ライフサイエンスコーパス: cross

1 ound the fence, hence allowing chameleons to cross.

2 re attached, adopting the shape of a Maltese cross.

3 ity under OA occurred in the fastest growing crosses.

4 e the roles of Akt isoforms in this model we crossed Akt1(-/-), Akt2(-/-), and Akt3(-/-) mice with PV

5 d nanoscopic protein aggregates comprising a cross-beta amyloid core and are associated with deadly h

6 changes in protein primary sequence trigger cross-beta fibril formation, with insights that have dir

7 Crosses between H2A.B KO males and females yield embryos

8 ionally, we found that the spatial extent of cross-boundary interactions was rarely assessed, prevent

9 Here, we take advantage of a natural cross-breeding incident to study migratory behaviour in

10 myofilament Ca(2+) sensitivity and increased cross-bridge cycling (k(tr)) at submaximal [Ca(2+)].

11 ed bacteriocin that cleaves the pentaglycine cross-bridge.

12 FemB to incorporate Gly-Ser dipeptides into cross-bridges and to confer resistance to lysostaphin, a

13 In Staphylococcus aureus, pentaglycine cross-bridges are synthesized by three proteins: FemX ad

14 ptidoglycan is characterized by pentaglycine cross-bridges that are cross-linked between adjacent wal

15 ght into the complex genetic architecture of cross-cancer susceptibility.

16 Data were cross-checked and any discrepancy discussed.

17 long with a cell's native mRNA and result in cross-contamination of transcripts between different cel

18 Using a novel GLD model, we show that cross-correction does not occur efficiently in vivo and

19 The efficiency of GALC cross-correction in vivo, the role of the GALC substrate

20 The average ensemble cross-correlation coefficient of the thyroid ultrasound

21 them for single-color fluorescence lifetime cross-correlation spectroscopy (sc-FLCCS).

22 ceptor, Frizzled1 (Fzd1), using fluorescence cross-correlation spectroscopy and show that the co-rece

23 attered signal with the maximum value of the cross-correlation was used to report the results.

24 late-stage diversification by Suzuki-Miyaura cross-coupling (SMC), resulting in new-to-nature biaryl

25 Herein, we report a sulfur (IV) mediated cross-coupling amendable for the efficient synthesis of

26 Ar, silylation, solvolysis, Pd catalyzed C-S cross-coupling and cycloadditions) is demonstrated, high

27 Inspired by the advantages of reductive cross-coupling approaches, we present here a highly effi

28 Catalytic cross-coupling can then furnish the desired Z-homoallyli

29 precedented decarboxylative radical addition/cross-coupling cascade of vinyl boronic esters.

30 The synthesis of aryl thioether through the cross-coupling of C-S bond is a highly attractive area o

31 Suzuki-Miyaura cross-coupling reactions between a variety of alkyl hali

32 e rational development of new stereospecific cross-coupling variants.

33 ons: Giese-type addition and Co/Ni-catalyzed cross-coupling.

34 esidual peridotites through dunitic conduits cross-cutting the uprising mantle.

35 Cross-dehydrogenative C-O coupling of N-hydroxyimides wi

36 cally, O(2) and FeCl(3).6H(2)O catalyzed the cross-dehydrogenative coupling and aromatization of diar

37 We crossed diabetic leptin receptor-mutant mice to mice lac

38 the extent to which donor sEVs might induce cross-dressing following liver and kidney transplantatio

39 ox catalytic protocol that enables the first cross-electrophile coupling of unactivated alkyl chlorid

40 erature gradient that enhances the southward cross-equatorial energy flux by up to 48%.

41 those observed for multiple other of the 56 cross feeding interactions we study.

42 The EBWs contribute to the cross-field diffusion of the electron-scale boundary of

43 simulations indicate that the observed rapid cross-frontal mixing occurs via shear dispersion, genera

44 Compared with fungi, the cross-habitat distribution pattern of bacteria was more

45 (CC) may represent the main responsible for cross-hemispheric slow-wave propagation.

46 ns unclear how such ecologic competition via cross-immunity and antigenic mutations that allow immune

47 used estimates of seasonality, immunity, and cross-immunity for human coronavirus OC43 (HCoV-OC43) an

48 Synoptophore cross-in-circle targets and the largest (of right or lef

49 Last, Neurog2 does not have cross-inhibitory effects on Neurog1, Neurog3, and Ascl1

50 ith these new examples, we perform the first cross-kingdom structural analysis of the OTU fold that h

51 lenging, with no robust method available for cross-laboratory reproducibility.

52 ophic levels was characterized over a 21 day cross-latitudinal vessel transit using a combination of

53 e to induce immunity, but may react with and cross-link preformed drug-specific IgE.

54 also provide catechol moieties for the iron cross-linkages.

55 th red phosphorus type moieties to produce a cross linked structure.

56 rized by pentaglycine cross-bridges that are cross-linked between adjacent wall peptides by penicilli

57 One eye of each pair was cross-linked by 0.1% riboflavin in hydroxylpropyl methyl

58 composed of repeating saccharides covalently cross-linked by peptide stems.

59 and fibrillin individually as well as in the cross-linked complex.

60 nterval from 15 to 60 degrees C using borate cross-linked dextran sieving matrix.

61 We cross-linked EPIC with gene ontology and anatomy ontolog

62 cilitate the detection and identification of cross-linked peptides using multistage mass spectrometry

63 x (ECM) is a complex and dynamic meshwork of cross-linked proteins that supports cell polarization an

64 We apply our approach to the actin cross-linker alpha-actinin-4 and show that the cross-lin

65 Varying the cross-linker loading or bottlebrush backbone degree of p

66 Using the MS-cleavable cross-linker, disuccinimidyl sulfoxide, inter-protein cr

67 series of sulfoxide-containing MS-cleavable cross-linkers to facilitate the detection and identifica

68 lopment of sulfoxide-containing MS-cleavable cross-linkers with new functionalities.

69 articularly with regards to the use of photo-cross-linking (i.e., light-based) techniques.

70 s directly correlated with levels of protein-cross-linking AGEs.

71 Inhibiting LOX reduces collagen cross-linking and fibronectin assembly, increases drug p

72 this, we performed enhanced ultraviolet (UV) cross-linking and immunoprecipitation followed by sequen

73 Enhanced UV-cross-linking and immunoprecipitation of these RBPs iden

74 y target tau pre-mRNA in cells, via chemical cross-linking and isolation by pull-down target profilin

75 This study reveals that cross-linking decreases NP diffusion coefficients and po

76 We further demonstrate that cross-linking impairs the cholesterol efflux mediated by

77 lysis, we analyzed the pattern of apoprotein cross-linking in isolated human HDL either by synthetic

78 integrin alphaLbeta2 (LFA-1) on T cells, and cross-linking layilin promoted the activated state of th

79 ng question is to understand how large-scale cross-linking mass spectrometry (XL-MS) can confirm and

80 ffinity purification, live cell imaging, and cross-linking mass spectrometry to build integrative str

81 ted using cryoelectron microscopy (cryo-EM), cross-linking mass spectrometry, and homology modeling.

82 All cross-linking methods reduced the enzymatic degradation

83 designed and synthesized new functional and cross-linking monomers, which are oxidized at sufficient

84 Here we demonstrate that glutaraldehyde cross-linking of PEGylated oligolysine-coated DNs extend

85 nd activate T cells with solution ligands by cross-linking pMHC or using multivalent antibodies to TC

86 Photochemical cross-linking reveals that the baboon amylin, like human

87 he antibody bound to TNFR2 through a natural cross-linking surface and that T(reg) cell expansion was

88 oss-linker alpha-actinin-4 and show that the cross-linking time of alpha-actinin-4 homodimers increas

89 ds at the interface as a result of oxidative cross-linking, even though the modulus of the bulk of th

90 rminal d-ala-d-ala and reduced peptidoglycan cross-linking, prompting us to investigate synergism bet

91 se functions through SEPT9-dependent F-actin cross-linking, which enables the generation of F-actin b

92 A cross-linking-informed high-resolution model of the CXCR

93 and state-dependent non-canonical amino acid cross-linking.

94 UV irradiation of the films resulted in cross-linking/polymerization of the molecular columns.

95 f the LBDs that might be trapped by cysteine cross-links and metal bridges.

96 ll MSC constituents were observed, including cross-links between eight protein pairs not previously k

97 We propose Sym004 cross-links EGFR physically triggering EGFR endocytosis

98 ker, disuccinimidyl sulfoxide, inter-protein cross-links spanning all MSC constituents were observed,

99 ome revealed the disruption of a C(32-)A(38) cross-loop interaction but failed to fully explain the m

100 o vinyl acetate-1-(13)C, resulting from zero-crossing magnetic field ramps of various durations, ampl

101 ta, which is in part addressed by the use of cross-matched laboratory source data, and the possibilit

102 te is first obtained through stereoretentive cross-metathesis between Z-crotyl-B(pin) (pin = pinacola

103 ition-specific facilitation effect driven by cross-modal recovery of auditory speech spectra.

104 These findings provide strong evidence that cross-modal temporal biases depend on sensory experience

105 cases, and one design led to improvement of cross-neutralization of heterologous viruses.

106 However, SARS-CoV-2 sera generally lacked cross-neutralization to a highly homologous pre-emergent

107 Crossing NO66(flox/flox) with MCK-Cre mice bred muscle-s

108 ern formed only with a copper(I)-coordinated crossing of particular handedness.

109 ines its directional coupling into a six-way crossing of photonic crystal waveguides.

110 After a 6-day washout, participants were crossed over to the treatment they did not receive durin

111 ebo according to a double-blind, randomised, cross-over design.

112 ng cathode reversibility by preventing anion cross-over in aqueous electrolytes.

113 We conducted a randomized, cross-over trial in consecutive patients with prior dete

114 This multicentre, randomised, controlled cross-over trial was designed to investigate the effect

115 (3 h sleep opportunity at the end of night), crossed-over with a full sleep condition in a balanced o

116 e of one knot, a lanthanide(III)-coordinated crossing pattern formed only with a copper(I)-coordinate

117 We find cross-population signals of African ancestry enrichment

118 ype 1 dendritic cells that are essential for cross-presentation and CD8 T cell-mediated immunity agai

119 1 (cDC1) subpopulation important for antigen cross-presentation, that CD40L-overexpressing CAR T cell

120 of cytotoxic T lymphocytes (CTLs) and CD103+ cross-presenting dendritic cells (DCs), as well as up-re

121 Activation of cytotoxic CD8(+) T cells by cross-priming DC contributes to exacerbation of postisch

122 The potential of cross-processing herring or salmon by-products with brow

123 nd active IgE sensitization, and resulted in cross-protection against different allergens.

124 specificity, potential cross-reactivity and cross-protectivity, the diagnostic value of antibodies o

125 d with the eye as the unit of analysis, with crossed random effects to adjust for correlation between

126 These cross react against parental, unmodified tumors and lead

127 y concern that elicited antibodies (Abs) may cross-react with other flaviviruses that share a similar

128 ites of the genotype 1 HEV p239 antigen, and cross-react with other genotypes.

129 whether T cells induced by one viral species cross-react with other related flaviviruses has not been

130 NS1-specific IgG in naive individuals, which cross-reacted with DENV-1, -3, and -4 NS1 to varying ext

131 Dy-I-PhiAB6TSP also cross-reacted with other pathogenic bacteria containing

132 ntibodies (human IgG4 homolog) that strongly cross-reacted with recombinant DSG1; these IgG1 antibodi

133 Cross-reaction of the sensor with four reference molecul

134 n Lactobacillus casei over-expressing myosin-cross-reactive antigen (LC(+mcra)).

135 phoidal serovar, Salmonella Typhi, generates cross-reactive immune responses, which provide far great

136 al studies demonstrated that the most potent cross-reactive neutralizing mAbs, HENV-26 and HENV-32, p

137 led three structural epitopes: two partially cross-reactive regions around alpha-helices 2 and 4 as w

138 se differences may contribute to the broadly cross-reactive response elicited by HN13.

139 And while depth, or the frequency of cross-reactive responses, did not correlate with viral l

140 , the single sensor device integrated in the cross-reactive sensor matrix exhibits multimodal detecti

141 we isolated, characterized, and humanized a cross-reactive, neutralizing anti-F mAb (h5B3.1).

142 ncluding sensitivity, specificity, potential cross-reactivity and cross-protectivity, the diagnostic

143 ral loads in recipients who became infected, cross-reactivity did appear to influence early viral evo

144 No interference/cross-reactivity from Salmonella enteritidis, Enterobact

145 ngue virus (DENV), the role of immunological cross-reactivity in ZIKV and DENV infections has become

146 he affinity maturation process and potential cross-reactivity of VH3-23/VK1-5 neutralizing Abs, infor

147 as well as an algorithmic approach, based on cross-reactivity studies, in patients with a suspicion o

148 Yet cross-reactivity to additional microbes is important to

149 ivity was analyzed in ELISA experiments, and cross-reactivity with allergens of other poultry species

150 Absence of cross-reactivity with mammalian species tested in the st

151 ut suffer from poor cell permeability and/or cross-reactivity with the cysteine protease cathepsin B.

152 tion of serologies is confounded by antibody cross-reactivity with viruses belonging to the same sero

153 y, intersubclass specificity, and class-wide cross-reactivity, suggesting that some conserved epitope

154 d it with the receptor, and confirmed murine cross-reactivity.

155 Such responses can be triggered by cross-recognition of the autoreactive TCR with foreign p

156 tionally, vaccine-induced CD8 T cells poorly cross-recognized variant epitopes encoding HLA-I-associa

157 addition, not only do FIGLA, LHX8 and SOHLH1 cross-regulate each other, they also cooperate by direct

158 to be understood about how such networks of cross-regulation are established and what the functional

159 y cyclic di-GMP, which provides evidence for cross-regulation between different CDN pathways.

160 Such cross-regulation has been proposed to be important to co

161 ontrol of allergen-induced Th2 responses via cross-regulation.

162 There was slight cross-resistance between topically applied fluralaner an

163 idrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-diver

164 In particular, cross-resistance to unrelated classes may occur by co-se

165 timising antitrypanosomal drugs and averting cross-resistance.

166 ssfully separated upon using the collisional cross section (CCS) as additional specific physical prop

167 ty to separate isomers and provide collision cross section (CCS) values that facilitate structural as

168 ion mobility mass spectrometer and collision cross section values of fragments measured.

169 ak mean' value averaged over the area of the cross section, denoted pm.

170 Improved cross-section data were obtained by exploiting the negli

171 compound has a good thermal-neutron-capture cross-section, a suitable bandgap (2.06 electronvolts) a

172 In the microchannel of a rectangular cross-section, this leads to formation of a "four-lane"

173 4 (mean +/-SD) years posttransplant; and the Cross sectional Cohort (CSC, n=446): patients developing

174 All the studies were cross sectional.

175 Study of Atherosclerosis) participants, the cross-sectional (exam 1) and longitudinal (exams 1 to 3)

176 The present cross-sectional 3T (1)H MRS study is the first to use a

177 associated with echocardiographic traits in cross-sectional analyses (false discovery rate <0.10), a

178 Cross-sectional analysis showed a significant decrease (

179 Five different hypotheses using a cross-sectional and a longitudinal design were tested to

180 Cross-sectional and longitudinal comparisons of K(i) and

181 Pathology studies, cross-sectional and longitudinal PET-only studies, and c

182 , 2.94) and 2.02 (95% CI=1.26, 3.23) for the cross-sectional and longitudinal studies, respectively.

183 protein levels and increased skeletal muscle cross-sectional area and contractility properties.

184 week (termination) time points to monitor PV cross-sectional area at each PV ablation site.

185 al activity increased lower extremity muscle cross-sectional area in patients with myotonic dystrophy

186 However, correlation with spinal cord cross-sectional area-a predictor of disability-is poor,

187 riate linear regression was used to test for cross-sectional associations between VF damage and activ

188 ing the correlation with clinical variables, cross-sectional brain imaging and neurophysiological dat

189 In 2016, we conducted a cross-sectional carriage survey (CSS5) in a community wh

190 The investigation of the largest cross-sectional cohort of CHIKV-deaths to date reveals t

191 shuttled by CD31(+) EVs in a large (n = 218) cross-sectional cohort of patients categorized as having

192 ation in COPD.Methods: We applied SuStaIn to cross-sectional computed tomography imaging markers in 3

193 s study was based on a secondary analysis of cross-sectional data collected as part of a randomised c

194 Cross-sectional data from 13 nationally representative s

195 ties: 1) a series of descriptive analyses of cross-sectional data from demographic and health surveys

196 Cross-sectional data from older adults (>=60 y; n = 2420

197 We pooled cross-sectional data from the 2004 to 2017 National Heal

198 Moreover, cross-sectional data revealed that infertile men with th

199 In a cross-sectional design, 36 patients with first onset of

200 tent with the hypothesis that when stone tip cross-sectional geometries become smaller over time in p

201 gs being equal, projectiles with smaller tip cross-sectional geometries should penetrate deeper into

202 to a target than projectiles with larger tip cross-sectional geometries.

203 ipped projectile each possessing a different cross-sectional geometry.

204 Cross-sectional images (B-scans) obtained with SD-OCT sh

205 CBCT images were compared with preprocedural cross-sectional images (CT/MRI).

206 esponse are currently assessed by endoscopy, cross-sectional imaging, and biomarkers.

207 Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint inter

208 A cross-sectional observational study assessed dietary int

209 We conducted a cross-sectional observational study of COVID-19 hospital

210 A cross-sectional observational study was conducted for a

211 This was a cross-sectional observational study.

212 s evaluated for both eyes by the revision of cross-sectional OCT images of 6-mm volume scans.

213 human prenatal neural development comes from cross-sectional or case studies that are not able to res

214 Findings of this cross-sectional representative study of an adult US popu

215 In this cross-sectional retrospective cohort study, we sought to

216 In a cross-sectional retrospective study of 3120 diabetic pat

217 estimates of statins on metabolites from the cross-sectional study are comparable to those from inter

218 matter connectivity and word production in a cross-sectional study of 42 participants with aphasia du

219 a metal mixture with general cognition in a cross-sectional study of adolescents residing near ferro

220 During 2015-2016 a cross-sectional study on 234 randomly-selected farms inv

221 A cross-sectional study was conducted with a twin cohort 8

222 We performed a cross-sectional study with 108 post-LT patients and foun

223 In this cross-sectional study, 50 participants (mean age 62.5 +/

224 In this cross-sectional study, 60 women over 40 years of age wer

225 For this cross-sectional study, in partnership with a central lab

226 Therefore, in this cross-sectional study, we characterized the brain inflam

227 lled intervention study and in subjects of a cross-sectional study.

228 We performed a cross-sectional survey in April-May 2018 among Rohingya

229 A cross-sectional survey was undertaken of all children ag

230 retion during a prospective nine year serial cross-sectional survey.

231 ence, clinical features), and study designs (cross-sectional).

232 itive impairment (MCI) have been examined in cross-sectional, but rarely in longitudinal studies.

233 d work productivity and activity level, both cross-sectionally (interindividually) and longitudinally

234 In structural biology, collision cross sections (CCSs) from ion mobility mass spectrometr

235 o compact monomers, dimers, and trimers with cross sections consistent with X-ray structures and repo

236 The highly structured differential cross sections directly reflect the increasing number of

237 rse DW motion along nanowires with polygonal cross-sections.

238 r membrane protein (rMOMP) vaccine to elicit cross-serogroup protection.

239 We developed a set of square-shaped, cross-shaped, and complex-slotted EBG ground planes betw

240 Awardees were required to participate in a cross-site evaluation that assessed the impact of BEST a

241 They thus emphasize the utility of cross-species analysis for understanding the predictors

242 nd highlight the challenge and power of such cross-species approaches in informing the 'next steps' t

243 Our cross-species comparative genomic analysis provides uniq

244 The occurrence of stratified layers, cross-stratification, and bedforms in these deposits has

245 lyses were conducted to assess the impact of cross-study variations.

246 Upper crossed syndrome (UCS) refers to the altered muscle acti

247 entified by the presence of leakage, and (3) cross-tabulation of CNV activity identified by FFA and S

248 e, distribution with mGluR5, and the dynamic cross talk between mGluR5 and VGLUT3 is key for the func

249 Therefore, VGLUT3-mGluR5 cross talk can significantly influence both physiologic

250 s of reduced phototoxicity, minimal spectral cross talk with visible light excitable optogenetic tool

251 ribing the effect of functional interaction (cross talk) between ryanodine receptor and IP(3)R channe

252 or understanding mechanisms of trans-histone cross-talk and the dynamic role of H2B ubiquitination in

253 To assess the role and cross-talk between autophagy and Lkb1 in normal tissue h

254 nsulin target cells and provide insight into cross-talk between the insulin and Hippo pathways.

255 '-3' exonuclease Xrn1, are responsible for a cross-talk between the two processes that buffers steady

256 hematical model to investigate the impact of cross-talk between tumor cell- and endothelial cell (EC)

257 ion is recognized as a result of an evolving cross-talk between tumor cells and their surrounding non

258 l-cycle proteins; thus, the WW-PPIase domain cross-talk mechanisms of Pin1 may be relevant for their

259 c activating signals, insulators prevent the cross-talk of regulatory elements within adjacent loci a

260 MEGF11 was found to cross-talk positively with IL-17A signalling.

261 acid metabolism in different cells and their cross-talk shape tumor immunity and therapy efficacy in

262 Only recently has the role of neuroimmune cross-talk surfaced as a key contributor to cancer progr

263 lls and of the direct orchestration of their cross-talk that is required for optimal anti-tumour immu

264 In addition, we exploit the absence of cross-talk with respect to the majority of well-characte

265 er and NMDA-receptor-mediated inter-synaptic cross-talk.

266 on factors that may potentially mediate this cross-talk.

267 esterase two dependent negative cGMP-to-cAMP cross-talk.

268 the terahertz electric field vector without cross-talk.

269 These studies captured unique heteroterminal cross talks between the fuzzy interprotofilament interfa

270 Using a series of genetic crosses that separate parental and zygotic contributions

271 ed in the infrared, and its orbit appears to cross the debris ring around the star without the expect

272 d the ability of this EVG nanoformulation to cross the in vitro BBB model and suppress the HIV-1 in m

273 Oral anti-hyperglycaemics cross the placenta, so effects on fetal anthropometry co

274 bat coronavirus, WIV1-CoV, which has not yet crossed the species barrier.

275 ram, respectively) indicating that (18)F-FAC crosses the BBB.

276 northern Latium toward the Neapolitan area, crossing the city of Rome.

277 ed for 3300-4800 km along a narrow corridor, crossing the Himalayas at extremely high elevations (up

278 nt in the presence/absence of autoantigen by crossing the Ig KI mice to Tgm2-/- mice.

279 Thus, our data argue against mHTT crossing the MOM and entering into the mitochondrial int

280 1(fl/fl); Myh6(Cre/Esr1*)) were generated by crossing the Tjp1 floxed mice and Myh6(Cre/Esr1*) transg

281 ase in their apparent (visual) size does not cross their prey's response threshold until after rapid

282 the gray-white matter interface places axons crossing this region at greater risk of mechanical damag

283 ic T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induc

284 The genome-wide cross-trait analysis features in several analytic aspect

285 veral analytic aspects: genetic correlation, cross-trait meta-analysis, Mendelian randomization, poly

286 amples demonstrating how it might be used to cross-validate and compare in vivo radiologic imaging wi

287 A two-variable classifier yielded a cross-validated area under the receiver operating charac

288 ci predicted future progression rates with a cross-validated mean absolute error of 0.13 mm/year and

289 stic regression with a nested leave-pair out cross validation (LPOCV) scheme and recursive feature el

290 ion to diabetes (AUC 0.92) based on standard cross-validation (CV).

291 AI predictions were evaluated using 10-fold cross-validation against annotations by expert surgeons.

292 algorithms, was evaluated by internal 5-fold cross-validation statistics.

293 Training models include nested leave-one-out cross-validation to select features, train the model, an

294 At cross-validation, the newly developed SYNTAX score II, t

295 tion pathway CNNs was trained using fivefold cross-validation.

296 model validated confirmed with and fivefold cross-validation.

297 %-25% training-validation split and fourfold cross-validation.

298 igh accuracy (92%) when evaluated via strict cross-validations.

299 In this study, 12 different genetic crosses were used, hundreds of neurons were electrophysi

300 high-fitness individuals of both reciprocal crosses, whereas maternal biases were largely absent in