ライフサイエンスコーパス: crystallography

1 pyrazole) and further characterized by X-ray crystallography.

2 ly characterized by NMR techniques and X-ray crystallography.

3 sis, UV-vis spectrum measurements, and X-ray crystallography.

4 ation of its structure and assembly by X-ray crystallography.

5 curacy of macromolecular structures in X-ray crystallography.

6 is-ethylene linkers was explored using X-ray crystallography.

7 mino-alpha-ketone group was secured by X-ray crystallography.

8 at has previously been accomplished by X-ray crystallography.

9 osteric regulation of isolated GCH1 by X-ray crystallography.

10 esolution cryo-electron tomography and X-ray crystallography.

11 ariable binding modes were observed by X-ray crystallography.

12 ferent DHHC-PATs were determined using X-ray crystallography.

13 by means of enzymatic assays, MS, and X-ray crystallography.

14 gated their binding modalities through X-ray crystallography.

15 y of NMR spectroscopic experiments and X-ray crystallography.

16 ic voltammetry, mass spectrometry, and X-ray crystallography.

17 ed to improve maps from macromolecular X-ray crystallography.

18 ansfer difference NMR spectroscopy and X-ray crystallography.

19 tructures of the inhibited protease by X-ray crystallography.

20 acilitates their precise characterization by crystallography.

21 or anticoagulant activity) as shown by X-ray crystallography.

22 of P at 1.4- angstrom resolution using X-ray crystallography.

23 followed by structure determination by X-ray crystallography.

24 r, and its structure was determined by X-ray crystallography.

25 mplex with the EGFR kinase domain with X-ray crystallography.

26 etic resonance (EPR) spectroscopy, and X-ray crystallography.

27 terized by NMR, mass spectroscopy, and X-ray crystallography.

28 ously reported homodimer identified by X-ray crystallography.

29 characterized by multinuclear NMR and X-ray crystallography.

30 lyst was prepared and characterized by X-ray crystallography.

31 are consistent with structures modeled from crystallography.

32 nd cyclic voltammetry measurements and X-ray crystallography.

33 making it unsuitable for conventional X-ray crystallography.

34 c studies, H/D isotopic labelling, and X-ray crystallography.

35 eshing a protein with a structure from x-ray crystallography.

36 damental mathematical framework of classical crystallography.

37 ere identified by NMR spectroscopy and X-ray crystallography.

38 are fully elucidated by single-crystal X-ray crystallography.

39 ed for samples that are intractable by X-ray crystallography.

40 ocused screen of proline analogs using X-ray crystallography.

41 ally used for structure elucidation by X-ray crystallography.

42 te models have been studied by NMR and X-ray crystallography.

43 acterized by (1)H NMR spectroscopy and X-ray crystallography.

44 microanalysis, mass spectrometry, and X-ray crystallography.

45 riboswitch ligand binding domain using X-ray crystallography.

46 HSPB6 that has recently been resolved using crystallography.

47 which was confirmed by single-crystal X-ray crystallography.

48 o C=C bond) has been confirmed through X-ray crystallography.

49 lying the approach was corroborated by X-ray crystallography.

50 -PH(2) (3a) have been characterized by X-ray crystallography.

51 ation of membrane proteins and time-resolved crystallography.

52 ion mass spectrometry (HRMS), NMR, and X-ray crystallography.

53 yrG promoter using soak-trigger-freeze X-ray crystallography.

54 now been structurally characterized by X-ray crystallography.

55 P11 and defined their interactions by X-ray crystallography.

56 lution by cryo-electron microscopy and X-ray crystallography.

57 nine was isolated and characterized by X-ray crystallography.

58 d, in many cases, using single-crystal X-ray crystallography.

59 electronic, and IR spectroscopy and by X-ray crystallography.

60 rotein co-structures are determined by X-ray crystallography.

61 echanisms using molecular dynamics and X-ray crystallography.

62 one structure was further confirmed by X-ray crystallography.

63 Here we use time-resolved serial femtosecond crystallography(1) using an X-ray free-electron laser(2)

64 cluding national security(1,2), medicine(3), crystallography(4) and astronomy(5).

65 igated by electron microscopy(4,5) and X-ray crystallography(6-8).

66 Here, we demonstrate via X-ray crystallography a nanobody-targeted allosteric binding s

67 rmations of MdfA have been captured by X-ray crystallography: An outward open (O(o)) conformation, st

68 try, small-angle X-ray scattering, and X-ray crystallography analyses, we have pinpointed a critical

69 stry of two products were confirmed by X-ray crystallography analysis.

70 products is discussed on the basis of X-ray crystallography analysis.

71 We used x-ray crystallography and biochemical approaches to show that

72 is both structurally characterized by X-ray crystallography and capable of activating strong C-H bon

73 We, therefore, characterized the crystallography and carbon uptake in the shells of S. gl

74 In the following, we use crystallography and computational modeling to show that

75 tural studies using techniques such as x-ray crystallography and cryo-electron microscopy (cryo-EM).

76 X-ray crystallography and cryo-electron microscopy have reveal

77 Structure determination by X-ray crystallography and cryo-electron microscopy not only co

78 form self-recognition complexes, using X-ray crystallography and cryo-electron tomography.

79 he SOSIP structures determined by both x-ray crystallography and cryo-EM.

80 The reported results complement existing crystallography and cryoelectron tomography data on the

81 While X-ray crystallography and electron microscopy have revealed st

82 Recent crystallography and electron microscopy studies have ref

83 ge mass spectrometry, room-temperature X-ray crystallography and EPR spectroscopy on four SLO variant

84 Nowadays, it is possible to combine X-ray crystallography and fragment screening in a medium throu

85 A structural study was undertaken by X-ray crystallography and in silico tools to assess the ligand

86 By crystallography and isothermal titration calorimetry (IT

87 NMR spectrometry, X-ray crystallography and mass spectrometry confirm the format

88 X-ray crystallography and molecular docking analysis of PioOH-

89 X-ray crystallography and molecular dynamics simulations provi

90 Using X-ray crystallography and molecular dynamics simulations, we d

91 X-ray crystallography and mutagenesis confirmed a structure wi

92 ated structural biology approach using X-ray crystallography and NMR spectroscopy and evaluate their

93 eaction products were characterized by X-ray crystallography and NMR spectroscopy.

94 e trapped, off-pathway oligomers using X-ray crystallography and NMR, providing insight into why tetr

95 using a combination of single-crystal X-ray crystallography and paramagnetic (1)H NMR spectroscopy,

96 Here we used a combination of X-ray crystallography and protein engineering to define the de

97 ario emerged from previous findings of X-ray crystallography and rapid kinetics supporting a pre-exis

98 s (Tth) has been unambiguously determined by crystallography and reveals it to occupy the peptidyl tr

99 Integrating x-ray crystallography and SAXS, we also describe the structure

100 X-ray crystallography and SDS-PAGE further show that trimer 4(

101 rming hexamers that can be observed by X-ray crystallography and SDS-PAGE.

102 In this work, NMR crystallography and single-crystal X-ray diffraction are

103 Here, we use X-ray crystallography and single-particle cryo-electron micros

104 ism, we determined eight structures by X-ray crystallography and single-particle cryo-electron micros

105 X-ray crystallography and small-angle X-ray scattering showed

106 he proposed EnT acceptors were elucidated by crystallography and spectroscopic binding studies.

107 sis, we have used ultrahigh-resolution X-ray crystallography and the recently approved beta-lactamase

108 the only system where high-resolution X-ray crystallography and toxicity data are available.

109 We solve its 3D structure by NMR and x-ray crystallography and validate leads with 3 different radi

110 pounds with binding modes confirmed by X-ray crystallography and yielded unexpectedly accurate and st

111 Combining experimental biochemistry, protein crystallography, and advanced computer simulations we sh

112 R, and EPR spectroscopies with magnetometry, crystallography, and advanced theoretical treatments sug

113 of cryo-electron microscopy (cryo-EM), x-ray crystallography, and computational predictions were used

114 using molecular dynamics simulations, X-ray crystallography, and cryoEM.

115 /mechanics molecular mechanics calculations, crystallography, and detection of intermediate (hypohalo

116 EPR spectroscopy, elemental analysis, X-ray crystallography, and DFT calculations.

117 mobility macromolecular analysis, EM, X-ray crystallography, and enzyme assays.

118 inetic analyses, fluorescence binding, X-ray crystallography, and gel filtration experiments with asp

119 Functional analysis, x-ray crystallography, and molecular dynamics simulations reve

120 and membrane permeabilization assays, X-ray crystallography, and molecular dynamics simulations.

121 ining kinetic and biophysical methods, X-ray crystallography, and molecular modeling, as well as usin

122 Here, we employ enzymatic assays, X-ray crystallography, and molecular simulations to resolve th

123 found using cryo-electron microscopy, x-ray crystallography, and other methods.

124 ucture of the hItln-1.KO complex using X-ray crystallography, and our 1.59 angstrom resolution struct

125 pai-dimer) by UV-vis spectroscopy and X-ray crystallography, and performing computational analysis.

126 nology advancements, first in macromolecular crystallography, and recently in Cryo-electron microscop

127 selectively by stopped-flow kinetics, X-ray crystallography, and solution-state NMR.

128 lying a suite of nuclear magnetic resonance, crystallography, and stopped-flow techniques to an enzym

129 tation, we combined virtual screening, x-ray crystallography, and structure-guided design to develop

130 d into an RNA octamer were analysed by X-ray crystallography, and the structure explains the loss in

131 BC-Cullin5 has recently been solved by X-ray crystallography, and, using molecular dynamics simulatio

132 NMR-based crystallography approaches involving the combination of

133 at could not be captured by the conventional crystallography approaches used to obtain prior structur

134 Key differences from applications in crystallography are that the errors in Fourier coefficie

135 Data from X-ray crystallography at 2.85 angstrom, as well as kinetic dat

136 om resolution by serial synchrotron rotation crystallography at a cryogenic temperature, and at 1.8 a

137 using a combination of time-resolved serial crystallography at an X-ray free-electron laser and ns-r

138 the C5_MG4-CirpT complex was solved by X-ray crystallography (at 2.7 angstrom).

139 Since the advent of protein crystallography, atomic-level macromolecular structures

140 Crystallography-based fragment screening reveals a bindi

141 Crystallography-based X-ray diffraction technique is the

142 Combined data from crystallography, biochemistry, small angle X-ray scatter

143 er coefficients are largely in the phases in crystallography but in both phases and amplitudes in cry

144 f metal centers derived from zero dose X-ray crystallography can advance our mechanistic understandin

145 broadly, these findings suggest that racemic crystallography can provide insight on native quaternary

146 Isolated and fully characterized (X-ray crystallography) Co(I)-complexes, (dppp)(3)Co(2)Cl(2) an

147 Besides X-ray crystallography, complete spectroscopic and electrochemi

148 in assembly strength, revealed through X-ray crystallography, computational analysis, and solution-ph

149 Here we combine NMR, crystallography, computer simulations, protein engineeri

150 X-ray crystallography, cryo-electron microscopy, and hydrogen-

151 termination methods including macromolecular crystallography, cryo-electron microscopy, and integrati

152 The crystallography data and theoretical calculations sugges

153 osals, we collected "room temperature" X-ray crystallography data for Pseudomonas putida ketosteroid

154 Intact protein mass spectrometry and protein crystallography demonstrated 8 and 9 as covalent inhibit

155 ectroscopy, reaction product analysis, X-ray crystallography, density functional theory calculations,

156 X-ray crystallography depicted the binding mode of phosphonic

157 This X-ray crystallography driven study shows that the rim of the i

158 , which previously was not detected by X-ray crystallography due to crystal packing effects.

159 Here, using a combination of X-ray crystallography, electron microscopy, and functional and

160 Using X-ray crystallography, electron microscopy, and mass spectrome

161 spectroscopy, global kinetic modeling, X-ray crystallography, electron paramagnetic resonance spectro

162 Experimental evidence (e.g., X-ray crystallography, electron paramagnetic resonance, electr

163 ompounds 1 and 2 were characterized by X-ray crystallography, electronic and NMR spectroscopy, and th

164 X-ray crystallography enabled structure-guided design, leading

165 Through X-ray crystallography, engagement of both the catalytic Zn(2+)

166 2MeOH were confirmed by single crystal X-ray crystallography, EPR spectroscopy, and DFT calculations.

167 lization is the bottleneck in macromolecular crystallography; even when a protein crystallises, cryst

168 X-ray crystallography experiments allowed structural assignmen

169 aset in static and time-resolved synchrotron crystallography experiments at RT.

170 he LCP-matrix causes difficulties in protein crystallography experiments in meso, this feature of ERO

171 have been precisely identified through x-ray crystallography experiments.

172 ified sensitively and unambiguously by X-ray crystallography, exploiting the anomalous scattering of

173 We conducted x-ray crystallography, F-actin binding and bundling assays, an

174 rus-induced gene silencing (VIGS), and X-ray crystallography for structure-guided mutagenesis, to inv

175 Detailed experimental studies (X-ray crystallography, gas sorption, and quartz-crystal microb

176 A long-standing goal of X-ray crystallography has been to combine structural informati

177 X-ray crystallography has facilitated the majority of protein

178 By combining crystallography, hydrogen-deuterium exchange coupled to

179 Using X-ray crystallography, identical conductive MthK structures we

180 nanomolar affinity (JH112) was determined by crystallography in complex with the OX1R and corresponde

181 JMS-053 binding site was identified by X-ray crystallography in human serum albumin at drug site 3, w

182 ption, achieved using a combination of X-ray crystallography, in vitro enzyme assays and site-directe

183 ntinues to be refined with cryo-EM and x-ray crystallography, in vivo conformational changes of the N

184 X-ray crystallography indicates that intermolecular pai-pai st

185 X-ray crystallography indicates that the amino groups of some

186 Mix-and-inject serial crystallography is an emerging technique that utilizes X

187 g ligand-protease structures solved by X-ray crystallography led to the identification of 3 and 4.

188 NMR and X-ray absorption spectroscopy, X-ray crystallography, mass spectrometry, chromatography and h

189 In this work, the serial X-ray crystallography method was successfully adopted to probe

190 D trajectories using standard macromolecular crystallography methods.

191 e employed a combination of time-lapse X-ray crystallography, molecular dynamics simulations, and DNA

192 However, by combining kinetic crystallography, molecular dynamics simulations, and Ram

193 of several disciplines including chemistry, crystallography, molecular engineering and advanced mate

194 tpyPY2Me)](0), and characterization by X-ray crystallography, Mossbauer spectroscopy, X-ray absorptio

195 pumila (OpSTR) using a combination of X-ray crystallography, mutational, and molecular dynamics (MD)

196 re not amenable to characterization by x-ray crystallography, NMR or EM.

197 ultiple biophysical methods, including x-ray crystallography, NMR spectroscopy, and small angle x-ray

198 Here, we use a combination of X-ray crystallography, NMR spectroscopy, functional analyses,

199 ngle-particle cryoelectron microscopy, X-ray crystallography, NMR, and other biophysical methods.

200 stay structural biology techniques are X-ray crystallography, nuclear magnetic resonance (NMR) imagin

201 X-ray crystallography of 11s and related thieno[3,2-d]pyrimidi

202 Herein, we describe an analysis using X-ray crystallography of a diverse library of compounds prepar

203 al delivery medium in the serial femtosecond crystallography of Adenosine A(2A) receptor (A(2A)R).

204 Using X-ray crystallography of four apo- and cofactor-bound Mtb-MenD

205 rom nuclear magnetic resonance, modeling and crystallography of homologous receptors.

206 cture of human EMC using biochemical assays, crystallography of individual subunits, site-specific ph

207 y NMR analysis of free peptides and by X-ray crystallography of peptides in complex with antibody 6E2

208 Subsequent X-ray crystallography of the A(2A) AR with a low and a high af

209 ly depth-resolved composition and real-space crystallography of the silicide films using a single sam

210 X-ray crystallography often requires non-native constructs inv

211 High-resolution X-ray crystallography on selected derivatives in the adduct wi

212 seen experimentally, for example with x-ray crystallography or cryo-electron microscopy.

213 nal structure-determining techniques such as crystallography or nuclear magnetic resonance spectrosco

214 N terminus insertion and, as shown by X-ray crystallography, partly by Tyr-172 inserting into a cavi

215 mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct fea

216 anistic docking, machine learning, and X-ray crystallography, pointing the way for future terpene syn

217 es, such as coherent diffraction imaging and crystallography, provides a nonperturbing environment wh

218 gues using single-particle cryo-EM and x-ray crystallography, respectively.

219 X-ray crystallography revealed a slightly twisted geometry for

220 enesis of a Der p 2 epitope defined by x-ray crystallography revealed an IgE Ab binding site that wil

221 X-ray crystallography revealed that a potent, reversible, firs

222 X-ray crystallography revealed that Aequorea CPs contain a che

223 of the three-dimensional structure by X-ray crystallography revealed that CopG consists of a thiored

224 X-ray crystallography revealed the structure of Bs164, the fir

225 phenyl) structural characterization by X-ray crystallography reveals a short Al-N distance, which is

226 X-ray crystallography reveals distinctly different positions o

227 X-ray crystallography reveals face-to-face alignment of naphth

228 X-ray crystallography reveals that 34 occupies the classical q

229 X-ray crystallography reveals that peptide N+1 assembles to fo

230 X-ray crystallography reveals that these CNT mimics exhibit un

231 X-ray crystallography reveals that they bind in the enzyme RNA

232 While X-ray crystallography routinely provides structural characteri

233 les, which we further analyzed by ITC, X-ray crystallography, selectivity studies, the NCI60 cell-pan

234 crystals are amenable to serial femtosecond crystallography (SFX) analyses using X-ray free-electron

235 Serial femtosecond crystallography (SFX) with X-ray free electron lasers (X

236 arly for membrane protein serial femtosecond crystallography (SFX), leveraging orders-of-magnitude fa

237 Using serial femtosecond X-ray crystallography (SFX), we have determined the pristine s

238 Single crystal X-ray crystallography showed that in some cases, fulvenes poss

239 X-ray crystallography showed the inhibitors to bind to a previ

240 2 was structurally characterized by X-ray crystallography, showing a square pyramidal geometry wit

241 X-ray crystallography shows that peptide 3(F20Cha) forms a hex

242 While structural analysis by X-ray crystallography shows that the majority of these compoun

243 Single crystal X-ray crystallography shows that the mononuclear [CuOH](1+) co

244 Depth-resolved crystallography shows that the Ni films transform from a

245 cture, determined using single-crystal X-ray crystallography, shows that quantum dots (QDs) of [Na(4)

246 nced in the last decade by advances in X-ray crystallography, single-molecular imaging, and theoretic

247 lab has focused on CYP2B enzymes using X-ray crystallography, site-directed mutagenesis, deuterium-ex

248 Herein we use X-ray crystallography, solution-state NMR, and solid-state NMR

249 the cluster in three oxidation levels using crystallography, spectroscopy, and ab initio calculation

250 -triazine), thus allowing for utilization of crystallography, spectroscopy, and theoretical simulatio

251 and maltosides are frequently used in x-ray crystallography structure determination.

252 Additionally, x-ray crystallography studies identified key amino acid residu

253 X-ray crystallography studies identify subtle changes in the p

254 cells, both hexamers and octamers exist, and crystallography studies predicted the order of the hexam

255 e binding of B2 versus DDM in tubulin, X-ray crystallography studies revealed a shift in the position

256 Our thermostability and X-ray crystallography studies, together with the molecular dyn

257 (mu-NO)](2+) complex with IR, EPR, and X-ray crystallography suggests a localized mixed-valent Cu(III

258 X-ray crystallography supports a role for the selectivity base

259 Serial crystallography (SX) with X-ray free-electron lasers has

260 t be high enough to couple with conventional crystallography techniques.

261 near-infrared (NIR) spectroscopy, and X-ray crystallography techniques.

262 We show, by means of X-ray crystallography, that the two target nitrogen atoms-the

263 As revealed by X-ray crystallography, the highly contorted tetra-anion is sta

264 In the case of virus crystallography this method does not require freezing of

265 finition of the RAF dimer interface (DIF) by crystallography, this review focuses on the implications

266 e of recombinant BcelPL6 was solved by X-ray crystallography to 1.3 angstrom resolution, revealing a

267 tally solved its apo-structure through X-ray crystallography to a resolution of 2.60 angstrom.

268 This study used high-resolution X-ray crystallography to demonstrate the detailed nature of th

269 Here, we use serial femtosecond crystallography to determine the Cyt1Aa protoxin structu

270 use of LMNG, a mild detergent developed for crystallography to increase membrane protein stability.

271 al time single molecule FRET experiments and crystallography to investigate the open- to closed-state

272 Here, we used X-ray crystallography to investigate these Dsl1-SNARE interact

273 cal synthesis, biophysical mapping and X-ray crystallography to reveal the binding mode of an antagon

274 Here, we use room-temperature X-ray crystallography to study changes in the conformational e

275 equencing, biolayer interferometry and X-ray crystallography to trace mutation selection pathways whe

276 other antibodies with Pfs25 are analyzed by crystallography to understand structural requirements fo

277 ration (SILCS), and experimentally, by X-ray crystallography, to map potential interaction sites on t

278 Pv-M17 by cryoelectron microscopy and X-ray crystallography together with solution studies revealed

279 oaches, site-directed mutagenesis, and X-ray crystallography uncovered an additional nickel-binding s

280 performed sequential serial raster-scanning crystallography using a microfocused synchrotron beam th

281 nd at 1.8 angstrom by LCP-serial femtosecond crystallography, using an X-ray free-electron laser at 4

282 X-ray crystallography validated the dimeric mechanism of inhib

283 n analysis of the selected products by X-ray crystallography was carried out to obtain a better insig

284 lt targets for structural biology when X-ray crystallography was the mainstream approach.

285 With X-ray crystallography, we detected an unexpected photochemical

286 optimized (TROSY) NMR spectroscopy and X-ray crystallography, we established that the DcpS substrate

287 Using X-ray crystallography, we have discovered a domain-swap homodi

288 Using X-ray crystallography, we here show how Drosophila CAL1, an ev

289 By using time-resolved serial femtosecond crystallography, we identified a key oxygen intermediate

290 Using x-ray crystallography, we show how a preTCR applies the concav

291 Here using X-ray crystallography, we show that human HC1 has a structure

292 nts, steady-state enzyme kinetics, and X-ray crystallography, we show that the P167S/D240G double mut

293 Here, using electrophysiology and X-ray crystallography, we show that UBP791 ((2S*,3R*)-1-(7-(2-

294 e investigated by NMR spectroscopy and X-ray crystallography, which revealed the occurrence of a sign

295 The recent advent of serial crystallography, which spreads the absorbed energy over

296 n the context of recent progress using X-ray crystallography with free-electron lasers on these inter

297 By combining X-ray crystallography with molecular dynamics simulations, in

298 ectroscopy ((1,2)H HYSCORE, ENDOR) and X-ray crystallography, with corresponding DFT studies, cement

299 istent with expectation from models based on crystallography, x-ray diffraction, and cryo-electron mi

300 fully synthesized and fully studied by X-ray crystallography, X-ray photoelectron spectroscopy, hydro