ライフサイエンスコーパス: cross-link

1 on correlates with the hydrophilicity of the cross-link.

2 small relative to the mean distance between cross-links.

3 ion repair (TC-NER) of cisplatin-induced DNA cross-links.

4 that enable facile and cytocompatible photo-cross-linking.

5 ,2'-(ethylenedioxy) diethanethiol (EDT)) for cross-linking.

6 ations in the degree of iron-induced protein cross-linking.

7 to address a larger part of the proteome by cross-linking.

8 eases the oxygen availability during corneal cross-linking.

9 and state-dependent non-canonical amino acid cross-linking.

10 oxygen allowing a potentially more efficient cross-linking.

11 Bacteria with these non-canonical cell-wall cross-links achieve a high optical density in culture, d

12 sembles into ensembles that bind, slide, and cross-link actin filaments (F-actin).

13 How cells regulate microtubule cross-linking activity to control the rate and duration

14 Using a combination of cross-linking/affinity pull-downs and two-hybrid assays,

15 d by higher protein cross-linking and higher cross-linking AGE levels.

16 ed carbon electrode (SPCE) using chitosan as cross-linked agent for 5-HT sensing studies; conducted t

17 kout cells to a low concentration of the DNA cross-linking agent mitomycin C (MMC).

18 s directly correlated with levels of protein-cross-linking AGEs.

19 drive the symptoms of allergic disease upon cross-linking allergens on mast cells or basophils.

20 Apolipoprotein A-I (apoA-I) is cross-linked and dysfunctional in human atheroma.

21 er networks that are, in their design, fully cross-linked and fully pai-conjugated.

22 imulated cylindrical bundles of MTs that are cross-linked and powered by molecular motors by iterativ

23 an imaging could rapidly identify degrees of cross-linking and detected calcified regions with high c

24 Inhibiting LOX reduces collagen cross-linking and fibronectin assembly, increases drug p

25 this loss was accompanied by higher protein cross-linking and higher cross-linking AGE levels.

26 AGO cross-linking and immunoprecipitation (CLIP) experiments

27 this, we performed enhanced ultraviolet (UV) cross-linking and immunoprecipitation followed by sequen

28 Enhanced UV-cross-linking and immunoprecipitation of these RBPs iden

29 tended the target validation method chemical cross-linking and isolation by pull-down (Chem-CLIP) to

30 y target tau pre-mRNA in cells, via chemical cross-linking and isolation by pull-down target profilin

31 this review is on the fundamentals of photo-cross-linking and key criteria identified for the succes

32 ibroblast polarization; elastomers with high cross-linking and low deformability were required for po

33 rom resolution, in conjunction with chemical cross-linking and mass spectrometric analysis of conform

34 dent manner, providing a mechanism for HC.HA cross-linking and matrix stabilization.

35 Furthermore, cross-linking and mutagenesis studies indicated that thi

36 ially inhibit XCTK2 antiparallel microtubule cross-linking and sliding by decreasing the microtubule

37 We developed viral cross-linking and solid-phase purification (VIR-CLASP) t

38 We established VIR-CLASP (VIRal Cross-Linking And Solid-phase Purification) to identify

39 orks by using data from structural, chemical cross-linking and various high-throughput studies.

40 f the LBDs that might be trapped by cysteine cross-links and metal bridges.

41 chemical modifications, e.g., (succinylation/cross-linking) and two enzymes modification (alpha-amyla

42 all-angle x-ray scattering, targeted protein cross-linking, and cryo-electron microscopy.

43 ectron-transfer dissociation (ETD), chemical cross-linking, and molecular docking.

44 regulate glycan strand length, the degree of cross-linking, and the addition of other modifications t

45 imal keratometry (K(max)) at 12 months after cross-linking, and we considered additional topographic,

46 g whether transepithelial and epithelium-off cross-linking are comparable in their safety and efficac

47 nstrated in vitro, the in vivo mechanisms of cross-linking are not well-established.

48 a bacterium where up to 31% of the cell-wall cross-links are formed by a non-enzymatic reaction betwe

49 Fibrils cross-linked artificially by glutaraldehyde do not show

50 llowing a straightforward synthetic route by cross-linking arylamine-based ligands with a simple thie

51 ified IAA response and lignin synthesis/wall cross-linking as some of the key processes occurring dur

52 dant unit on the polymer allowed PSBBB to be cross-linked at temperatures of 120 degrees C, thus rend

53 ntified a total of 2,052 unique residue pair cross-links at 1% FDR.

54 of disordered domains and breaking of native cross-links at different stages of strain.

55 cially for RNA tertiary structures involving cross-linked base pairs.

56 ical constraints on RNA global fold than non-cross-linked base pairs.

57 rized by pentaglycine cross-bridges that are cross-linked between adjacent wall peptides by penicilli

58 ic unit extended farther away from the core, cross-linking between neighboring columns was suggested

59 ll MSC constituents were observed, including cross-links between eight protein pairs not previously k

60 forming a network structure via non-covalent cross-links between mucin chains.

61 eacted with MexR, forming di- and trisulfide cross-links between two Cys residues, to derepress the m

62 uccessful design and implementation of photo-cross-linked bioinks and bioresins in extrusion-based an

63 whose structure and dynamics are modified by cross-linking, bridging proteins, and cleavage by matrix

64 One eye of each pair was cross-linked by 0.1% riboflavin in hydroxylpropyl methyl

65 tion of hub proteins into filaments that are cross-linked by dimerization into dynamic three-dimensio

66 dues in helices 5-8 of apoA-I are preferably cross-linked by oxPLs, forming stable pyrrole adducts wi

67 composed of repeating saccharides covalently cross-linked by peptide stems.

68 nal properties of peanut protein hydrolysate cross-linked by TGase were tested.

69 in reconstituted and native chromatin after cross-linking by ultraviolet (UV) light.

70 Our data suggest that RTX cross-links CD20 into circular assemblies and lead to a

71 the compacted cells and the increased Ca(2+)-cross linked cell-cell adhesion.

72 od development, combining several orthogonal cross-linking chemistries as well as improvements in sea

73 We then investigate the cross-linking chemistries of two poorly characterized re

74 Here, we applied a novel cross-linked coating to functionalize core/shell lead su

75 ion is often limited by the low abundance of cross-links compared to non-cross-linked peptides in the

76 and fibrillin individually as well as in the cross-linked complex.

77 ir ability to form spontaneous noncovalently cross-linked complexes with specific multivalent ligands

78 Here, we combine in vitro biochemistry, cross-linking coupled to mass spectrometry, and in vivo

79 Chemical cross-linking coupled with mass spectrometry offers an a

80 lagen is a structural protein whose internal cross-linking critically determines the properties and f

81 g., free radical chain polymerization, click cross-linking, cross-linking due to oxidation of phenoli

82 Cysteine-cross-linking, cryo-electron microscopy multivariate ana

83 le cross-linkers to generate highly reliable cross-link data.

84 This study reveals that cross-linking decreases NP diffusion coefficients and po

85 Intra-protein cross-links defined new structural relationships between

86 he linker concentration still determines the cross-linking degree of the vitrimers, which originates

87 on nano-textured non-wovens encoded by their cross-linking degree.

88 We further demonstrate that this level of cross-linking density is sufficient to model the archite

89 by 92% from 407 to 31 g/g because of higher cross-linking density.

90 of the hIgE that bind different epitopes to cross-link Der p 2 was demonstrated in a mouse model of

91 ometry (XL-MS), the depth and sensitivity of cross-link detection is often limited by the low abundan

92 nterval from 15 to 60 degrees C using borate cross-linked dextran sieving matrix.

93 These studies indicate that myrocins do not cross-link DNA, suggesting an alternative mode of action

94 mutant CTxB-single-GM1 complexes by antibody cross-linking does not rescue the membrane curvature phe

95 X toxin with three effector domains-an actin cross-linking domain (ACD), a Rho inactivation domain (R

96 l chain polymerization, click cross-linking, cross-linking due to oxidation of phenolic groups), (ii)

97 discussed in detail, including (i) covalent cross-linking (e.g., free radical chain polymerization,

98 The general mechanisms associated with photo-cross-linking (e.g., free-radical chain polymerization,

99 e Diels-Alder reactions), and (iii) physical cross-linking (e.g., guest-host interactions, hydrogen b

100 n of phenolic groups), (ii) dynamic covalent cross-linking (e.g., Schiff base formation, disulfide fo

101 benzylic leaving groups greatly affected DNA cross-linking efficiency.

102 We propose Sym004 cross-links EGFR physically triggering EGFR endocytosis

103 ll to rapidly tune its mechanics from highly cross-linked, elastic networks to weakly cross-linked vi

104 Weakly cross-linked elastomers supported efficient focal adhesi

105 The distance restraints derived from the cross-links enable building high-confidence models of PD

106 These results indicate that dynamic actin cross-linking enables the cytoplasm to flow at long time

107 We cross-linked EPIC with gene ontology and anatomy ontolog

108 ds at the interface as a result of oxidative cross-linking, even though the modulus of the bulk of th

109 er-order, nanoscale control over associative cross-link exchange and flow.

110 level information all from a single in vivo cross-linking experiment.

111 ward-facing conformation and verify it using cross-linking experiments.

112 h FcepsilonRs decrease ability to indirectly cross-link FcepsilonRI.

113 ional changes associated with gating promote cross-linking for I409C/R410C, which in turn decreases c

114 We excluded studies evaluating cross-linking for nonectatic indications, as well as non

115 ctions of tropoelastin and fibrillin and how cross-link formation stabilises the elastin precursor so

116 the internal polymer structure together with cross-links formed by the protein complex.

117 e in SikuliX to coordinate image capture and cross-linking functions in Zeiss Zen Black with image pr

118 estraints from both genetic interactions and cross-links further improves model accuracy and precisio

119 e to Wnt3a versus a 'surrogate agonist' that cross-links Fzd to LRP6, revealed identical structure-ac

120 This composite material consisted of a cross-linked gelatin network with incorporated caprylic

121 X concentrations leading to the formation of cross-linked gels.

122 nd chemical conjugation methods to introduce cross-linking groups are described.

123 eptor coactivators, and induction of protein cross-linking have also been described.

124 Although multiple mechanisms of apoA-I cross-linking have been demonstrated in vitro, the in vi

125 abilized helices, beta-hairpin peptides, and cross-linked helix dimers in 11 different cell lines.

126 To improve the identification efficiency of cross-links, here, we present a gas-phase separation str

127 ow concentrations of nanoclay are applied to cross-link hyaluronic acid polymers derivatised with a p

128 energy into mechanical deformation of the 3D cross-linked hydrogel matrix.

129 al transduction of energy mediated by the 3D cross-linked hydrogel network facilitates pairwise inter

130 articularly with regards to the use of photo-cross-linking (i.e., light-based) techniques.

131 which together constitute a DNA interstrand cross-link (ICL) repair, or the FA pathway.

132 DNA interstrand cross-links (ICLs) are a form of DNA damage that require

133 randed DNA (ssDNA) and unhooking interstrand cross-links (ICLs) at fork structures.

134 e improving the efficiency and confidence of cross-link identification.

135 the FAIMS device, we increase the number of cross-link identifications by 22% for a medium complex s

136 inds RNA in mouse embryonic stem cells by UV-cross-linked immunoprecipitation of Sox2 and more than a

137 We further demonstrate that cross-linking impairs the cholesterol efflux mediated by

138 poly(4-methylcaprolactone) side chains were cross-linked in formulations that include a bislactone a

139 fety and efficacy of transepithelial corneal cross-linking in comparison with the established epithel

140 While the role of actin cross-linking in controlling actin network mechanics is

141 lysis, we analyzed the pattern of apoprotein cross-linking in isolated human HDL either by synthetic

142 m these mice, indicate that overall collagen cross-linking in mouse tendon decreases with age.

143 We detected a similar pattern of apoprotein cross-linking in oxidized murine HDL.

144 rmation of a tetramer was further studied by cross-linking in the presence of detergents and lipids.

145 a vital role in catalyzing the formation of cross-links in fibrillar elastin and collagens leading t

146 icians analyse the intertwined relations and cross-links in tumours.

147 ation in collagen, which is not considered a cross-link, increased dramatically with age.

148 urrent scientific consensus is that collagen cross-linking increases with age and that this increase

149 A cross-linking-informed high-resolution model of the CXCR

150 mation and is categorized as a new adipokine cross-linking innate immunity and metabolic disorders in

151 cal consequence of introducing non-canonical cross-links into the cell wall of Escherichia coli, we g

152 nerated by Cin8 and Kip3 through microtubule cross-linking is essential for signaling efficient cohes

153 e mechanism that has been implicated in this cross-linking is glycation through formation of advanced

154 integrin alphaLbeta2 (LFA-1) on T cells, and cross-linking layilin promoted the activated state of th

155 es to nutrient availability, we performed UV cross-linking, ligation and sequencing of hybrids (CLASH

156 e used an integrated combination of chemical cross-linking mass spectrometry (CXMS), molecular geneti

157 We have taken advantage of cross-linking mass spectrometry (XL-MS) and molecular do

158 ng question is to understand how large-scale cross-linking mass spectrometry (XL-MS) can confirm and

159 Cross-linking mass spectrometry (XL-MS) has become a pow

160 In cross-linking mass spectrometry (XL-MS), the depth and s

161 Here, we have developed a multichemistry cross-linking mass spectrometry approach enabled by thre

162 Finally, cross-linking mass spectrometry reveals likely interacti

163 ffinity purification, live cell imaging, and cross-linking mass spectrometry to build integrative str

164 By coupling SCAP to cross-linking mass spectrometry, an integrative structur

165 ted using cryoelectron microscopy (cryo-EM), cross-linking mass spectrometry, and homology modeling.

166 Mycoplasma pneumoniae We combined whole-cell cross-linking mass spectrometry, cellular cryo-electron

167 n nuclear magnetic resonance (NMR), chemical cross-linking, mass spectrometry, and molecular docking.

168 These results uncover a protein cross-linking mechanism in the lens and suggest that AGE

169 The application of all cross-linking methods increased the resistance of rabbit

170 All cross-linking methods reduced the enzymatic degradation

171 Cross-linking methods to form biopolymer networks are th

172 sis on biopolymer chemical modifications and cross-linking methods.

173 Additionally, cross-linking might inhibit degrading processes in idiop

174 linear peptides can be used to characterize cross-link modifications in pairs of peptides.

175 sides can be utilized to functionalize or to cross-link monomeric nucleosides or DNA for diagnostic o

176 designed and synthesized new functional and cross-linking monomers, which are oxidized at sufficient

177 The cross-linked nature of CPPs means that they have permane

178 the impact of sequence on the properties of cross-linked networks remains largely unknown.

179 sm in the lens and suggest that AGE-mediated cross-linking of alpha-crystallin-client complexes could

180 es is therefore related to a peptide-induced cross-linking of bilayers.

181 olution pH, which promoted oxidation-induced cross-linking of catechol and subsequently decreased its

182 ngagement of both the BCR and CD40 or strong cross-linking of CD40 alone.

183 life-threatening allergic reaction caused by cross-linking of high-affinity IgE antibodies on the sur

184 Ab cross-linking of HLA class I (HLA I) molecules on the su

185 phylaxis is classically mediated by allergen cross-linking of IgE bound to the alpha chain of Fcepsil

186 By UV cross-linking of isolated nuclei we determined the cross

187 C, which in turn decreases channel currents, cross-linking of L402C/L403C is functionally silent in m

188 te with maize psbA mRNA by: (i) formaldehyde cross-linking of leaf tissue followed by antisense oligo

189 A, reconstituted in nanodiscs, with cysteine cross-linking of natively expressed membrane-embedded Md

190 cule, which we denote RIPR-PD1, that induces cross-linking of PD-1 to CD45 and inhibits both tonic an

191 Here we demonstrate that glutaraldehyde cross-linking of PEGylated oligolysine-coated DNs extend

192 Cross-linking of Pgamma to GAFab in conjunction with sol

193 to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptid

194 ntinuous tuning of RBC strains, and chemical cross-linking of RBCs, a model for diseased cells, leads

195 nm thick carbon nanomembrane (CNM) made from cross-linking of terphenylthiol (TPT) self-assembled mon

196 Allergen cross-linking of the IgE/FcepsilonRI complex activates t

197 results in topological [2 + 2] cycloaddition cross-linking of the pai-stacked layers in 3D COFs.

198 Collagen cross-linking of the sclera is a promising approach to s

199 propose that increased signaling by FcgammaR cross-linking on TLR-stimulated macrophages can paradoxi

200 fabrication, achieved by oxidative covalent cross-linking or formation of metal coordination interac

201 forded both a soluble linear copolymer and a cross-linked organogel.

202 that exhibits preferential fragmentation of cross-links over peptide backbones, a desired feature fo

203 identified at least two distinct DOPA-based cross-linking pathways during byssus fabrication, achiev

204 responsible for the generation of the highly cross-linked peptide aglycone at the core of this compou

205 e cross-linker design, allowing for isobaric cross-linked peptide pairs originating from different sa

206 e yeast proteasome, identifying 3,893 unique cross-linked peptides in 3 mass spectrometry runs.

207 low abundance of cross-links compared to non-cross-linked peptides in the digestion mixture.

208 cilitate the detection and identification of cross-linked peptides using multistage mass spectrometry

209 ptides are not applicable to the case of two cross-linked peptides.

210 al peptide synthesis with oxidative aromatic cross-linking performed by cytochrome P450 enzymes.

211 diversity is explored, and the synthesis of cross-linked PG fragments, carrying biologically relevan

212 nd activate T cells with solution ligands by cross-linking pMHC or using multivalent antibodies to TC

213 Hydrogels consist of a cross-linked polymer matrix imbibed with a solvent such

214 UV irradiation of the films resulted in cross-linking/polymerization of the molecular columns.

215 esistance, suggesting new ways of processing cross-linked polymers in industry, of which the design p

216 polymer network in hydrogels, where densely cross-linked polymers serving as a framework are functio

217 ational cost to achieve coverage of 1 unique cross-linked position pair for every 7 amino acids at a

218 The dataset includes 1,704 unique cross-linked position pairs for the proteasome subunits,

219 e to induce immunity, but may react with and cross-link preformed drug-specific IgE.

220 r with the elimination of detectable peptide cross-linked product.

221 ccessibility of lysine sites, dead end iqPIR cross-linked products can provide protein abundance and/

222 rminal d-ala-d-ala and reduced peptidoglycan cross-linking, prompting us to investigate synergism bet

223 esults will support the development of novel cross-linked proteins and enable a more rational design

224 x (ECM) is a complex and dynamic meshwork of cross-linked proteins that supports cell polarization an

225 d morphology, targeting vimentin or vimentin cross-linking proteins could provide a therapeutic appro

226 al conditions in the absence of any specific cross-linking proteins, which suggests that it is driven

227 Chemical cross-linking provides complementary information on one

228 We observe a clear dependency of cross-linking rates on the electrophilicity.

229 with a 2-methoxy substituent showed a faster cross-linking reaction rate and higher ICL efficiency th

230 ins within those structures by a photodriven cross-linking reaction so that they can be affinity puri

231 a complementary approach, we utilized HaXS8 cross-linking reactions between Halo and SNAP proteins a

232 ebrates, and there is evidence for oxidative cross-linking reactions occurring in extracellular prote

233 ed with conventional methods using redundant cross-linking reactions, our method is simpler, faster,

234 In addition, the impact on cross-linking reactivity was evaluated.

235 y adding either supplemental TNF ligand or a cross-linking reagent, suggesting that the antibody agon

236 dox chemistry of catechol groups complicates cross-link regulation, hampering fabrication and the lon

237 The efficacy of transepithelial cross-linking remains inferior to the epithelium-off app

238 overall to those of other members in the DNA cross-link repair gene SNM1 family and in mRNA 3'-end-pr

239 the base excision repair and the interstrand cross-link repair pathways via its DNA glycosylase and/o

240 Ligand-induced changes in cross-linked residues implicate multiple conformational

241 amages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell dea

242 Photochemical cross-linking reveals that the baboon amylin, like human

243 efficient and reproducible method to purify cross-linked RNA-protein adducts in an unbiased way.

244 digestion was slowed down by 3 hours in the cross-linked samples (P = .036).

245 A method for optimizing interprotein cross-link score cut-offs was developed, through use of

246 ics to introduce cysteine mutations that can cross-link sigma1 by establishing disulfide bonds betwee

247 eoviruses containing cysteine mutations that cross-link sigma1 monomers in nonreducing conditions.

248 linking of isolated nuclei we determined the cross-linking sites of several factors including chromat

249 ker, disuccinimidyl sulfoxide, inter-protein cross-links spanning all MSC constituents were observed,

250 multi-subunit ubiquitin ligase and chemical cross-linking steps.

251 th red phosphorus type moieties to produce a cross linked structure.

252 a major limitation in current proteome-wide cross-linking studies and demonstrates how to address a

253 f point mutants in both AimB and MreB, photo-cross-linking studies with site-specific unnatural amino

254 on native tissues, as well as peptide-based cross-linking studies, we have identified at least two d

255 G (4) and related structures, as well as DNA cross-linking studies.

256 Here we show that transglutaminase cross-linking supports formation of a 1:1 stoichiometric

257 he antibody bound to TNFR2 through a natural cross-linking surface and that T(reg) cell expansion was

258 A cross-linking technique involving application of Bacteri

259 Moreover, the analysis indicates that (cross-linked) tertiary contacts can cause much stronger

260 lient complexes underwent greater extents of cross-linking than did uncomplexed protein mixtures.

261 a suggest a long-range stabilising effect of cross-linking that occurs due to the covalent linkage of

262 res (160-180 degrees C) due to dynamic ester cross-links that undergo transesterification with residu

263 We next cross-link the yeast proteasome, identifying 3,893 uniqu

264 challenge and chemically or photochemically cross-linking the cornea for therapy presents a unique a

265 The latter has been implicated in cross-linking the protofilaments.

266 ate arginine and serine residues in GSTP and cross-link them to adjacent cysteine residues.

267 ynamin 1 polymerized around microtubules and cross-linked them into bundles, and increased their resi

268 The formation of the cross-linked thioether bond is accompanied by a C-H bond

269 oss-linker alpha-actinin-4 and show that the cross-linking time of alpha-actinin-4 homodimers increas

270 Calcified areas of GA cross-linked tissue showed characteristic hydroxyapatite

271 des within the U6 PSE at positions that also cross-link to DmSNAPc.

272 n fatty acid metabolism in cells, MBLAC2 was cross-linked to a photoactivatable fatty acid in a manne

273 precursor called lipid II is polymerized and cross-linked to produce mature peptidoglycan.

274 chored at one end, and the other end becomes cross-linked to the matrix(2-4).

275 s unique arginine (Arg59) and simultaneously cross-linking to another arginine (Arg45) located across

276 l to promote Kinesin-14 parallel microtubule cross-linking to help focus spindle poles for efficient

277 eover, we find that this same region of Bdp1 cross-links to nucleotides within the U6 PSE at position

278 tosis, are mediated by FcgammaRs, which upon cross-linking transduce signals that modulate the functi

279 in 98-week-old C57BL/6 mice, while the other cross-links typical of tendon collagen either decreased

280 underwent multimerization by o,o'-dityrosine cross-linking under reducing conditions that disrupt dis

281 Scleral patches from rabbit eyes were cross-linked using paraformaldehyde, glutaraldehyde or r

282 racy is comparable to that based on chemical cross-links; using restraints from both genetic interact

283 Disulfide cross-linking validates the physiological relevance of t

284 ects the relative contribution of ensembles' cross-linking versus motoring activities.

285 hly cross-linked, elastic networks to weakly cross-linked viscous networks.

286 Transepithelial cross-linking was associated with significantly fewer co

287 Using in vivo cross-linking, we found that the extracellular juxtamemb

288 se functions through SEPT9-dependent F-actin cross-linking, which enables the generation of F-actin b

289 tudies by expanding the proteome coverage of cross-links while improving the efficiency and confidenc

290 ngineered antigen removed BP (ARBP) that was cross-linked with 0.2% and 0.6% glutaraldehyde (GA), and

291 thout PAD, recruited from 1993 to 1997, were cross-linked with Danish nationwide registries.

292 These resources are cross-linked with related data and tools registries, and

293 Residues cross-linked with SS-31 reveal binding regions that in m

294 Here, intact yeast nuclei were subject to cross-linking with disuccinimidyl sulfoxide (DSSO) and a

295 Here we utilize chemical cross-linking with mass spectrometry to identify protein

296 Especially, gentle cross-linking with riboflavin and UV-A or blue light mig

297 Cross-linking with riboflavin/blue light reduced the deg

298 Cross-linking with riboflavin/UV-A-light reduced the deg

299 e surface, followed by physical and covalent cross-linking with the tissue surface.

300 Hyaluronic acid (HA) forms dynamic cross-links with branched polyethylene glycol polymers e