ライフサイエンスコーパス: corona

1 ona") as well as physisorbed proteins ("soft corona").

2 ionized gas around the LMC (the 'Magellanic Corona').

3 Rosuvastatin Multinational Trial in HF-REF (CORONA).

4 ystyrene, also in the presence of a thin eco-corona.

5 ry showed subsequent heating of the adjacent corona.

6 ally triggering electron acceleration in the corona.

7 hase and stabilized by a polymer based outer corona.

8 her in comparison to its counterpart ex vivo corona.

9 ic particles akin to those seen in the solar corona.

10 - 12 gauss magnetic field measurement in the corona.

11 g a continuous layer visually appearing as a corona.

12 a densely functionalized aptamer-displaying corona.

13 rresponding to radio wave propagation in the corona.

14 of 50 to 150 kilometers per second into the corona.

15 d size because of the formation of a protein corona.

16 metric poly(3-hexylthiophene) or polystyrene corona.

17 ) W m(-2)) is transferred onto the overlying corona.

18 lease of magnetic energy stored in the Sun's corona.

19 the chemical composition of the SNA protein corona.

20 MTT assay in the presence and absence of the corona.

21 fter intravenous injection to form a protein corona.

22 f the corresponding proteins in the original corona.

23 anes, was reduced in the presence of protein coronas.

24 by a reduction in the spatial extent of the corona(10,11).

25 in (for example, about the initiation of the corona(12) and the production of solar energetic particl

26 Here we report imaging of the solar corona(15) during the first two perihelion passes (0.16-

27 igh-energy) X-ray spectrum produced by a hot corona(4,5) positioned above its accretion disk, and the

28 ) intensification of Maxwell stresses in the corona above newly emerging ARs, days before first flare

29 arrier, and a densely packed alendronic acid corona acting as a stabilizer and targeting moiety.

30 at plasma accelerates as it emerges from the corona, aided by unidentified processes that transport e

31 planation for the composition of the protein corona, aiding in the development of safe and effective

32 th a solvophilic poly(ethylene glycol) (PEG) corona, an inner crystalline core that consists of poly(

33 er issues such as the formation of a protein corona and antibody multivalency interfere with the labe

34 to play a role in heating the million-degree corona and are associated with Alfvenic waves that help

35 ibodies represent a link between biomolecule corona and C3 opsonization, and may determine individual

36 nd, challenging models of circulation in the corona and calling into question our understanding of ho

37 gineering of hollow structures with suitable corona and canopy species.

38 viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assist

39 e nanoparticles thus prepared showed surface corona and exhibited free radical scavenging and enzyme

40 n shocks and compressions moving through the corona and inner solar wind and are the dominant source

41 such a process because they are seen in the corona and solar wind and contain considerable energy(5-

42 Here, the processing of the protein corona and the corresponding protein-nanoparticle intera

43 ion time lags between the continuum-emitting corona and the irradiated accretion disk are 6 to 20 tim

44 al distribution of the plasma density in the corona and the phase speed of the prevailing transverse

45 te to atmospheric phenomena such as glories, coronas and rainbows(19).

46 th biological fluids, is termed the "protein corona" and it is gradually seen as a determinant factor

47 ospheric light scattered by electrons (the K-corona) and dust (the F-corona or zodiacal light) have b

48 statin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopr

49 f key epitopes exposed on the surface of the corona, and able to engage the biological machinery, is

50 old nanoparticle system packaged with a SipA corona, and found this bacterial mimic not only accumula

51 al gold nanoplasmonics, nanoparticle-protein corona, and nanoparticle-membrane interaction.

52 active sequences displayed from the particle corona, and the ability to easily encapsulate biologics

53 sought-after scaffold that links MAD1 to the corona, and this specific pool of MAD1 is needed to gene

54 raphical evidence of case studies on adeno-, corona-, and rotaviral spike proteins, the relationship

55 The seemingly inevitable protein corona appears to be an insurmountable obstacle to wider

56 This is because the corona architecture is not a monolayer, but an assembly

57 surements of the magnetic field in the Sun's corona are difficult to obtain.

58 ork, we demonstrate that Pt NPs with protein coronas are generated in vivo in human blood when a pati

59 se To evaluate if the formation of a protein corona around ferumoxytol nanoparticles can facilitate s

60 Conclusion The protein corona around ferumoxytol nanoparticles can facilitate s

61 y elusive or postulated formation of protein corona around nanoparticles in vivo in humans and illust

62 ntal data suggests that the microgels form a corona around the microspheres and induce a soft repulsi

63 We demonstrate changes in protein coronas around these particles within biological media,

64 Our results highlight the viral protein corona as an acquired structural layer that is critical

65 litative in situ characterization of protein corona as well.

66 e used to detect chemisorbed proteins ("hard corona") as well as physisorbed proteins ("soft corona")

67 Though the onset of corona, as detected by the appearance of light, was alwa

68 ficantly lower detection limits by employing corona-assisted particle microconcentration for efficien

69 ofiles and to mechanistically understand the coronas' biological/ecological impact, we present a tier

70 , relatively straight branch with a streamer corona burst at its far end.

71 ufficient Poynting flux not only to heat the corona but also to originate the supersonic solar wind.

72 onfirm the large-scale topology of the solar corona, but also reveal that, as recently predicted(19),

73 recognition at the surface of a nanoparticle corona, but it remains an important question whether suc

74 ich can be clearly monitored and imaged by a corona camera in daylight and room light.

75 include bioactive lipids, the polymer outer corona can be used for targeting and they are highly sta

76 oxide NPs that were surrounded by a protein corona, can cross plasma membranes.

77 ns to limit the dynein-mediated stripping of corona cargoes through a direct interaction with Nde1.

78 cluding stability, biocompatibility, protein corona, cellular internalization pathway of EVG nanoform

79 L1) and coronal steric effects (via the PtBA corona chain length in the P segment, L2 related to the

80 namely coronal steric effects (via the PtBA corona chain) and attractive interaction strength (via t

81 PFS cylinders with a residual percentage of corona chains dependent on the photoirradiation time.

82 nanoparticles (NPs) that dictate the protein corona characteristics.

83 The corona charge of the droplets was theoretically calculat

84 the calculated specific charge generated by corona charging was in good agreement with the experimen

85 icelles with variable and spatially distinct corona chemistries, including amphiphilic nanostructures

86 aphene surface quickly and tightly to form a corona complex.

87 nt role in the formation of protein-graphene corona complexes.

88 vity is crucial for maintaining the required corona composition and ensuring efficient kinetochore bi

89 fibrinogen highly contributed in the protein corona composition at the surface of zeolite nanoparticl

90 We characterize corona composition by mass spectrometry, revealing high-

91 While the full biomolecular corona composition can be investigated by conventional b

92 key proteins that participate in the protein corona composition of many types of nanoparticles (NPs),

93 Knowledge of protein corona composition, formation mechanisms, and dynamics i

94 and the fibre length, and is independent of corona composition.

95 The cationic corona conferred CBLG with superior integrity and drug r

96 Patchy block copolymer micelles with a corona consisting of two chemically different patches ha

97 Centromere protein F (CENP-F) is part of the corona, contains two microtubule-binding domains, and ph

98 nt of Reduction in Mortality and Morbidity], CORONA [Controlled Rosuvastatin Multinational Trial in H

99 shown that the formation of protein-graphene corona could effectively reduce its cytotoxicity; howeve

100 e length using a strategy that also involved corona cross-linking.

101 sequently, we will discuss about the protein corona derived from blood with foci on the physiochemica

102 o reliably and easily estimate the detergent corona diameter and select the smallest size, critical f

103 the self-assembled micelles (e.g., core and corona diameters, aggregation number) as well as the con

104 introduction method employing direct current corona discharge (CD) coupled to a surface acoustic wave

105 Ionization mechanisms, including corona discharge and electrospray, are involved in the i

106 signment of oxidation artifacts formed under corona discharge conditions.

107 instrument with a commercially available AC corona discharge device in a novel setup via an adapter.

108 plied on the carbon fiber bundle to initiate corona discharge for ionization of analytes.

109 We have successfully reduced corona discharge in negative ion mode by trace addition

110 Under high aqueous solvent conditions, corona discharge is commonly observed at emitter tips, r

111 nerates up to +/-5 kV dc voltage to ignite a corona discharge plasma in air for up to 12 h of continu

112 After ion irradiation in a corona discharge the iCVD PTFE thin films exhibit stable

113 sing by a nonradioactive one, i.e., by an AC corona discharge unit.

114 ospray ionization (ESI) is often affected by corona discharge when spraying 100% aqueous solutions as

115 omena linked to negative ionization, such as corona discharge, arcing, and electrospray destabilizati

116 headspace vapor of the selected reagents to corona discharge, solvent-free Borsche-Drecsel cyclizati

117 ssure when the proximal sample is exposed to corona discharge.

118 this corona exchange assay to study protein corona dynamics on ssDNA-SWCNT-based dopamine sensors.

119 e as a fluorescence quencher, and apply this corona exchange assay to study protein corona dynamics o

120 presents a generic route to assess real-time corona exchange on nanoparticles in solution phase and m

121 ompared to nanoparticles without a dense PEG corona following local administration by either manual i

122 ld, we introduce the potential impact of the corona for NM-microbiome-(human)host interactions and th

123 main of thrombomodulin (TM) onto the micelle corona for the local generation of activated protein C,

124 lly review and present an updated concept of corona formation and evolution.

125 nce and of the biophysical forces regulating corona formation is mandatory.

126 Herein, we measure protein corona formation on DNA-functionalized single-walled car

127 erum proteins, virtually eliminating protein corona formation on the nanoprobes.

128 nsional oligonucleotide structure on protein corona formation, we studied the identity and quantity o

129 and entropic interactions driving selective corona formation.

130 e, the previously unreported in vivo protein corona formed in human systemic circulation is described

131 The human-derived protein corona formed onto PEGylated doxorubicin-encapsulated li

132 and also the chemistry of the complementary corona-forming block.

133 owth of PLLA block copolymers with different corona-forming blocks.

134 on of the composition and ratio of core- and corona-forming polymers (indirectly tuning PEGylation de

135 orporated BMA in both the polyplex core- and corona-forming polymers, resulting in robust endosomolys

136 ratios of core-forming polymers to PEGylated corona-forming polymers.

137 oly(ferrocenyldimethylsilane) (PFS) block, a corona-forming segment of poly(2-vinylpyridine) (P2VP),

138 PEGylated, diblock polymers were screened as corona-forming units.

139 The derived field strengths in the corona, from 1.05 to 1.35 solar radii, are mostly 1 to 4

140 on loses dependence on MPS1 kinase after the corona has been established, ensuring that corona-locali

141 The transient nature of the corona has been well characterized for large events, but

142 ntities and amounts of the proteins in this "corona" have been thoroughly examined, the spatial arran

143 delivery is the quick formation of a protein corona (i.e., protein adsorbed on the nanoparticle surfa

144 y cannot be used as an adequate indicator of corona ignition.

145 ublic Health, Swiss School of Public Health (Corona Immunitas research program), Fondation de Bienfai

146 As the corona impacts the in vitro and/or in vivo NM applicatio

147 f the spatial orientation of proteins in the corona in a high-throughput fashion is still challenging

148 the exploitation of the nanoparticle-protein corona in analytical chemistry.

149 1) accumulate a rich and distinctive protein corona in different biological fluids.

150 igated, the crucial role of the biomolecular corona in drug delivery and the release efficacy of nano

151 we report that, by including this Magellanic Corona in hydrodynamic simulations of the Magellanic Clo

152 designed to elucidate the role of the ligand corona in shaping the thermodynamics and kinetics of BNS

153 totoxicity, pointing to the role of protein "corona" in conferring the biological impact of amyloidog

154 The liposome-protein corona is a dynamic interface that regulates the interac

155 A protein corona is a protein layer adsorbed onto NPs upon contact

156 e black-hole systems(12,13) suggest that the corona is compact and that the disk extends nearly to th

157 previous investigations in mice, the in vivo corona is found to be molecularly richer in comparison t

158 rtificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly i

159 ent is the shedding of the outermost fibrous corona layer of the kinetochore following microtubule at

160 oint mutations in this sequence abolish MAD1 corona localisation and weaken the SAC.

161 e corona has been established, ensuring that corona-localised MAD1 can still be phosphorylated when M

162 Therefore, this study explains how corona-MAD1 generates a robust SAC signal, and it reveal

163 Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces

164 We engineered nanomedicine with the stealth corona made up of densely packed bone seeking ligand, al

165 This can impact how the corona mediates cell and tissue interactions.

166 segments provides a promising route to core-corona nanoparticles (micelles) with a wide range of pot

167 sphere to heat up the local chromosphere and corona, observationally validating their ubiquity has pr

168 timing and magnitude of upward motion to the corona observed 29 s after the event onset in 171 A by t

169 Conjugation to the corona of a single-chain antibody (scFv), which binds to

170 and optionally also bio-conjugates, and the corona of adsorbed biological molecules.

171 lts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the

172 xt of what is currently known of the protein corona of graphene-based nanomaterials.

173 PT, 1c), are synthesized on the basis of the corona of indeno[1,2-b]fluorene.

174 on oxide nanoparticles surrounded by a dense corona of many brightly luminescent semiconductor quantu

175 ta-amino esters) (PBAEs), possessing a dense corona of polyethylene glycol.

176 rotein (C3) was dependent on the biomolecule corona of the nanoparticles.

177 Cross-linking of the P2VP corona of the peripheral block in the 2D block co-micell

178 ion environment in the region just above the corona of the Sun and directly explore the physics of pa

179 ropes are structures that are common in the corona of the sun and presumably all stars.

180 mpetition between the proteins to occupy the corona of the zeolite nanoparticles.

181 o the ROD-Zw10-Zwilch complex in the fibrous corona of unattached kinetochores.

182 The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (in vivo

183 phine ligands immobilized within the soluble coronas of block copolymer micelles is found to induce i

184 low-degree nodes surrounded by hierarchical coronas of hubs, and are uncovered only through the opti

185 , we show that acquisition of a coating, or "corona", of NOM alters the hydrodynamic and electrokinet

186 The protein composition (corona) of zeolite nanoparticles has been shown to be mo

187 nal and structural insights into the protein corona on nanomaterials and offers a new strategy to man

188 The formation of a protein corona on nanoprobes in the blood can not only reduce th

189 To evaluate the effect of a protein corona on stem cell labeling, human mesenchymal stem cel

190 ideration of the effects of the biomolecular corona on the controlled release and drug delivery of na

191 have demonstrated that formation of protein corona on the surface of [60]fullerene derivatives is ch

192 al bovine serum (FBS), which forms a protein corona on the surface of the AuNPs.

193 We find that the presence of a serum protein corona on the tip strongly modifies the interaction as i

194 nfluenced by the conformation of the protein coronas on GO.

195 results demonstrate that the effects of NOM coronas on nanoparticle properties and interactions with

196 to other triblock comicelles with different coronas on the central or end segment where "cross" supe

197 cs of AgNWs, due to the formation of a lipid corona or aggregation of the AgNWs.

198 by electrons (the K-corona) and dust (the F-corona or zodiacal light) have been made from the ground

199 ario was designed to investigate the protein corona pattern on the pillar-layer surface of a Cu-based

200 ngineered NPs translates to distinct protein corona patterns enabling differential and reproducible i

201 modulate the formation of the serum protein corona (PC) and the resultant immune response.

202 to form a protein layer termed the "protein corona" (PC).

203 l environments, NPs are coated by a 'protein corona' (PC), critically affecting physiological and the

204 ne C3 deposition efficiency, the biomolecule corona per se enhances immunoglobulin binding to all nan

205 The corona phase binds selectively to a PDE5 inhibitor, Vard

206 nique three-dimensional configuration of the corona phase formed at the nanotube surface.

207 We then extend this system to the Corona Phase Molecular Recognition (CoPhMoRe) approach o

208 Corona phase molecular recognition (CoPhMoRe) uses a het

209 This work conclusively shows that corona phase molecular recognition can mimic key aspects

210 Corona phase molecular recognition is a technique introd

211 f human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high select

212 nd sensitivity of polymer "mutations" to the corona phase, as well as direct competitions with the na

213 e transition also changes the observed SWCNT corona phase, modulating the recognition of riboflavin.

214 dynamics between solution-phase and adsorbed corona-phase DNA and protein biomolecules on single-wall

215 alled carbon nanotube, some of the resulting corona phases demonstrate binding specificity remarkably

216 Moreover, we show that corona pre-coating differentially affects viral infectiv

217 In order to comprehensively analyse corona profiles and to mechanistically understand the co

218 We show that manipulation of the corona protein composition and assembly can influence th

219 mass spectrometry, revealing high-abundance corona proteins involved in lipid binding, complement ac

220 In this work, we show that labeling corona proteins with isobaric tags in their native condi

221 rls showed persistently lower FA in anterior corona radiata (ACR) (group, P = .04; group x age x sex,

222 asciculus, posterior thalamic radiation, and corona radiata (all p < 0.05).

223 dal cingulate (M4) motor regions through the corona radiata (CR), internal capsule (IC) and crus cere

224 (CC), superior longitudinal fasciculus (LF), corona radiata (CR), internal capsule (IC) and external

225 The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), sp

226 ying white matter microstructure at the left corona radiata and also associated with overall symptoms

227 ts, with the highest lesion frequency in the corona radiata and between C2 and C4 vertebral levels.

228 -0.02 (P = .02); MD, beta = -0.01 (P = .03)] corona radiata and external capsule [right FA, beta = 0.

229 ractional anisotropy in the corpus callosum, corona radiata and external capsule, and increased mean

230 tions of the corpus callosum and beyond (eg, corona radiata and inferior longitudinal fasciculus) acr

231 ous tracts including the corpus callosum and corona radiata compared to mature-born adults.

232 LIC, the cerebral peduncle, and the superior corona radiata than did the HC.

233 corpus callosum, longitudinal fasciculus and corona radiata were independent contributors to the Brie

234 l-motor cortex FC significantly mediated the corona radiata white matter effects on SICI (p = .007).

235 A) in callosal and projection fibers (IC and corona radiata) relative to controls, but lower FA than

236 ecifically by axial diffusivity of the right corona radiata, (maximum indirect effect beta = -0.034 (

237 erior limb of the internal capsule, superior corona radiata, and cerebellar peduncles), the associati

238 Parietal operculum, corona radiata, and internal capsule differences between

239 ingulum, fornix, stria terminalis, posterior corona radiata, and superior longitudinal fasciculus in

240 lum, fornix, and stria terminalis, posterior corona radiata, and superior longitudinal fasciculus.

241 corpus callosum, the superior and posterior corona radiata, and the cingulum.

242 of internal capsule, superior and posterior corona radiata, bilateral external capsule and the right

243 d increases in MD in the bilateral posterior corona radiata, bilateral superior longitudinal fascicul

244 co-cortical and cortico-thalamic fibers: the corona radiata, corpus callosum, superior longitudinal f

245 was whole-brain FA in parts of the anterior corona radiata, external capsule, and cerebellum (P<0.05

246 ed by a higher fractional anisotropy of left corona radiata, predicted fewer inhibitory deficits, sug

247 tracts, specifically within right posterior corona radiata, right tapetum, and bilateral corpus call

248 um of corpus callosum, anterior and superior corona radiata, superior longitudinal and inferior front

249 respectively, including the corpus callosum, corona radiata, superior longitudinal fasciculus, and co

250 white matter microstructure of the anterior corona radiata, then cognition (working memory, focused

251 tional anisotropy in the corpus callosum and corona radiata.

252 , predominantly in the centrum semiovale and corona radiata.

253 ces were observed in the corpus callosum and corona radiata.

254 d increased mean diffusivity of the anterior corona radiata.

255 iffusivities in superior (SCR) and posterior corona radiatae (PCR) (group x age x sex, P = .002; grou

256 splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superio

257 sts a reduction in the spatial extent of the corona, rather than a change in the inner edge of the ac

258 The formation of the biomolecular corona represents a crucial factor in controlling the bi

259 We comment on how corona signatures may be linked to effects at the nano-b

260 nts and by the agreement in micelle core and corona sizes obtained from microscopy of the in vitro so

261 uch breaks also happened before the onset of corona, so they cannot be used as an adequate indicator

262 However, the inhomogeneous turbulent corona strongly affects the propagation of the emitted r

263 ) could be achieved by engineering a protein corona structure consisting of a ribonuclease-A (RNase-A

264 LPHN features a core-shell-corona structure that facilitates the transfer and mixin

265 Using structure perturbation, corona surface characterization, and molecular dynamics

266 the high-density filament into a low-density corona surrounding the target.

267 D-Zwilch-ZW10 (RZZ) complex builds a fibrous corona that assembles on mitotic kinetochores before MT

268 groups to present a positively charged outer corona that attracts negative PFOA molecules.

269 y bind to NMs, forming a protein/biomolecule corona that critically affects the NMs' (patho)biologica

270 a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synth

271 The protein corona that forms upon exposure of nanoparticles to bovi

272 BPN) coated with a dense polyethylene glycol corona that prevents adhesion to ECM components.

273 at possess a dense polyethylene glycol (PEG) corona that prevents them from being trapped by adhesion

274 ed by a rapid release of energy in the solar corona, thought to be produced by the decay of the coron

275 ained magnetohydrodynamic model of the solar corona to calibrate heliospheric reconstructions based s

276 Magnetic tension forces the corona to co-rotate with the Sun, but any residual rotat

277 ch template pDNA winding around the cationic corona to form micelleplexes.

278 y the crucial importance of the biomolecular corona to the drug release capacity of various types of

279 h the right proportion of the flexible alkyl corona to the rigid core, mesomorphic behavior of one co

280 eric layers, i.e., the transition region and corona, to high temperatures is a long-standing problem

281 n and structural organization of the protein corona using an immunoassay approach.

282 amyloid plaque cores compared to peripheral coronas using neutral compared to anionic bis-styryl lig

283 ), and a frame-shifting element from a human corona virus (59 nt).

284 Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-C

285 facing the COVID-19 pandemic caused by SARS corona virus 2 (SARS-CoV-2).

286 Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (corona

287 ombosis in severe acute respiratory syndrome corona virus 2 pneumonia is linked to both acute respira

288 The current health crisis of corona virus disease 2019 (COVID-19) highlights the urge

289 nd clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) in Beijing.

290 The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by

291 The 2019 Novel Corona virus infection (COVID 19) is an ongoing public h

292 neurogenic bladder dysfunction in mice with corona-virus induced encephalitis (CIE).

293 Formation of a protein corona was characterized by means of dynamic light scatt

294 ndem mass spectrometry of the extracted hard corona, we directly identified protein fragments, some o

295 The P2VP coronas were readily removed by photocleavage at the ONB

296 egion of the outer kinetochore, known as the corona, where it scaffolds the spindle assembly checkpoi

297 idly coated by proteins, forming a so-called corona which may strongly modify their interaction with

298 nments, proteins adsorb to form the "protein corona" which alters nanoparticle biodistribution and to

299 We predict that the Magellanic Corona will be unambiguously observable via high-ionizat

300 atform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for

301 ed from magnetic reconnection in the tenuous corona, would cause a direct perturbation of the dense p