ライフサイエンスコーパス: cortical plate

1 migratory streams and prematurely enter the cortical plate.

2 tion of immature projection neurons into the cortical plate.

3 re APP to migrate correctly into the nascent cortical plate.

4 migrate tangentially up into the developing cortical plate.

5 embryonic brain, expression appeared in the cortical plate.

6 Cx43 impairs the migration of neurons to the cortical plate.

7 ir migration and settling in the superficial cortical plate.

8 fferentiate into neurons, and migrate to the cortical plate.

9 to terminal cellular localization within the cortical plate.

10 ventricular zone and high in the developing cortical plate.

11 r somal translocation through the cell-dense cortical plate.

12 omprised of neurons that failed to reach the cortical plate.

13 of positional guidance in both subplate and cortical plate.

14 tant scaffold for neurons migrating into the cortical plate.

15 usually through a perforation of the lingual cortical plate.

16 toward the ventricle before migration to the cortical plate.

17 medial prefrontal and temporal areas of the cortical plate.

18 tical proliferative zones and neurons in the cortical plate.

19 ells and in molecular regionalization of the cortical plate.

20 cellular lamination and connectivity of the cortical plate.

21 fection alone, such as calcifications in the cortical plate.

22 mpromise the overall thickness of the facial cortical plate.

23 the pial surface to take up positions in the cortical plate.

24 xtend side-branches in the subplate and deep cortical plate.

25 tatin-expressing interneurons throughout the cortical plate.

26 some GABAergic interneurons to the subjacent cortical plate.

27 e radial pathway from proliferative zones to cortical plate.

28 d not reach their proper position within the cortical plate.

29 ir migration defect and enter later into the cortical plate.

30 cal neurons migrate along radial glia to the cortical plate.

31 , and differentiation to generate the mature cortical plate.

32 e-out pattern of neuronal migration into the cortical plate.

33 BrdU-positive cells from the vz/svz into the cortical plate.

34 , as well as layer-specific patterns, in the cortical plate.

35 ventricular zone of the forebrain and in the cortical plate.

36 d consequently, they do not align within the cortical plate.

37 al plate, although some were retained in the cortical plate.

38 the intermediate and subplate zones and the cortical plate.

39 al zone neuropil, and processes spanning the cortical plate.

40 es to reach their final positions within the cortical plate.

41 e found dorsal and ventral to the developing cortical plate.

42 he cerebellum and in columns of cells in the cortical plate.

43 of neurons expressing Golli mRNAs within the cortical plate.

44 ghtly packed immature cell bodies, i.e., the cortical plate.

45 P = 0.0001) and were distributed through the cortical plate.

46 axons establish the first synapses with the cortical plate.

47 tected fewer mitotically active cells in the cortical plate.

48 glial scaffolding and the lamination of the cortical plate.

49 zone, but not in those migrating through the cortical plate.

50 f epiphyseal trabecular bone and subchondral cortical plate.

51 itor cells as well as disorganization of the cortical plate.

52 junction with APP to regulate entry into the cortical plate.

53 multipolar cell phase and to enter into the cortical plate.

54 fetal human and embryonic mouse VZ, SVZ, and cortical plate.

55 ough the intermediate zone to enter into the cortical plate.

56 al stem cells into the intermediate zone and cortical plate.

57 el role for pancortins in migration into the cortical plate.

58 urons to polarize their migration toward the cortical plate.

59 ge into bipolar cells necessary to enter the cortical plate.

60 They must exit these streams to invade the cortical plate.

61 to the subventricular zone or the developing cortical plate.

62 rly oscillatory activity into the developing cortical plate.

63 tical) ontogenetic columns in the overlaying cortical plate.

64 until 1-2 days after its emergence from the cortical plate.

65 tricle and migrate radially to the overlying cortical plate.

66 f the cell soma to the top of the developing cortical plate.

67 formed precipitates premature entry into the cortical plate.

68 ion and buildup of neurons at the top of the cortical plate.

69 which embryonic neurons migrate to reach the cortical plate.

70 ial intermediate zone, i.e., between the two cortical plates.

71 cells to both the normotopic and heterotopic cortical plates.

72 splitting of the PPL by the formation of the cortical plate (7-8 weeks of gestation), reelin-immunore

73 ly expressed in the ventricular zone and the cortical plate [9,10], and its product, Lis1, has seven

74 The cortical plate (a zone avoided by thalamic axons in vivo

75 ng is required for the formation of a normal cortical plate, a step that is dependent upon Reelin sig

76 adhesion mediated by N-cadherin in the upper cortical plate, allowing migrating neurons to traverse t

77 ns arrive at their terminal positions in the cortical plate along outer radial glia (oRG) cell fibers

78 nd migrate radially to their position in the cortical plate along radial glial fibers.

79 ed from the marginal zone and from below the cortical plate, although some were retained in the corti

80 is most abundant in postmitotic cells of the cortical plate and absent from proliferative zones.

81 ial events are followed by disruption of the cortical plate and appearance of subventricular zone nod

82 cytoarchitectonic differentiation within the cortical plate and before the establishment of reciproca

83 poptosis, resulting in an enlarged, indented cortical plate and cellular heterotopias within the vent

84 glia to temporally appropriate layers of the cortical plate and differentiating into lamina-appropria

85 Some of these LGE-derived cells invade the cortical plate and express GABA, while others remain wit

86 ration that allows interneurons to enter the cortical plate and find their correct laminar position.

87 igratory substrates at the interface between cortical plate and marginal zone in the developing cereb

88 subplate and smaller proportions were in the cortical plate and marginal zone.

89 nce between excitatory neurons of the dorsal cortical plate and other lineages such as early-generate

90 itecture, including formation of a polarized cortical plate and radial units.

91 upts migration of rat newborn neurons to the cortical plate and results in the ectopic localization o

92 Thus, at E95, after connections between the cortical plate and thalamus have formed, receptor subtyp

93 shment of reciprocal connections between the cortical plate and thalamus.

94 age of OA is more readily discernible in the cortical plate and that morphological characterisation o

95 onal processes, before the appearance of the cortical plate and the establishment of thalamocortical

96 Cell death within the cortical plate and the proliferative zones was substanti

97 and relay this information to the developing cortical plate and thereby can influence cortical activi

98 At E17, Nrg3 was detected within the cortical plate and ventricular zone suggesting possible

99 that EGFRs mediate migration radially to the cortical plate and ventrolaterally in the LCS, but not t

100 ells born on embryonic day 11 were below the cortical plate, and a smaller proportion were above it.

101 tions, differential tangential growth in the cortical plate, and axonal connectivity form and regulat

102 ssociated with malformation in the overlying cortical plate, and have limited connectivity with other

103 tricular zone, intermediate zone, developing cortical plate, and marginal zone as early as embryonic

104 equent neuronal migration into the incipient cortical plate, and the final arrangement of its vertica

105 axons reach the cortex, accumulate below the cortical plate, and then start to extend side-branches i

106 urons, ascending processes of neurons in the cortical plate, and ventricular zone cells.

107 ed in cell cycle activities are found in the cortical plate, and, in vitro, class III beta-tubulin-po

108 topias, alters intralayer positioning in the cortical plate, and, surprisingly, blocks axon fiber tra

109 We find that silent synapses from the cortical plate are present on SPNs and that they origina

110 In contrast, two cortical plates are formed: one in a normotopic position

111 tercalation of new neurons at the top of the cortical plate, as a likely proximate force for tangenti

112 f the development of a biologically relevant cortical plate assembly outside of the body.

113 iferative ventricular zone to the overlaying cortical plate, assume multipolar morphology while passi

114 fy molecular distinctions between VZ-derived cortical plate astrocytes and OSVZ-derived white matter

115 Cortical plate astrocytes emerge from VZ progenitors and

116 centrosome and Golgi are oriented toward the cortical plate at a time when axons grow toward the vent

117 ned statistically significant thicker buccal cortical plate at all sites (P <0.0001).

118 These cells were restricted to the cortical plate at birth.

119 lar patterns are already apparent within the cortical plate at E65, before the formation of thalamoco

120 ree mRNAs were highly expressed in the dense cortical plate at P1.

121 Freezing injury to the cortical plate at postnatal day (P) 1 initiates a cascad

122 pression in several structures including the cortical plate, basal ganglia, thalamus, inferior olives

123 The cortical plate became dyslaminated, and there was a subs

124 mRNA was observed in the subplate and inner cortical plate between two layers of c-met expression, w

125 AN to the: 1) alveolar crest (CN); 2) buccal cortical plate (BN); 3) lingual cortical plate (LN); and

126 the blur and to aid in identification of the cortical plate borders and the mandibular canal.

127 used accelerated migration of cells past the cortical plate boundary, confirming that normal APP leve

128 does not progress smoothly from ventricle to cortical plate, but is instead characterized by distinct

129 e is expressed in postmitotic neurons in the cortical plate, but not in progenitors within the ventri

130 e speed at which neurons migrate through the cortical plate by reducing the time spent stationary and

131 latively uniform labelling of the developing cortical plate by various molecular markers and retrogra

132 form two layers, one above and one below the cortical plate, called the marginal zone (future layer 1

133 Cortical plate cells do not aggregate within the preplat

134 ther, these findings indicate that misplaced cortical plate cells, but not preplate cells, comprise t

135 at is initiated before the migration of most cortical plate cells.

136 of axons at the transition zone between the cortical plate (CP) and the differentiating cortical lay

137 echnique was used to separate differentiated cortical plate (cp) cells from immature ventricular zone

138 as detected in the ventricular zone (VZ) and cortical plate (CP) compared to control cells, suggestin

139 overmigrated neurons did not participate in cortical plate (CP) development; rather they formed a di

140 ng neurons and is enriched in the developing cortical plate (CP) during the formation of the superfic

141 RNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual co

142 ate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown.

143 rmal in progenitors but strongly affected in cortical plate (CP) neurons.

144 bers passing through the upper strata of the cortical plate (CP) where neurons end their migration.

145 to terminate at the front of the developing cortical plate (CP), leading to the outward expansion of

146 performed region-of-interest analysis in the cortical plate (CP), subplate (gyral crest and sulcal bo

147 ween layer I and the subplate zone, from the cortical plate (CP), which represents a multilayered mam

148 ex (ventricular zone, intermediate zone, and cortical plate [CP]) containing green fluorescent protei

149 rid1a sufficiency in subplate, we generate a cortical plate deletion of Arid1a that spares SPNs.

150 factor (BDNF), a critical process for proper cortical plate development.

151 As the cortical plate develops, WNT7b expression shifts, demarc

152 cortex prior to thalamocortical ingrowth and cortical plate differentiation.

153 gration routes with a decreased frequency of cortical plate-directed migration at later stages of neu

154 bsent, the intermediate progenitor layer and cortical plate do not segregate properly, and corticofug

155 INs, leading to their ectopias and a thinner cortical plate due to diminished production of glutamate

156 lace of birth to their final position in the cortical plate during development.

157 tic neurons from the ventricular zone to the cortical plate during embryogenesis comprises one of the

158 in the postmitotic cells of the subplate and cortical plate during mid- and late stages of cortical n

159 er migration of neuronal precursors into the cortical plate during the development of the mammalian b

160 y non-Gaussian diffusion barriers inside the cortical plate during the third trimester.

161 shift regional identity in the subplate and cortical plate either in or out of register.

162 At 7 g.w., as the cortical plate emerged in the ventrolateral region of th

163 Whereas knock-down of APP inhibited cortical plate entry, overexpression of APP caused accel

164 acts downstream of APP for this function in cortical plate entry.

165 e selectively expressed, but only within the cortical plate: EphA6 was present posteriorly, and ephri

166 mus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding

167 lencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and t

168 tricular NSPCs and especially neurons of the cortical plate, expressed nuclear GR.

169 human developing cortex slightly before the cortical plate formation and beginning of synaptogenesis

170 lnexin-deficient mouse embryos show impaired cortical plate formation and elevated levels of transact

171 nd subplate after the preplate is divided by cortical plate formation.

172 mpaired radial migration of neurons into the cortical plate from the ventricular zone.

173 Background The cortical plate (future cortex) is readily identifiable i

174 ons migrate from the ventricular zone to the cortical plate, GABA localizes within the target destina

175 ex patterns may occur in locations where the cortical plate grows faster than the cortex of the brain

176 Cortical plate growth patterns constrained to narrower a

177 ortex after the arrival of cells of the true cortical plate has split the preplate into marginal zone

178 Thick cortical plates have been the primary way to achieve pri

179 us, thalamus, lateral ventricle, cerebellum, cortical plate, hemispheric white matter, internal capsu

180 teins are highly expressed in the developing cortical plate in cells bordering Reelin-expressing Caja

181 rvous system, particularly in the developing cortical plate in embryos.

182 eurogenesis and settling of neurons into the cortical plate in primates, including humans, are comple

183 resence within the human germinal matrix and cortical plate in situ, and demonstrate gIPC states bein

184 ry AMPAR-mediated inputs from the developing cortical plate in the second postnatal week.

185 itch from tangential migration to invade the cortical plate in which reducing SDF signaling increases

186 one, with markedly reduced expression in the cortical plate; in contrast, alphaN-catenin expression i

187 nificant glutamatergic synaptic input to the cortical plate, including the neurons of layer 4.

188 luding displaced progenitor cells within the cortical plate, increased early neural differentiation,

189 f calretinin-positive cells in the overlying cortical plate, indicating that the migratory defect whi

190 axons are oblique and cut across the entire cortical plate, instead of being oriented tangentially i

191 anching frequency results in stream exit and cortical plate invasion in mouse brain slices.

192 13-Cul3-RhoA pathway in layer 4 of the inner cortical plate is crucial for controlling brain size and

193 As the normotopic cortical plate is formed, it characteristically separate

194 ression of Lhx2, SCIP, Emx1, and Cad8 in the cortical plate is not evident until after TCAs reach the

195 In contrast, the heterotopic cortical plate is not intercalated between the preplate

196 om tangential stream migration to invade the cortical plate is unknown.

197 ubplate, but they do not penetrate the dense cortical plate itself.

198 ); 2) buccal cortical plate (BN); 3) lingual cortical plate (LN); and 4) inferior border (IN) were me

199 proliferative compartment (intermediate zone/cortical plate/marginal zone) were examined separately.

200 The feedback projections from the cortical plate might enable SPNs to amplify thalamic inp

201 atory inputs and project into the developing cortical plate, mostly to layer 4.

202 e and ventricular zone) rises and falls with cortical plate neurogenesis.

203 rficial layer containing abundant CSPGs, and cortical plate neurons accumulate below them.

204 Furthermore, the presence of late-born cortical plate neurons in the marginal zone reveals a re

205 Finally, the migration of the earliest born cortical plate neurons is normal in p35 mutant mice; cor

206 In cortical plate neurons of lamin B1-deficient embryos, we

207 ct layers of the cerebral cortex begins when cortical plate neurons take up positions within the extr

208 The failure of cortical plate neurons to aggregate within the framework

209 est that the p35/cdk5 kinase is required for cortical plate neurons to migrate past preexisting neuro

210 ement for reelin-Dab1 signaling in late-born cortical plate neurons, and helps distinguish models for

211 s including neuroepithelial precursor cells, cortical plate neurons, and postnatal neocortical neuron

212 etal brain, LAMC3 is enriched in postmitotic cortical plate neurons, localizing primarily to the soma

213 g neurons, including Cajal-Retzius cells and cortical plate neurons, passed the meninges or terminate

214 l-Retzius cells, and subsequent dysplasia of cortical plate neurons, the present data establish a cau

215 s neurons, then deep and finally superficial cortical plate neurons.

216 l boundaries before the arrival of the first cortical plate neurons.

217 critical for proper positioning of migrating cortical plate neurons.

218 one of the neocortex is invaded by late-born cortical plate neurons.

219 ediate zone, and mHuC is expressed in mature cortical plate neurons.

220 ing them to remake preplate neurons and then cortical-plate neurons.

221 Soon after migrating to the cortical plate, neurons extend an apical dendrite direct

222 proliferative germinal matrix and laminating cortical plate of 15 prenatal, non-pathological postmort

223 Normally, a thin cortical plate of bone protects the nerve.

224 Migrating neurons within the cortical plate of E18.5 Lmnb1-deficient embryos exhibite

225 apposition through selectively injuring the cortical plate of the alveolus has been an approach to s

226 In the cortical plate of the developing cortex, GPR88 presents

227 entral expansion of Reelin expression in the cortical plate of the frontal cortex, concomitant with a

228 Freezing injury to the cortical plate of the newborn rat results in the formati

229 Already at E14.5, the incipient cortical plate of the p73 KO brains showed a reduced wid

230 Within the cortical plate of the temporal lobe, the pattern of MET

231 n plus flap plus 3 small perforations of the cortical plate (OFP), and a control group (C).

232 Sparsely branched TCAs invade the cortical plate on P1 in CxNR1KO mice as in control mice.

233 ally all transfected cells found deep in the cortical plate or beneath it.

234 igrate toward their final destination in the cortical plate, project axons to appropriate targets, an

235 of basal progenitors and show a reduction in cortical plate radial thickness.

236 another in a radial pile in the cortex; the cortical plate received very few lateral projections.

237 ength transcriptome of the germinal zone and cortical plate regions of the developing human neocortex

238 rity of subplate neurons projecting into the cortical plate reside in the upper half of the subplate.

239 the intermediate zone and locomotion in the cortical plate, respectively.

240 al migration along the top of the developing cortical plate, resulting in aberrant interneuronal posi

241 Analysis focused on the cortical plate revealed greater volume increases in pari

242 time the gross anatomical structures of the cortical plate, subplate and marginal zone persisted, wh

243 migration of neurons from the VZ/SVZ to the cortical plate/subplate (CP/SP) region.

244 s after thalamocortical afferents invade the cortical plate, suggesting that thalamic axons may influ

245 rs before the emergence of layer IV from the cortical plate, thalamic axon ingrowth through deep laye

246 e of the SVZ was more similar to that of the cortical plate than that of the VZ, whereas in human the

247 resence of supernumerary neurons beneath the cortical plate that could be the result of migration def

248 ed neurogenesis and formation of an expanded cortical plate that establishes distinct upper and deep

249 the widening cerebral wall, and it is in the cortical plate that they attain their final positions an

250 The average buccal cortical plate thickness in dentate mandibles was 2.76 +

251 ein (APP) plays a role in migration into the cortical plate through its interaction with two cytosoli

252 bout potential feedback projections from the cortical plate to SPNs.

253 stance of the external surface of the buccal cortical plate to the inferior alveolar canal in the man

254 bral mantle and the accelerating rate in the cortical plate undergoing folding.

255 er IV/lower layer II/III at P3-P5 and in the cortical plate/upper layer V at P0-P1.

256 cortex, signaling cells to migrate into the cortical plate via NMDA receptor activation.

257 Although most staining in the cortical plate was absent several days after birth, subp

258 at E14.5 and the advanced appearance of the cortical plate was frequently observed at this stage.

259 g to a 50% greater density of neurons in the cortical plate was observed.

260 Using atomic force microscopy to target the cortical plate, we found that the occipital cortex incre

261 tion, cells in the intermediate zone and the cortical plate were also frequently clustered, indicatin

262 tnatal development, migrating neurons in the cortical plate were immunonegative, whereas neurons deep

263 Maxillary buccal and lingual cortical plates were injured in 36 healthy adult rats ad

264 subplate, and marginal zones, as well as the cortical plate, were positive for particular EphA genes

265 a high mitotic index proliferate and in the cortical plate where new neurons settle.

266 , is selectively expressed in the developing cortical plate, where neurons terminate their migration

267 r loops are also enriched in the human fetal cortical plate, where the axonal growth potential is hig

268 cross the intermediate zone to the overlying cortical plate, where they differentiate and form the ne

269 m germinal zones near the ventricle into the cortical plate, where they organize into layers.

270 6.5 g.w., i.e., before the appearance of the cortical plate, which gives rise to a majority of the ad

271 homozygous mutants showed undulation of the cortical plate, which in the most severely affected brai

272 s of developing cortex, including the deeper cortical plate, which incorporated the subplate in young

273 in Cdk5(-/-) cells that have migrated to the cortical plate while these same cells continue to expres

274 fferentiate into neurons, and migrate to the cortical plate, while normal neighboring precursors are

275 ferative ventricular zone and the developing cortical plate, yet is conspicuously less prominent in t