ライフサイエンスコーパス: cryptophane

1 the aqueous behavior of the large, nonpolar cryptophane.

2 ed in aqueous solution using two enantiopure cryptophanes.

3 The known xenon-binding (+/-)-cryptophane-111 (1) has been functionalized with six [(e

4 ies of xenon and krypton clathrates of (+/-)-cryptophane-111 (111).

5 give, in 89% yield, the first water-soluble cryptophane-111 derivative, namely [(Cp*Ru)(6)1]Cl(6) ([

6 ion at pH 5.5 generated a 13.4 ppm downfield cryptophane-(129)Xe NMR chemical shift relative to pH 7.

7 This was made possible by preparing new cryptophane-223 derivatives bearing two different chemic

8 We show that the cryptophane-223 skeleton can be modified to introduce a

9 ensor based on refractive index changes in a cryptophane A (CryptA)-doped polystyrene membrane.

10 ional affinity to tris-(triazole ethylamine) cryptophane, a previously unsynthesized water-soluble or

11 spite the large structural similarities with cryptophane-A (1) and -B (2), these two new compounds sh

12 figuration was thus established for the anti-cryptophane-A (1) and its congeners 2 and 4.

13 D) experiments and were compared to those of cryptophane-A (1) derivative.

14 e structural analogues of the two well-known cryptophane-A (1; chiral) and cryptophane-B (2; achiral)

15 Adamantyl-functionalized cryptophane-A (AFCA) was synthesized and characterized f

16 Adamantyl-functionalized cryptophane-A (AFCA) was synthesized and characterized f

17 deeper insight into the binding behavior of Cryptophane-A and enables quantification of its relative

18 e report high-resolution X-ray structures of cryptophane-A and trifunctionalized derivatives in crown

19 In the preparation of a tethered cryptophane-A cage for biosensor applications, some achi

20 m at the same strategic position within an L cryptophane-A cage, under the influence of chiral potent

21 In contrast to what is observed for the cryptophane-A congener, the synthesis of these highly su

22 Following this scheme, a triacetic acid cryptophane-A derivative (TAAC) was indirectly detected

23 A water-soluble triacetic acid cryptophane-A derivative (TAAC) was synthesized and dete

24 ly synthesized tris(triazole propionic acid) cryptophane-A derivative (TTPC) showed how solvation of

25 Of note are trifunctionalized, water-soluble cryptophane-A derivatives, which exhibit exceptional aff

26 provide direct and unambiguous evidence that Cryptophane-A exhibits measurable affinity for three maj

27 Since the affinity of Cryptophane-A for methane was first reported in 1993, cr

28 Functionalization of cryptophane-A has permitted the development of Xe as a b

29 according to the amount of CH4 bound to the cryptophane-A in the film and is determined using surfac

30 Cryptophane-A serves as a chemical host for hyperpolariz

31 xide shows a 1.5-times stronger affinity for Cryptophane-A than methane, while nitrogen relative affi

32 direct detection of Xe host molecules (e.g., cryptophane-A).

33 Cryptophane-A, comprised of two cyclotriguaiacylenes joi

34 spin-hyperpolarized xenon ((129)Xe) atoms in cryptophane-A-monoacid (CrAma) and their indirect detect

35 ttle as 20 nM of the xenon MRI readout unit, cryptophane-A.

36 xane (PDMS) layer incorporating molecules of cryptophane-A.

37 cancers, to the xenon-binding organic cage, cryptophane-A.

38 gh (100 muM) AFCA concentration, where small cryptophane aggregates were observed, and was only detec

39 igh (100 uM) AFCA concentration, where small cryptophane aggregates were observed, and was only detec

40 As previously observed with the tris-aza-cryptophanes analogs anti-1 and syn-2 (J.

41 ical resolution of C(3)-symmetrical tris-aza-cryptophanes anti-3 and syn-4, as well as the study of t

42 two well-known cryptophane-A (1; chiral) and cryptophane-B (2; achiral) diastereomers since these new

43 compound, which is a regioisomer of the syn-cryptophane-B derivative.

44 uration (AC) of a chiral isotopologue of syn-cryptophane-B.

45 of nitrogen atoms grafted directly onto the cryptophane backbone has a strong impact on the in-out e

46 the introduction of nitrogen atoms into the cryptophane backbone has an effect on the binding proper

47 ry to elicit a (129)Xe NMR chemical shift in cryptophane-based sensing.

48 ry to elicit a (129)Xe NMR chemical shift in cryptophane-based sensing.

49 axation rate induced by slowed tumbling of a cryptophane-based sensor upon target binding.

50 egation phenomenon, highlight limitations of cryptophane-based Xe sensing, and offer insights into th

51 On a per cryptophane basis, this equates to 1.2 x 10(4)(129)Xe at

52 rivatives can be used to design new anti/syn cryptophanes bearing suitable ligands in order to consti

53 ed at preparing functionalized syn- and anti-cryptophanes (Brotin J.

54 rms binding measurements indicating that the cryptophane cage does not strongly interact with the sur

55 Xenon associated with the target-bound cryptophane cage is rapidly relaxed and then detected af

56 The sensor comprises a xenon-binding cryptophane cage, a target interaction element, and a me

57 Cryptophane cages serve as host molecules to a Xe atom.

58 Pd3L2 metallo-cryptophane cages with cyclotriveratrylene-type L ligand

59 tion of the physical properties of the xenon@cryptophane complexes, only based on structural paramete

60 An anti-cryptophane decorated with three aromatic amine and thre

61 This result contrasts with the case of other cryptophanes decorated solely with methoxy substituents.

62 We report the synthesis of C(3)-symmetric cryptophanes decorated with three aromatic amine groups

63 his article the synthesis of an asymmetrical cryptophane derivative (possessing only C(3)-symmetry) b

64 We report the synthesis of new cryptophane derivatives 1-4 bearing nine (1, 2) and twel

65 se compounds represent the first examples of cryptophane derivatives bearing more than six substituen

66 Enantiopure cryptophane derivatives bearing nine (2, 3) and 12 (4) m

67 This result demonstrates that cryptophane derivatives decorated with a higher number o

68 determine the absolute configuration (AC) of cryptophane derivatives.

69 o ascertain the stereochemistry of these new cryptophane derivatives.

70 nt of the substituents never encountered for cryptophane derivatives.

71 The 1.70 A resolution crystal structure of a cryptophane-derivatized benezenesulfonamide complexed wi

72 While the use of cryptophane-doped layers has improved methane sensitivit

73 ne-A for methane was first reported in 1993, cryptophane-doped polymer films have been extensively st

74 The cryptophane effectively "catalyzes" this process by prov

75 n and to ascertain the high affinity of this cryptophane for cesium and thallium.

76 ng both the limitations and the potential of cryptophane for future sensing applications.

77 r, the synthesis of these highly substituted cryptophanes gives rise to the two anti- and syn-diaster

78 nocyclohexane (R)-5, which leads to a chiral cryptophane (>90% yield) that is built-up from two (P)-2

79 equent reactions allowed the design of a new cryptophane host able to bind zinc or nickel cations.

80 which is the highest reported affinity for a cryptophane host in phosphate-buffered saline (pH 7.2).

81 which is the highest reported affinity for a cryptophane host in phosphate-buffered saline (pH 7.2).

82 To a cryptophane host molecule with high Xe affinity, we conj

83 Cryptophane host molecules provide ultrasensitive contra

84 We report the synthesis of new water-soluble cryptophane host molecules that can be used for the prep

85 lta = 67.6 ppm at pH 5.5, where Trp(peptide)-cryptophane interactions were evidenced by Trp fluoresce

86 Cryptophane internal volume varied by more than 20% acro

87 consider multiple Xe exchange processes for cryptophane-mediated bulk (129)Xe depolarization, which

88 t room temperature, debunking old beliefs of cryptophane-methane selectivity and reformulating the ro

89 Hydrolysis of this cryptophane provides (P)-2 with >99% ee.

90 n was determined radiometrically to give the cryptophane-radon association constant K(a)=49,000 +/- 1

91 Cryptophanes represent an exciting class of xenon-encaps

92 Irradiation at the appropriate Xe-cryptophane resonant radio frequency results in relaxati

93 Synthetic routes used to prepare cryptophanes result in racemic mixtures of the chiral ca

94 artitioning of radon between air and aqueous cryptophane solutions of varying concentration was deter

95 Cryptophane syn-1, a compound decorated with three aceta

96 A comparison with other cryptophanes that bind these two cations shows that the

97 the efficient large-scale production of new cryptophanes that can be used as chemical platforms read

98 his article, we present the synthesis of new cryptophane-type hosts capable of binding xenon in aqueo

99 A xenon-binding cryptophane was substituted with linkers of varying leng

100 The preparation of these highly substituted cryptophanes was achieved due to the synthesis of a new

101 behavior, we designed a novel water-soluble cryptophane with a pendant hydrophobic adamantyl moiety,

102 behavior, we designed a novel water-soluble cryptophane with a pendant hydrophobic adamantyl moiety,

103 To investigate key features of cryptophane-Xe sensing behavior, we designed a novel wat

104 To investigate key features of cryptophane-Xe sensing behavior, we designed a novel wat

105 The cryptophane-xenon association constant, K(a)=42,000 +/-