ライフサイエンスコーパス: crotonyl-CoA

1 the thermodynamically stable normal product, crotonyl-CoA.

2 h both crotonyl-ACP and the model substrate, crotonyl-CoA.

3 ylation of glutaryl-CoA to produce CO(2) and crotonyl-CoA.

4 i) of 4.0 and 12.9 microM, respectively, for crotonyl-CoA.

5 upon binding of the high potential acceptor crotonyl-CoA.

6 loyl-CoA, 3-oxopimeloyl-CoA, glutaconyl-CoA, crotonyl-CoA, 3-hydroxybutyryl-CoA and acetyl-CoA as obs

7 positive (+38 mV) than did optimal product (crotonyl-CoA) (+31 mV), a finding opposite of that obser

8 Catalysis of the syn hydration of crotonyl-CoA, absent in the wild-type 4-chlorobenzoyl-Co

9 s are observed that are assigned to bcd(red):crotonyl-CoA and bcd(ox):butyryl-CoA charge-transfer com

10 e catalyzes the oxidation of glutaryl-CoA to crotonyl-CoA and CO(2) in the mitochondrial degradation

11 ation and decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2).

12 1), leading to accumulation of intracellular crotonyl-CoA and histone H4 lysine crotonylation.

13 s following the reaction of reduced bcd with crotonyl-CoA and oxidized bcd with butyryl-CoA, long-wav

14 edoxin reduction are independent of [NADH], [crotonyl-CoA], and [ferredoxin], with an observed rate o

15 acid of Glu370 also protonates the transient crotonyl-CoA anion following decarboxylation.

16 Protonation of the crotonyl-CoA anion occurs by a 1,3-prototropic shift cat

17 725 nm-absorbing species is the delocalized crotonyl-CoA anion that follows decarboxylation and that

18 xylation, and Arg94 stabilizes the transient crotonyl-CoA anion.

19 also driven by the concomitant reduction of crotonyl-CoA by NADH, a process called electron bifurcat

20 on of the DeltaacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from R. sphaeroides w

21 sion is based on the following findings: (i) crotonyl-CoA carboxylase/reductase, a key enzyme of the

22 inhibited by a mutation in the gene encoding crotonyl-CoA carboxylase/reductase, demonstrating that a

23 d the midpoint potential for the butyryl-CoA/crotonyl-CoA couple (E(BCoA/CCoA)) to shift 14 mV negati

24 kinetic behavior of the electron-bifurcating crotonyl-CoA-dependent NADH: ferredoxin oxidoreductase E

25 (bcd) component of the electron-bifurcating crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase (E

26 of two bifurcating flavoprotein systems, the crotonyl-CoA-dependent NADH:ferredoxin oxidoreductase fr

27 CoA with bulk solvent and (b) protonation of crotonyl-CoA dienolate by solvent-derived protons under

28 The protonation of crotonyl-CoA dienolate following decarboxylation of glut

29 lar 1,3-prototropic shift for protonation of crotonyl-CoA dienolate.

30 Ldh(FN)/ETF(FN)/Bcd(FN) reaction (lactate + crotonyl-CoA -> pyruvate + butyryl-CoA) yielded a k(cat)

31 erization of enzyme activity with respect to crotonyl-CoA, hexenoyl-CoA, and dodecenoyl-CoA substrate

32 rchaeal 3HP/4HB cycle, functioning as both a crotonyl-CoA hydratase (CCAH) and 3-hydroxypropionyl-CoA

33 ydrogenase (GCDH) with downregulation of the crotonyl-CoA hydratase enoyl-CoA hydratase short chain 1

34 (2015) discover that levels of intracellular crotonyl-CoA impact the histone acylation landscape, pro

35 ance (lambda(max) approximately 725 nm), and crotonyl-CoA is found as the sole product.

36 e availability of the appropriate substrate (crotonyl-CoA) is limiting.

37 or decreasing the cellular concentration of crotonyl-CoA leads to enhanced or diminished gene expres

38 in the presence and absence of a butyryl-CoA/crotonyl-CoA mixture.

39 recycled, resulting in the simple equation: crotonyl-CoA + NADH + H(+) = butyryl-CoA + NAD(+) with K

40 polymerase (Lpp0650), but not enzymes of the crotonyl-CoA pathway (Lpp0931-0933) are involved in PHB

41 transporter SLC7A2 and crotonyl-coenzyme A (crotonyl-CoA)-producing enzyme glutaryl-CoA dehydrogenas

42 ing these crotonylated/acetylated factors, a crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase

43 of the H3K27cr mark is also dependent on the crotonyl-CoA-producing enzyme GCDH.

44 ifferentiation of hESCs, whereas deletion of crotonyl-CoA-producing enzymes reduces histone crotonyla

45 to increase plasmid-based expression of both crotonyl CoA reductase gene (ccr) and the erythromycin r

46 A ccr-blocked mutant showed no detectable crotonyl-CoA reductase activity and, compared to the wil

47 In addition to a crotonyl-CoA reductase gene (fkbS), at least two other g

48 r the heterologous AT seemed to be limiting, crotonyl-CoA reductase, a primary metabolic enzyme invol

49 The product of orf4* (cer) is crotonyl-CoA reductase, which converts acetoacetyl-CoA t

50 ha, beta-unsaturated thioesters catalysed by crotonyl-CoA reductase/carboxylase (CCRC) homologues.

51 o and in vitro experiments revealed that the crotonyl-CoA reductase/carboxylase SalG has broad substr

52 crR, was shown to regulate the expression of crotonyl-CoA reductase/carboxylase, an enzyme of the eth

53 ds, correlating with the reduced activity of crotonyl-CoA reductase/carboxylase.

54 e and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to eva

55 eover, octenoyl-CoA blocked the hydration of crotonyl-CoA suggesting short chain enoyl-CoA hydratase

56 In the presence of crotonyl-CoA there is an accumulation of semiquinone tha

57 hydratase catalyzes the hydration of trans-2-crotonyl-CoA to 3(S)-HB-CoA, 3(S)-hydroxybutyryl-CoA wit

58 The final reduction of crotonyl-CoA to butyryl-CoA completes the cycle, which w

59 ase (CCR), which catalyzes the conversion of crotonyl-CoA to butyryl-CoA in the presence of NADPH, wa

60 ans, which couple the exergonic reduction of crotonyl-CoA to butyryl-CoA to the endergonic reduction

61 cd); two such transfers enable Bcd to reduce crotonyl-CoA to butyryl-CoA.

62 uced ferredoxin and Dh-FADH(-) that converts crotonyl-CoA to butyryl-CoA.

63 ion of D-lactate to Bcd for the reduction of crotonyl-CoA to butyryl-CoA.

64 cd); two such transfers enable Bcd to reduce crotonyl-CoA to butyryl-CoA.

65 In the presence of crotonyl-CoA, two simultaneous one-electron transfers fr

66 potential ferredoxin (Fd) and high potential crotonyl-CoA using NADH as an electron donor.

67 E144-catalyzed stepwise addition of water to crotonyl-CoA which is bound in an s-trans conformation i

68 e regulated by the cellular concentration of crotonyl-CoA, which can be altered through genetic and e

69 a) a rapid exchange of C-4 methyl protons of crotonyl-CoA with bulk solvent and (b) protonation of cr

70 hydrogenase decarboxylates glutaconyl-CoA to crotonyl-CoA without oxidation-reduction reactions of th