ライフサイエンスコーパス: corticosterone

1 nd the glucocorticoid receptor (activated by corticosterone).

2 ed result in elevated plasma vasopressin and corticosterone.

3 in muscle glycogen storage in mice receiving corticosterone.

4 res with the stress hormones epinephrine and corticosterone.

5 ice exhibited a threefold increase in plasma corticosterone.

6 hese effects were abrogated by coinfusion of corticosterone.

7 ibitor, metyrapone and mimicked by exogenous corticosterone.

8 ut not on FKBP5 and UTS2B nor on circulating corticosterone.

9 and can be elicited by the administration of corticosterone.

10 levating plasma angiotensin II, potassium or corticosterone.

11 to the glucocorticoid receptor (GR) ligand, corticosterone.

12 e abrogated by an intra-arterial infusion of corticosterone.

13 sive precursors are selectively modulated by corticosterone.

14 in, and molybdenum levels, and males, higher corticosterone.

15 counted for by the subgroup bearing elevated corticosterone.

16 ther corticotropin-releasing factor (CRF) or corticosterone.

17 he behavioral effects of stress and systemic corticosterone.

18 ure variation in the stress-related hormone, corticosterone.

19 anism that ends with the production of 18-OH corticosterone.

20 h a second surge of exogenously administered corticosterone.

21 S GLP-1-expressing neurons, we microinjected corticosterone (0.5 mug) directly into the hindbrain fou

22 The OCT3 inhibitor corticosterone (10 mg kg(-1) ) had no effect.

23 dosterone, cortisol, 11-deoxycorticosterone, corticosterone, 11-deoxcortisol, progesterone, and 19-no

24 ldren (reductions of 17-hydroxyprogesterone, corticosterone, 11-deoxycortisol and testosterone).

25 ary morphogen controlling metamorphosis) and corticosterone (a stress hormone acting synergistically

26 n that light exposure can result in elevated corticosterone, a response that is not compatible with s

27 ety-like behaviors and circulating levels of corticosterone, a stress hormone, in female prairie vole

28 ted in both acute kidney injury and in deoxy-corticosterone acetate and sodium chloride (deoxy-cortic

29 costerone acetate and sodium chloride (deoxy-corticosterone acetate salt)-induced chronic hypertensiv

30 CMS-induced increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin

31 her early-life changes in the stress hormone corticosterone affect gut microbiota by experimentally i

32 BMI associated with lower maternal cortisol, corticosterone and 11-dehydrocorticosterone.

33 resulted in a significant decrease in plasma corticosterone and a consequent increase in ACTH, as exp

34 s, these tumors produced increased levels of corticosterone and aldosterone and showed a high prolife

35 ion, nest scores, sucrose consumption, fecal corticosterone and blood for hematology were collected.

36 we demonstrate novel synergistic actions of corticosterone and corticotropin-releasing hormone (CRH)

37 We show that corticosterone and cortisol and their less active precur

38 Therefore, the synergistic actions of corticosterone and CRH at hippocampal synapses underlie

39 we demonstrate novel synergistic actions of corticosterone and CRH on hippocampal synaptic plasticit

40 Combined application of the stress hormones corticosterone and CRH recapitulated the physiological a

41 Mechanistically, corticosterone and CRH synergized at the spine-actin reg

42 Therefore, synergistic actions of corticosterone and CRH underlie enduring memory impairme

43 Mechanistically, corticosterone and CRH, via their cognate receptors, act

44 70 nm) causes behavioural arousal, elevating corticosterone and delaying sleep onset.

45 nfusion rate (GIR) and exhibited less robust corticosterone and growth hormone responses.

46 -KO mice during the clamps, increased plasma corticosterone and growth hormone.

47 During stress, adrenal corticosterone and hippocampal corticotropin-releasing h

48 Although C1 stimulation elevated plasma corticosterone and increased both vagal and sympathetic

49 efeated B6 females exhibited elevated plasma corticosterone and increased c-Fos activation in the med

50 ) mice showed elevated levels of circulating corticosterone and increased hippocampal Bdnf expression

51 ld potential) required combined chronic high corticosterone and maternal presence (not maternal behav

52 However, corticosterone and normetanephrine failed to potentiate

53 these effects, we examined the abilities of corticosterone and normetanephrine to potentiate cocaine

54 Thus, despite similar effects on plasma corticosterone and on hypothalamic stress-sensitive cell

55 ative relationship observed between baseline corticosterone and plasma oxidative damage to proteins.

56 days of CUS decreased basal plasma levels of corticosterone and produced a shorter latency to immobil

57 reduced chronic stress-induced elevations in corticosterone and proinflammatory cytokine levels and d

58 ed plus maze or sacrificed for basal diurnal corticosterone and quantification of neuronal glucocorti

59 d behavioral emotionality, high basal plasma corticosterone and reduced gene expression of Bdnf, Cort

60 also develop kyphosis, elevated circulating corticosterone and severe adrenal cortex disruption.

61 ss-predictive cues exhibited increased serum corticosterone and significantly greater reinstatement o

62 damage, or alterations in concentrations of corticosterone and thyroid hormones was observed.

63 Stress elevated plasma corticosterone and upregulated the expression of glucoco

64 mimicked by infusing rats with Intralipid or corticosterone and were corrected by leptin replacement.

65 Glucocorticoids (cortisol and corticosterone) and their inactive versions (cortisone a

66 eight gain, an abnormal circadian pattern of corticosterone, and an attenuated increase of corticoste

67 sed rats presented high levels of C-peptide, corticosterone, and glucose (P <0.05).

68 Circulating melatonin and corticosterone, and mRNA expression levels of pro- (IL-1

69 Corticosterone application attenuated inhibitory synapti

70 h)], glucocorticoid receptor (GR) and plasma corticosterone, as well as brain-derived neurotrophic fa

71 they displayed higher levels of blood serum corticosterone, as well as decreased body weight.

72 s not impacted by systemic administration of corticosterone at a dose that maintained elevated plasma

73 assay to measure endogenous acyl-ghrelin and corticosterone at time points surrounding auditory fear

74 Intraventricular corticosterone attenuated cocaine self-administration an

75 esulted in lower stress-driven production of corticosterone, augmented mouse proinflammatory immune r

76 pacity of sustained increases in circulating corticosterone (B) alone to alter dendritic spine morpho

77 There were no marked differences in plasma corticosterone between genotypes, suggesting that behavi

78 ditionally, we found that a systemic dose of corticosterone blocked the depressive-like phenotype eli

79 one 2-fold in human trophoblast cells and of corticosterone by 90% in rat adrenocortical cells when c

80 although the immobilization-induced surge in corticosterone by itself has delayed detrimental effects

81 Measures of corticosterone, c-Fos activation in hypothalamic and lim

82 ic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian levels.

83 A-axis dysfunction, namely loss of plasmatic corticosterone circadian oscillation, and promotes reduc

84 les had significantly higher levels of basal corticosterone compared to dominant females.

85 We showed that the initial increase in corticosterone concentration is followed by a return to

86 ed the adult stress response, as measured by corticosterone concentration, such that a history of chr

87 el was associated with lower plasma baseline corticosterone concentrations and enhanced corticosteron

88 and measured cloacal temperatures and plasma corticosterone concentrations at baseline and after expo

89 temperature can significantly affect plasma corticosterone concentrations in reptiles, which may be

90 a through increased plasma catecholamine and corticosterone concentrations secondary to volume deplet

91 tress condition had better memory and higher corticosterone concentrations than rats trained at the l

92 Both baseline and stress-induced corticosterone concentrations were lower in lizards with

93 Melatonin and corticosterone concentrations were significantly rhythmi

94 degrees C showed a robust increase in plasma corticosterone concentrations with restraint stress, but

95 sed food intake, reduced plasma glucagon and corticosterone concentrations, and decreased ectopic lip

96 nt on body condition, immune metrics, plasma corticosterone concentrations, total antioxidant capacit

97 ch results from decreases in plasma ACTH and corticosterone concentrations.

98 at 22 degrees C showed no such increases in corticosterone concentrations.

99 riod, highest whole-body thyroid hormone and corticosterone content, and highest SMR, and these trait

100 ss in two mouse strains by utilizing chronic corticosterone (CORT) administration or contextual fear

101 mice and resulted in a shorter time to peak corticosterone (CORT) and a more rapid decay of CORT fol

102 e sex differences in stressor-induced plasma corticosterone (CORT) elevations and defensive behaviors

103 ment of C57Bl/6J male breeders with low-dose corticosterone (CORT) for 28 days prior to mating yielde

104 that exposure to the primary glucocorticoid corticosterone (CORT) in adolescent mice recapitulates m

105 We examined the role of corticosterone (CORT) in SEFL.

106 Corticosterone (CORT) is known to negatively correlate w

107 d increases anxiety-like behavior and plasma corticosterone (cort) levels in rats, whereas central GL

108 e behavior and amygdala dysfunction, reduces corticosterone (CORT) levels, and exerts repair-related

109 e PFC were found to be correlated with blood corticosterone (CORT) levels.

110 el, learned helplessness (LH), and a chronic corticosterone (CORT) model in mice, we tested if ketami

111 (Ucn), beta-endorphin (beta-END), ACTH, and corticosterone (CORT) or the brain was fixed for immunoh

112 bjected to (1) a forced swim test (FST), (2) corticosterone (Cort) or vehicle injections, (3) CRS for

113 and hippocampal neurogenesis in the repeated-corticosterone (CORT) paradigm.

114 The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultrad

115 Chronic corticosterone (CORT) treatment was given to adult mice

116 Here we test the effects of corticosterone (CORT), a common glucocorticoid, on a sec

117 d behaviors in mice treated chronically with corticosterone (CORT), a mouse model of stress.

118 (-/-) mice were also resilient to developing corticosterone (CORT)-induced escape deficits and chroni

119 hol following exposure to the stress hormone corticosterone (CORT).

120 L, 0.43 ng/uL, 0.0076 ng/uL for aldosterone, corticosterone, cortisol, and beta-estrone, respectively

121 Together, these observations suggest that corticosterone, delivered through drinking water even 24

122 Three weeks after corticosterone delivery, there was reduced sensitivity t

123 st traumatic experience a suppression of the corticosterone-dependent response protects against the d

124 dent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficit

125 Restoring plasma corticosterone did not reverse the anxiolytic phenotype

126 Causation was shown by blocking corticosterone during maltreatment and suppressing amygd

127 raction of corticosterone with OCT3 mediates corticosterone effects on drug-seeking behavior and esta

128 Corticosterone effects on reinstatement were attenuated

129 signalling in these tissues in mice drinking corticosterone either from day (D) 11 to D16 or D14 to D

130 In animal models, corticosterone elevations are associated with hippocampa

131 Do stress hormones, such as corticosterone, enhance bird susceptibility to mosquitoe

132 creased feeding and elevation of circulating corticosterone, epinephrine, and glucose.

133 ch produce antidepressant effects in chronic corticosterone-exposed animals through GABAergic synapti

134 pressant effects on acute stress- or chronic corticosterone-exposed mice, respectively, through GABAe

135 pressant effects in acute stress- or chronic corticosterone-exposed mice, respectively.

136 LTD), without significant effects on chronic corticosterone-exposed mice.

137 Acute corticosterone exposure accelerated metamorphosis increa

138 and delayed metamorphosis, although chronic corticosterone exposure accelerated rate of metamorphosi

139 reductions in either host immunity (through corticosterone exposure) or antiparasite behaviours (thr

140 Using a mouse model of excess corticosterone exposure, we found that the ability of gl

141 ing ChIP-exo in mouse liver under endogenous corticosterone exposure, we report here that monomeric G

142 We also show that the reported corticosterone extraproduction during the RF active phas

143 Corticosterone failed to re-establish extinguished prefe

144 Interestingly, responders released less corticosterone following acute restraint stress and had

145 Delivery of corticosterone for 7 d (without stressors) or RU486 (bef

146 y, or given daily subcutaneous injections of corticosterone, for 10 consecutive days.

147 We observed that post-stress corticosterone, given 1 day after acute stress in drinki

148 c activity in skeletal muscle of mice in the corticosterone group relative to vehicle control.

149 to the vehicle control group, mice receiving corticosterone had a significant enhancement in pancreat

150 Corticosterone-implanted chicks and their siblings were

151 bedding impaired peripherally-measured basal corticosterone in adult males only.

152 erfluorotetradecanoate to decreased baseline corticosterone in both sexes; and perfluorododecanoate w

153 between body temperature and baseline plasma corticosterone in field-caught lizards.

154 g of a single natural (cortisol in human and corticosterone in mice) and synthetic [e.g., dexamethaso

155 ven Tspo cKO mice lost their ability to form corticosterone in response to adrenocorticotropic hormon

156 orticosterone, and an attenuated increase of corticosterone in response to stress.

157 or receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expressed in ex

158 perarousal, generalization, and dysregulated corticosterone in stress-susceptible male mice.

159 ever, when stress was followed 24 h later by corticosterone in the drinking water, the surge in corti

160 ally modifying the level of stress hormones (corticosterone) in brood mates, we demonstrate that the

161 levels of the glucocorticoid stress hormone, corticosterone, in broiler chickens produced a pessimist

162 atins acutely inhibited aldosterone, but not corticosterone, in response to different secretagogues.

163 ear response, anxiety-related behaviors, and corticosterone increase of the stressed cagemate, sugges

164 ing, or blockade of pups' alarm odor-induced corticosterone increase prevented transfer of fear.

165 ng, aberrant basal circadian fluctuations of corticosterone, increased amygdalar glucocorticoid recep

166 In mice, CTRND05 blocks stress-induced corticosterone increases, counteracts effects of chronic

167 chronic DBS showed a decrease in hippocampal corticosterone, indicating that DBS may have a regulator

168 Stress and the major stress hormone corticosterone induce profound influences in the brain.

169 transmission, because an elevation of pups' corticosterone induced by the odor of the frightened mot

170 t stimulated ERK42/44 corrected long-lasting corticosterone-induced behavioral abnormalities.

171 nd that this potentiation appears to involve corticosterone-induced blockade of dopamine clearance vi

172 Corticosterone-induced hyperglycemia, insulin resistance

173 fed to control intake, aiming to prevent the corticosterone-induced increase in food consumption, (3)

174 dipose triglyceride lipase inhibitor blocked corticosterone-induced increases in plasma glucose conce

175 demonstrated that AKG effectively attenuated corticosterone-induced protein degradation and rescued t

176 bserve that PNN expression is increased in a corticosterone-induced stress model of disease and reduc

177 Treating leptin- and corticosterone-infused rats with an adipose triglyceride

178 ketogenesis; these effects were reversed by corticosterone infusion.

179 Systemic corticosterone injection immediately after the traumatic

180 terozygous (Sst(HZ)) mice show that elevated corticosterone is not sufficient to reproduce the behavi

181 nce correlates with an inverted U profile of corticosterone level in the circulation and of brain-der

182 mone, which was only partly reflected in the corticosterone level.

183 an increase in startle amplitude and plasma corticosterone levels 30 min following intra-BNST PACAP

184 kinase (ERK), P70S6K), as well as increased corticosterone levels and activation of the innate immun

185 able to demonstrate increased intra-adrenal corticosterone levels and an increase in steroidogenic a

186 ne taking is associated with elevated plasma corticosterone levels and that systemic infusion of coca

187 ad smaller spleens and lower baseline plasma corticosterone levels compared to controls.

188 ped normally but at the age of 1 year, their corticosterone levels decreased; this was associated wit

189 tic responsiveness, and chronically elevated corticosterone levels driven by hypothalamic hyperactiva

190 al polypeptide (VIP) had no effect on plasma corticosterone levels even in previously stressed male r

191 e mice displayed similar increases in plasma corticosterone levels following CNSDS exposure relative

192 We conclude that changes in corticosterone levels in chickens are sufficient to caus

193 Further, stress elevated serum corticosterone levels in rats that received vehicle in t

194 ase from the pituitary and lowers peripheral corticosterone levels in response to acute stress.

195 However, this was transient, as corticosterone levels normalized later, followed by the

196 were not explained by differences in plasma corticosterone levels or numbers of Fos-labeled neurons

197 Moreover, serum corticosterone levels predicted expression of brain prot

198 In peripheral blood, ANXA1 and corticosterone levels showed no significant modification

199 High baseline corticosterone levels were associated with an up-regulat

200 Serum corticosterone levels were higher in male and female MOF

201 drawal symptoms or alterations in the plasma corticosterone levels were observed after 7 days of abst

202 Elevated corticosterone levels were observed in both XY and XX KO

203 percentage DNA methylation levels and serum corticosterone levels, whereas F3 males showed Pb- and P

204 ponded to LPS by a 5-fold increase of plasma corticosterone levels, which were only moderately lower

205 for hormonal response to stress or in blood corticosterone levels.

206 raining, and decreased stress as measured by corticosterone levels.

207 ivity and increase in serum noradrenalin and corticosterone levels.

208 ronic stress) and stress-induced increase in corticosterone levels.

209 anges were positively correlated with plasma corticosterone levels.

210 ctivation of NTS GLP-1-expressing neurons by corticosterone may represent a homeostatic response to c

211 ollected for adrenocorticotropic hormone and corticosterone measurement.

212 microbial endotoxin exposure through direct corticosterone-mediated effects on NKp46-expressing inna

213 Faecal corticosterone metabolites (FCM) levels, offspring repro

214 Plasma corticosterone, microbiota composition, and cecal short-

215 amined stress physiology (plasma glucose and corticosterone), mitochondrial performance and the muscl

216 Using the mouse corticosterone model of anxiety/depression, we assessed

217 Corticosterone modified dendritic spine density in these

218 We found that chronic corticosterone not only induces marked deficits in olfac

219 Endocannabinoid-dependent effects of corticosterone on inhibitory synaptic transmission in th

220 ing in the PL to the effects of stress-level corticosterone on PL neurotransmission and cocaine seeki

221 ects of glucocorticoid stress hormones (e.g. corticosterone) on mitochondrial function.

222 ays of non-invasive administration of either corticosterone or vehicle control, we tested the birds'

223 ndently dampened stress-induced increases in corticosterone plasma levels, but did not significantly

224 in mice to directly test the hypothesis that corticosterone potentiates cocaine-primed reinstatement

225 reviously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement

226 st the effects of body temperature on plasma corticosterone (predominant glucocorticoid in reptiles)

227 rough promoting LPS clearance and modulating corticosterone production and leukocyte recruitment.

228 ngs suggest that stress-induced increases in corticosterone promote cocaine seeking by mobilizing 2-a

229 Physiological levels of corticosterone promote HSC migration via the GC receptor

230 e corticosterone concentrations and enhanced corticosterone reactivity.

231 persisted after subdiaphragmatic vagotomy or corticosterone receptor blockade.

232 The expression of corticosterone receptors, their regulator Fkbp5, cortico

233 campal deficits were induced by chronic high corticosterone regardless of social context.

234 vealed that rapid-eye-movement sleep (REMS), corticosterone regulation, and coat state were most resp

235 and theta activity shared many pathways with corticosterone regulation, in particular pathways implic

236 the lateral hypothalamic area (LHA) regulate corticosterone release and a variety of behaviours and p

237 HPA activity, based upon averaged values of corticosterone release from each animal obtained from re

238 In addition to significantly reduced corticosterone release in response to these two distinct

239 verexpression in BLA dampened stress-induced corticosterone release, reduced anxiety-like behaviors,

240 LA), which correlates with protracted plasma corticosterone release.

241 fear memory without blunting stress-induced corticosterone release.

242 e FOS+GOS combination reduced stress-induced corticosterone release.

243 Intra-accumbens administration of corticosterone reproduced the behavioral effects of stre

244 Lastly, corticosterone rescued the anxiety-like phenotype and me

245 on was sufficient to reproduce the decreased corticosterone response after acute stress.

246 ce resulted in a significant blunting of the corticosterone response during pregnancy.

247 treated animals displayed a blunted HPA axis corticosterone response to acute footshock that did not

248 confirmed adult females exhibit a heightened corticosterone response when in SA photoperiod.

249 avoidance of the predator scent, a prolonged corticosterone response, and higher anxiety long after e

250 emory enhancement as well as the potentiated corticosterone response, indicating the dependence of th

251 eptor type 2 (SSTR2) normalizes glucagon and corticosterone responses to hypoglycemic clamp in diabet

252 s oxytocin injections reduced behavioral and corticosterone responses to immobilization, whereas inje

253 cuit functional connectivity, behavioral and corticosterone responses to trauma exposure, and post-tr

254 asal, diurnal and stressor-stimulated plasma corticosterone secretion and basal plasma adrenocorticot

255 ess level triggers similar stress responses (corticosterone secretion) in brood bystanders.

256 group on subsequent elicitation of feeding, corticosterone secretion, and respiratory quotient.

257 Stimulation of GCG neurons had no effect on corticosterone secretion, body weight, or conditioned ta

258 uitry in the daily control of heart rate and corticosterone secretion, collectively establishing SCN

259 the stress-related hormones epinephrine and corticosterone selectively modulate acute HSV-1 and HSV-

260 hypothesize that stress-induced increases in corticosterone "set the stage" for relapse by promoting

261 er and length, whereas aged animals with low corticosterone showed an upward shift in these indices.

262 In contrast, corticosterone significantly decreased the levels of HSV

263 te the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for th

264 paired with males also showed an increase in corticosterone, suggesting an increased stress response.

265 gut microbiota by experimentally inhibiting corticosterone synthesis with metyrapone.

266 urons are more responsive to epinephrine and corticosterone than are sensory neurons, demonstrating t

267 ose housed with vasectomised males had lower corticosterone than those with castrated males.

268 a pattern of adrenocorticotropic hormone and corticosterone that was similar to patients undergoing c

269 explore the relationships between PFASs and corticosterone (the major glucocorticoid in birds), and

270 t was recapitulated by intra-PL injection of corticosterone, the CB1R agonist WIN 55,212-2, or the mo

271 nvestigate how chronic and acute exposure to corticosterone, the dominant amphibian glucocorticoid ho

272 Increased corticosterone then activates AgRP neurons to fully incr

273 he ability of the intermediate product 18-OH corticosterone to exist as a lactol form, with the equil

274 posure markedly increased serum cortisol and corticosterone together with increases in monoacylglycer

275 However, when corticosterone-treated animals were pair-fed to control

276 decision making, dubbed 'pessimism', whereby corticosterone-treated birds showed an increased expecta

277 Corticosterone-treated birds were more likely than contr

278 yl-d-glucose clearance was reduced by 33% in corticosterone-treated dams (P < 0.05).

279 th mice that receive concurrent venlafaxine, corticosterone-treated mice also display reduced ex vivo

280 On the final day of administration, corticosterone-treated mice were hyperinsulinaemic (P <

281 sed Slc2a2 glucose transporter expression in corticosterone-treated mice, on D16 only (P < 0.05).

282 Corticosterone treatment 1 h after PSS-exposure prevente

283 ressor (electric footshock) nor stress-level corticosterone treatment alone reinstates cocaine seekin

284 metamorphosis and survival depended on both corticosterone treatment and infection status.

285 nhanced negative biases in response to acute corticosterone treatment but without effects on antidepr

286 Depending upon gestational age, corticosterone treatment increased phosphorylation of th

287 ChIP sequencing of GR showed that corticosterone treatment induced a dose-dependent associ

288 Interestingly, when administered a corticosterone treatment to mimic hypercorticism conditi

289 The ability of systemic stress-level corticosterone treatment to potentiate cocaine-primed re

290 plication rate increased only in the chronic corticosterone treatment.

291 Corticosterone treatments affected immune function, as b

292 In the control and chronic corticosterone treatments, ranavirus infection decreased

293 Corticosterone upregulated the stress-inducible mechanis

294 rats, pretreatment of male C57/BL6 mice with corticosterone (using a dose that reproduced stress-leve

295 osterone in the drinking water, the surge in corticosterone was prevented.

296 cal alterations associated with chronic oral corticosterone were investigated using male nonobese dia

297 Although elevated plasma levels of corticosterone were normalized by i.v. leptin infusion a

298 Cortisol and corticosterone were significantly higher in maternal tha

299 irst direct evidence that the interaction of corticosterone with OCT3 mediates corticosterone effects

300 ion) and resilience (spine proliferation) to corticosterone within the orbital cortex.