ライフサイエンスコーパス: coxsackievirus

1 ood mononuclear immune cells that respond to Coxsackievirus.

2 for some adenovirus (AdV) types and group B coxsackieviruses.

3 -fold more resistant to in vitro cleavage by Coxsackievirus 2A protease (2A(Pro)) than wild-type eIF4

4 man K562 cells were cleaved with recombinant Coxsackievirus 2A protease and the N- terminal domains p

5 nt for viral myocarditis is the B3 strain of coxsackievirus, a positive-sense RNA enterovirus.

6 Coxsackievirus A10 (CV-A10) is responsible for an escala

7 Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the major etiological agen

8 ssay, neutralizing antibodies titers against coxsackievirus A16 (CA16), enterovirus 71 (EV71), PV I-I

9 e two serotypes Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16) being responsible for the ma

10 inant virus types enterovirus 71 (EV-71) and coxsackievirus A16 (CV-A16) may account for the differen

11 Coxsackievirus A16 (CV-A16), CV-A6, and enterovirus D68

12 Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the primary causes of the

13 causative agents are enterovirus 71 (EV71), coxsackievirus A16 (CVA16), and, most recently, coxsacki

14 common childhood illness primarily caused by coxsackievirus A16 (CVA16), for which there are no curre

15 interspersed phylogenetically with clades of coxsackievirus A16 and other EV species A serotypes.

16 s most typically caused by enterovirus 71 or coxsackievirus A16 and results in asymptomatic infection

17 Unlike coxsackievirus A16, which also causes HFMD, EV71 induces

18 poliovirus 2C(ATPase) interacts with VP3 of coxsackievirus A20, in the context of a chimeric virus.

19 Coxsackievirus A21 (CAV21) is classified within the spec

20 In vivo mouse RT-adapted, variant coxsackievirus A21 exhibited replication competence in t

21 ution of variants of the common-cold-causing coxsackievirus A21, an EV with tropism for the human int

22 Coxsackievirus A24 (CV-A24) was not originally associate

23 Incubation of coxsackievirus A24 and enterovirus 70 with 2.5 mM NVC-42

24 everal serotypes of human adenovirus (HAdV), coxsackievirus A24, enterovirus 70, and herpes simplex-v

25 ent targets for designing anti-CVA6 vaccines.Coxsackievirus A6 (CVA6) causes hand, foot and mouth dis

26 Coxsackievirus A6 (CVA6) DNA was identified in the blist

27 Coxsackievirus A6 (CVA6) has recently emerged as a major

28 sackievirus A16 (CVA16), and, most recently, coxsackievirus A6 (CVA6).

29 viruses), and 292 (65%) of 448 patients with coxsackievirus A6 infection with available clinical data

30 His infection with coxsackievirus A6 was confirmed based on polymerase chai

31 Coxsackievirus A6 was the most frequently detected enter

32 ar with the severe variant of HFMD caused by coxsackievirus A6, include it in their differential diag

33 se severe cases were most commonly caused by coxsackievirus A6.

34 Coxsackievirus A9 (CAV9), a member of the Picornaviridae

35 ntains the echoviruses, coxsackie B viruses, coxsackievirus A9, and enterovirus 69.

36 ral loads were in meningitis cases caused by coxsackievirus A9, B4, and B5 genotypes.

37 -B) in the family Picornaviridae consists of coxsackievirus A9; coxsackieviruses B1 to B6; echoviruse

38 ith different fiber shaft lengths and either coxsackievirus-Ad receptor (CAR)-interacting Ad serotype

39 t HD-RIGIE injections efficiently transduced coxsackievirus adenovirus receptor-expressing keratocyte

40 racting with soluble extracellular domain of coxsackievirus adenovirus receptors (s-CAR).

41 Adenoviruses that infect through the coxsackievirus-adenovirus receptor (CAR) (Ad2 and Ad5) a

42 The coxsackievirus-adenovirus receptor (CAR) and decay-accel

43 While the majority of serotypes utilize coxsackievirus-adenovirus receptor (CAR) as their primar

44 d5) involves fiber capsid protein binding to coxsackievirus-adenovirus receptor (CAR) at the cell sur

45 majority of adenovirus serotypes utilize the coxsackievirus-adenovirus receptor (CAR) for virus-host

46 We hypothesized that the expression of the coxsackievirus-adenovirus receptor (CAR), a viral recept

47 Both the coxsackievirus-adenovirus receptor (CAR), an Ig-like mol

48 e variant of the extracellular domain of the coxsackievirus-adenovirus receptor (sCAR-Fc) was express

49 reatment with an engineered sCAR-Fc (soluble coxsackievirus-adenovirus receptor fused to the carboxyl

50 rabasal cells that express the high-affinity coxsackievirus-adenovirus receptor, CAR, whereas the pro

51 Here, we show that coxsackievirus, an enteric virus in the picornavirus fam

52 Ad) fiber protein mediates Ad binding to the coxsackievirus and Ad receptor (CAR) and is thus a major

53 have shown that although Ad2ts1 can bind the coxsackievirus and Ad receptor and undergo internalizati

54 hafted Ad vectors had no impact on knob-CAR (coxsackievirus and Ad receptor) interaction compared to

55 ished Ad receptors, namely, integrins or the coxsackievirus and Ad receptor.

56 onal adhesion molecule 1 (JAM1), but not the coxsackievirus and Ad receptor.

57 creening in Vero cells, which identified the coxsackievirus and adenovirus receptor (CAR) as a candid

58 onal assays, we identified and validated the coxsackievirus and adenovirus receptor (CAR) as a functi

59 While group B coxsackieviruses (CVB) use the coxsackievirus and adenovirus receptor (CAR) as the rece

60 ruses into target cells is expression of the coxsackievirus and adenovirus receptor (CAR) at the cell

61 The coxsackievirus and adenovirus receptor (CAR) has been id

62 The coxsackievirus and adenovirus receptor (CAR) is a compon

63 The coxsackievirus and adenovirus receptor (CAR) is a compon

64 The coxsackievirus and adenovirus receptor (CAR) is a member

65 The coxsackievirus and adenovirus receptor (CAR) is a primar

66 The coxsackievirus and adenovirus receptor (CAR) is a transm

67 The coxsackievirus and adenovirus receptor (CAR) is both a v

68 we demonstrate that in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located

69 The coxsackievirus and adenovirus receptor (CAR) mediates en

70 rity of adenovirus serotypes can bind to the coxsackievirus and adenovirus receptor (CAR) on human ce

71 Vesicles shed by U87-MG cells contain coxsackievirus and adenovirus receptor (CAR) protein tha

72 In this study, a zebrafish homologue of the coxsackievirus and adenovirus receptor (CAR) protein was

73 The human coxsackievirus and adenovirus receptor (CAR) represents

74 The coxsackievirus and adenovirus receptor (CAR) serves as a

75 novirus serotype 5 fiber protein engages the coxsackievirus and adenovirus receptor (CAR) to bind cel

76 This study addressed the role of the coxsackievirus and adenovirus receptor (CAR), a single-p

77 this work, we investigated the roles of the coxsackievirus and adenovirus receptor (CAR), CD46, and

78 s many adenoviruses infect cells through the coxsackievirus and adenovirus receptor (CAR), group B ad

79 The coxsackievirus and adenovirus receptor (CAR), which medi

80 PEGylation completely abrogated coxsackievirus and adenovirus receptor (CAR)-knob intera

81 cytokine responses than Ad5, which uses the coxsackievirus and adenovirus receptor (CAR).

82 -accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR).

83 low virus interaction with DAF, and with the coxsackievirus and adenovirus receptor (CAR).

84 s can initiate infection by attaching to the coxsackievirus and adenovirus receptor (CAR).

85 -accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR).

86 The LG abundantly expresses the coxsackievirus and adenovirus receptor (CAR); furthermor

87 rosclerotic plaques we hypothesized that the coxsackievirus and adenovirus receptor (CXADR/CAR), alth

88 us virus with high concentrations of soluble coxsackievirus and adenovirus receptor (sCAR) were simil

89 V3 cells transfected to stably express human coxsackievirus and adenovirus receptor [CAR]).

90 presence of varied concentrations of soluble coxsackievirus and adenovirus receptor showed that the o

91 es), cardiac fibrosis, apoptosis, lower CAR (Coxsackievirus and adenovirus receptor) expression and C

92 tudy demonstrates that hiPSC-CMs express the coxsackievirus and adenovirus receptor, are susceptible

93 inity of Ad5 fiber for the cellular receptor coxsackievirus and adenovirus receptor, CAR.

94 beta, tumor-derived growth factor beta; CAR, coxsackievirus and adenovirus receptor; MLV, murine leuk

95 is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays

96 FP(A20) exhibited up to 50-fold increases in coxsackievirus- and-adenovirus-receptor-independent tran

97 binds with high affinity to the cell surface coxsackievirus-and-adenovirus receptor (CAR), and penton

98 egression to test for an association between coxsackievirus antibody titer and the presence or absenc

99 Coxsackievirus antibody titers correlated positively wit

100 = .12), human bocavirus (aOR 9.1, P < .01), Coxsackieviruses (aOR 5.1, P = .09), rhinovirus A (aOR 3

101 Group B coxsackieviruses are associated with chronic inflammator

102 ous observations suggesting that the group B coxsackieviruses are associated with the risk of type 1

103 Group B coxsackieviruses are responsible for chronic cardiac inf

104 Coxsackieviruses are significant human pathogens causing

105 Coxsackieviruses are significant human pathogens, and th

106 Previous studies have suggested that coxsackievirus B (CVB) activates CD8(+) T cells in vivo,

107 adenovirus receptor (CAR) mediates entry of coxsackievirus B (CVB) and adenovirus (Ad).

108 al dissemination in released EMVs.IMPORTANCE Coxsackievirus B (CVB) can cause a number of life-threat

109 Coxsackievirus B (CVB) is a common cause of acute and ch

110 Coxsackievirus B (CVB) is a common enterovirus that can

111 Many coxsackievirus B (CVB) isolates bind to human decay-acce

112 alized host factor that negatively regulates coxsackievirus B (CVB) replication through its control o

113 ental murine infections and in cell culture, coxsackievirus B (CVB) RNA can persist for weeks in the

114 eptors for poliovirus, human rhinovirus, and coxsackievirus B (CVB) serve to bind the viruses to targ

115 Coxsackievirus B (CVB), a member of the enterovirus fami

116 enteroviruses, including echovirus 11 (E11), coxsackievirus B (CVB), and enterovirus 71 (EV71), and t

117 These viruses, which include coxsackievirus B (CVB), poliovirus (PV), and enterovirus

118 sponses to candidate viral pathogens such as coxsackievirus B (CVB).

119 Coxsackievirus B infections are suspected environmental

120 Many coxsackievirus B isolates bind to human decay-accelerati

121 rategies based on specific inhibitors of the coxsackievirus B proteinase 2A activity for acute and ch

122 pDC activation by Coxsackievirus B requires the presence of specific antiv

123 The shared cellular receptor, the Coxsackievirus B-Adenovirus receptor (CAR), for the two

124 cognizes the genome of ssRNA viruses such as Coxsackievirus B.

125 Mice infected with myopathic coxsackievirus B1 Tucson (CVB1(T)) develop chronic infla

126 Coxsackievirus B1 was associated with an increased risk

127 sting immunological cross-protection against coxsackievirus B1.

128 icornaviridae consists of coxsackievirus A9; coxsackieviruses B1 to B6; echoviruses 1 to 7, 9, 11 to

129 uvirus, human rhinovirus 14, poliovirus, and coxsackievirus B2, B3, and B5.

130 fection with a suspected diabetogenic virus, Coxsackievirus B3 (CB3), NOD.Ncf1(m1J) mice remained res

131 of IL-12 and IFN-gamma on the development of Coxsackievirus B3 (CB3)-induced myocarditis, we examined

132 The first-described DAF-binding isolate, coxsackievirus B3 (CB3)-RD, was obtained during passage

133 ngth VP1 genes of poliovirus 1 (Polio 1) and coxsackievirus B3 (Cox B3) were cloned, and the encoded

134 Coxsackievirus B3 (CV-B3) is a cardiovirulent enteroviru

135 d identified RIP3 as a positive regulator of coxsackievirus B3 (CVB) replication in intestinal epithe

136 ne was effective against poliovirus (PV) and coxsackievirus B3 (CVB3) and exhibited greater activity

137 Here, we orally infected mice with coxsackievirus B3 (CVB3) and found that CVB3 replication

138 With Coxsackievirus B3 (CVB3) being a single-stranded RNA vir

139 The myocarditic (H3) variant of Coxsackievirus B3 (CVB3) causes severe myocarditis in BA

140 B infection, we previously demonstrated that coxsackievirus B3 (CVB3) could infect neuronal progenito

141 larized human intestinal epithelial cells by coxsackievirus B3 (CVB3) depends on virus interaction wi

142 ar to humans, male BALB/c mice infected with coxsackievirus B3 (CVB3) develop more severe inflammatio

143 Male BALB/c mice infected with coxsackievirus B3 (CVB3) develop more severe inflammator

144 Three strains of coxsackievirus B3 (CVB3) differ by single mutations in c

145 Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational rob

146 we describe the generation of a recombinant coxsackievirus B3 (CVB3) expressing the enhanced green f

147 Coxsackievirus B3 (CVB3) generates 5'-terminally deleted

148 flammation that resulted from infection with Coxsackievirus B3 (CVB3) in a mouse model.

149 Passage of coxsackievirus B3 (CVB3) in adult murine cardiomyocytes

150 eviously described a neonatal mouse model of coxsackievirus B3 (CVB3) infection and determined that p

151 Coxsackievirus B3 (CVB3) infection induces death of card

152 Acute coxsackievirus B3 (CVB3) infection is one of the most co

153 Acute coxsackievirus B3 (CVB3) infection is one of the most pr

154 ate immunity can determine susceptibility to coxsackievirus B3 (CVB3) infection, the present study ev

155 Using the Coxsackievirus B3 (CVB3) IRES as a model system, here we

156 Coxsackievirus B3 (CVB3) is a causative agent of viral m

157 Coxsackievirus B3 (CVB3) is a major cause of acute myoca

158 Coxsackievirus B3 (CVB3) is a major heart pathogen again

159 Coxsackievirus B3 (CVB3) is a picornavirus which causes

160 Coxsackievirus B3 (CVB3) is a principal viral cause of a

161 The initiation codon of coxsackievirus B3 (CVB3) is flanked by both R-3 and G+4

162 Coxsackievirus B3 (CVB3) is known to infect stem cells i

163 esent recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal mod

164 f a 3C protease inhibitor (3CPI) in a murine coxsackievirus B3 (CVB3) myocarditis model.

165 l mouse model, we previously determined that coxsackievirus B3 (CVB3) preferentially targets prolifer

166 We have previously shown that three coxsackievirus B3 (CVB3) proteins (2B, 2BC, and 3A) targ

167 ed in pancreatic acinar cells, and show that coxsackievirus B3 (CVB3) requires autophagy for optimal

168 Previously, we described the ability of coxsackievirus B3 (CVB3) to infect proliferating neurona

169 We used the enterovirus coxsackievirus B3 (CVB3) to investigate the effects of h

170 We previously demonstrated the ability of coxsackievirus B3 (CVB3) to persist within the neonatal

171 Here we investigate coxsackievirus B3 (CVB3) tropism and pathology in the CN

172 Here, we describe how Coxsackievirus B3 (CVB3) utilizes polyamines to attach t

173 xchanges between poliovirus type 1 (PV1) and coxsackievirus B3 (CVB3) utilizing an in vitro translati

174 Two coxsackievirus B3 (CVB3) variants infect and replicate i

175 ct of antibiotic treatment on infection with coxsackievirus B3 (CVB3), a picornavirus closely related

176 Coxsackievirus B3 (CVB3), an important human causative p

177 The IRESs of poliovirus, the cardiotropic coxsackievirus B3 (CVB3), and the hepatotropic hepatitis

178 Picornaviruses, including Coxsackievirus B3 (CVB3), are sensitive to the depletion

179 1 reduced encephalomyocarditis virus (EMCV), coxsackievirus B3 (CVB3), poliovirus and enterovirus D68

180 spite this barrier, enteroviruses, including coxsackievirus B3 (CVB3), successfully penetrate the int

181 mice, IL-13 KO BALB/c mice developed severe coxsackievirus B3 (CVB3)-induced autoimmune myocarditis

182 In this study, we examined the role of CR on coxsackievirus B3 (CVB3)-induced myocarditis using mice

183 e of protease-activated receptor-2 (PAR2) in coxsackievirus B3 (CVB3)-induced myocarditis.

184 und that signaling via IL-12Rbeta1 increases coxsackievirus B3 (CVB3)-induced myocarditis.

185 sL) interactions regulate disease outcome in coxsackievirus B3 (CVB3)-induced myocarditis.

186 We aimed to investigate their role in Coxsackievirus B3 (CVB3)-induced myocarditis.

187 T-cell receptor (TCR) promote myocarditis in coxsackievirus B3 (CVB3)-infected BALB/c mice.

188 ve been identified as cellular receptors for coxsackievirus B3 (CVB3).

189 es that evaluate the effects on autophagy of coxsackievirus B3 (CVB3).

190 ve been identified as cellular receptors for coxsackievirus B3 (CVB3).

191 , CAR4/7 but not CAR2/7 was found to bind to coxsackievirus B3 (CVB3).

192 ed enteroviruses poliovirus type 1 (PV1) and coxsackievirus B3 (CVB3).

193 yopathy include cardiotropic viruses such as coxsackievirus B3 (CVB3).

194 Giving C57BL/6 mice 10(4) PFU of coxsackievirus B3 (H3 variant) fails to induce myocardit

195 oliovirus, foot-and-mouth disease virus, and coxsackievirus B3 and can lead to reduced cell surface e

196 f the genomic deletions observed in vivo for coxsackievirus B3 biology.

197 l targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine po

198 rditis in some patients, and the role of the coxsackievirus B3 has been debated.

199 iants corresponding to Poliovirus type 1 and Coxsackievirus B3 have virtually the same structure, bas

200 N receptors has little or no effect on acute coxsackievirus B3 infection in the heart.

201 Furthermore, Coxsackievirus B3 infection of cell lines expressing mut

202 the assay to monitor kinase signaling during coxsackievirus B3 infection of two different host-cell t

203 t expression of full-length dystrophin after coxsackievirus B3 infection.

204 induced after intraperitoneal inoculation of coxsackievirus B3 into C57Bl/6 IRAK4-deficient mice and

205 Coxsackievirus B3 mRNA and hepatitis C virus mRNA were f

206 inistration on the development of autoimmune coxsackievirus B3 myocarditis and dilated cardiomyopathy

207 The crystal structure of the coxsackievirus B3 polymerase has been solved at 2.25-A r

208 have previously engineered more than a dozen coxsackievirus B3 polymerase mutations that significantl

209 d to characterize 15 engineered mutations in coxsackievirus B3 polymerase.

210 s were infected with a luciferase-expressing coxsackievirus B3 strain (CVB3-Luc).

211 Recently, coxsackievirus B3 strains with 5'-terminal deletions in

212 esults from receptor-catalyzed conversion of coxsackievirus B3 to non-infectious A-particles.

213 zed the structure of 5' UTR genomic RNA from coxsackievirus B3 using selective 2'-hydroxyl acylation

214 BL/6 endothelial cells with a nonmyocarditic coxsackievirus B3 variant, H310A1, which is a poor induc

215 ated that infection by another picornavirus (coxsackievirus B3) causes SRp20 to relocalize from the n

216 bitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus.

217 f Aichi virus, bovine kobuvirus, poliovirus, coxsackievirus B3, and human rhinovirus 14 all copurify

218 exposure to heat or bleach, but poliovirus, coxsackievirus B3, and reovirus can be stabilized by bac

219 on is enhanced in cells infected with the EV coxsackievirus B3, but the related poliovirus has no sig

220 om the binding site of DAF on the surface of coxsackievirus B3, indicating that there are independent

221 this study, we analyzed the role of PAR-1 in coxsackievirus B3-induced (CVB3-induced) myocarditis and

222 re profiled in both human myocarditis and in Coxsackievirus B3-injected mice, comparing myocarditis-s

223 conjugated to enteroviruses echovirus 1 and coxsackievirus B3.

224 he cloverleaf RNA structure of the 5'-UTR of coxsackievirus B3.

225 enerating chimeric RdRPs from poliovirus and coxsackievirus B3.

226 pes, including survival after infection with coxsackievirus B3.

227 nst hepatitis C virus, human rhinovirus, and coxsackievirus B3.

228 phosphoproteome of human cells infected with coxsackievirus B3.

229 A59, Theiler's encephalomyelitis virus, and Coxsackievirus B3] in mice with autoantibodies to a cent

230 Two other coxsackieviruses, B3 and B6, were associated with a redu

231 In mice, coxsackievirus B4 (CB4) induces insulin-dependent diabet

232 Coxsackievirus B4 (CBV4), a member of the Picornavirus g

233 tion in nonobese diabetic (NOD) mice through coxsackievirus B4 (CVB4) infection requires a preexistin

234 This study of the pancreatropic enterovirus Coxsackievirus B4 (CVB4) shows that although infection a

235 nse plays a critical role in protection from coxsackievirus B4 (CVB4)-induced diabetes.

236 uman fetal thymus organ cultures (FTOC) with coxsackievirus B4 E2 (CVB4 E2) was investigated.

237 pancreatitis by using a virulent variant of coxsackievirus B4, CVB4-V.

238 ve analysis of global gene expression during coxsackievirus B4-induced acute and chronic pancreatitis

239 -cell biology, we investigated the impact of coxsackievirus B5 (CVB5) infection on the cellular expre

240 itive-sense single-stranded RNA human virus, coxsackievirus B5, by applying both qPCR- and culture-ba

241 beacons (MBs) for the real-time detection of coxsackievirus B6 replication in living Buffalo green mo

242 uced into BGMK cell monolayers infected with coxsackievirus B6, a discernible fluorescence was observ

243 Group B coxsackieviruses can initiate rapid onset type 1 diabete

244 Newborn pups were extremely vulnerable to coxsackievirus CNS infection, and this susceptibility de

245 ovirus (E) 6 (7.6%), E14 (7.6%), E11 (7.4%), coxsackievirus (CV) B3 (7.4%), E25 (5.6%), CVB5 (4.9%),

246 e consequence of myocarditis associated with Coxsackievirus (CV) infection.

247 Coxsackievirus (CV) is an important human pathogen that

248 of public health concern, including EV-A71, coxsackievirus (CV)-A24v, and EV-D68.

249 The group B coxsackieviruses (CVB) are commonly named as putative T1

250 Maternal-fetal transmission of group B coxsackieviruses (CVB) during pregnancy has been associa

251 Type B coxsackieviruses (CVB) frequently infect the CNS and, to

252 Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimm

253 While group B coxsackieviruses (CVB) use the coxsackievirus and adenov

254 Group B coxsackieviruses (CVB) use the CVB and adenovirus recept

255 Group B coxsackieviruses (CVBs) must cross the epithelium as the

256 type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabe

257 ended this phenotype to Zika virus; however, coxsackievirus did not similarly produce noninfectious p

258 Despite replicating to very high titers, coxsackieviruses do not elicit strong CD8 T-cell respons

259 Infections with the group B coxsackieviruses either can be asymptomatic or can lead

260 Both poliovirus and coxsackievirus encode a small polypeptide, VPg, which se

261 Enteroviruses, including coxsackieviruses, exhibit significant tropism for the ce

262 Coxsackievirus group B (CVB) adhered to the surface of C

263 PAR2 negatively regulates expression during coxsackievirus group B infection.

264 Structures of 3D(pol) from poliovirus, coxsackievirus, human rhinoviruses, and other picornavir

265 e replication of poliovirus, rhinovirus, and coxsackievirus in cell culture.

266 ntified as the cellular receptor for group B coxsackieviruses, including serotype 3 (CVB3).

267 espect, IKK-induced cardiomyopathy resembled Coxsackievirus-induced myocarditis, during which the NF-

268 be used to model the pathogenic processes of coxsackievirus-induced viral myocarditis and to screen a

269 eplication, cardiomyopathy, and mortality in coxsackievirus-infected mice.

270 0; P=.75), indicating no association between coxsackievirus infection and cardiac impairment.

271 extreme susceptibility of newborn infants to coxsackievirus infection and viral tropism for the CNS,

272 Serologic evidence of coxsackievirus infection was present in all children, wi

273 and adenovirus receptor, are susceptible to coxsackievirus infection, and can be used to predict ant

274 of the microbiota was sufficient to decrease coxsackievirus infection, while poliovirus infection was

275 hanisms of innate immune responses following coxsackievirus infection.

276 e of one antibiotic was sufficient to reduce coxsackievirus infection.

277 peroxynitrite in the host immune response to Coxsackievirus infection.

278 hermore, a sex bias for severe sequelae from coxsackievirus infections has been observed in humans.

279 Neonates are particularly susceptible to coxsackievirus infections of the central nervous system

280 Coxsackievirus is an enteric virus that initiates infect

281 s as an antiviral factor during infection by coxsackievirus or human rhinovirus, suggesting a common

282 he RNA template sequence, the origin of VPg (coxsackievirus or poliovirus), the origin of 3D polymera

283 or poliovirus), the origin of 3D polymerase (coxsackievirus or poliovirus), the presence and origin o

284 by picornaviruses, such as human rhinovirus, coxsackievirus, poliovirus, foot-and-mouth disease virus

285 In a previous study, we found that coxsackievirus polymerase activity increased or decrease

286 Here we use coxsackievirus polymerase to show that elongation activi

287 sults contribute to our understanding of the coxsackievirus-receptor interactions.

288 Enteroviruses such as poliovirus and coxsackievirus recruit PI4KIIIbeta to their replication

289 Thus, coxsackieviruses rely on the combined effects of several

290 merase; we suggest that this may represent a coxsackievirus replication complex.

291 viral replication, we sought to investigate coxsackievirus replication within the intestine.

292 pathogens for humans, including poliovirus, coxsackievirus, rhinovirus, as well as newly emerging gl

293 ally important pathogens such as poliovirus, coxsackievirus, rhinovirus, enterovirus 71 and foot-and-

294 ypes of cardiomyocytes, we demonstrated that coxsackievirus RNAs harboring 5' deletions ranging from

295 Of interest, only T1D-associated Coxsackievirus serotype B4 but not B3 induced majority o

296 experiments use intraperitoneal injection of coxsackievirus to infect mice, bypassing the intestine.

297 study, we created a library of 135 barcoded coxsackieviruses to examine viral population diversity a

298 pro) proteins from diverse enteroviruses and coxsackieviruses to interfere with type I IFN induction

299 ribe an "Open sesame!" strategy developed by coxsackieviruses to invade the organism through the inte

300 encapsidation of poliovirus and of C-cluster coxsackieviruses, which are prototypes of enteroviruses,