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1 site of binding for the most potent sulfated coumarin.
2 nstrated on a new vinyltetrazine-derivatized coumarin.
3 Claisen rearrangement of a 1,1-dimethylallyl coumarin.
4 ties should enhance biological properties of coumarin.
5 Interface into MS, confirmed the identity of coumarin.
6 dependent on the secretion of plant-derived coumarins.
7 rized belonging to flavonoids, limonoids and coumarins.
8 ghly oxygenated rather than monohydroxylated coumarins.
9 ion of (E)-cinnamic acid analogues to afford coumarins.
10 echanisms by alkyl adenylates and diarylated coumarins.
11 ydroxy aromatic aldimines with 3-substituted coumarins.
12 of inhibitors when compared to isostructural coumarins.
13 molecular Friedel-Crafts reaction of benzo[f]coumarins.
14 technological and biochemical importance of coumarins.
15 n unsymmetrical product derived from the two coumarins.
16 chemical properties and possible toxicity of coumarins.
17 biologically important pi-electron extended coumarins.
18 small-molecule phytoalexins, flavonoids, and coumarins.
19 to access optically active planar chiral 3D coumarins.
21 differently sized luminescent guests, namely coumarin 1, coumarin 4, fluorescein, [Ru(bpy)3 ]Cl2 , an
24 hyl-6-propionyl-2-naphthylamine (prodan) and coumarin 153 (C153) in a series of toluene/dimethyl sulf
25 marin 343, after receiving energy from donor Coumarin 2 emitted higher fluorescence intensity than wh
26 ceptor Coumarin 343 in the core to the donor Coumarin 2 on the periphery, and the average distance be
27 n efficient energy transfer from the excited Coumarin 2 to the ground-state Coumarin 343 in the core,
29 solated a lignan sesamin (1), two prenylated coumarins (2 and 3) and a marmesin glycosides (4) from M
30 presentative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 groups) is descri
31 t AND molecular logic gates are based on the coumarin-3-aldehyde scaffold and designed to give a turn
32 weight carbonylated LPP with 7-(diethylamino)coumarin-3-carbohydrazide (CHH) and analyze all compound
34 We present here the inhibitory properties of coumarin-3-carboxylate derivatives against these enzymes
35 2-ethylpyrrole, and 2-methylallylsilane) to coumarin-3-carboxylates has been developed to afford chr
36 t reaction was designed by bringing together coumarin-3-carboxylates with indoles and amines to affor
37 eaction is developed using readily available coumarin-3-carboxylic acids and aldehydes as reactants u
40 electron-rich phenols reacted with esters of coumarin-3-carboxylic acids, leading to substituted chro
41 ons in the intracellular environment using a Coumarin 343 (C343)-conjugated drug and hmKeima8.5 as a
42 tachment of 4-nitrophenyl-acetylacetonate or coumarin 343 adsorbates, exhibit hole injection into sur
43 for example, the molar ratio of the acceptor Coumarin 343 in the core to the donor Coumarin 2 on the
44 m the excited Coumarin 2 to the ground-state Coumarin 343 in the core, with the efficiency of the ene
47 sized luminescent guests, namely coumarin 1, coumarin 4, fluorescein, [Ru(bpy)3 ]Cl2 , and rhodamine
48 gher sensitivity than conventional 7-methoxy-coumarin-4-yl acetic acid (MCA)/Lys(DNP) substrates; thu
50 on and removal of the 7-hydroxy group led to coumarin 59, which had increased potency and improved ra
51 ells catalyzed the coupling of the monomeric coumarin 7-demethylsiderin both regio- and stereoselecti
52 efficiency with 7-ethoxy-4-(trifluoromethyl)coumarin (7-EFC), followed by 7-methoxy-4-(trifluorometh
55 NOO(-) with the aid of boronate probes, e.g. coumarin-7-boronic acid or 4-boronobenzyl derivative of
56 elum minutum leaves together with four known coumarins, 8,4''-dihydroxy-3'',4''-dihydrocapnolactone-2
58 s containing ethanol are correlated with the coumarin absorbances in summer, winter and spring wherea
59 l monomers based on different aminoacids and coumarin allowed isolation of polymers with very good re
60 n their rates of hydrolysis of 5-aminomethyl coumarin (AMC) from C-terminally labeled peptide, ubiqui
61 hromenes were converted to the corresponding coumarin analogues by a pyridinium dichromate (PDC)-medi
66 y of the immobilized CYP2A6-FLD, toward both coumarin and nicotine substrates, by tranylcypromine, a
67 Experimental results indicated that both coumarin and p-chlorobenzoic acid are oxidized via direc
68 f the ratio of fluorescence intensities from coumarin and the NBD-Cys or NBD-Hcy adducts generates a
69 ted ground state for the cation, whereas for coumarin and xanthenyl cations substituted with strong d
70 iolamides in formation of 3-organoselenyl-2H-coumarins and 3-organoselenyl-quinolinones, respectively
73 a are those producing cyanogenic glycosides, coumarins and benzofuranocoumarins, being predominantly
75 ification of small molecules (coumarins, iso-coumarins and pyrido-pyrimidinones) that modify the alte
78 2] photocycloaddition of three 4-(alk-4-enyl)coumarins and three 1-(alk-4-enoyl)-2,3-dihydropyridones
79 f activators (tanshinones, dalbergiones, and coumarins) and inhibitors (flavonoids and resveratrol) r
80 center are derived from alkylidene oxindole, coumarin, and malonate substrates with high stereoselect
81 aimed to quantify the levels of resveratrol, coumarin, and other bioactives in pulps and by-products
82 alkoxycoumarins, 7-alkoxy-4-(trifluoromethyl)coumarins, and 7-alkoxy-4-methylcoumarins-with a C1-C7 s
83 s, flavonoid aglycones, C- and O-glycosides, coumarins, and lignans) in plant extracts was developed,
86 first time, a study was performed to compare coumarin- and chomone-3-phenylcarboxamide scaffolds.
87 t in contrasting excited-state properties of coumarin-annelated heptahelicenes; in addition to the in
89 ic investigation revealed the formation of a coumarin as a side product, which was identified by 2D N
91 ta-arrestin assays to identify 3-substituted coumarins as a novel class of antagonists and performed
92 Arabidopsis plants release Fe(III)-chelating coumarins as part of the strategy I-type Fe acquisition
93 ,8-naphthalimides, fluoresceins, rhodamines, coumarins, azo-dyes, oxadiazoles, diverse aromatic dyes
95 subcellular accumulation of nonconventional coumarin-based COUPY fluorophores can be fine-tuned thro
96 the C-S bond coupling reaction by applying a coumarin-based fluorogenic probe in bacterial lysates.
97 of organic host materials, we synthesized a coumarin-based ligand that was cyclometalated onto an ir
103 from droplets, no exchange of the sulfonated coumarins being detected over 24 h at 30 degrees C.
105 er treatment, the distribution of individual coumarins between roots and exudates in the investigated
106 orted structure of a 2OGD enzyme involved in coumarin biosynthesis and closely resembles the structur
108 ic approach has been utilized to emulate the coumarin biosynthesis pathway, which features a key phot
109 l chemical families of fluorophores (such as coumarin, BODIPY, and oxygen/carbon/silicon-rhodamine),
110 droethidine, hydropropidine, Amplex Red, and coumarin boronate) with well defined redox chemistry tha
111 this study, we show that the profluorescent coumarin boronic acid (CBA) probe reacts with amino acid
114 cesses of p-type NiO films cosensitized with coumarin C343 and a bioinspired proton reduction catalys
115 synthesis and photochemical properties of a coumarin-caged cyclic RGD peptide and demonstrate that u
116 ortance of linker selection in the design of coumarin-caged oligonucleosides and other conjugates.
117 unique uncaging properties displayed by two coumarin-caged thymidine compounds, each conjugated with
119 compounds incorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatize
120 roadband and simultaneous emission involving coumarin carboxylic acid, furocoumarin and dansyl anilin
121 arison of the kinetic parameters showed that coumarin catalysis was carried out with a higher efficie
123 ically relevant therapeutic drugs (nicotine, coumarin, chlorzoxazone, and acetaminophen) and the prod
124 have demonstrated that the structure of the coumarin chromophore influences the rate of the uncaging
125 al led to strong fluorescence emitted by the coumarin chromophore, enabling D-F07 to be tracked insid
126 previously described hydroperoxide-sensitive coumarin-conjugated phosphine probe to enable rapid quan
130 A and exotine B, which comprise the unusual coumarin-cyclohepta[b]indole ring system, have been achi
131 veral analogs, including a C-terminus-linked coumarin derivative (22) that exhibited appreciably incr
132 anidin, Cya), the interaction of Glia with a coumarin derivative (3-ethoxycarbonylcoumarin, 3-EcC), h
134 effect of a methyl group incorporated in the coumarin derivative near the ester bond linking both moi
136 nt years, several laboratories have used the coumarin derivative, 4-methylumbelliferone, as a potent
141 Gs, the emission of the mononitro-containing coumarin derivatives in the red region upon excitation w
142 cterized the inhibition of four psoralen and coumarin derivatives toward ALDH2 and compared them to t
143 dition of gamma-butyrolactam onto the 3-acyl coumarin derivatives was observed rather than the gamma-
144 um graminearum and Fusarium verticillioides, coumarin derivatives were proven to possess a very high
146 Two new ligands, out of a library of 17 coumarin derivatives, were identified, and the half-maxi
147 d as templates for docking the 7-substituted coumarin derivatives, which revealed orientations consis
150 e, we characterize the utility of osthole, a coumarin derived from a traditional Chinese medicine, in
151 In the first type of micelles, hydrophobic coumarin-derived dyes were encapsulated noncovalently in
152 ization led us to discover a novel series of coumarin-dihydropyridine hybrids that have potent osteob
156 onyl of the lactone function of the original coumarin dyes has been replaced by the cyano(4-nitrophen
158 Photon counts and optical fluctuations from coumarin encoded within TRPV1 tetramers correlates with
160 e optically pure enantiomers of heptahelical coumarins exhibit helicity-dependent chiroptical propert
162 ld be attributed to ABCG36 function, whereas coumarin exudation was strongly reduced only in ABCG37 d
164 nd a number of anthocyanins, phenolic acids, coumarins, flavanols, dihydrochalcones and flavonols wer
165 out, three major chemical classes (steroids, coumarins, flavonoids) were identified from the Spectrum
168 rmally unfolded protein and a thiol-specific coumarin fluorophore that is only fluorescent upon conju
171 te group effectively prevents leakage of the coumarin from droplets, no exchange of the sulfonated co
172 olomic strategies; the OHC fraction includes coumarins, furocoumarins, and polymethoxylated flavonoid
173 efficient procedure for the synthesis of bis-coumarins fused at the pyranone ring has been developed.
174 light, the pyrrolo[2,1- a]isoquinoline- and coumarin-fused pentacycles B were found to undergo aerob
175 A series of pyrrolo[2,1- a]isoquinoline and coumarin-fused pentacyclic derivatives were synthesized
176 operation provides access to the pentacyclic coumarin-fused pyrrolo-dihydroisoquinoline core present
177 t we tested, naturally occurring fluorescent coumarin glucosides (esculin and fraxin) were phloem loa
179 es revealed that 5-hydroxy-naphtho[2,1,8-def]coumarin has the most bathochromically shifted both abso
180 nent tandem synthesis of 3-N-sulfonylamidine coumarins has been accomplished by the coupling of salic
181 egioselective synthesis of naphtho[2,1,8-def]coumarins has been realized through a concise route that
185 ies of novel tacrine derivatives and tacrine-coumarin heterodimers were designed, synthesized, and bi
189 in guava and surinam cherry by-products and coumarin in passion fruit, guava and surinam cherry by-p
192 nstrate a potential role for iron-mobilizing coumarins in sculpting the A. thaliana root bacterial co
193 ransferase (MTase) NovO forms C-(m)ethylated coumarins in superior yield and greater substrate scope
198 The absorption and emission profiles of the coumarin-IPP derivatives can be fine-tuned: an electron-
201 rial root microbiota, stimulated by secreted coumarins, is an integral mediator of plant adaptation t
202 ently the identification of small molecules (coumarins, iso-coumarins and pyrido-pyrimidinones) that
207 mber of solutes per vesicle as a function of coumarin:lipid ratio and average number of solutes per v
208 The site-specific incorporation of three new coumarin lysine analogues into proteins was achieved in
214 assay-guided isolation, two new monoterpene coumarins, minutin A and minutin B, were purified from M
216 switchable DNA cross-linking reaction of the coumarin moieties can potentially serve as mechanistic p
217 s-link (ICL) formation was observed with the coumarin moieties containing a flexible two-carbon or lo
218 ced [2 + 2] cycloaddition occurs between the coumarin moiety and the thymidine upon 350 nm irradiatio
219 ional molecules through energy transfer to a coumarin molecule, a process termed bioluminolysis.
220 oncovalently associated with the substituted coumarin molecule, blocking the pores and preventing the
222 gn principle is based on a nitrobenzofurazan-coumarin (NBD-Coum) construct, which fragments into spec
224 hylase (EROD), benzyloxy-4-[trifluoromethyl]-coumarin-O-debenzyloxylase (BFCOD), and 7-ethoxycoumarin
225 inescent lanthanide (Ln(III)) complexes with coumarin or carbostyril antennae were synthesized and th
226 hod conducted through the reaction of either coumarins or coumarin-3-carboxylic acids with aromatic a
229 igated the suitability of four OH(*) probes (coumarin, p-chlorobenzoic acid, terephthalic acid, and p
230 chanical activation to release a fluorogenic coumarin payload from a polymer incorporating a chain-ce
232 ino-3-((((2-maleimidyl)ethyl)amino)carbonyl) coumarin) placed at the same positions, which suggests a
233 ad of an alkyne as reaction partner leads to coumarin products which formally result from a (5 + 1) c
235 constitutive concentrations of bark lignans, coumarins, proline, tyramine and defensive proteins, and
236 that this interaction between commensals and coumarins promotes growth by relieving iron starvation.
239 The mechanistic course of the uncatalyzed coumarin reactions was found to be a singlet pathway, wh
243 s of push-pull chromophores based on a novel coumarin scaffold in which the carbonyl of the lactone f
245 ess, opening the way to exploiting these new coumarin scaffolds as caging groups that can be removed
246 nthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a sol
247 llfully embraced with oxindole, pyrrole, and coumarin scaffolds, which are well-known for their enric
250 s including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran
252 polymer PAVE containing photo-cross-linkable coumarin segments and carboxylic groups was co-assembled
254 identification of a 4,6-diaryl-5,7-dimethyl coumarin series that kills M. tuberculosis by inhibiting
256 ng based on quantifying 18 furocoumarins and coumarins, some of which are regulated by law, and (ii)
258 route for the construction of functionalized coumarin structural frameworks in a single operation wit
259 Nanoluc-Halotag chimera protein (H-Luc) to a coumarin substrate yields the excited state of coumarin,
260 actor production with C-(m)ethyl transfer to coumarin substrates catalyzed by the methyltransferase (
261 was impaired in the presence of the sulfated coumarins suggesting that allosteric partial inhibition
262 between a set of drugs (i.e., indomethacin, coumarin, sulfadymethoxine, warfarin, and salicylic acid
263 ion of a series of [2.2]paracyclophane-fused coumarin systems through a simple and general procedure
265 required for the biosynthesis of fluorescent coumarins that are released into the rhizosphere, some o
266 lator 2-isocyano-6,7-dihydroxycoumarin (ICDH-Coumarin) that directly senses and modulates environment
269 This versatility in the binding mode of coumarins/thioxocoumarins has important consequences for
270 ioanalytical tool for risk assessment showed coumarin to be active against Aliivibrio fischeri bacter
271 ak arises from one-electron reduction of the coumarin to form a radical-anion intermediate, which is
272 ation at 800 nm cleaves the bond holding the coumarin to the nanopore, releasing both the CD cap and
273 esized a focused library of some 36 sulfated coumarins to discover two agents that display sub-maxima
275 ated regioselective C-H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarin
276 ng, the fluorescent non-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a res
279 ng from assembly of the suitably substituted coumarin via the Pechmann reaction of 2-naphthols with a
281 The specificity of ABCG37 for individual coumarins was further verified by a targeted LC-MS based
282 orescent small bioprobes based on lipophilic coumarin were developed, which exhibited high selectivit
286 printed polymers (MIP), selective for simple coumarins, were used in three forms, as sorbents in soli
288 umarin substrate yields the excited state of coumarin, which in turn triggers hydrolysis to uncage a
289 ICL formation quenches the fluorescence of coumarin, which, for the first time, enables fast, easy,
290 photocycloaddition of 4-alkenyl-substituted coumarins, which led to the corresponding products with
291 fferent from the one observed for hydrolyzed coumarins, which occlude the entrance of the active site
292 hesis of flagella and the iron chelator ICDH-Coumarin whose production requires the pvc cluster.
293 e intermolecular [2+2] photocycloaddition of coumarin with tetramethylethylene mediated by thiourea c
295 ctron-deficient phenolic acetates, affording coumarins with excellent regioselectivity, and proceeds
296 , including chalcones, pyrazoles, chromones, coumarins, xanthines, isatin derivatives, thiazolidindio
297 ese include flavonoids, hydroxynaphthalenes, coumarins, xanthones, anthraquinones, phloroglucinols, p
298 uorescent unnatural amino acid, (7-hydroxy-4-coumarin-yl) ethylglycine, which provides a signal for e
299 orescent un-natural amino acid, (7-hydroxy-4-coumarin-yl)-ethylglycine, using orthogonal amber suppre
300 m hydroxide solution resulted in fluorescent coumarin zones, measured at 365/>400nm after stabilizati