ライフサイエンスコーパス: critical pathway

1 ility that bigger eukaryotes possess in this critical pathway.

2 ens up a novel avenue to interfere with this critical pathway.

3 stigation of the mechanisms involved in this critical pathway.

4 role for the VapC4 toxin in mediating these critical pathways.

5 patients with tumors somatically altered for critical pathways.

6 ic signatures for each subtype, highlighting critical pathways.

7 ficiency and G6PD deficiency as paradigms of critical pathways.

8 ion of a neuropeptide to activate additional critical pathways.

9 rainment and enrichment of MPs in ice can be critical pathways affecting their fate in cold regions.

10 ts reconstruct via a hitherto unexplored yet critical pathway - alkali cation-induced cathodic corros

11 Although CD73 is emerging as a critical pathway and therapeutic target in cardiovascula

12 dase (CD73) on immune cells is emerging as a critical pathway and therapeutic target in cardiovascula

13 and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally import

14 ssue hypertrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipos

15 Overall, these results revealed critical pathways and networks that exhibit sustained al

16 is was utilized to characterize and evaluate critical pathways and reactions in G. metallireducens.

17 mportance of this class of proteins in these critical pathways and structures.

18 in leukemogenesis may provide insights into critical pathways and suggest targets for therapy and pr

19 nt PAH, but the druggable regulators of this critical pathway are unknown.

20 Yet, these critical pathways are maintained by species with narrow,

21 enomics analysis highlighted novel genes and critical pathways associated with kidney function for fu

22 We identify critical pathways associated with nutrient sensing, insu

23 to coordinately regulate multiple members of critical pathways associated with PCD.

24 el in susceptible individuals by providing a critical pathway by which relative tolerance for nucleic

25 Postnatal manipulation of these critical pathways can normalize cerebellar myelin conten

26 eation of a cadre of physicians committed to critical pathways; clinical guidelines; quality assuranc

27 inding to a common site within Smoothened, a critical pathway component.

28 cellular pathway, in which perturbations to critical pathway components are analyzed using DNA micro

29 Our data showed that manipulation of these critical pathway components led to varying degrees of di

30 ntially expressed miRNAs that might regulate critical pathways contributing to CKD progression in dog

31 These data reveal a critical pathway controlling NF-kappaB function in the l

32 Here we define a critical pathway controlling the fate of inflammatory ve

33 ral location in tubular epithelium may alter critical pathways controlling normal tubulogenesis leadi

34 to recognition as a key player in regulating critical pathways controlling the cell cycle and oncogen

35 Gaining a fundamental understanding of the critical pathways defining pathogenic macrophage populat

36 The critical pathways determining the resistance of tumor ce

37 TAK1-mediated activation of p38 MAPK as the critical pathway driving conversion.

38 We identify critical pathway enzymes, including the FAD-binding mono

39 rom Fanconi anemia patients, which lack this critical pathway, fail to be reprogrammed to iPSC under

40 n of PKR and its downstream targets may be a critical pathway for Ad-mda7-mediated apoptosis.

41 tions to the dorsomedial striatum (DMS) as a critical pathway for age-related execution of impulsive

42 We conclude that activation of JNK is a critical pathway for bacterially induced mucosal hyperpl

43 tial steps in translesion synthesis (TLS)--a critical pathway for cell survival and for maintenance o

44 A loop extrusion by cohesin has emerged as a critical pathway for chromosome organization.

45 These results reveal a critical pathway for courtship hearing in male and femal

46 Since the ISR is a critical pathway for determining cell survival or death,

47 or stabilizing low-inertia grids, offering a critical pathway for enabling the reliable integration o

48 suggests that legume-based rotations offer a critical pathway for enhancing global crop production, e

49 Here we identify glutaminolysis as a critical pathway for leukemia cell growth downstream of

50 tify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstr

51 andling independent of voltage and reveals a critical pathway for maintaining ER lumen Ca(2+) levels

52 Transvascular transport is a critical pathway for NC delivery from vessels to tumors,

53 nd phosphorylation at serine 133, which is a critical pathway for neuronal differentiation.

54 exchange associated with wave breaking is a critical pathway for ocean-atmosphere exchange of low so

55 or pathogenesis in TSC and identify a novel, critical pathway for potential therapeutic targeting.

56 Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and androgen

57 rafish development and adulthood, defining a critical pathway for stem cell specification.

58 ll contribute to a better understanding of a critical pathway for T. cruzi biology allowing the ident

59 insensitive mTORC1 signaling via 4E-BP1 is a critical pathway for TGF-beta(1) stimulated collagen syn

60 ls to cone photoreceptors is regarded as the critical pathway for the formation of the antagonistic s

61 between the cerebellum and motor cortex is a critical pathway for the integrity of everyday movements

62 One critical pathway for the regulation of potassium efflux

63 rom boreal peatlands is recognized as both a critical pathway for the remobilization of peat C stocks

64 Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand bre

65 However, the role of BRCA1 in NHEJ, a critical pathway for the repair of double strand breaks

66 radiation, suggesting that NHEJ is indeed a critical pathway for the repair of DSBs.

67 t signaling cascade has been identified as a critical pathway for the transduction of extracellular s

68 )-cyclin-dependent kinase 8 (CDK8) axis as a critical pathway for these processes, and deregulation o

69 ducible factor (HIF) pathway activation is a critical pathway for this process regardless of the oxyg

70 merous miRNA-mRNA interactions that regulate critical pathways for gut barrier function after alcohol

71 nisms of disease pathogenesis, and elucidate critical pathways for immune cell development and differ

72 nthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes.

73 Alternative methods of targeting critical pathways, for example Blys inhibition (atacicep

74 ota and their colonized environments mediate critical pathways from biogeochemical cycles to homeosta

75 Despite critical pathway functions, gene variants have not previ

76 surfaces of the NAPA conformers along these critical pathways have been characterized more accuratel

77 ince blocking CCN1 simultaneously blocks two critical pathways (i.e. SHh and Notch1) associated with

78 n are often observed in cancer and influence critical pathways implicated in tumor initiation and gro

79 Our data suggest that CD134-CD134L is a critical pathway in alloimmune responses, especially rec

80 recycling process, has been implicated as a critical pathway in cancer.

81 ositol 3-kinase [PI (3)K]/Akt signaling is a critical pathway in cell survival.

82 to assess the general applicability of this critical pathway in community-based hospitals.

83 beta-catenin and canonical Wnt signaling, a critical pathway in cystic renal disease.

84 transport of carbon into Earth's mantle is a critical pathway in Earth's carbon cycle, affecting both

85 aims to examine ferroptosis as a potentially critical pathway in effective targeting of thyroid cance

86 One such critical pathway in eukaryotic cells is the unfolded pro

87 des novel insights into EWS-FLI1 turnover, a critical pathway in Ewing sarcoma pathogenesis, and lays

88 In human cells, a critical pathway in gene regulation subjects mRNAs with

89 c signaling, through Cx43 hemichannels, as a critical pathway in leader cell function and collective

90 ults demonstrate that HIF1alpha represents a critical pathway in LSCs and inhibition of the HIF1alpha

91 , we sought to discern whether RasGRP1 was a critical pathway in Ras activation, using a RasGRP1 knoc

92 ally, we identify Wnt/B-catenin signaling, a critical pathway in stem cell and cancer cell biology, a

93 We conclude that the Nrf-2/HO-1 axis is a critical pathway in the hyperglucidic-mediated dysregula

94 they define calcium-NFAT-Skp2 signaling as a critical pathway in the mechanoregulation of proliferati

95 B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell m

96 s CD45(+)lin(-)Thy1(hi)NKp46(-)) is a second critical pathway in this model.

97 Our results define a critical pathway in which decreased LRP6-mediated Wnt si

98 lts establish a mechanistic link between two critical pathways in cancer metastasis, identifying nucl

99 erapies has focused largely on inhibition of critical pathways in cancer.

100 ing lupus disease progression by targeting 2 critical pathways in disease pathogenesis, type I IFN ac

101 plication of targeted therapies that inhibit critical pathways in malignant cells have shown tremendo

102 ostate could provide important insights into critical pathways in normal development as well as eluci

103 NAc in cell signaling that may also regulate critical pathways in other organisms.

104 nds to proteins and substantially influences critical pathways in plants, including central carbon me

105 Identifying critical pathways in sarcomagenesis, susceptible subtype

106 t 20 years, genetic studies have illuminated critical pathways in the hypothalamus and brainstem medi

107 sis with the ability to intervene at several critical pathways in the tumorigenesis process will have

108 set of markers to outline the disruption of critical pathways in tumorigenesis and for derivation of

109 marate but also directs its utilization into critical pathways including the tricarboxylic acid (TCA)

110 patients with tumors somatically altered for critical pathways, including receptor tyrosine kinases (

111 hyroid hormone action, suggesting that these critical pathways interact in the regulation of craniofa

112 y also function in the regulation of another critical pathway involved in cellular and tissue homeost

113 urther establish the Ras/MAPK pathway as the critical pathway involved in cytoskeleton disruption dur

114 element binding protein (CREB) activation, a critical pathway involved in learning and memory.

115 -cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimate

116 Hedgehog (HH) signaling has emerged as a critical pathway involved in the pathogenesis of a varie

117 One critical pathway involves the change of mitochondrial fu

118 One critical pathway is the methionine cycle, in which folat

119 Promoter hypermethylation of key genes in critical pathways is common in head and neck cancer and

120 egulatory role of microRNA (miRNAs) in these critical pathways is poorly understood.

121 samples and integrative genomics to uncover critical pathways linked to HCC subtypes with prognostic

122 s the epigenome, leading to an activation of critical pathways mediating metabolic alterations, fibro

123 With aggressive application of critical pathway methods, significant reduction in cost

124 erstanding of genetic defects affecting this critical pathway of antifungal immunity.

125 hus, we identify ferroptotic cell death as a critical pathway of Candida-mediated renal immunopatholo

126 tol (PI) 3'kinase signaling, implicated as a critical pathway of cell survival control in epithelial

127 The model identified staff reentry as the critical pathway of contagion, and provided estimates of

128 formation and the resulting inhibition of a critical pathway of growth factor cell signaling may rep

129 d A component of LPS stimulates a unique and critical pathway of innate immune responses that is inde

130 Our results emphasize the sensitivity of the critical pathway of recent photosynthate transfer from p

131 Homologous recombination (HR) repair is a critical pathway of repairing DNA double strand breaks,

132 Thus critical pathways of circadian synchronization are media

133 To begin to determine critical pathways of paraquat + maneb neurotoxicity, the

134 Tractography is being used to define critical pathways prior to surgery.

135 the PTEN/AKT signaling axis was defined as a critical pathway regulated by betaIII-tubulin in NSCLC c

136 CLIP-seq and transcriptional targets reveals critical pathways regulated by FMR1 in human neural deve

137 pulations, can yield an understanding of the critical pathways regulating cancer stem cells.

138 signaling pathway has emerged as one of the critical pathways regulating cell proliferation, differe

139 l for tissue growth and maintenance, but the critical pathways regulating protein ubiquitination and

140 e enrichment analysis identified a series of critical pathways related to smoking such as synaptic tr

141 ions to meningomyelocele risk, and highlight critical pathways required for neural tube closure in hu

142 initiated, functional mapping identified two critical pathways, response to viral infections and inte

143 el therapies specifically designed to thwart critical pathways responsible for this malignancy.

144 y autonomic nervous system activity, but the critical pathway(s) that mediate this influence are uncl

145 This catalyst, absent in humans, provides critical pathway-specific enzymatic steps in the product

146 ed, but the roles of some components of this critical pathway still remain uncharacterized in mammals

147 uter spheroids inhibits proteins involved in critical pathways such as mTOR signaling, extracellular

148 genomic regions containing genes enriched in critical pathways such as Wnt signaling and promoter mot

149 However, critical pathways synergizing antigen-BCR interaction an

150 ed degradation of promoter-bound Pol II as a critical pathway that allows cells to cope with DNA dama

151 Autophagy is a critical pathway that integrates numerous regulatory inp

152 nd RIM1alpha, an active zone protein, is the critical pathway that is required for the lasting enhanc

153 r of transcription) in the hypothalamus is a critical pathway that mediates leptin's action.

154 t that Sema3E/plexinD1 signaling in IMs is a critical pathway that modulates airway inflammation, air

155 These studies have identified a novel and critical pathway that promotes aberrant vascular prolife

156 this study, we identify Notch signaling as a critical pathway that regulates the balance between prog

157 ion inhibits the IL-13 activation of several critical pathways that are required for macrophage alter

158 Proteins were identified from several critical pathways that changed at early and late disease

159 and overexpression has provided insight into critical pathways that determine the fate of these multi

160 iprotease imbalance and oxidative stress are critical pathways that exacerbate the pulmonary phenotyp

161 of human prostate cancers, can activate two critical pathways that have been linked to prostate canc

162 mate release and uptake by astrocytes form a critical pathway through which neural activity is linked

163 The critical pathways through which ionizing radiation induc

164 alloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA-expressing macrophag

165 Parent-child interactions are a critical pathway to emotion socialization, with disrupti

166 ese findings support the hypothesis that the critical pathway to end-stage fibrosis is not "alveoliti

167 In the absence of an established critical pathway to evaluate patients with syncope prese

168 cipients in the emergency department (ED), a critical pathway to readmission.

169 the identification of ASF1 function in this critical pathway uncovers an interesting connection betw

170 These results elucidate a critical pathway underlying leptin's induction of dendri

171 Currently, it is unclear how this critical pathway unfolds, in particular, where and when

172 TNFalpha) mRNA levels indicating that these critical pathways were otherwise intact.

173 us illustrating how phenogenomics can reveal critical pathways within emerging pathogenic bacteria.

174 ly of secreted proteins constitutes one such critical pathway: Wnt proteins rank among the most poten