ライフサイエンスコーパス: critical role

1 t methodology, diagnostic agents undertake a critical role.

2 y, among which Sox2 has been shown to play a critical role.

3 ng new disease areas in which opioids play a critical role.

4 ating at ~12 m/s along the equator, play the critical role.

5 stages of differentiation autophagy plays a critical role.

6 and inflammation in which macrophages play a critical role.

7 latency and establishes that they may hold a critical role.

8 read modification of DNA that plays numerous critical roles.

9 Thus, our study shows a critical role and mechanisms of Foxm1 in MA9-LSCs, and i

10 hich cytoplasmic lipid droplets (LDs) play a critical role as depots for energy-rich storage lipids.

11 retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large s

12 This and other studies show the critical role [Ca(2+) ] and the actin cytoskeleton play

13 coding RNA molecules have been implicated in critical roles covering a broad range of biological proc

14 entricular apex resection, autophagy plays a critical role during cardiac regeneration and its regula

15 The vasculature has a critical role during early stages of development and reg

16 Src family kinase Lck plays critical roles during T cell development and activation,

17 This study therefore establishes a critical role for ADAR1 and its A-to-I editing activity

18 Our data reveal a critical role for angiotensin II in regulating burst occ

19 Here, we report a critical role for B2, B3 and B4 subfamilies of Raf-like

20 Our findings support a critical role for both PV(+) and SST(+) interneurons in

21 en used unbiased proteomics and discovered a critical role for emc1 in WNT signaling.

22 Together, these results reveal a critical role for endocardium in HLHS etiology and provi

23 Taken together, these results support a critical role for ER Ca(2+) depletion-activated Ca(2+) c

24 , contrary to previous models that propose a critical role for forces driving talin-vinculin associat

25 An increasingly critical role for IFNs in evolution of skin inflammation

26 ntal and epidemiological evidence supports a critical role for inflammation and adaptive immunity in

27 eficiency in adaptive immunity, indicating a critical role for innate immunity in endometrial control

28 These studies reveal a critical role for miR-466o-3p, a novel microRNA that has

29 Here, we demonstrate a critical role for morphogen sensing by a gene enhancer,

30 We further show a critical role for mTOR in expression and localization of

31 Despite a critical role for MYC as an effector of oncogenic RAS, s

32 Here we identify a critical role for NOTCH3 signalling in the differentiati

33 These results suggest a critical role for PAT1 in BDNF-induced beta-actin mRNA t

34 icrobe, Guo, Kasahara et al. (2020) reveal a critical role for pDCs in antifungal immunity.

35 Collectively, these findings establish a critical role for Prdm12 in the anorexigenic neuron iden

36 Here, we report a critical role for proline catabolism in non-small cell l

37 We demonstrate a critical role for Sac1 in TBSV replicase assembly in a c

38 Taken together, these results suggest a critical role for skeletal muscle lamin A/C to prevent c

39 Altogether, our data support a critical role for Slug in determining the angiogenic res

40 her the content of response feedback plays a critical role for the acquisition and long-term retentio

41 First, we demonstrated a critical role for the host Golgi compartment-resident AT

42 Herein, we show that Lon-1 plays a critical role for the infection of B. burgdorferi in a m

43 Here we demonstrate a critical role for the input from the paraventricular tha

44 Our data support a critical role for the PHD fingers of NUP98-PHF23, and re

45 -induced alpha5beta1 integrin and supports a critical role for the RAP1/RAC1 signaling axis in HNSCC

46 Together, these data demonstrate a critical role for the Reissner fiber for the maintenance

47 The simulations suggest a critical role for the SMC coiled-coil regions, where the

48 ppression of virus replication, confirming a critical role for these cells in suppressing virus produ

49 rial tumor samples is observed, suggesting a critical role for these pDGVs in tumor progression.

50 omeostatic synaptic plasticity, suggesting a critical role for this resting form of signalling in reg

51 Our results underline a critical role for TLR2 in regulating milk components tha

52 c dysregulation upon TSC2 loss, highlighting critical roles for ATX in TSC2-deficient cell fitness an

53 ecent advances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes

54 Emerging studies have also begun to reveal critical roles for distinct innate immune pathways in AD

55 ne responses against C. auris and identifies critical roles for fungal mannans and mannoproteins.

56 Increasing evidence points to critical roles for the urothelium in the developing urin

57 22-regulated functions in vitro demonstrated critical roles for USP22 in prostate cancer.

58 portions of the hemagglutinin protein play a critical role in achieving fusion.

59 aris IFG, PMv and IPL, each of which plays a critical role in action perception and execution.

60 Thyroid hormone signaling plays a critical role in activating M-opsin and repressing S-ops

61 CD8(+) T cells play a critical role in adaptive immunity, differentiating into

62 B lymphocytes play a critical role in adaptive immunity.

63 n of C/EBPbeta and C/EBPdelta, PAGR1 plays a critical role in adipogenesis.

64 actor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung i

65 inositide 3-kinase (PI3K)/Akt, which plays a critical role in angiogenesis.

66 Smooth muscle cells (SMC) play a critical role in atherosclerosis.

67 MENT Dopamine signals in the striatum play a critical role in basal ganglia function, such as reinfor

68 ct air capture (DAC) is positioned to play a critical role in carbon removal, yet remains under paced

69 two invariant histidine residues that play a critical role in catalytic activity.

70 MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regu

71 Multisite protein phosphorylation plays a critical role in cell regulation [1-3].

72 nastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration f

73 Microglia and macrophages play a critical role in choroidal neovascularization (CNV) and

74 complex-dependent actin nucleation, plays a critical role in CNS myelination, and its absence leads

75 dings reveal that VAN signaling also plays a critical role in cognitive processes, including affectiv

76 a-catenin (CTNNB1) signaling pathway plays a critical role in colorectal carcinogenesis.

77 piRNAs, however, have a critical role in controlling histone gene expression.

78 It is now apparent that p53 plays a critical role in controlling immune recognition and resp

79 The marine phosphorus cycle plays a critical role in controlling the extent of global primar

80 The prefrontal cortex (PFC) plays a critical role in curbing impulsive behavior, but the und

81 ade by key brain genes-stoichiometry-plays a critical role in defining the clinical features of autis

82 the notion that species interactions play a critical role in determining upslope range limits.

83 d with TBI, where acute inflammation plays a critical role in disease progression.

84 region indicated that these proteins play a critical role in driving in vivo fitness and virulence o

85 tomotor, and posterior insula regions play a critical role in dysconnectivity shared across deletions

86 a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic r

87 namide adenine dinucleotide (NAD(+)) plays a critical role in energy metabolism and bioenergetic home

88 Promoters serve a critical role in establishing baseline transcriptional c

89 The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes in a changing envir

90 National Institutes of Health (NIH) plays a critical role in funding scientific endeavors in biomedi

91 Direct Cx43 interaction with ZO-1 plays a critical role in gap junction regulation.

92 The deep sea plays a critical role in global climate regulation through uptak

93 member 2) has recently been shown to have a critical role in granulopoiesis in humans, mice, and zeb

94 Feature screening plays a critical role in handling ultrahigh dimensional data ana

95 transmission of BMF, thereby confirming its critical role in hematopoiesis in humans.

96 Our data show that MN1 plays a critical role in human craniofacial and brain developmen

97 or histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger

98 ells are CD4(+) effector T cells that play a critical role in immunity by shaping the inflammatory cy

99 rated that HIV-induced telomeric DDR plays a critical role in inducing telomere loss, premature cell

100 Thus, Chd4 plays a critical role in integrating Fezf2- and Aire-mediated ge

101 tylases (HDACs), and Tet2 hydroxylase play a critical role in keeping cancer cells in a highly metast

102 poor diagnosis and outcome but also plays a critical role in leukemia transformation and maintenance

103 Instead, I suggest that sodium's critical role in limiting herbivore performance makes it

104 Immune microenvironment plays a critical role in lung cancer control versus progression

105 he recent recognition that B cells also play critical role in maintaining peripheral tolerance and su

106 Electron-electron interactions play a critical role in many condensed matter phenomena, and it

107 he function of macrophages (M ) which play a critical role in many physiological processes in healthy

108 Microglia play a critical role in many processes fundamental to learning

109 ly(ADP-ribose) polymerase 1 (PARP1), plays a critical role in mediating IAV HA-induced degradation of

110 iculum (SR) calcium has been shown to play a critical role in mediating mitochondrial dysfunction in

111 hemical cycling, soil microorganisms exert a critical role in mediating the direction and strength of

112 We show that ORAI2 and ORAI3 channels play a critical role in mediating the regenerative Ca(2+) oscil

113 Whether this clustering plays a critical role in membrane fusion is poorly understood in

114 (SWRs), hippocampal population events with a critical role in memory consolidation.

115 ogous proteins in eukaryote cells, playing a critical role in mitochondrial fusion.

116 results indicate that astrocytic YY1 plays a critical role in Mn-induced neurotoxicity in vivo, at le

117 mer conditions, while precipitation played a critical role in moderating the balance between concentr

118 te that radiation dose fractionation plays a critical role in modulating levels of KLF2, its upstream

119 is strongly argues that the pallidum plays a critical role in motor control, it has been difficult to

120 Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development.

121 Inflammation plays a critical role in osteoarthritis (OA).

122 Chlamydia muridarum, IL-1R signaling plays a critical role in oviduct tissue damage.

123 vaccination, suggesting that cDC1s played a critical role in pDC-mediated cross-priming independent

124 yer of soil surrounding plant roots, plays a critical role in plant's adaptation to the environment.

125 of entangled photons in TPA process plays a critical role in probing the detailed electronic structu

126 it signals between synapses and soma, play a critical role in processing functions, such as nonlinear

127 le NAC transcription factor, TaNAC2, plays a critical role in promoting crop growth and nitrogen use

128 The tumor microenvironment plays a critical role in prostate cancer (PC) development and pr

129 s all non-keratinized epithelia, and plays a critical role in protecting the human body from infectio

130 activation of T helper 17 signaling plays a critical role in psoriasis pathogenesis, and systemicall

131 ep in blood-feeding arthropods, which have a critical role in public health as disease vectors.

132 Twitching motility plays a critical role in redistributing cells on surfaces prior

133 erythroid-2-related factor 2 (Nrf2) plays a critical role in reducing oxidative stress by promoting

134 Aurora B kinase has a critical role in regulating attachments between kinetoch

135 MT)-motor-mediated transport dynamics have a critical role in regulating both factors.

136 DNA methylation plays a critical role in regulating gene expression, genomic sta

137 central pair apparatus (CPA), which plays a critical role in regulating proper ciliary function.

138 e data indicate that phosphorylation plays a critical role in regulating the structure and function o

139 Nuclear YAP1 plays a critical role in regulation of stem cell proliferation,

140 Uncertainty plays a critical role in reinforcement learning and decision mak

141 ed potassium 11.1 (K(v)11.1) channels play a critical role in repolarization of cardiomyocytes during

142 The Hippo (MST1/2) pathway plays a critical role in restricting tissue growth in adults and

143 duction of urates and renal function plays a critical role in serum uric acid levels.

144 mammalian male-specific Y chromosome plays a critical role in sex determination and male fertility.

145 Dendritic cells (DCs) play a critical role in shaping adaptive immunity.

146 Corneal stiffness plays a critical role in shaping the cornea with respect to intr

147 The hippocampus plays a critical role in sleep-related memory processes [1-3], b

148 descriptors of neuron type, but also have a critical role in specifying neuronal identity.

149 ach nucleus transcribes even-skipped plays a critical role in stripe formation.

150 EphB2 plays a critical role in synaptic development; its potent activa

151 tu generated oxides/hydroxides, which play a critical role in synergistically reducing energetic barr

152 re, we report that CD2 costimulation plays a critical role in target cell killing by freshly isolated

153 nteractions in the PTC and demonstrate their critical role in termination.

154 m molecules define Tpm continuity and play a critical role in the ability of Tpm to cooperatively bin

155 The Akt/mTOR pathway played a critical role in the AML-EV-induced phenotypical and fun

156 AA unfoldases include spastin, which plays a critical role in the architecture of eukaryotic cells by

157 and the formation of F-actin patches plays a critical role in the assembly of gap junction channels.

158 e that BZR1-dependent ROS production plays a critical role in the BR-mediated regulation of tapetal c

159 Dopamine (DA) plays a critical role in the brain, and the ability to directly

160 astrocytes are urgently needed, given their critical role in the central nervous system.

161 sources of H(2) and abiotic CH(4) have had a critical role in the evolution of our planet and the dev

162 Hepatic LDLr plays a critical role in the flow of macrophage-derived UC to fe

163 For example, iron plays a critical role in the generation of reactive oxygen inter

164 pleting agent, nitrous oxide (N(2)O) plays a critical role in the global climate.

165 The human cathelicidin LL-37 serves a critical role in the innate immune system defending bact

166 l neurons, we show here that tamalin plays a critical role in the ligand-dependent internalization of

167 correct, and that solvation dynamics plays a critical role in the mechanism.

168 explain how periodic microstructures play a critical role in the midinfrared.

169 ve activity of parkin has been linked to its critical role in the mitochondria maintenance.

170 The complement system serves a critical role in the modulation of immune response and r

171 NA-dependent protein kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) r

172 y and reinforces the concept that RA plays a critical role in the pathophysiology of arrhythmogenesis

173 doxal 5'-phosphate-dependent enzyme, plays a critical role in the progression of hepatocellular carci

174 Consequently, RNA-binding proteins play a critical role in the regulation of mRNA and protein abun

175 piRNAs play a critical role in the regulation of transposons and other

176 been linked to flash droughts and can play a critical role in the spread of human ignited wildfires.

177 synaptic transmission within the NAc plays a critical role in the stress response.

178 Hence, Dot1l plays a critical role in the thermogenic program and may present

179 ns and thus, their genetic diversity plays a critical role in their functions.

180 w that histone acetyltransferase MOF plays a critical role in this process through directly activatin

181 membrane of epithelial cells, where it has a critical role in transport.

182 TING (stimulator of interferon genes) play a critical role in vascular inflammation and destruction.

183 the Golgi apparatus and is thought to play a critical role in vesicular trafficking.

184 sforming growth factor-beta (TGFbeta) play a critical role in wound healing.

185 ng RNAs (lncRNAs) have been revealed to play critical roles in a wide variety of biological processes

186 heir role in development, neurotrophins have critical roles in adult brain plasticity.

187 putative SNX-BAR ligands, many of which play critical roles in apoptosis, cell adhesion, signal trans

188 are a family of mammalian kinases that have critical roles in autophagy and development.

189 d effect on the urinary phenotype due to its critical roles in both the formation and the maintenance

190 The accumulation of somatic mutations plays critical roles in cancer development and progression.

191 mily encompasses several proteases that play critical roles in cancer progression; however, the expre

192 Our study demonstrates that FTO plays critical roles in cancer stem cell self-renewal and immu

193 are essential cellular organelles that play critical roles in cancer.

194 ough degradation of cyclic nucleotides, play critical roles in cardiovascular biology and disease.

195 The Hippo pathway plays critical roles in cell growth, differentiation, organ de

196 Super enhancers (SEs) play critical roles in cell type-specific gene regulation.

197 es of some native-like nucleosomes that play critical roles in chromatin functions.

198 of the Wnt/beta-catenin pathway, which plays critical roles in CRC pathogenesis.

199 RNA-binding proteins (RNA-BPs) play critical roles in development and disease to regulate ge

200 Primary cilia play critical roles in development and disease.

201 HMG-box repressor Capicua (Cic), which plays critical roles in development and is deregulated in huma

202 ghly versatile signaling system, which plays critical roles in developmental morphogenesis as well as

203 functions define cellular identity and have critical roles in diseases such as cancer, although the

204 However, other cell types play critical roles in establishing where a lesion is conduci

205 ssing factors, these regulatory RNAs perform critical roles in gene expression.

206 ntial for early mammalian development, plays critical roles in GSC maintenance and M2-like TAM polari

207 Also, bacteria have critical roles in human health as pathogens and commensa

208 te blood cells of the immune system and play critical roles in immune cell signaling.

209 Macrophages are highly plastic cells with critical roles in immunity, cancer, and tissue homeostas

210 nctions are ubiquitous in metazoans and play critical roles in important biological processes, includ

211 tivation and proliferation, supporting their critical roles in in CNS pathogenesis.

212 Microbicides play critical roles in infection prevention and control of Eb

213 logical stresses, support biofilms, and play critical roles in interactions between bacteria and thei

214 Autophagy plays critical roles in neurodegeneration and development, but

215 f biochemical signaling in neurons and plays critical roles in neuronal function.

216 hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress response, and

217 FXR plays critical roles in other lipid metabolic pathways, includ

218 Despite their critical roles in physiology, methods for broad and dire

219 s are dynamic and adaptable organs that play critical roles in plant development.

220 way is essential for organogenesis and plays critical roles in postnatal tissue maintenance and renew

221 ce suggests that SNARE fusion machinery play critical roles in postsynaptic neurotransmitter receptor

222 h-temperature superconductivity(4)-and their critical roles in present-day technical devices.

223 The immune system plays critical roles in promoting tissue repair during recover

224 signature that includes genes known to play critical roles in PSCs and synapses.

225 Inhibitory neurons play critical roles in regulating and shaping olfactory respo

226 With critical roles in regulating gene expression, miRNAs are

227 cetylate histone lysine side chains and play critical roles in regulating gene transcription.

228 Cytokines play critical roles in regulating the development, survival,

229 and HSL1-dependent histone methylation plays critical roles in regulation of seed dormancy during see

230 The oxytocin receptor (OTR) plays critical roles in social behavior development.

231 sulfonated groups and Arg/Lys residues play critical roles in the binding of suramin to the "AT-hook

232 N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system.

233 ate, directly interacts with Rab7a and plays critical roles in the control of the endosomal-lysosomal

234 a, RsmA is an RNA-binding protein that plays critical roles in the control of virulence, interbacteri

235 ects of human TREM2 biology that likely play critical roles in the development and progression of AD.

236 Autophagy plays critical roles in the maintenance of endothelial cells i

237 We tested hypothesis that ANG II plays critical roles in the transcriptional repression of Npr1

238 ing cassette (ABC) transporters play several critical roles in this process, and mutations in these s

239 complex SWI/SNF is highly conserved and has critical roles in various cellular processes, including

240 n the budding and fission yeasts have played critical roles in working out how the eukaryotic cell cy

241 We demonstrate the critical role of a reduction in prefronto-striatal struc

242 m(6)A modifiers and uncover a selective and critical role of ALKBH5 in AML that might act as a thera

243 The critical role of blood lipids in a broad range of health

244 tively, our data provide an insight into the critical role of C/EBPgamma in acute lung injury.

245 Increasing evidence supports a critical role of CD8+ T-cell immunity against influenza.

246 These observations have demonstrated a critical role of Chlamydia-specific T cells in chlamydia

247 Despite increasing recognition of the critical role of coastal wetlands in mitigating climate

248 Mutagenesis studies demonstrate the critical role of consecutive aromatic residues at the ti

249 In summary, our results identify a critical role of CXCR6 in the development of inflammatio

250 These findings support a critical role of DBP in migraine susceptibility and shar

251 xisting models and, together, they support a critical role of E2F signaling for Theileria-induced hos

252 sient absorption spectroscopy, elucidate the critical role of electron transfer (ET) from CdS NRs to

253 The combined results demonstrate a critical role of eosinophils in tumor control in CRC and

254 the HT1080 xenograft model and highlight the critical role of fibrillar collagen and DDRs in supporti

255 ed only by recognizing and responding to the critical role of fire.

256 Our results indicate a critical role of force in promoting axon growth by facil

257 nknown ecological contexts, highlighting the critical role of genetic constraints in shaping the shor

258 Furthermore, it reveals the so far neglected critical role of grain boundaries in the conventional ma

259 pied this hepatoprotection, highlighting the critical role of hepatocytes in fueling the cGAS-IRF3 re

260 d deletion of HIF-1alpha, we demonstrate the critical role of HIF-1alpha-derived from macrophages in

261 Furthermore, this work demonstrates the critical role of host metabolism in surviving infection.

262 Our study reveals a critical role of Hv1 during innate immune responses and

263 We have described the critical role of innate immune signaling via Toll-like r

264 ditionally, our work begins to elucidate the critical role of isotype for an influenza A monoclonal a

265 fewer signaler-recipient dyads downplays the critical role of learning and memory in primate communic

266 Our study reveals a critical role of lipin1 and DGATs as intrinsic regulator

267 the entire acylation reaction and reveal the critical role of Lys73.

268 The critical role of M2 macrophages in this process was esta

269 Unlike the critical role of O-GlcNAc in regulating the animal circa

270 the face of oxidative stress and point to a critical role of obesity in T2DM cardiomyopathy.

271 ding converging cross-species evidence for a critical role of OFC in model-based but not model-free c

272 gnitive models of chronic pain emphasize the critical role of pain catastrophizing in attentional bia

273 -based assay has led to the discovery of the critical role of phosphatidylserine in TBSV replication

274 climate change on migratory species and the critical role of plant phenology in mediating the abilit

275 el with the available data, highlighting the critical role of post-Bronze-Age migrations into the reg

276 Our findings highlight the critical role of rhythmic deadenylation in regulating po

277 This study not only demonstrates the critical role of SFTSV NSs in viral pathogenesis but als

278 f these SHP2 mutants unexpectedly revealed a critical role of SHP2 in GI biology.

279 Together, these data support a critical role of SIRT1 in inflammation and insulin resis

280 The critical role of suppressive myeloid cells in immune reg

281 d epileptic encephalopathy and underline the critical role of the FHF2A isoform in regulating Na(v) c

282 rafish (Liu et al., 2020) now demonstrates a critical role of the Piezo1 mechanosensitive ion channel

283 Given the critical role of the placenta to transfer oxygen and nut

284 ly detected in large intestine, indicating a critical role of the plasmid in chlamydial differentiati

285 The critical role of the regulatory elements at the 5' end o

286 erlie the psychedelic state and pinpoint the critical role of the serotonin 2A and 1A receptor system

287 provide definitive genetic evidence for the critical role of the Tarp F-actin-binding domains in hos

288 However, the critical role of transient intermolecular interactions b

289 These findings support a critical role of Tregs in the pathogenesis of persistenc

290 Using the SNO system, we further identify a critical role of WNT/beta-catenin signaling in regulatin

291 ts may be a very rare cause of AI due to the critical roles of SP6 in development and that the relati

292 Together, our study uncovers critical roles of the actin bundler T-Plastin to promote

293 nalyses of high-order mutants of RAFs reveal critical roles of the RAFs in osmotic stress tolerance a

294 We demonstrate the critical role played by hinge confinement in stabilizing

295 Calculations highlight the critical role played by the two degrees of freedom of th

296 Here, we discuss the critical role T cells play in the orchestration of the a

297 Due to the critical role that this pathway has in regulating cell c

298 Despite their critical roles, the precise mechanics governing TRM cell

299 osal HIV infection, demonstrating the likely critical role these innate immune responses play in earl

300 Angiogenesis plays a critical role within the human body, from the early stag