinery to produce the cornified cell.
40 sitive cells in stratum granulosum and newly cornified cells by electron microscopy.
41 We determined the citrulline contents in the cornified cells of the epidermis of newborn rats, as wel
42 hly ordered macrofibrils that crisscross the cornified cells of the stratum corneum imparting structu
43 tal hyperkeratosis (abnormal accumulation of cornified cells) resulting from impaired desquamation.
44              When PAI-2, purified from human cornified cells, was added to synchronized keratinocytes
45 to the cell envelope and in the shape of the cornified cells.
46 ere surrounded by a thick, compact sheath of cornified cells.
47 t of mucin contents in the remaining ones by cornifying cells that block the egress of mucin contents
48 h loricrin is the predominant protein of the cornified envelope (CE) in keratinocytes, loss or gain o
49                                          The cornified envelope (CE) is an insoluble sheath of epsilo
50                                              Cornified envelope (CE) precursor protein expression and
51    Real-time PCR evaluated the expression of cornified envelope (CE) precursor proteins (involucrin a
52 t S100A11 is a component of the keratinocyte cornified envelope (CE) suggests that S100A11 is a trans
53 cross-linked in an orderly fashion to form a cornified envelope (CE).
54  epidermis, disturbed cornification, fragile cornified envelope (CE, a skin barrier structure), and i
55                                     The late cornified envelope (LCE) gene cluster within the epiderm
56                             Deletion of late cornified envelope (LCE) genes LCE3B and LCE3C (LCE3B/C-
57                                         Late cornified envelope (LCE) genes, located in the epidermal
58                Six SNPs associated with late cornified envelope (LCE3) genes were present at greater
59 in knockout mouse skin and confirm that late cornified envelope 1 genes are transcriptional targets o
60                We also demonstrate that late cornified envelope 1 genes are upregulated at the transc
61 we present evidence suggesting that the late cornified envelope 1 proteins are also compensatory comp
62 cross-linked keratin filaments enclosed in a cornified envelope [1].
63 amellar body, corneocyte lipid envelope, and cornified envelope abnormalities.
64 ly during fetal days E15.5 to E16.5, and the cornified envelope and desmosomes in the newborn mice we
65 eratinocytes reinforced by proteins of their cornified envelope and sequestered intercellular lipids.
66 eability assays to show that final stages of cornified envelope assembly are coordinated with initial
67 tain keratin filaments bound to a peripheral cornified envelope composed of cross-linked proteins.
68                        This directly affects cornified envelope cross-linking rather than corneodesmo
69 al proteins involved in the formation of the cornified envelope during squamous cell differentiation.
70 responsible for assembly of the keratinocyte cornified envelope during terminal keratinocyte differen
71 anced Oral Squamous Cell Carcinoma, with the cornified envelope formation and antigen processing cros
72 Ca2+-induced differentiation, as assessed by cornified envelope formation or transglutaminase activit
73 f the TIG3-positive cells and the effects on cornified envelope formation suggest that TIG3 is an act
74                                  The rate of cornified envelope formation was increased 3-fold in ker
75 t, corneocyte-bound lipid envelopes, whereas cornified envelope formation was unchanged.
76                                     Rates of cornified envelope formation, a marker of keratinocyte t
77                                     Rates of cornified envelope formation, an indicator of terminal d
78 LE may also provide a scaffold for subjacent cornified envelope formation, evidenced by restoration o
79 and mRNA levels of two proteins required for cornified envelope formation, involucrin (INV) and trans
80 ression of structural proteins necessary for cornified envelope formation, involucrin, loricrin, and
81 ed in SCC 12F cells, including inhibition of cornified envelope formation, reduction of involucrin mR
82 ikely to have a similar functional effect on cornified envelope formation, with disturbance of transg
83  possible link between connexin function and cornified envelope formation.
84 cessation of cell proliferation and enhanced cornified envelope formation.
85  inflammatory responses, keratinization, and cornified envelope formation.
86 nced transglutaminase activity and excessive cornified envelope formation.
87 mal skin barrier requires the formation of a cornified envelope from terminally differentiating kerat
88                                          The cornified envelope is a layer of transglutaminase cross-
89                                          The cornified envelope is assembled from transglutaminase cr
90 ins may provide a scaffolding onto which the cornified envelope is assembled.
91 art of the scaffold onto which the epidermal cornified envelope is assembled.
92 tase/MT-SP1 perturbs lipid matrix formation, cornified envelope morphogenesis, and stratum corneum de
93 n and infection is bacterial adhesion to the cornified envelope of corneocytes in the outer layer, th
94  proteins that becomes incorporated into the cornified envelope of cultured epidermal keratinocytes,
95  of periplakin, and is incorporated into the cornified envelope of cultured keratinocytes.
96    Involucrin is a protein that makes up the cornified envelope of keratinocytes and is expressed in
97         Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o
98         Involucrin is a major protein of the cornified envelope of keratinocytes that provides much o
99               Sciellin is a precursor of the cornified envelope of mammalian stratified epithelia cha
100 on microscopy showed no defect in either the cornified envelope or the adjacent cornified-bound lipid
101 hornerin [hrn] and filaggrin 2 [flg-2]); the cornified envelope precursor (ie, SPRR3); mattrin, which
102 kers K1 and K10 and the cross-linking of the cornified envelope precursor protein involucrin.
103 ssion of ZNF750-dependent genes encoding key cornified envelope precursor proteins and lipid-processi
104 xamine the intracellular distribution of the cornified envelope precursor S100A11 (S100C) and the eff
105 affinity column made with an antibody to the cornified envelope precursor sciellin.
106                                Involucrin, a cornified envelope precursor, and the cross-linking enzy
107 ), functions as a transglutaminase substrate/cornified envelope precursor, signal transduction protei
108 imulates ocular surface epithelia to produce cornified envelope precursors and the tissue transglutam
109 ne repeat organization is unique among other cornified envelope precursors characterized by homologou
110                          Several cytoplasmic cornified envelope precursors have been described.
111 to evaluate the presence and distribution of cornified envelope precursors in human corneal epitheliu
112 cal epithelia expressing increased levels of cornified envelope precursors.
113                          Desquamation of and cornified envelope protein (involucrin and small proline
114 corneocytes in the stratum corneum where the cornified envelope protein loricrin is the main ligand f
115 ing insertional mutants of Loricrin, a major cornified envelope protein of the epidermis, suggest a p
116                                          The cornified envelope protein small proline-rich protein 1B
117 pidermal keratins was unchanged, whereas the cornified envelope proteins involucrin and loricrin were
118                                    Levels of cornified envelope proteins mRNA were measured by real-t
119                   Thus, combined loss of the cornified envelope proteins not only impairs the epiderm
120 on, we identified three transcripts encoding cornified envelope proteins with altered expression in t
121 eramides covalently linked by ester bonds to cornified envelope proteins, most abundantly to involucr
122 uman SPRR1 gene and other genes encoding for cornified envelope proteins.
123 cal desquamation and increased expression of cornified envelope proteins.
124 ant structural component of the keratinocyte cornified envelope that is expressed early in the kerati
125 in (hINV) is a precursor of the keratinocyte cornified envelope that is specifically expressed in the
126 diate filaments and is cross-linked into the cornified envelope to form the epidermal barrier.
127   Involucrin is an integral component of the cornified envelope which is a characteristic feature of
128 y being structural protein precursors of the cornified envelope) and the other 13 belong to the S100
129 ggested that SerpinB2 (cross-linked into the cornified envelope) is present in the stratum corneum an
130 n barrier, which is normally imparted by the cornified envelope, a composite of protein and lipid tha
131 res are selectively perturbed, including the cornified envelope, a likely scaffold for lipid organiza
132 oteins are cross-linked together to form the cornified envelope, an essential and discrete unit of th
133 various protein and lipid components for the cornified envelope, and the controlled dissolution of ce
134    The third wave contains components of the cornified envelope, as keratinocytes enhance the epiderm
135                 Sciellin, a precursor of the cornified envelope, contains a LIM domain that is known
136 e loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barr
137 gulating the expression of genes of the late cornified envelope-1 (Lce1) family involved in epidermal
138 uclear shrinkage, and increased formation of cornified envelope-like structures.
139 he late marker, loricrin, a component of the cornified envelope.
140 tuents of both keratohyalin granules and the cornified envelope.
141 that TGX contributes to the formation of the cornified envelope.
142 n by covalent binding of acylceramide to the cornified envelope.
143 responsible for assembly of the keratinocyte cornified envelope.
144 and that FATP4 functions in establishing the cornified envelope.
145 ier structure on their periphery, termed the cornified envelope.
146 nocyte and critical for the formation of the cornified envelope.
147 ent proteins leading to the formation of the cornified envelope.
148  than to corneocyte fragility or an abnormal cornified envelope/cornified-bound lipid envelope scaffo
149                    Comparative proteomics of cornified envelopes (CEs) from prenatal KtyI(-/-) and Kt
150 elope formation, evidenced by restoration of cornified envelopes after CLE rescue.
151 NIKS keratinocytes produce similar levels of cornified envelopes and nucleosomal fragmentation in res
152 rkedly increased the number of cells forming cornified envelopes and the number of cells staining wit
153                             However, because cornified envelopes are attenuated in these autosomal re
154 d in CNBr extracts of purified keratinocytes cornified envelopes by western blot.
155                                              Cornified envelopes form but are ultrastructurally abnor
156 bstrates, the small proline-rich proteins of cornified envelopes found in stratified squamous epithel
157 e-rich (Sprr2) protein, a major component of cornified envelopes in keratinized epidermis, were subst
158 own that cyanogen bromide (CNBr) cleavage of cornified envelopes isolated from cultured foreskin kera
159               Sciellin is a precursor of the cornified envelopes of mammalian keratinizing tissues.
160 s peptide from recombinant hINV and from the cornified envelopes yields the sequence G-Q-L-K-H-L-E-Q-
161  (LBs) and LB secretion, thinner lipid-bound cornified envelopes, and a defective permeability barrie
162 ation of the epidermis and the production of cornified envelopes, structures essential for barrier ac
163 inal differentiation markers and assembly of cornified envelopes.
164  junctions and terminally differentiate into cornified envelopes.
165 erentiation, as measured by the formation of cornified envelopes.
166 ced lower levels of cross-linked protein and cornified envelopes.
167 ycle, stratification, and even production of cornified envelopes.
168  reduced mechanical strength detected in the cornified envelopes.
169 dermal differentiation, leading to thickened cornified envelopes; and (ii) enhanced epidermal lipid s
170 lieved necessary for normal formation of the cornified epidermal barrier.
171 d with the cell envelope at the periphery of cornified epidermal cells.
172  is confined to differentiating granular and cornified epidermal cells.
173 comes a part of the keratinized cells of the cornified epidermal layer.
174  organics represent condensed remains of the cornified epidermis and, likely also, deeper anatomical
175 esponds to biological stimulation, while the cornified epidermis functions as a protective barrier.
176  cells undergo squamous differentiation into cornified (i.e., 1% SDS insoluble) envelopes and death i
177 nuclease Trex2 are expressed specifically in cornifying keratinocytes.
178 of epidermis (acanthosis), thickening of the cornified layer (hyperkeratosis), and increased vascular
179 ht-junctions in combination with a defective cornified layer allow the accessibility of nectin-1 to H
180 e, due to a combination of thickening of the cornified layer and an increase in the production of non
181 iers, which not only include a dysfunctional cornified layer but also depend on impaired tight juncti
182                                          The cornified layer is a compacted lattice of lipid-embedded
183                              The impermeable cornified layer of the stratum corneum is maintained by
184 , in a patient's skin, its expression in the cornified layer was significantly decreased.
185 nd involucrin (EPI-/- mice)-have a defective cornified layer, reduced epidermal gammadelta T cells, a
186 nd involucrin-(EPI-/- mice) have a defective cornified layer, reduced epidermal gammadelta T cells, i
187 thout a reduction in non-polar lipids in the cornified layer, which has the potential to reduce scali
188  epidermis, and a mild hyperkeratosis in the cornified layer.
189 turation undergo enucleation to generate the cornified layer.
190 kedly reduced granular layer and a condensed cornified layer.
191 active state in the keratinized cells of the cornified layer.
192 comes a part of the keratinized cells of the cornified layer.
193 tinocyte transition from the granular to the cornified layer.
194  corneocytes, and a morphologically abnormal cornified layer.
195 sal region and a pronounced but disorganized cornified layer.
196 py showed marked thickening of the epidermal cornified layers and increased epidermal TUNEL staining,
197 loricrin staining is markedly reduced in the cornified layers and increased in the nucleus.
198 filaggrin, and filaggrin was absent from the cornified layers of ft/ft epidermis.
199 9C7 was abundantly expressed in granular and cornified layers of the epidermis.
200 accumulation of DNA fragments throughout the cornified layers of the tongue epithelium.
201 lated cultures also had reduced granular and cornified layers, and produced lower levels of cross-lin
202 ies between its basal, spinous, granular and cornified layers.
203  exhibit nuclear staining of granular and/or cornified layers.
204 composed of the basal, spinous, granular and cornified layers.
205 ng multiple steps within both suprabasal and cornified layers.
206 ulation of DNA fragments in the cytoplasm of cornifying lingual keratinocytes and co-deletion of DNas
207     The shafts emerge from the follicle with cornified material still attached.
208 his essential epidermal barrier, composed of cornified proteins encased in lipids, prevents both wate
209 is expressed in the suprabasal layers of non-cornified stratified epithelia.
210 pole epidermis that functions in lieu of the cornified, stratified epithelium of the adult epidermis.
211 n an approximately 0.1-mm-thick layer in the cornified tips of the filiform (but not fungiform) papil

 
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