ライフサイエンスコーパス: crocidolite

1 uman lung epithelial cells to the carcinogen crocidolite.

2 increased with increasing treatment dose of crocidolite.

3 ocation, were induced by both chrysotile and crocidolite.

4 se dependent for all types of asbestos, with crocidolite (5 microg/cm2) inducing 15.0+/-1.1% (mean+/-

5 Crocidolite also catalyzed the nitration of cellular pro

6 (rabbit or human) were exposed to asbestos (crocidolite, amosite, or chrysotile) or control particle

7 ing the similarities and differences between crocidolite and chrysotile asbestos in terms of their tr

8 Crocidolite and chrysotile induced differential expressi

9 Inhalation models of crocidolite- and chrysotile-induced inflammation and asb

10 The mutations induced by crocidolite appeared to be due to the generation of reac

11 d that incubation with low concentrations of crocidolite asbestos (0.5-1.25 microg/cm(2)) resulted in

12 Crocidolite asbestos also induced AP-1 transactivation i

13 (MET5A) exposed to various concentrations of crocidolite asbestos and man-made vitreous fibers (MMVF-

14 In in vitro studies, crocidolite asbestos caused a dose- and time-dependent i

15 Crocidolite asbestos elicits oxidative stress and cell p

16 e, to focus on a specific membrane effect of crocidolite asbestos exposure, which deserves to be test

17 ls and in cells after mechanical wounding or crocidolite asbestos exposure.

18 room air (sham-exposed) or to chrysotile or crocidolite asbestos fibers.

19 57/BL6 mice were exposed to 7-mg/m(3) air of crocidolite asbestos for 5 and 30 days, the times requir

20 te asbestos was addressed by instillation of crocidolite asbestos in a series of wild-type or SPARC-n

21 ew of the transcriptional changes induced by crocidolite asbestos in A549 human lung epithelial cells

22 Intratracheal injection of crocidolite asbestos in mice leads to pulmonary inflamma

23 We show here that crocidolite asbestos induces the DNA repair enzyme, apur

24 enitor cells of lung cancers, we report that crocidolite asbestos initially depletes intracellular gl

25 Crocidolite asbestos is known to cause cellular damage,

26 terations in gene expression associated with crocidolite asbestos or cristobalite silica exposures in

27 ells to nitric oxide (NO) in the presence of crocidolite asbestos resulted in a marked decrease in in

28 We recently reported that crocidolite asbestos was able to interact with the cell

29 ole of SPARC in the in vivo lung response to crocidolite asbestos was addressed by instillation of cr

30 Activation of activator protein (AP-1) by crocidolite asbestos was examined in vitro in a JB6 P+ c

31 esothelial (RPM) cells, RPM cells exposed to crocidolite asbestos, and rat mesotheliomas, subsets of

32 cell signaling, we evaluated the effects of crocidolite asbestos, EGF and H2O2, on MAPK activation i

33 nucleus determines cell fate in response to crocidolite asbestos.

34 to increase worldwide because of exposure to crocidolite asbestos.

35 que to alpha-quartz, being also increased by crocidolite asbestus fibers but not by titanium dioxide

36 n, was evident in lungs from chrysotile- and crocidolite-exposed rats at 1 and 6 wk.

37 ssively increased for 10 or more weeks after crocidolite exposure, but returned to background levels

38 We found that chrysotile and crocidolite exposures have similar effects on human meso

39 Our present data confirm that crocidolite fibers can indeed trigger ROS-mediated damag

40 human-hamster hybrid (A(L)) cells induced by crocidolite fibers in an attempt to determine the role o

41 dy specific for 8-OHdG, we demonstrated that crocidolite fibers induced a dose-dependent increase in

42 CD59 locus induced by a 4 microg/cm2 dose of crocidolite fibers was increased by more than 3-fold (P

43 Treatment with 6 microg/cm2 crocidolite for 24 h caused a 2-fold increase in the mut

44 minerals-grunerite (amosite) and riebeckite (crocidolite)-have been almost completely eliminated from

45 ffect of nitric oxide on the mutagenicity of crocidolite in G12 cells.

46 analyses was used to explore the effects of crocidolite in the context of known molecular interactio

47 G12 cells were treated with 3 microg/cm2 of crocidolite in the presence of nitric oxide-generating c

48 These inhibitors decreased crocidolite-induced c-fos but not c-jun levels, suggesti

49 bust, comprehensive data set documenting the crocidolite-induced changes in the A549 transcriptome wa

50 Crocidolite-induced gene alterations were sustained, whe

51 Among asbestos fibers, crocidolite is considered the most and chrysotile the le

52 Methods: Subjects were from two cohorts: 1) crocidolite mine and mill workers and Wittenoom Township

53 Crocidolite, one of the most carcinogenic forms of asbes

54 h inhibits membrane actin repair mechanisms, crocidolite or applied Fe(3+)/H(2)O(2) invariably produc

55 d to a level that was more than additive for crocidolite or diethyltriamine/NO treatment alone.

56 Crocidolite rapidly scavenged NO with concomitant conver

57 ed for the identification of novel, putative crocidolite-related genes, leading to several new hypoth

58 tion paints a much broader landscape for the crocidolite response than was previously appreciated and

59 lectrophysiological modifications induced by crocidolite suggested a modification of an intrinsic chl

60 Similar to crocidolite, these changes peaked within 30 minutes of i