ライフサイエンスコーパス: crowded

1 ronment inside a metazoan organism is highly crowded.

2 bered heteroaromatic rings at the sterically crowded 7,8 and 7',8' positions of BINOL.

3 HEWL is systematically crowded alternatively with polyethylene glycol (PEG) or

4 points of interest that they visit are more crowded and are therefore associated with higher risk.

5 functional, OMPs must fold and insert into a crowded and asymmetric OM that lacks much freely accessi

6 ficantly lowest firmness (N) was observed in crowded and chilled salmon whereas the cathepsin L activ

7 rol), just crowded, uncrowded and chilled or crowded and chilled.

8 uin children (for whom living conditions are crowded and colonization occurs during early life) and i

9 Cell membranes are crowded and complex environments.

10 plore the dynamics of proteins and lipids in crowded and complex plasma membrane models, thereby clos

11 of knots and links by TopoII enzymes even in crowded and confined conditions.

12 In vivo, myosin is crowded and constrained by the fiber lattice as side cha

13 Crowded and dispersed glycans are differently ordered, c

14 ntage to corals in the rigors of the reef, a crowded and fiercely competitive ecosystem.

15 to promote the desired function even in the crowded and fluctuating cellular environment.

16 ns so that their transient interactions in a crowded and heterogeneous environment of cytosol can be

17 of many other regulatory molecules and in a crowded and noisy cellular environment.

18 ring in restrictive environments such as the crowded and relatively rigid active site of enzymes.

19 in boron chemistry, is a consequence of the crowded and rigid chemical environment of the boron atom

20 nstructured peptides labeled at pD 4.0 under crowded and uncrowded conditions confirmed that Ficoll d

21 45481 ), residues 2059-2117, at pD 6.5 under crowded and uncrowded conditions.

22 close together, visual features can become "crowded" and perceptually indistinguishable.

23 ccurs in structurally organized, molecularly crowded, and dimensionally constrained amphiphilic fluid

24 creening tool that can be used in busy, over-crowded, and low-resource primary health care settings t

25 hen subdivided AAC eyes into four subgroups: crowded-angle (CR), lens subluxation (LS) pupillary bloc

26 led extrusion and increased proliferation in crowded areas of the tissue.

27 a technology can be successful in an already crowded arena.

28 In this crowded assay, SNAREs and SM proteins acted in concert t

29 nthesis of DPM is described (90% yield), and crowded beta-diketones featuring bulky o-biphenyl or m-t

30 f exogenous ligands driven by the sterically crowded binding sites.

31 ifying possible interactions taking place in crowded biological media.

32 quickly couple mechanosensitive elements in crowded biological membranes.

33 ow as a dispersed film, in contrast to their crowded "bottom-dweller" (B) ancestors.

34 The size of the crowded boundary layer near the overlap ends is also dep

35 odel explains robust and precise wiring in a crowded brain region despite extensive growth cone overl

36 of this downstream kinase cascade produced a crowded branching defect in the intrahepatic biliary net

37 mpared to the case of diluted or molecularly crowded buffer solutions, the G-quadruplex inside the na

38 er a banal scenario: a seated passenger on a crowded bus stands up and someone takes his seat.

39 The nuclear environment is highly crowded by biological macromolecules, including chromati

40 These spaces are crowded by cells and extracellular matrix, generating ma

41 As the membrane becomes crowded by ENTH proteins, the polymer chain extends, inc

42 ypically characterized, the cell interior is crowded by macromolecules, which affects both the thermo

43 Me5)3M complexes in reactions that form less crowded (C5Me5)2M-containing products.

44 emble performance, or to follow a voice in a crowded cafe.

45 the context of an outbreak at its peak, with crowded care centers, randomizing patients to receive ei

46 ations including the dynamics of proteins in crowded cell membranes and the adsorption on nano-struct

47 How cargoes move within a crowded cell-over long distances and at speeds nearly th

48 he chromatin fiber to find each other in the crowded cell?

49 t it relies on diffusive encounters with the crowded cellular background, made up of protein surfaces

50 The cytoplasm of bacterial cells is a highly crowded cellular compartment that possesses considerable

51 amics of DNA segments in spatially confined, crowded cellular compartments as well as during bacteria

52 r show, by using both an in vitro mimic of a crowded cellular environment and eukaryotic cell lysates

53 significant biological implication is that a crowded cellular environment could influence the mechani

54 These results suggest that in vivo, the crowded cellular environment could strongly influence th

55 esentation of the interactomes in vivo, in a crowded cellular environment, as well as membranes and m

56 gap exists because proteins function in the crowded cellular environment, but are traditionally stud

57 To approximate the crowded cellular environment, it is very important to pa

58 sphorylation can be pseudo-processive in the crowded cellular environment, since rebinding after the

59 identifying molecular components within the crowded cellular environment.

60 reconstituted fusion reactions to mimic the crowded cellular environment.

61 ity and high degree of colocalization in the crowded cellular environment.

62 expected to be particularly sensitive to the crowded cellular environment.

63 ference from promiscuous interactions in the crowded cellular environment.

64 ed from cryo-electron tomograms (cryo-ET) of crowded cellular environments is often limited owing to

65 folding and protein-protein interactions in crowded cellular environments) and important aspects of

66 ucial to realistically simulate tomograms of crowded cellular environments, which can then serve as g

67 at p-PALM is well-suited to explore numerous crowded cellular environments.

68 ll biological processes take place in highly crowded cellular environments.

69 -to-nanometer resolution of complexes inside crowded cellular environments.

70 acromolecular interactions that organize the crowded cellular interior, requires the measurement of e

71 anced facilitated diffusion of DBPs inside a crowded cellular milieu through, to our knowledge, novel

72 d in vitro, assuming similar activity in the crowded cellular milieu.

73 l contributions to the physics governing the crowded cellular milieu.

74 hts into gene regulation kinetics inside the crowded cellular milieu.

75 transitions during epidermal stratification crowded cellular spaces with liquid-like KGs whose coale

76 is at the individual molecule level within a crowded, cellular environment.

77 Photochemical isomerization in sterically crowded chiral alkenes is the driving force for molecula

78 on and heterogeneity, such that epidemics in crowded cities are more spread over time, and crowded ci

79 rowded cities are more spread over time, and crowded cities have larger total attack rates than less

80 sive data on human mobility and predict that crowded cities worldwide could experience more prolonged

81 just as humans can respond to one voice at a crowded cocktail party.

82 of the simulated cryo-ET is more complex and crowded compared with previous ones, it will pose a grea

83 Complex 3 also forms more crowded complexes in reactions with I2, PhCl, and Al2Me6

84 reacts with MeI to make two sterically more crowded complexes, (C5Me5)3ThI, 4, and (C5Me5)3ThMe, 1,

85 [3.3.0]octenone occur on the more sterically crowded concave face.

86 cipants aged 20-59 years and those living in crowded conditions (4.4% [3.5-5.6] for those living with

87 traditional theory, which predicts that more crowded conditions can only increase protein stability,

88 how enzymatic reactions could be affected by crowded conditions in the cellular milieu.

89 onal and rotational motion of proteins under crowded conditions is highly relevant for understanding

90 Such crowded conditions promote protein-protein interactions,

91 ble transfer to visual acuity measured under crowded conditions resulted in reduced processing time o

92 inhibited by collisions with neighbors under crowded conditions, whereas its plus end-directed action

93 are important under physiologically relevant crowded conditions.

94 ructure and dynamics of these proteins under crowded conditions.

95 olymer, for HX-MS analysis of proteins under crowded conditions.

96 mestication may involve adaptation to highly crowded conditions.

97 aracteristics of processive motor enzymes in crowded conditions.

98 re processive motor enzymes might operate in crowded conditions.

99 culated from single particle trajectories in crowded conditions.

100 evel of dependence on direct transmission in crowded, confined environments and establish that incuba

101 onconclusive, e.g., if spectra are extremely crowded, coupling patterns are not resolved, or if symme

102 proposed a unified framework for simulating crowded cryo-electron tomogram images including non-defo

103 , the fidelity of the interfaces observed in crowded crystalline arrays has been difficult to establi

104 w catalyst for the preparation of sterically crowded cyclobutane structures is highlighted through th

105 ssembly of large multimeric complexes in the crowded cytoplasm is challenging.

106 xplain how organelles orderly cohabit in the crowded cytoplasm.

107 ports diverse regulatory programs within the crowded cytoplasm.

108 at have become misfolded in the context of a crowded cytosol.

109 The more sterically crowded diplumbyne Ar(Pri(8))PbPbAr(Pri(8)) (Ar(Pri(8))

110 However, little is known about how crowded DNA modulates facilitated diffusion and target r

111 ryotic mismatch repair complex, navigates on crowded DNA.

112 ility reduction and coil elongation of large crowded DNAs are due to a complex interplay between entr

113 When regioisomers are possible, the more crowded (doubly ortho-substituted) product is formed pre

114 te to productive thiol oxidation in complex, crowded, dynamic environments.

115 The crowded electron transport proteins in the periplasm of

116 retain their native secondary structure in a crowded environment and are stabilized against degradati

117 nofiber substrate coverage, providing a less crowded environment around fibers, appear to play a role

118 The efficiency of finding an object in a crowded environment depends largely on the similarity of

119 The interior of the cell is a densely crowded environment in which protein stability is affect

120 It is clear that a crowded environment influences the structure, dynamics,

121 A DNA strand displacement reaction in a crowded environment is also studied with the model and w

122 ferred by RyR because they can fit into this crowded environment more easily.

123 on cryotomography, we identified, within the crowded environment of eukaryotic cells, a unique nanosc

124 eroxiredoxin quaternary structure inside the crowded environment of living cells.

125 suited to engage interaction partners in the crowded environment of synapses, permitting the formatio

126 Diffusional motion within the crowded environment of the cell is known to be crucial t

127 otic chromosomes, whilst jostling within the crowded environment of the cell, cannot yet be achieved

128 Noncoding RNAs must function in the crowded environment of the cell.

129 high efficiency and fidelity in the densely crowded environment of the cell.

130 h to unambiguously highlight the impact of a crowded environment on a fundamental biological process,

131 modynamics of nucleic acid interactions in a crowded environment remain poorly understood.

132 The nucleus in eukaryotic cells is a crowded environment that consists of genetic code along

133 In cells, proteins are embedded in a crowded environment that controls their properties via m

134 ngs extend our knowledge of the synapse as a crowded environment that counteracts molecular diffusion

135 The movement through the cytoplasm-a crowded environment where diffusion is slow-is thought t

136 t polypeptide exit site of the ribosome is a crowded environment where multiple ribosome-associated p

137 The ribosome exit site is a crowded environment where numerous factors contact nasce

138 c physical constraints on probes inside this crowded environment will help inform studies on binding

139 tations of a crab inhabiting a flat, densely crowded environment, where most object motions are gener

140 of sufficient copy numbers of complexes in a crowded environment.

141 al applications, are strongly modulated by a crowded environment.

142 mong distinct biogenesis machineries in this crowded environment.

143 ibril formation and protein suspensions in a crowded environment.

144 e a fundamental design principle of PPI in a crowded environment.

145 m and ClpB, which in vivo occurs in a highly crowded environment.

146 urs in a timely and selective manner in this crowded environment.

147 cumented that humans yawn less frequently in crowded environments and when under direct observation,

148 t mabs reveal that diffusion coefficients in crowded environments are markedly impacted by intermolec

149 Nucleic acid interactions under crowded environments are of great importance for biologi

150 Protein dynamics in crowded environments is important for understanding prot

151 or how motor proteins behave in these highly crowded environments remains unknown.

152 Because virus capsids naturally assemble in crowded environments such as the cell cytoplasm but also

153 g range interactions on soft NPs dynamics in crowded environments, and help rationalize the design of

154 By migrating to less crowded environments, individuals can escape IC.

155 o continuously translate and rotate, even in crowded environments, thereby impacting the spatial orga

156 To better understand how translocases act in crowded environments, we used single-molecule imaging to

157 Membrane proteins are frequently present in crowded environments, which favour lateral association a

158 sions of virus shells with macromolecules in crowded environments.

159 amics of DNA duplex and hairpin formation in crowded environments.

160 get complexes in subtomograms extracted from crowded environments.

161 ve systems is how to prevent traffic jams in crowded environments.

162 tablished that both features show systematic crowded errors (biased predominantly toward the flanker

163 tions with furans preferentially on the more crowded face.

164 polar, and ionic solutes, in both dilute and crowded fluids.

165 oncentration-pressure curves and is thus not crowded from an osmotic perspective.

166 evant mutations, further supporting that the crowded fusion assay accurately recapitulates the vesicl

167 Using this crowded fusion assay, we also showed that the SNARE-SM m

168 he influence of hydrogel formation at highly crowded gammaS-WT concentrations up to 500 mg/mL, the pr

169 faces, their bulky disordered domains become crowded, generating steric pressure that destabilizes li

170 st how Msh2-Msh3 and Msh2-Msh6 navigate on a crowded genome and suggest how Msh2-Msh3 locates DNA les

171 ic targets via facilitated diffusion along a crowded genome.

172 -helicenoids have an overlapping, sterically crowded geometry.

173 and thiotolyl donors as well as differently crowded glycosyl acceptors; subtle differences in the st

174 Because crowded growth generally limits nutrient access in biofi

175 Here, we show via a minimal model that crowded hard-particle systems governed solely by entropy

176 picosecond protein and hydration dynamics of crowded hen egg white lysozyme (HEWL) labeled with a met

177 The cytoplasm of Escherichia coli is a crowded, heterogeneous environment.

178 cerbate infectious disease risks by creating crowded, high-contact conditions and straining the capac

179 ome from ARI was associated with living in a crowded home (odds ratio [OR], 3.73; 95% confidence inte

180 92-9.20), and children living under the most crowded household conditions (RR 5.53, 95% CI 2.36-12.98

181 urban or densely-populated or that had more crowded housing, air pollution, women, 20-49-year-olds,

182 Indistinguishable aggregates form in crowded in vitro solutions and in complex environments o

183 r human alphaB-crystallin, which is strongly crowded in vivo and inter alia responsible for preventin

184 ro data cannot be simply extrapolated to the crowded in vivo environment.

185 High volume fractions mimicking the crowded interior of biological cells were used.

186 elf-organization events are modulated by the crowded interior of live cells.

187 the dynamic type VI secretion system in the crowded interior of Myxococcus xanthus.

188 d bioreactors with aqueous, macromolecularly crowded interiors can be assembled by liposome stabiliza

189 nders), refugees/internees who were forcibly crowded into camps, and military recruits.

190 by strong internal forces arising from being crowded into the small space of the nucleoid.

191 the quaternization reaction in a sterically crowded intraannular position is investigated, and diffe

192 specific 20-nucleotide target sequence in a crowded intracellular environment packed with mega bases

193 The crowded intracellular environment, in contrast to in vit

194 Protein signaling occurs in crowded intracellular environments, and while high conce

195 addressable sub-diffraction volumes, within crowded intracellular environments.

196 Indeed, the biophysical behavior of water in crowded intracellular milieu is a long-debated issue.

197 landing success within colonies is higher on crowded ledges with more airspace for manoeuvring.

198 In a crowded, low income setting, oseltamivir treatment of in

199 at cargo recruitment into vesicles creates a crowded lumen that drives selectivity.

200 lamin-associated chromatin organization in a crowded macromolecular environment by systematically var

201 icant ecological effects is encouraging for "crowded" marine environments.

202 e intracellular environment is a complex and crowded medium where the diffusion of proteins, metaboli

203 Intracellular reactions are carried out in a crowded medium where the macromolecules occupy approxima

204 cytoplasm and its assembly is away from the crowded membrane surface.

205 erience is truly comparable to the immensely crowded, membrane-subdivided interior of a eukaryotic ce

206 The integration of molecularly crowded microenvironments into membrane-enclosed protoce

207 fail to do so in elongated cells within the crowded midline, where tension is low, or in regions tha

208 narily selected to function optimally in the crowded milieu of the cell.

209 We present a framework to generate crowded mixtures of macromolecular complexes for realist

210 ly entering another colony, especially under crowded modern apiary conditions.

211 function of the intrinsic properties of the crowded molecular environment.

212 es such as azobenzenes or spiropyrans within crowded molecular environments, which may allow control

213 by random co-localization incidents between crowded molecular species and the intrinsic heterogeneit

214 tive size of their transition states and the crowded nature of CO*-covered surfaces.

215 Despite the crowded nature of the cellular milieu, ligand-GPCR-G pro

216 This volume reduction increases the crowded nature of the cytoplasm, which is expected to af

217 These sterically crowded nickel and copper hydroxides catalyze the key al

218 nd were cared for in environments which were crowded, noisy and lacked privacy.

219 rapidly moving, sub-diffraction objects in a crowded, noisy environment.

220 f cat fleas as vectors of human pathogens in crowded northeastern U.S, cities and suburbs where free-

221 The findings reveal a new role for the crowded nuclear environment in facilitating DNA damage d

222 We report that deficiencies in CROWDED NUCLEI (CRWN), which are candidate nuclear lamin

223 e connection between the lamin-like protein, CROWDED NUCLEI1 (CRWN1), and the chromatin- and PcG-asso

224 realistic conditions, diffusion of vesicles crowded on the ribbon surface gives rise to a flow field

225 al acuity, hyperopia, short axial length and crowded optic discs.

226 concentrations sufficient to fold the RNA in crowded or dilute solution.

227 ep of the CaM-target binding mechanism under crowded or osmolyte-rich environments mimicked by ficoll

228 (eg, food insecurity, perinatal infections, crowded or rural living conditions, and interpersonal vi

229 line with models of indirect reciprocity, is crowded out by indirect punishment opportunities.

230 following the megafaunal extinctions likely crowded out their disturbed-ground niche.

231 e proposed multi-ball model can achieve more crowded packaging results and contains richer elements w

232 as well as quenching dye-dye interactions on crowded particle surfaces.

233 cal paradigm that allows systematic study of crowded perception within the orientation domain, and we

234 ectron microscopy, but their location in the crowded perinuclear area has hampered their analysis via

235 talization into model liquid organelles in a crowded polymer solution.

236 n microscopy suggests that the PSD is highly crowded, potentially restricting the diffusion of recept

237 re major determinants of vesicle mobility in crowded presynaptic terminals.

238 disproportionate incarceration of BIPOC into crowded prisons with low tuberculosis screening rates; a

239 In particular, random collisions among crowded proteins generate substantial pressure, which if

240 anical robustness and generate a molecularly crowded reaction environment; and (iii) self-production

241 o observe the motion of IFT proteins in this crowded region using conventional microscopy.

242 mbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

243 articularly useful when resonance overlap in crowded regions of the HSQC spectra hampers accurate met

244 the importance of maintaining intracellular crowded regions to favor the feasibility of a pathway th

245 evels of background noise that approximate a crowded restaurant.

246 when competing speakers are present, as in a crowded restaurant.

247 ignal intensities of myoglobin peptides from crowded samples containing 300 g L(-1) Ficoll and from u

248 Added to the crowded scene for helper T-cell subsets is the continuou

249 test particle-picking methods in a realistic crowded setting.

250 Our model is generally applicable to other crowded settings.

251 ks (ie, close-up work or finding things on a crowded shelf), mobility (ie, walking down steps, stairs

252 es indicates that alcohol attack to the more crowded side of the acyl-catalyst intermediate is favour

253 lows the CO to move into the sterically less crowded side of the molecule is preferred.

254 research to improve compartmental models in crowded situations.

255 months of age, warm season, male gender, and crowded sleeping conditions.

256 nd spread to various environments, including crowded slums and refugee camps.

257 In contrast, the less crowded Sn(II) hydride [Ar((i)Pr4)Sn(mu-H)]2 (Ar((i)Pr4)

258 driven by 3 symptomatic persons who attended crowded social events.

259 While conversing in a crowded social setting, a listener is often required to

260 The model predicts that in a crowded solution, at critical values of the volume fract

261 Moreover, in a crowded solution, the chemical potential depends on the

262 forces that push macromolecules together in crowded solutions and thus promotes aggregation and phas

263 compare folding free energies in dilute and crowded solutions containing 18% PEG1000.

264 Here, we report that crowded solutions promote intramolecular DNA translocati

265 When epithelia become too crowded, some cells are extruded that later die.

266 10(5) M(-1) s(-1)) for esters with the least crowded space around their carbonyl group.

267 o accelerate specific reactions within their crowded space.

268 to complex multiplets and severe overlap in crowded spectra, greatly complicating their measurement.

269 Direct application of PCA to crowded spectra, images, and movies (without selecting p

270 ge subunits (>150 residues), the analysis of crowded spectral data presents a challenge, even if thre

271 ostasis when an epithelial layer becomes too crowded; spindle orientation ensures two-dimensional gro

272 However, due to the compact and crowded status, the missing edge effect, and low signal

273 ties required for high resolution of densely crowded structures.

274 The steric hindering of the crowded substitution at the central amine group was foun

275 is suppressed in the present sterically very crowded system, N(2)-to-NH(3) conversion can nevertheles

276 ges provides access to nonplanar, sterically crowded systems that display complex reactivity patterns

277 e that LBM over-predicts the diffusion in 2D crowded systems, while the proposed coupled SPT-LBM pred

278 ons even though these play a crucial role in crowded systems.

279 We report that both saccade precision and crowded-target reports vary idiosyncratically across the

280 y the phenomenological misidentifications of crowded targets: using stimuli that do not easily combin

281 When epithelial cells become too crowded, they activate the stretch-activated channel Pie

282 Here we directly investigate how crowded this sequence space is, by generating novel two-

283 tial organization of molecular assemblies in crowded three-color super-resolution (SR) images.

284 g short-range diffusion of PQ in the protein-crowded thylakoid membrane, thereby optimizing photosynt

285 ar diffusion of photosynthetic components in crowded thylakoid membranes.

286 ful chromosome segregation and division in a crowded tissue environment.

287 o a backpack to facilitate measurement under crowded transportation conditions and to quantify person

288 nfinement like those experienced by cells in crowded tumors.

289 ther the fish were uncrowded (control), just crowded, uncrowded and chilled or crowded and chilled.

290 al use of MDMA at rave parties or other hot, crowded venues.

291 assembly of chemically encoded, molecularly crowded, water-rich micro-droplets into periodic defect-

292 However, cell cytoplasm is highly crowded, which makes particle detection challenging.

293 s function in cellular environments that are crowded with biomolecules, and in this reduced available

294 The field of cluster analysis is crowded with diverse methods that make special assumptio

295 such as growth retardation; hypoplastic jaws crowded with multiple supernumerary, yet unerupted, teet

296 rface of differentiating epithelial cells is crowded with nascent microvilli, persistent motility pro

297 oteins must travel along substrates that are crowded with other proteins.

298 Cells are highly crowded with proteins and polynucleotides.

299 ntain a large variety of lipid types and are crowded with proteins, endowing them with the plasticity

300 (compared to random coil conformations) when crowded, with elongation states that are gamma distribut