1 uire multi-unit assembly around one of seven
cullin proteins.
2 w that SAP130 can interact with a variety of
cullin proteins.
3 as a regulatory mechanism for cullin and non-
cullin proteins.
4 N protein through interactions with both the
cullin protein and an E2 enzyme such as UBC12.
5 g enzymes, thereby preventing neddylation of
Cullin proteins and preventing the degradation of CRL ta
6 Cdc34, Rad6B, and the
Cullin proteins are expressed in a developmentally regul
7 ylating enzyme NEDP1, implying that many non-
cullin proteins are neddylated.
8 We also show that the majority of
cullin proteins are progressively neddylated during the
9 Cullin proteins assemble a large number of RING E3 ubiqu
10 ee subunits are the Skp1 protein; one of the
cullin proteins (
Cul1 in metazoans and Cdc53 or Cul A in
11 forms of RUB1 and RUB2 conjugate to the same
cullin protein,
CUL1, and produce the same conjugation p
12 rt of an E3 ligase complex that includes the
cullin proteins Cul4A and Cul4B.
13 Cullin proteins form a scaffold for two functional modul
14 d by conjugation of a Nedd8 polypeptide onto
Cullin proteins in a process called neddylation.
15 Nedd8 is conjugated to
cullin proteins in a process that alters SCF E3 ubiquiti
16 tinctly different patterns for Cdc34 and the
Cullin proteins in germ cells.
17 However, the roles of
cullin proteins in regulating adipocyte biology are stil
18 lation (the conjugation of a Nedd8-moiety to
Cullin proteins)
in the fine tuning of the NF-kappaB res
19 Neddylation of individual
cullin proteins is essential for the activation of each
20 Hence, combinations of ROC/APC11 and
cullin proteins proteins potentially constitute a wide v
21 Conjugation of Nedd8 to a
cullin protein,
termed neddylation, is an evolutionarily
22 Among all mammalian
cullin proteins that were targeted by TAS4464, we identi
23 Other F-box proteins interact with SKP1 and
cullin proteins to form SCF complexes that selectively r
24 Cul3 belongs to the family of
cullin proteins,
which function as scaffold proteins of