ライフサイエンスコーパス: cotton rat

1 PFU/g; guinea pigs) to 1.8 x 10(5) PFU/gram (cotton rat).

2 a (eastern wood rat), and Sigmodon hispidus (cotton rat).

3 ERD, confirming the observations made in the cotton rat.

4 in the upper and lower respiratory tracts of cotton rats.

5 ns and can be resistant to PZ prophylaxis in cotton rats.

6 ttenuated yet retains high immunogenicity in cotton rats.

7 , has been shown to resist PZ prophylaxis in cotton rats.

8 and were tested for susceptibility to PZ in cotton rats.

9 cation in the respiratory tracts of mice and cotton rats.

10 (PIV3) infection led to laryngotracheitis in cotton rats.

11 in replication in the respiratory tracts of cotton rats.

12 Ad2E4ORF6, which is replication defective in cotton rats.

13 tion against RSV A and B strains and hMPV in cotton rats.

14 , viral mutants did not grow in the lungs of cotton rats.

15 in culture and to cause pulmonary disease in cotton rats.

16 levated in the airways of infected geriatric cotton rats.

17 resulted in delayed viral clearance in adult cotton rats.

18 nd CD8+ T-cell responses to RSV in geriatric cotton rats.

19 ithelial cultures, and respiratory tracts of cotton rats.

20 binding site of the G protein were tested in cotton rats.

21 ntributes to impaired clearance in geriatric cotton rats.

22 ttenuation in the upper and lower airways of cotton rats.

23 s were highly attenuated in cell culture and cotton rats.

24 cells and in the upper and lower airways of cotton rats.

25 and triggered strong protective immunity in cotton rats.

26 nic, and protective against RSV challenge in cotton rats.

27 nic, and protective against RSV challenge in cotton rats.

28 n cell culture and were highly attenuated in cotton rats.

29 so triggered a strong protective immunity in cotton rats.

30 ivity, replicated as efficiently as rhMPV in cotton rats.

31 o influence the RSV lung titer in challenged cotton rats.

32 in the upper and lower respiratory tracts of cotton rats.

33 NHBE cells and in the respiratory tracts of cotton rats.

34 nfluenza, only the H5N1 virus was lethal for cotton rats.

35 conferred protection from HPIV3 challenge in cotton rats.

36 ared to live and formalin inactivated RSV in cotton rats.

37 ll tested HPIV strains, both in vitro and in cotton rats.

38 oliferation of spleen cells from MV-infected cotton rats.

39 ollowed by the live measles virus vaccine in cotton rats.

40 cacy of these vaccine candidates in mice and cotton rats.

41 cacy of these vaccine candidates in mice and cotton rats.

42 ipts were more abundant in the lungs of aged cotton rats.

43 ect on cytokine expression in aged and young cotton rats.

44 ered as either a DNA or a protein vaccine in cotton rats.

45 cell culture and establishment of latency in cotton rats.

46 Intranasal DAS181 in cotton rats, a model for human disease, significantly cu

47 Here we report that immunization of pregnant cotton rats, a surrogate model for human maternal immuni

48 the first time that SARS-CoV-2 infection in cotton rats affects multiple organs and systems, targeti

49 s and chemokines was studied in the lungs of cotton rats after primary or secondary infection with re

50 ls and injected intraperitoneally into young cotton rats also resulted in detection of virus in the C

51 on mouse, two from wood rats, and one from a cotton rat) also were compared by sodium dodecyl sulfate

52 RSV F (PIV5/F) or G (PIV5/G) protein in the cotton rat and African green monkey models for their rep

53 Results indicate that HIV-1 does infect the cotton rat and S. fulviventer is more susceptible than S

54 component of efficacy by palivizumab in the cotton rat and that antibody-dependent cell-mediated cyt

55 The phenomenon was reproduced in the cotton rat and the mouse, and both preclinical models ha

56 ss if those observations are specific to the cotton rat and to elucidate the mechanism by which vacci

57 ir immunogenicity and protective efficacy in cotton rats and African green monkeys, which are among t

58 Similar enhanced disease has been seen in cotton rats and children immunized with formalin-inactiv

59 DB1 was also highly immunogenic in cotton rats and elicited broadly neutralizing antibodies

60 e a compromised immune response in geriatric cotton rats and identify an inflammatory pathway that co

61 ia bissettii was found in a cotton mouse and cotton rats and in I. affinis ticks.

62 The gD/AS04 vaccine was immunogenic in cotton rats and induced serum IgG directed against gD-2

63 ion RSV F elicits neutralizing antibodies in cotton rats and induces complete protection against vira

64 It also induced long-lasting antibodies in cotton rats and protected a rhesus macaque from RSV chal

65 RSV reduced viral loads in lungs of mice and cotton rats and protected from HRSV.

66 es (GUDs), we assessed the responses of both cotton rats and raccoons to life-size replicas of Burmes

67 with DS-Cav1 F VLPs as maternal vaccines in cotton rats and report that UC-3 F VLPs significantly in

68 at CX3CR1 functions as a receptor for RSV in cotton rats and, in combination with data from human air

69 minor, the wood rat (Neotoma floridana), the cotton rat, and the cotton mouse in South Carolina and F

70 isolated from I. minor and the cotton mouse, cotton rat, and wood rat.

71 Hamsters, guinea pigs, cotton rats, and nine inbred strains of mice were inocul

72 bust immunity against RSV infection in mice, cotton rats, and nonhuman primates.

73 as less than that of HSV-2 genital herpes in cotton rats, and yet the model allowed for comparative e

74 as the receptor for RSV in vivo, we used the cotton rat animal model because of its high permissivene

75 All vectors were evaluated in the cotton rat animal model for their in vivo immunogenicity

76 Cotton rat antiserum to RSV/B protected against RSV/A an

77 Cotton rats are a clinically relevant small animal model

78 tudies requiring gene expression analysis in cotton rats are severely limited.

79 This study set out to determine whether cotton rats are susceptible to infection with HIV type 1

80 iche following predation-induced declines of cotton rats associated with prescribed burn events.

81 We then immunized cotton rats at 0 and 14 days with either control vector,

82 ion mutant established a latent infection in cotton rats at a frequency and with a number of VZV geno

83 In cotton rats, at equivalent concentrations, motavizumab r

84 hortly after demyelination in HSV-1-infected cotton rats but could be incomplete, resulting in "scars

85 ed interferon in vivo and were attenuated in cotton rats but retained high immunogenicity.

86 EV-D68-associated with EVs produced in cotton rat cells and injected intraperitoneally into you

87 lobulin production and cell proliferation in cotton rat cells in vitro.

88 re-exposed mice and provides protection in a cotton rat challenge model (female).

89 r adjuvant) in a preclinical RSV susceptible cotton rat challenge model compared to formaldehyde inac

90 ive transfer of serum from gD/AS04-immunized cotton rats conferred stronger protection against HSV-1

91 otential for producing enhanced disease in a cotton rat (CR) model.

92 V challenge without enhanced lung disease in cotton rats (CRs).

93 Sequencing the cotton rat CX3CR1 gene revealed 91% amino acid similarit

94 Here, we report that the cotton rat CX3CR1, which is similar to the human molecul

95 Studies in cotton rats demonstrate the prophylactic efficacy of the

96 erse genetics, and intranasal inoculation of cotton rats elicited RSV-specific antibody and elicited

97 2a CVD 1208 vaccines to deliver mucosally to cotton rats eukaryotic expression plasmid pGA3-mH and Si

98 Cotton rats express alpha2,3-linked sialic acid (SA) and

99 traperitoneal infection with EV-D68 in young cotton rats featuring dissemination of the virus to spin

100 ate of EV-D68 of clade B3 in immunocompetent cotton rats featuring systemic dissemination of the viru

101 ical trials to prevent HSV and HIV, protects cotton rats from HSV.

102 e prophylactic dose of 15 mg/kg PZ protected cotton rats from infection with F212 but not with MS412.

103 SC-Ad-vaccinated cotton rats had markedly lower influenza titers than RD-

104 VZV-infected cotton rats have been used as a model for latency; viral

105 The CpG ODN markedly increased the cotton rat humoral neutralizing-antibody response to res

106 domain (RBD) and evaluated their efficacy in cotton rat, IFNAR(-/-)mice, IFNAR(-/-)-hCD46 mice, and g

107 ant vaccine virus was created which secretes cotton rat IL-4.

108 e used as a mucosal adjuvant in the noses of cotton rats immunized via this route with respiratory sy

109 In cotton rats immunized with NDV-H, neutralizing antibodie

110 iting this inflammatory pathway in geriatric cotton rats improves immune parameters and speeds cleara

111 Although cotton rats increased their GUD in the presence of all t

112 an deliver measles DNA vaccines mucosally in cotton rats, inducing measles immune responses (includin

113 ells derived from bronchioalveolar lavage of cotton rats infected with RSV.

114 Cotton rats infected with the ORF29 deletion mutant had

115 Cotton rats inoculated with VZV lacking ORF4 showed redu

116 This study demonstrates that the cotton rat is a permissive small animal model of hMPV in

117 Our data indicate that the cotton rat is a suitable small-mammal model to study the

118 ty of HPF3 to cause extensive disease in the cotton rat lung and that this effect is dissociated from

119 A reduction in CX3CR1 expression in the cotton rat lung through the use of peptide-conjugated mo

120 MeV F, this virus infects and replicates in cotton rat lung tissue more efficiently than the wt viru

121 n Vero and murine neuroblastoma cells and in cotton rat lung, although Ed N-522D virus exhibited an a

122 hMPV-infected cotton rat lungs examined on day 4 postinfection exhibit

123 The peak virus titer in cotton rat lungs occurred on day 4 postinfection.

124 omplete protection against hMPV challenge in cotton rats, making the highly stable, double-cleaved hM

125 Together, these studies suggest that the cotton rat may provide an excellent model to study genit

126 teristics, suggesting predation risk altered cotton rat microhabitat use.

127 Geriatric cotton rats mimic this prolonged clearance kinetic and s

128 lycoproteins are a far superior vaccine in a cotton rat model compared with VLPs containing only F pr

129 r analysis of RSV replication in vivo in the cotton rat model in naive animals and in animals rendere

130 rvations are relevant to the validity of the cotton rat model itself and to safe development of nonli

131 ty using an array of cell-based assays and a cotton rat model of HAdV respiratory infection.

132 e previously reported the development of the cotton rat model of hMPV infection and pathogenesis.

133 d against infection and disease in vivo in a cotton rat model of hPIV3 infection, suggesting correlat

134 enital herpes in the novel DMPA-synchronized cotton rat model of HSV-1 and HSV-2 infection.

135 Here we report that in the cotton rat model of measles virus (MV) vaccination passi

136 ctive against A and B subtypes of RSV in the cotton rat model of RSV infection, 2- to 4-fold higher d

137 and dose-dependent antiviral efficacy in the cotton rat model of RSV infection.

138 We recently observed in the cotton rat model that suboptimal immunizations with RSV

139 ture gene expression analysis studies in the cotton rat model, as well as provides gene sequences for

140 ing adjuvant, unexpectedly led to ERD in the cotton rat model.

141 wt HPF3 and the three variant viruses in the cotton rat model.

142 is protective against RSV/A infection in the cotton rat model.

143 the differences in virulence observed in the cotton rat model.

144 sion (SE) (GLA-SE) and alum adjuvants in the cotton rat model.

145 lly administered DAS181 was assessed using a cotton rat model.

146 antibody for depletion of CD4 T cells in the cotton rat model.

147 d tested their efficacies in both murine and cotton rat models of RSV infection.

148 hMPV-infected cotton rats mounted virus-neutralizing antibody response

149 nd subsequently inoculated intranasally into cotton rats, no virus was found in the lungs 4 days post

150 In cotton rats, passive transfer of MV-specific IgG mimics

151 never exceeded one provirus per 1.8 x 10(5) cotton rat peripheral blood mononuclear cells.

152 In cotton rats, recombinant hMPV with the R329K mutation in

153 Because cotton rat respiratory tract is susceptible to measles v

154 ecreased during early infection in geriatric cotton rats, resulting in delayed generation of cytotoxi

155 al development over a wide dose range in the cotton rat RSV enhanced-disease model, as suboptimal dos

156 myelination in an otherwise normal host, the cotton rat Sigmodon hispidus For a long time, demyelinat

157 t medroxyprogesterone acetate (DMPA)-treated cotton rat Sigmodon hispidus model of HSV-2 and HSV-1 ge

158 s work, we found that HSV-1 infection of the cotton rat Sigmodon hispidus via a common route (lip abr

159 tavirus from Florida which is carried by the cotton rat (Sigmodon hispidus) and is associated with ha

160 We previously reported the permissiveness of cotton rat (Sigmodon hispidus) to infection with differe

161 ks Ixodes scapularis and Ixodes affinis, the cotton rat (Sigmodon hispidus), and cotton mouse (Peromy

162 he common raccoon (Procyon lotor) and hispid cotton rat (Sigmodon hispidus), two native mammal specie

163 The cotton rat (Sigmodon) is the gold standard pre-clinical

164 Cotton rats (Sigmodon hispidus and S. fulviventer) are s

165 We show that cotton rats (Sigmodon hispidus) are susceptible to avian

166 Intranasal infection of cotton rats (Sigmodon hispidus) resulted in high numbers

167 se of three small mammal populations [hispid cotton rats (Sigmodon hispidus), cotton mice (Peromyscus

168 virus type 2 (HSV-2) readily infects inbred cotton rats (Sigmodon hispidus).

169 ung (<2 months old) and aged (>9 months old) cotton rats (Sigmodon hispidus).

170 ivore exclusion affected body mass of hispid cotton rats (Sigmodon hispidus).

171 Cotton rats (Sigmodon spp.) were significantly more like

172 y reflects that seen in an animal model, the cotton rat, suggesting that HAE cells provide an ideal s

173 ells more accurately predicts virus yield in cotton rats than does growth in LLC-MK2 cells.

174 ~10-fold higher serum-neutralizing titers in cotton rats than DS-Cav1.

175 n in the lower respiratory tract of mice and cotton rats than rA2-P172.

176 tome from multiple tissues of two species of cotton rats that are commonly used as animal models (Sig

177 ministered intranasally or subcutaneously in cotton rats, the candidates were highly immunogenic and

178 escribe an inflammatory pathway in geriatric cotton rats, the preferred small animal laboratory model

179 In cotton rats, the vaccines elicited RSV F- or G-specific

180 In the cotton rat, there was no delayed clearance of any of the

181 In cotton rats, this RSV vaccine candidate is highly attenu

182 SceD is essential for nasal colonization in cotton rats, thus demonstrating the importance of cell w

183 he F and G glycoproteins (FG) were tested in cotton rats to evaluate efficacy and safety.

184 e inflammatory response of Sigmodon hispidus cotton rats to pulmonary infection with wild-type 5 aden

185 us type 3 bronchiolitis and pneumonia in the cotton rat using topical IgG cleared infectious virus wi

186 Densities of cotton rats varied greatly across years but were similar

187 In RSV-naive cotton rats, VLPs assembled with only the pre-F protein

188 Conversely, higher relative abundance of cotton rats was associated with lower cotton mouse and o

189 per and lower respiratory tracts of mice and cotton rats was highly restricted.

190 Reimmunization of RSV-immune cotton rats was most effective with rVSV-F.

191 Finding adult male cotton rats were 9% heavier with mesocarnivore exclusion

192 a subsequent experiment of identical design, cotton rats were challenged with wild-type MV 1 month af

193 When vaccinated cotton rats were challenged with wild-type RSV A, DB1 re

194 Cotton rats were immunosuppressed with cyclophosphamide,

195 Cotton rats were intramuscularly vaccinated using a prim

196 Cotton rats were pretreated intranasally with RSVIg or w

197 2-P172 and rA2-P176 in the lungs of mice and cotton rats were reduced.

198 inflammatory corticosteroid) in RSV-infected cotton rats were used to evaluate the contribution of vi

199 -specific CD8+ T-cell responses in geriatric cotton rats, whereas activation of DP1 receptor through

200 suppression in specific-pathogen-free inbred cotton rats which were infected with measles vaccine and

201 ajor RSV subgroups, A and B. Immunization of cotton rats with a bivalent vaccine formulation of these

202 Immunization of cotton rats with a split HSV-1 vaccine protected animals

203 Treatment of cotton rats with indomethacin significantly mitigated lu

204 Pretreatment of cotton rats with MEDI-493 resulted in 99% reduction of l

205 Pretreatment of cotton rats with PRO 2000 gel, a candidate vaginal micro

206 we previously reported (4) that infection of cotton rats with the human respiratory syncytial virus (

207 Inoculation of cotton rats with the ORF17 deletion mutant resulted in a

208 Inoculation of cotton rats with the ORF21 deletion virus resulted in la

209 Immunization of cotton rats with the recombinant vaccinia viruses provid

210 e generated; however, in vivo prophylaxis of cotton rats with these antibodies conferred only about a

211 Importantly, inoculation of cotton rats with these mutants triggered a high level of

212 Importantly, vaccination of cotton rats with these recombinant hMPVs (rhMPVs) with d

213 in the nose and in the respiratory tract of cotton rats without prior adaptation and produced strong

214 s protection against an RSV challenge in the cotton rat, without causing enhanced disease.