ライフサイエンスコーパス: coronary stenosis

1 n [MI], coronary revascularization, or >=70% coronary stenosis).

2 (CAD) (prior MI, revascularization, or >=70% coronary stenosis).

3 ndromes (ACS) with non-critical angiographic coronary stenosis.

4 dobutamine stimulation before and during the coronary stenosis.

5 This response was blunted during coronary stenosis.

6 major branches in 15 dogs to create chronic coronary stenosis.

7 presence of different degrees of noncritical coronary stenosis.

8 not exacerbate ischemia in canine models of coronary stenosis.

9 with myocardial blood flow and can identify coronary stenosis.

10 failure, or subsequent development of >/=50% coronary stenosis.

11 specially in patients with lesser degrees of coronary stenosis.

12 ndependent of the severity of the underlying coronary stenosis.

13 less significant with increasing degrees of coronary stenosis.

14 l stenosis, and in the larger subset without coronary stenosis.

15 (IBV) mediate autoregulatory adaptations to coronary stenosis.

16 bernating myocardium resulting from a severe coronary stenosis.

17 hysiological significance of an intermediate coronary stenosis.

18 sodilatation in dogs with various degrees of coronary stenosis.

19 sed hibernating myocardium subtending severe coronary stenosis.

20 There were 587 (62.2%) patients with coronary stenosis.

21 index to exclude the presence of significant coronary stenosis.

22 est swine (n = 20) were prepared with an 80% coronary stenosis.

23 low-pressure balloon occlusion across their coronary stenosis.

24 y, resulted in reversible spasm but no fixed coronary stenosis.

25 both in significant coronary spasm and fixed coronary stenosis.

26 ior MI, coronary revascularization, or >=70% coronary stenosis.

27 PET MPI was used in assessing significant coronary stenosis.

28 ively assess the physiologic significance of coronary stenosis.

29 CA to predict the functional significance of coronary stenosis.

30 assessment of the functional significance of coronary stenosis.

31 from age and sex matching and the extent of coronary stenosis.

32 ement can aid in the assessment of left main coronary stenosis.

33 ilitating a cardiac death without verifiable coronary stenosis.

34 ide assessment of functional significance of coronary stenosis.

35 dial infarction patients without significant coronary stenosis.

36 %, respectively, for identifying significant coronary stenosis.

37 plaques, even in the absence of significant coronary stenosis.

38 re independently associated with significant coronary stenosis.

39 Scans were visually interpreted for coronary stenosis.

40 n imaging for the detection of flow-limiting coronary stenosis.

41 th the advantage of providing information on coronary stenosis.

42 er physiologic evaluation of the severity of coronary stenosis.

43 and appears functionally significant during coronary stenosis.

44 iction losses are negligible across a native coronary stenosis.

45 -143] J, P=0.03) and less incidence of fixed coronary stenosis (18% versus 80%, P=0.04).

46 s with greater than 50% (vs <=50%) left-main coronary stenosis, 3 or more (vs <3) diseased coronaries

47 left ventricular dysfunction, or significant coronary stenosis: 3.57; 95% confidence interval: 2.30 t

48 by one, three, or six episodes of 90 min of coronary stenosis (30% reduction in baseline coronary fl

49 Severity of CAD was defined as obstructive (coronary stenosis 50%) or nonobstructive.

50 on) and had greater maximum percent diameter coronary stenosis (59+/-35% versus 38+/-36%; P<0.001).

51 associated with a significant inhibition in coronary stenosis (63+/-3.4% versus 36+/-4.5%; P<0.001),

52 the myocardial segments subtended by severe coronary stenosis (8+/-17% to 40+/-19% and 6.5+/-1.1 to

53 An artificial coronary stenosis (82% diameter reduction) was mounted o

54 resting myocardium subtended to progressive coronary stenosis, a delayed onset of subendocardial thi

55 phy (MCE) can quantify changes in IBV during coronary stenosis and (2) the relation between coronary

56 m/10(4))(-1) in segments without significant coronary stenosis and 0.7+/-0.2 mL . min(-1) . g(-1) . (

57 n opacifying the myocardium and in detecting coronary stenosis and altered transmural distribution of

58 on 3-year clinical outcomes in patients with coronary stenosis and among a subgroup of patients with

59 shes the baseline functional significance of coronary stenosis and its effect on procedural and clini

60 Although the relationship between coronary stenosis and myocardial perfusion is well estab

61 readmill performance, quality of life score, coronary stenosis and myocardial perfusion were compared

62 it could potentially be used to detect both coronary stenosis and myocardial viability after a singl

63 are equivalent in their ability to identify coronary stenosis and quantify altered MBF.

64 were arteriographic evidence of a change in coronary stenosis and the occurrence of a first cardiova

65 high exercise capacity are unlikely to have coronary stenosis and therefore may benefit from initial

66 oncordance of clinical risk with severity of coronary stenosis and to develop and validate a preopera

67 dies in dogs were performed with and without coronary stenosis and validated with simultaneously acqu

68 f 83% to predict the presence of significant coronary stenosis and was more accurate than analysis of

69 who underwent combined CMR for suspicion of coronary stenosis and/or ischemia at 2.6 +/- 1.2 years,

70 ary stenosis, subjected to non-flow-limiting coronary stenosis, and after preadministration of caffei

71 s, helps prevent angiographic progression of coronary stenosis, and may prevent cardiovascular events

72 ation class IV, cardiogenic shock, left main coronary stenosis, and valve procedure (c index=0.755).

73 the assumption that friction losses across a coronary stenosis are negligible.

74 d very strongly with the severity of luminal coronary stenosis (area stenosis, r=0.83; P<0.001).

75 with abnormal function for the detection of coronary stenosis as well as the higher sensitivity of d

76 large animal models (eg, swine with chronic coronary stenosis); as well as human subjects.

77 the effect of improved spatial resolution on coronary stenosis assessment and reclassification.

78 re derived fractional flow reserve (FFR) for coronary stenosis assessment depend on the induction of

79 Conclusion In vivo and in vitro coronary stenosis assessment improved for calcified sten

80 nostic accuracy for detection of obstructive coronary stenosis at both thresholds of 50% and 70% sten

81 yocardial infarction but without significant coronary stenosis at CA underwent late gadolinium-enhanc

82 in myocardial VI has the potential to detect coronary stenosis at rest without recourse to any form o

83 The ICAs were evaluated for coronary stenosis based on quantitative coronary angiogr

84 reases with increasing levels of noncritical coronary stenosis because of adaptive changes in the mic

85 ) . (mm Hg . bpm/10(4))(-1) in segments with coronary stenosis before PCI (mixed model controlling fo

86 oninvasive imaging modality for detection of coronary stenosis, but it has limited accuracy in demons

87 tric to assess physiological significance of coronary stenosis, but requires an invasive procedure.

88 imaging to opacify the myocardium and detect coronary stenosis by myocardial contrast echocardiograph

89 ncalcified plaque burden and maximal area of coronary stenosis (C statistic, 0.75 [95% CI: 0.67, 0.83

90 Angiographically, 549 pt had severe (>60% coronary stenosis) CAD, and 170 had normal coronary arte

91 he aim of the study was to determine whether coronary stenosis can be detected and myocardial viabili

92 nd severity of a physiologically significant coronary stenosis can be detected at rest by measuring t

93 giography-defined moderate to severe (>=50%) coronary stenosis, cardiac MR-defined myocardial fibrosi

94 tly, MFR(regional) varied widely within each coronary stenosis category, even in vessels with nonobst

95 perfusion defect (RevPD) from flow-limiting coronary stenosis, CMR late gadolinium enhancement (LGE)

96 nly measure of the hemodynamic severity of a coronary stenosis comparable to fractional flow reserve

97 In patients with intermediate coronary stenosis, coronary pressure and flow velocity w

98 e, coronary thrombosis, myocardial ischemia, coronary stenosis, coronary restenosis, cerebrovascular

99 smatch during hyperemia in the presence of a coronary stenosis correlated closely with the magnitude

100 onally by 6 repetitive episodes of 90-minute coronary stenosis (CS) (30% reduction in baseline corona

101 o represent hibernating myocardium involve a coronary stenosis (CS) to reduce blood flow (BF) and fun

102 In patients with coronary stenosis, CTA-derived physiological assessment

103 The overall sensitivity for the detection of coronary stenosis decreased from 0.76 (95% confidence in

104 ocardial contrast echocardiography, allowing coronary stenosis detection at rest without recourse to

105 Clinical studies have shown a comparable coronary stenosis detection rate between 99mTc-tetrofosm

106 In the absence of coronary stenosis, dobutamine stimulation caused a signi

107 iases due to age and sex matching, extent of coronary stenosis, ethnicity, and study quality.

108 ow reserve (FFR) is a physiologic measure of coronary stenosis expressing the amount of coronary flow

109 During coronary stenosis, flow reserve in the adjacent nonsteno

110 nonischemic (normal) regions after 90-minute coronary stenosis followed by 60-minute reperfusion.

111 69 to 0.94]; P = 0.005) were associated with coronary stenosis greater than 50%.

112 e greater than 0 (45.1% vs 63.2%; P < .001), coronary stenosis greater than or equal to 50% (32 [8.7%

113 arteries (group I) and 19 with single-vessel coronary stenosis (group II) underwent quantitative coro

114 ars (range 21 to 83 years), and only 18% had coronary stenosis > or =50%.

115 The ability of CMR to detect coronary stenosis >/=70% on X-ray angiography was determ

116 characteristic curve of 0.87 (p < 0.001) for coronary stenosis >/=70%.

117 low-risk patients (score >/=+5), 60% had no coronary stenosis >/=75% and 16% had single-vessel >/=75

118 The entry criteria were > or =1 angiographic coronary stenosis >20% and diastolic BP <100 mm Hg.

119 n <50% (OR 2.49, 95% CI 1.30 to 4.74), final coronary stenosis >30% (OR 2.57, 95% CI 1.28 to 5.15), a

120 A coronary stenosis >=50% was found by coronary CTA in 68.

121 Valves) were stratified by obstructive CAD (coronary stenosis >=50%, prior myocardial infarction, or

122 ncluded after successful PCI of at least one coronary stenosis (> or =50%).

123 tative angiography (n = 67), 57 patients had coronary stenosis (>50%).

124 alysis, and sensitivity for the detection of coronary stenosis (>or=50% luminal diameter reduction on

125 mibi SPECT imaging for enhanced detection of coronary stenosis has not been established.

126 igh accuracy of CTA in detecting significant coronary stenosis has promoted CTA as a substitute for c

127 ls in the CCTA group (n = 3323), significant coronary stenosis (hazard ratio [HR], 7.21; 95% CI, 1.94

128 al stunning was induced in conscious pigs by coronary stenosis, ie, 40% reduction of coronary blood f

129 Coronary stenosis impairs flow reserve in the adjacent n

130 ed normal coronary arteries or insignificant coronary stenosis in 11 patients and significant (> or =

131 ter TAVI changed the indication to treat the coronary stenosis in 8 of 133 (6%) lesions.

132 71%, respectively, for the detection of >75% coronary stenosis in group 1 patients, whereas a ratio o

133 determine: 1) if the presence of significant coronary stenosis in patients presenting with non-ST-seg

134 ood at flow conditions modeling medium-grade coronary stenosis in the Badimon perfusion chamber.

135 cilitate systematic anatomical assessment of coronary stenosis in the clinical workflow.

136 By QCA, 25 women (27%) had > or = 50% coronary stenosis, including 10 with single-vessel obstr

137 Focal coronary stenosis increased by 1.4% in the placebo group

138 bility that an angiographically intermediate coronary stenosis is functionally significant.

139 limited accuracy in demonstrating whether a coronary stenosis is hemodynamically significant.

140 Myocardial regions perfused through a coronary stenosis may cease contracting, but remain viab

141 Under left-anterior descending coronary stenosis, MBF increased in response to hypercap

142 inear relation was noted between the percent coronary stenosis measured using quantitative coronary a

143 are indices of functional significance of a coronary stenosis measured without hyperemia.

144 act of ultrahigh-spatial-resolution (UHR) on coronary stenosis measurements and Coronary Artery Disea

145 A cardiac motion simulator with a coronary stenosis mimicking a 50% eccentric calcium plaq

146 sed a closed-chest pig model of nonocclusive coronary stenosis (n = 14) created by inflating an angio

147 k factors for coronary artery disease, prior coronary stenosis of 50% or more, ST-segment deviation o

148 idetector CT angiography and QCA to detect a coronary stenosis of at least 50%.

149 sitivity and specificity in the detection of coronary stenosis of more than 50% compared with detecti

150 Thus, when coronary stenosis of uncertain functional significance i

151 schemia on stress cardiac MRI or significant coronary stenosis on coronary CTA were referred for conv

152 of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MP

153 e of coronary calcium could rule out >or=50% coronary stenosis or the need for revascularization.

154 ions with a heterogeneous cohort, unreported coronary stenosis, or exclusively focusing on MINOCA-mim

155 diameter (P = 0.001) and less progression of coronary stenosis (P = 0.002) during follow-up.

156 ounting for 37% of the variance of change in coronary stenosis (P<0.01), followed by reduction in apo

157 l combined with angiographically significant coronary stenosis (P=0.0007), LV ejection fraction (P=0.

158 nts with medically treated angina and severe coronary stenosis, PCI did not increase exercise time by

159 In dogs with coronary stenosis, perfusion anomalies were detected on

160 the pathophysiological relationship between coronary stenosis, perfusion, ventricular scar, and myoc

161 ore, CCTA allows comprehensive assessment of coronary stenosis, plaque burden, left ventricular morph

162 rity at CCTA was performed using an AI-based coronary stenosis quantification (AI-CSQ) software servi

163 photon-counting detector CT, particularly in coronary stenosis quantification.

164 low-pressure balloon occlusion across their coronary stenosis, randomly paired with 4 episodes of pl

165 ous pigs were subjected to either repetitive coronary stenosis (RCS) or a traditional protocol of sec

166 calcium scores, presence of coronary stents, coronary stenosis, REACH and SMART scores, the Duke coro

167 Coronary stenosis regressed, however, and the primary cl

168 The severity of coronary stenosis related to the double product achieved

169 Coronary stenosis resistance was unchanged.

170 Coronary stenosis resulted in similar reduction in wall

171 n of the occluder to produce a wide range of coronary stenosis severities, we determined the coronary

172 thod may allow the noninvasive assessment of coronary stenosis severity and the detection of microvas

173 Quantitative analysis of coronary stenosis severity at CCTA was performed using a

174 equivalent agreement with classification of coronary stenosis severity by HSR.

175 or resting-state physiological assessment of coronary stenosis severity using the instantaneous wave-

176 eversibility at CT perfusion imaging, and (c)coronary stenosis severity was reclassified according to

177 r increase in FFR is associated with greater coronary stenosis severity.

178 FFR is a validated index of coronary stenosis severity.

179 n physicians' angiographic interpretation of coronary stenosis severity.

180 osine-independent, pressure-derived index of coronary stenosis severity.

181 th adenosine in 3 groups of canines: without coronary stenosis, subjected to non-flow-limiting corona

182 a noninvasive anatomic test for diagnosis of coronary stenosis that does not determine whether a sten

183 easurement used to assess the potential of a coronary stenosis to induce myocardial ischemia and guid

184 Long-term benefits of coronary stenosis treatment with an everolimus-eluting b

185 A total of 1058 patients with de novo native coronary stenosis undergoing clinically indicated percut

186 Finally, we estimated the severity of coronary stenosis using the Gensini Scoring system and d

187 Although cardiac CT can identify coronary stenosis, very little data exist on the ability

188 for diagnosis of hemodynamically significant coronary stenosis was 98% and 96% respectively, compared

189 Coronary stenosis was assessed by core laboratory quanti

190 Change in coronary stenosis was assessed by quantitative angiograp

191 Functionally significant coronary stenosis was defined as </=0.8 on FFR.

192 Functionally significant coronary stenosis was defined as FFR </=0.8.

193 At the end study, fixed coronary stenosis was demonstrated in 44% intracoronary

194 ion method was validated in healthy animals, coronary stenosis was induced in seven dogs and contrast

195 eater among patients with more risk factors, coronary stenosis was not present among men <40 years ol

196 was found in 55%, 34%, and 18% and a >/=90% coronary stenosis was present in 25%, 27%, and 19% of pa

197 Significant (>/=50%) coronary stenosis was present in 64 (9.5%) of 674 partic

198 significant coronary artery disease (>/=70% coronary stenosis) was found in 35 (52.2%) patients.

199 , areas under the ROC curve for detection of coronary stenosis were 0.89 and 0.80 (P = .21) for 3.0 a

200 to year and when alternative definitions of coronary stenosis were applied.

201 trumented closed-chest dogs with multivessel coronary stenosis were studied.

202 egative predictive value (>98%) in detecting coronary stenosis when compared with ICA.

203 nes advocating its use in most patients with coronary stenosis who are eligible for coronary interven

204 least 1 significant (> or =70%) angiographic coronary stenosis who were randomly assigned to an initi

205 total of 330 patients (338 vessels) who had coronary stenosis with FFR 0.80 but CFR > 2.0 were selec

206 n of Fractional Flow Reserve in Intermediate Coronary Stenosis With Guiding Catheter Disengagement) r

207 lymorphism significantly predicts changes in coronary stenosis with lipid-lowering treatment that app

208 st swine the effect of a persistent critical coronary stenosis with moderate flow reduction on ischem

209 ch enrolled 240 patients with single de novo coronary stenosis with reference vessel diameter 2.5 to

210 logists to accurately assess the severity of coronary stenosis without resorting to invasive techniqu