ライフサイエンスコーパス: covalent bond

1 escent probe in tissue by the formation of a covalent bond.

2 cysteine residue with which they form a key covalent bond.

3 ew strategy to construct a B(sp(3))-B(sp(3)) covalent bond.

4 lyst activity is modulated through a dynamic covalent bond.

5 replacing an interhelical ionic bond with a covalent bond.

6 ganic reaction: the breaking and making of a covalent bond.

7 ivalent to half the mechanical strength of a covalent bond.

8 weak van der Waals interaction with a strong covalent bond.

9 ffects the formation of a single short-lived covalent bond.

10 e a benzophenone moiety is linked to C7 by a covalent bond.

11 chemically inert and held together by strong covalent bonds.

12 rogen bonds, coordination bonds, and dynamic covalent bonds.

13 of atoms, including the potential of forming covalent bonds.

14 wo components are linked through two dynamic covalent bonds.

15 s the two systems by forming very stable B-O covalent bonds.

16 only been realized in materials with strong covalent bonds.

17 ising monoaromatic units that are linked via covalent bonds.

18 A that controls and records the formation of covalent bonds.

19 before reaching forces sufficient to cleave covalent bonds.

20 ic and more than 1300 have other intra-chain covalent bonds.

21 ork polymers typically crosslinked by strong covalent bonds.

22 ugh space", rather than through conventional covalent bonds.

23 h is observed in transition metal coordinate covalent bonds.

24 OFs by reversible formations of two types of covalent bonds.

25 ysis was used to break down proanthocyanidin covalent bonds.

26 ticles to the surface of the TFBG using only covalent bonds.

27 arge neutral and more stable due to existing covalent bonds.

28 t bonding mechanism from that of traditional covalent bonds.

29 ers of different layers are interlinked with covalent bonds.

30 ecting their molecular precursors by dynamic covalent bonds.

31 able to bind to bioactive molecules through covalent bonds.

32 ) showed the formation of Si-O-Si and Si-O-C covalent bonds.

33 accelerates the dissociation of interlocked covalent bonds.

34 lize structures corresponding to boron-boron covalent bonds.

35 m which we infer the presence of significant covalent bonding.

36 e of poly(ether sulfone) (PES) membranes via covalent bonding.

37 works 1-6 provides fundamental insights into covalent bonding.

38 oupling to the substrate without significant covalent bonding.

39 topic abundance (4.7%) establish the through-covalent-bond (29)Si-O-(29)Si connectivities of distinct

40 Through-covalent-bond 2D (27) Al{(29) Si} J-correlation NMR spec

41 ation of the actinide 5f valence orbitals in covalent bonds across the actinide series.

42 The non-covalent bonds allow the extrusion of the inks into supp

43 as strong, or stronger, mechanically as the covalent bonds along the polymer backbone.

44 ing UV light which photochemically forms new covalent bonds among PQWs.

45 an off-centre position, forming a short H-S covalent bond and a longer H...S hydrogen bond in a stru

46 mparable to the theoretical value of a La-La covalent bond and is shorter than reported values for ot

47 lization protocols such as physisorption and covalent bonding and detection techniques such as ampero

48 epends on matrix-material properties such as covalent bonding and soft versus hard materials.

49 tical responses due to their strong in-plane covalent bonding and weak out-of-plane interactions.

50 found to sensitize ground-state Cu(I)-Au(I) covalent bonds and near-unity phosphorescence quantum yi

51 onfinement by a highly rigid network, stable covalent bonding, and 3D spatial restriction efficiently

52 ation/photoreduction, breaking and making of covalent bonds, and excited-state proton transfer (ESPT)

53 can and mixed-linkage beta-glucan-xyloglucan covalent bonds, and may therefore strengthen ageing Equi

54 the substrate by electrostatic interactions, covalent bonds, and physical interpenetration.

55 d material, a robust framework consisting of covalent bonds, and, most importantly, pronounced stabil

56 olyketide biosynthesis, indicate how dynamic covalent bonds are best used in functional systems.

57 cylboronate-hydroxylamine ligation, in which covalent bonds are broken in each of the reactants as th

58 examples in which different types of dynamic covalent bonds are similarly used in tandem.

59 Dynamic covalent bonds are unique because of their dual nature.

60 triazine frameworks (CTFs) with ultrastrong covalent bonds (aromatic C N) from the triazine linkage

61 (IV)-imido complexes revealed a notably more covalent bonding arrangement for the Ce=N bond compared

62 Exploiting exchangeable covalent bonds as dynamic cross-links recently afforded

63 Adhesion occurs by covalent bonding, as in reactive structural adhesives, o

64 ation of Pb dimers and I trimers with strong covalent bonds at some of the intrinsic defects.

65 noscale filler and the orientation of X-type covalent bonds at the nanoparticle-ligand interface are

66 hibitors exhibited hindered rotation along a covalent bond axis, and the existence of atropisomer chi

67 for the definition of the bond order of the covalent bonds being (3-beta)/2, and this accounts for t

68 urred via ester and ether and other types of covalent bonds besides HA sequestration.

69 tion involving an intermediate with a single covalent bond between a quinoid adduct and cofactor is p

70 ssociation is followed by the formation of a covalent bond between an electrophile on the ligand and

71 from lattice mismatch and formation of Co-S covalent bond between Co and MoS(2) during the assembly,

72 On the basis of the covalent bond between enzyme and isomerized 5-FU we prop

73 ization strategy based on the formation of a covalent bond between propargyl-terminated glycans and s

74 large value of binding enthalpy suggesting a covalent bond between selenium and AtSBP1.

75 ydride transfer precedes the cleavage of the covalent bond between the enzymatic cysteine and the pro

76 involving an activated glycosyl donor with a covalent bond between the glycosyl moiety and the leavin

77 tituted by 5-fluorouridine (5-FU), reveals a covalent bond between the isomerized target base and tyr

78 ordinate heme chemistry and bears an unusual covalent bond between the nonaxial His(117) and a heme p

79 ting provided evidence of the formation of a covalent bond between the probe and the NK(1) receptor u

80 al and experimental studies suggest that the covalent bond between the protein and substrate is actua

81 These results predict a covalent bond between the serine nucleophile and tungsta

82 e being formed prior to the formation of the covalent bond between the substrate and the active-site

83 experimentally and have found a nearly pure covalent bond between the two expected charged moieties.

84 reveals that PP1 selectivity is defined by a covalent bond between TTN and a PP1-specific cysteine re

85 Covalent bonding between C and S is observed in the nano

86 Current cell-wall models assume no covalent bonding between cellulose and hemicelluloses su

87 Particularly, our study shows weak covalent bonding between interlayers, making the evoluti

88 The intriguing covalent bonding between neighbouring tubes creates a un

89 wedge are correlated with periodic trends in covalent bonding between the metal and the cyclopentadie

90 dative interaction from rhenium to zinc and covalent bonding between the two zinc centers.

91 The selective generation of covalent bonds between and within proteins would provide

92 nclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic com

93 ins of mature MPO protomers, and (iii) three covalent bonds between heme and the protein.

94 improves the molecular anchoring by forming covalent bonds between molecular carbon and copper surfa

95 nd lactoperoxidase (LPO) is the existence of covalent bonds between the prosthetic group and the prot

96 erephthalate), resulting in the formation of covalent bonds between the underlying substrate and the

97 nzymatic, or chemoenzymatic formation of new covalent bonds between two polypeptides, or between a si

98 which involved formation of weak reversible covalent bonds between vicinal hydroxyl groups of arabit

99 he possible formation of hydrogen and ether (covalent) bonds between starch and phenolic compounds.

100 r structures, which are not held together by covalent bonds but by non-covalent mechanical interactio

101 drimers of fourth generation (PAMAM G4) with covalent bonding by electro-oxidation method.

102 Within both of them, a covalent bond can be formed and subsequently broken elec

103 Covalent bonds can be made in two ways, applying irrever

104 These reversible covalent bonds can be triggered through molecular trigge

105 The resulting materials with dynamic covalent bonds can show full property recovery after mul

106 d theoretical aspects are discussed, and the covalent-bond CEE, rigidity-aggregated CEE, or supramole

107 ieved in dynamic reversible covalent and non-covalent bonding chemistries for self-healing polymers,

108 According to the covalent bond classification (CBC) method, two-electron

109 hat have captured an electron and have had a covalent bond cleaved yet do not immediately dissociate

110 ng-coupled reactivity switch (termed a smart covalent bond) could allow the adhesin to undergo bindin

111 Dynamic covalent bonds (DCBs) have received significant attentio

112 non-covalent interactions or as permanent as covalent bonds, depending on conditions.

113 binding-induced cleavage of the Lys(629)-PLP covalent bond, dynamic motion of the cobalamin-binding d

114 espite numerous strategies involving dynamic covalent bond exchange for dynamic and self-healing mate

115 incorporates mechano-plasticity via dynamic covalent bond exchange for reconfiguring the shape of a

116 h that takes direct inspiration from diverse covalent bonds existing between atoms.

117 onance spectroscopy reveal that a variety of covalent bonds form between NH(3)-N and PyOM, more than

118 The rate of covalent bond formation ( k(inact)) does not correlate w

119 We report here on the use of covalent bond formation among monomers, compensating for

120 d a validated 8-N-benzyladenosine ligand for covalent bond formation and confirmed targeted irreversi

121 cysteine residue in the ATP binding site via covalent bond formation and demonstrates high levels of

122 gths or additional heat to induce reversible covalent bond formation and dissociation.

123 dy precipitated COF, indicating both dynamic covalent bond formation and irreversible precipitation.

124 chemistry the study of the interplay between covalent bond formation and noncovalent interactions has

125 Selective covalent bond formation at a protein-protein interface p

126 -receptor pair as an example, we demonstrate covalent bond formation between an alphaErbB2-VSF mutant

127 exation through coordination chemistry, (ii) covalent bond formation between existing pendant groups

128 ex was bound to the active site of GSTP1; no covalent bond formation between hPL and GSTP1 was observ

129 Our findings document covalent bond formation between the asparagusic acid moi

130 rements together provided strong evidence of covalent bond formation between the photoacids and the p

131 The mutational disruption of covalent bond formation between the receptor and the tar

132 Strategies for optimizing the rate of covalent bond formation by a reversibly bound inhibitor

133 Here, we report that covalent bond formation by an aryl sulfonyl fluoride ele

134 generally slow partly because of reversible covalent bond formation by some gliptins, and partly bec

135 thus providing diversity and flexibility in covalent bond formation for protein research and protein

136 rsible coordination chemistry and reversible covalent bond formation is described.

137 The mechanism by which a blue-light driven covalent bond formation leads to a global conformational

138 l reactivity of the electrophiles needed for covalent bond formation makes control of selectivity dif

139 trophiles that only become activated towards covalent bond formation on binding a specific protein.

140 Covalent bond formation to Cys-154 was confirmed by incu

141 metal cluster chemistry with dynamic organic covalent bond formation to give a new crystalline, exten

142 Reversible covalent bond formation under thermodynamic control adds

143 By using the Uaa and cysteine, spontaneous covalent bond formation was demonstrated between an affi

144 gen bonding, metal complexation, and dynamic covalent bond formation) are used to tune NCT assembly a

145 th processes, which involve a combination of covalent bond formation, degenerate bond exchange, and n

146 en bonds between peptides were reinforced by covalent bond formation, enabling the fiber elongation.

147 ACs is driven by reversible binding prior to covalent bond formation, while the reversible covalent P

148 lf-assembly pathways can enable control over covalent bond formation.

149 ectively modifying the lipid of interest via covalent bond formation.

150 ensation reactions based on only one type of covalent bond formation.

151 pyridinium and pyrimidinium ions, suggesting covalent bond formation.

152 ligands that bind to protein targets through covalent bond formation.

153 lely attributed to global enzyme closure and covalent-bond formation.

154 interactions (e.g. strept(avidin)/biotin) or covalent bond formations (e.g. inverse electron demand D

155 recombinant (r)C0C7 domains is achieved by a covalent bond formed between SpyCatcher (-sc; encoded at

156 the use of new thermodynamically controlled covalent bond forming methods.

157 heir subsequent closure by multiple directed covalent bond-forming reactions, provides a powerful str

158 tor proteins' with a spectrum of heterolytic covalent-bond-forming activity (that is, reacting divers

159 systems that employ a single type of dynamic covalent bonds have been reported.

160 rging class of framework materials linked by covalent bonds, hold potential for various applications

161 SCAN accurately describes the balance among covalent bonds, hydrogen bonds, and van der Waals intera

162 P surface via maleimide/thiol group-mediated covalent bonding improves the macrophage (MP)-targeting

163 ss that ultimately leads to the rupture of a covalent bond in the constricted section of the axle.

164 However, disulfide bonds being an additional covalent bond in the protein structure represent a chall

165 e fundamental nature of ionic, metallic, and covalent bonding in a range of elements and binary compo

166 re is a strong competition between ionic and covalent bonding in cubic phase providing a link between

167 role of directional coordination bonding or covalent bonding in extended crystalline frameworks.

168 theory was originally introduced to explain covalent bonding in the H2 molecule within a quantum mec

169 cture calculations to quantify the extent of covalent bonding in-arguably-one of the most difficult s

170 Here we show that rotation about covalent bonds in a peptide linker can change a flexible

171 The broad interest of using reversible covalent bonds in chemistry, in particular at its interf

172 acked, in a way that mimics the formation of covalent bonds in chemistry.

173 ed along polymer chains, is used to activate covalent bonds in mechanosensitive molecules (mechanopho

174 nging from the dissociation and formation of covalent bonds in non-covalent complexes through the rea

175 presence of components linked by reversible covalent bonds in slow exchange and bearing adequate coo

176 ress through the mechanochemical scission of covalent bonds in the backbone.

177 n from the MSW core, followed by scission of covalent bonds in the bottlebrush backbones.

178 s is determined by the force required to cut covalent bonds in the molecules.

179 Because of this, the use of reversible covalent bonds in the synthesis of bioconjugates has bee

180 Here, we show that covalent bonds in the zeolite chabazite (CHA) are labile

181 d on capturing molecules with a photodynamic covalent bond inside microemulsions as nanoreactors and

182 ur cores as modular units subject to various covalent bond interactions that lead to different struct

183 es electrostatically enhanced intermolecular covalent-bonding interactions in two dimensions.

184 ver, the incorporation of orthogonal dynamic covalent bonds into functional systems is a surprisingly

185 y dissipation pathways involved in forming a covalent bond is a longstanding challenge for chemistry.

186 lifetime for core-vacancies parallel to the covalent bond is a manifestation of non-local interactio

187 Upon blue light activation, a covalent bond is formed between VVD residue Cys108 and i

188 et of dynamic reactions involving reversible covalent bonding is actively being exploited for the des

189 e show that the unique directionality of the covalent bonding is found to stem from a chain of highly

190 expected 4f- and 5d-orbital participation in covalent bonding is presented in the context of recent s

191 In this context, the generation of transient covalent bonds is a fundamental tool for nonequilibrium

192 knotted polymers without breaking or forming covalent bonds is challenging, as the chain needs to be

193 3D N-doped graphene crosslinked by covalent bonds is fabricated through thermal treatment o

194 these protein macrocomplexes, by introducing covalent bonds, is a prerequisite before their analysis

195 ched to the template using kinetically inert covalent bonds it should be possible to operate at high

196 These labile covalent bonds may display similar behavior to sialic ac

197 Polymers bearing dynamic covalent bonds may exhibit dynamic properties, such as s

198 ectrophiles that are recognized by TRPA1 via covalent bond modifications of specific cysteine residue

199 ials are widely studied due to their dynamic covalent bond nature.

200 -of-plane weakening of the three-dimensional covalent bond network of boron along different shear def

201 he electronic structures of 1-3 and indicate covalent bonding of an E2(3-) ligand with a mixed-valent

202 ed to elucidate thermodynamic behaviors, non-covalent bonding of coacervates, and microstructure of c

203 HD/Se gel was fabricated by covalent bonding of dopamine group (in HD conjugate) and

204 Covalent bonding of graphene oxide quantum dots (GOQDs)

205 on the frequency shift before and after the covalent bonding of Lys.

206 on of additional polycation coatings and the covalent bonding of the semi-permeable membranes with bi

207 proteins that can be cross-linked, by either covalent bonds or association of helical domains or both

208 n of the biomolecules, with formation of new covalent bonds or cleavage of existing bonds.

209 +) and Na(+) in the absence of a net charge, covalent bonds, or lone-pair donor groups.

210 orbital-types are spatially coincident, the covalent bond-pairing is weakened by Pauli-repulsion wit

211 pinned, by the formation of a single metal-S covalent bond per OPT n or OPD n molecule.

212 electron transfer are often held in place by covalent bonds, pi-pi interactions or hydrogen bonds.

213 ydrogel coating on a substrate to be stable, covalent bonds polymerize monomer units into polymer cha

214 Interfacial covalent bonding, possibly strengthened by d-electron ac

215 polymer glasses, demonstrating that although covalent bonding promotes glass formation, bonding seque

216 ative dissociation and subsequently catalyze covalent bond rearrangement, affording selective assembl

217 Different from the strong U=C covalent bonding reported for U(2)C@C(80), the U-C bonds

218 uires hours, either because the formation of covalent bonds requires time or because first a metaboli

219 captured HIV-1 Env trimers via a more stable covalent bond, resulting in enhanced germinal center B c

220 that have been intramolecularly collapsed by covalent bonds show greater mechanochemical stability co

221 contacts were enzymatically ligated, and the covalent bonds significantly enhanced crystal stability,

222 interfacial interaction mechanisms of Ti-O-C covalent bonding, sliding of MXene nanosheets, and pai-p

223 ids connected by strong metallic, ionic, and covalent bonds, such as Ti2 AlC, Ti3 AlC2 , and Ta4 AlC3

224 self-healing mechanisms involving reversible covalent bonding, supramolecular chemistry, or polymers

225 Our work bridges the gap between covalent bonding taking place at an atomic level and col

226 These are covalent bonds that are capable of exchanging or switchi

227 Disulfide bridges are commonly found covalent bonds that are usually believed to maintain str

228 e release of small molecules via cleavage of covalent bonds that were not integral components of the

229 rst C-H functionalization could involve Ru-N covalent bond, the second C-H functionalization most lik

230 that, even in the absence of direct Cu-O-Mn covalent bonding, the interfacial CuO2 planes of superco

231 kg/mol) and reversible linkages that protect covalent bonds, these megasupramolecules overcome the ob

232 Aided by intertubular covalent bonding, this material takes full advantage of

233 s transforms the C-O bond from a principally covalent bond to a complete charge-shift bond with princ

234 tivation of the substrate via formation of a covalent bond to an active site cysteine.

235 d in the switch-II pocket of KRAS and make a covalent bond to cysteine 12.

236 tric data that reveal that pironetin forms a covalent bond to cysteine-316 in alpha-tubulin via a Mic

237 isplatin, phenanthriplatin can form only one covalent bond to DNA.

238 on acceptor by force-induced cleavage of the covalent bond to form a fluorescent dipolar dye.

239 system that rapidly forms a highly specific covalent bond to its cognate catcher linked to the grid

240 ded protein designed to spontaneously form a covalent bond to its peptide-partner SpyTag.

241 mechanism of inactivation occurring though a covalent bond to Lys257 of the CYP3A4 apoprotein.

242 irecting group to substrates via a transient covalent bond to render the directing group catalytic.

243 lpha-selective galactosylations by forming a covalent bond to the anomeric carbon in dioxolenium-type

244 ted activation and subsequent formation of a covalent bond to the apoprotein.

245 tive evaluation of the contribution from the covalent bond to the protein global conformational chang

246 with the peptide SpyTag form an irreversible covalent bond to the SpyCatcher protein via a spontaneou

247 ligand, which operates through a reversible covalent bond to the substrate, has been applied to the

248 out of the ribosome exit tunnel, after their covalent bond to transfer-RNA has been broken, has not b

249 te that U employs both 5f and 6d orbitals in covalent bonding to a significant extent.

250 ecular sulfur species in the cathode through covalent bonding to and physical confinement in a conduc

251 lize graphene oxide platelets through Ti-O-C covalent bonding to obtain MrGO sheets.

252 used and provide a mechanism of adhesion by covalent bonding to target molecules on host cells that

253 iew summarizes the use of orthogonal dynamic covalent bonds to build functional systems.

254 tubes glassy carbon electrode through -NHCO- covalent bonds to form a sensing surface.

255 a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions.

256 n which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is

257 em I, with a cleaved signal sequence and two covalent bonds to haem.

258 Linking molecular building units by covalent bonds to make crystalline extended structures h

259 ent inhibitors (cHBIs) that selectively form covalent bonds to only sIgEs, thereby permanently inhibi

260 150 years, chemical reactions that make new covalent bonds to polycyclic aromatic hydrocarbons (PAHs

261 shear forces that exceed the ability of non-covalent bonds to remain attached.

262 d particularly the irreversible formation of covalent bonds to specific amino acids in proteins, has

263 itin-related modifier (SUMO) is attaching by covalent bonds to substrate protein.

264 Here, organic molecules are linked by covalent bonds to yield crystalline, porous COFs from li

265 erates dissociation of a variety of internal covalent bonds, to an extent that correlates well with t

266 anic frameworks (COFs), the chemistry of the covalent bond was extended to two- and three-dimensional

267 rts the promise that with orthogonal dynamic covalent bonds we can ask questions that otherwise canno

268 New covalent bonds were genetically introduced into proteins

269 two dimensional sheets held together through covalent bonds which are then stacked together through n

270 his seminal work on what became known as the covalent bond, which has since occupied a central role i

271 4f-orbitals participated only marginally in covalent bonding, which was consistent with historical d

272 We also demonstrate how strong non-covalent bonds, which are versatile for controlled prote

273 actions, involving cleavage and formation of covalent bonds, which have not been obtainable from pure

274 active thioester-containing proteins to form covalent bonds, which may enable strong adhesion to host

275 ctivity associated with the formation of the covalent bond, while being able to dissociate and regene

276 The organophosphates (OPs) form a covalent bond with -OH groups of SB and form SB-OP which

277 difficult-to-drug target HSP72 could form a covalent bond with a small-molecule inhibitor.

278 ch exerted its inhibitory efficacy through a covalent bond with BTK Cys481.

279 MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent

280 ids) that directs binding and formation of a covalent bond with its binding partner, SpyCatcher (15 k

281 ts are linked by a genuine d(10)-d(10) polar-covalent bond with ligand-unassisted Cu(I)-Au(I) distanc

282 t, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in

283 ll molecules are tagged with alkyne and form covalent bond with proteins.

284 ustered near the residue K257, which forms a covalent bond with retinal through a Schiff base linkage

285 tion because the intermediate ketene forms a covalent bond with surrounding macromolecules.

286 ulfide pharmacophore that forms a reversible covalent bond with the catalytic cysteine in STEP.

287 ase activity by formation of an irreversible covalent bond with the catalytic cysteine residue, confi

288 We show that Ln can engage in covalent bonding with boron, and, in some members of the

289 omplexation of the catalytic nickel ions and covalent bonding with the thiol group of Cys322, respect

290 The formation of covalent bonds with graphitic carbon restrains edge reco

291 ability of boronic acids to form reversible covalent bonds with hydroxy groups can be exploited to e

292 mbly functionalization, where NCTs linked by covalent bonds with significantly enhanced stability are

293 sm-dependent thermodynamics of their dynamic covalent bonds with small molecules and macromolecules.

294 embly of molecules; atoms form molecules via covalent bonds with structures defined by the stationary

295 ine-reactive inhibitors that form reversible covalent bonds with their protein targets.

296 bly, even elimination of the retinal-protein covalent bond, with the fully conjugated bacterioruberin

297 erials are a family of materials with strong covalent bonding within layers and weak van der Waals in

298 hydrophobicity of the protein such that non-covalent bonding within network was modified.

299 g., aldehyde and hydrazide groups) that form covalent bonds within minutes when brought into contact

300 ible formation and breaking of rather strong covalent bonds within molecules under certain external s