ライフサイエンスコーパス: culture cell

1 than mutant dimer and trimers in Drosophila culture cells.

2 reduced the AAPH pro-oxidant capacity in co-culture cells.

3 C-terminal gene tagging in mammalian tissue culture cells.

4 and biochemical consequences in human tissue culture cells.

5 e lipolytic effect of GH in humans, mice and cultured cells.

6 ia (PML) nuclear bodies in breast cancer and cultured cells.

7 study the cortisol response in >6,000 single cultured cells.

8 lity of research results obtained from human cultured cells.

9 itro and transactivate SOX reporter genes in cultured cells.

10 back inhibition in Notch signaling assays in cultured cells.

11 n condensation in nuclear organelles of live cultured cells.

12 n of HOP did not disrupt CT activity against cultured cells.

13 s retained full sensitivity to ganetespib in cultured cells.

14 me in both the aerobically and anaerobically cultured cells.

15 n of histone methylation in a range of human cultured cells.

16 hat seen in studies of purified proteins and cultured cells.

17 they have proved challenging to propagate in cultured cells.

18 of fluorescence-labeled biomolecules inside cultured cells.

19 hould produce equivalent immunopeptidomes as cultured cells.

20 understanding of supplementation studies in cultured cells.

21 o creating viable synthetic embryos by using cultured cells.

22 wild-type viruses following transfection of cultured cells.

23 infections have focused on BV infections of cultured cells.

24 sis in both Drosophila tissues and mammalian cultured cells.

25 usually use either freshly isolated cells or cultured cells.

26 complex in individual blastocysts but not in cultured cells.

27 C2) signaling in an AMPK-dependent manner in cultured cells.

28 unted DAPLE--mediated apical constriction of cultured cells.

29 ts Nf1 RasGAP activity in vivo as it does in cultured cells.

30 re is much lower in human neurons than other cultured cells.

31 ects MKK and NLRP1B cleavage in vitro and in cultured cells.

32 ,000-fold MECP2 up-regulation from the Xi in cultured cells.

33 a general RNA-processing factor in yeast and cultured cells.

34 y compound glycosylation and growth phase of cultured cells.

35 rate of diversification can be controlled in cultured cells.

36 protein and lipid delivery to nascent NR in cultured cells.

37 netic, genomic or other biological assays in cultured cells.

38 -1 in vitro and inhibits MOAP-1 stability in cultured cells.

39 egy of serial passage in nonhost animals and cultured cells.

40 en used to transfer constructs directly into cultured cells.

41 mes modulates the length of primary cilia in cultured cells.

42 e most potent ones were not acutely toxic to cultured cells.

43 ies of the PSP extracts were investigated in cultured cells.

44 pplying complex dynamic mechanical forces to cultured cells.

45 docin through cis- and trans-associations in cultured cells.

46 processing of pri-mir-30c-1 in vitro and in cultured cells.

47 orylation and an increase in Abeta levels in cultured cells.

48 pecific approach used to model resistance in cultured cells.

49 y of bioengineering anticoagulant heparin in cultured cells.

50 er capacity to neutralize virus infection in cultured cells.

51 arly markers of adipocyte differentiation in cultured cells.

52 in real-time without the need for relocating cultured cells.

53 lism and those necessary for biosynthesis in cultured cells.

54 centrations of Ac(4)ManNAz and DBCO-Cy5.5 in cultured cells.

55 ellular rRNA expression and proliferation of cultured cells.

56 of a 24-kDa C-terminal Nogo-A fragment from cultured cells.

57 rough modulation of an observed phenotype in cultured cells.

58 e differentiation of adipocyte precursors in cultured cells.

59 ction TRPC6 channel variants is cytotoxic in cultured cells.

60 ues(4,5) and induces double-strand breaks in cultured cells(3).

61 alkyne conjugates were profiled directly in cultured cells, achieving thiol saturation in a few minu

62 ized the performance of the new NIR GECIs in cultured cells, acute mouse brain slices, and Caenorhabd

63 In cultured cells after a period of serum deprivation, trea

64 tous structures, or rodlets, in human tissue culture cells, after gene transfer to adult mice, and ex

65 FBS-cultured cells also showed higher MsgA and NanA activity

66 We show that 'EC-tagging' occurs in tissue culture cells and Drosophila engineered to express CD an

67 quiescent cells including G0-arrested tissue culture cells and prophase I-arrested oocytes.

68 Next, we explored the possibility to culture cells and tissues in these PDMS devices produced

69 gy to measure microtubule assembly in tissue culture cells and Xenopus egg extracts using two-photon

70 A55 or C2 have altered cytopathic effects in cultured cells and altered pathology in vivo Previous st

71 AV to study viral infection dynamics in both cultured cells and animal models of viral infection.

72 With demonstrated utility in both cultured cells and animals, this mRNA delivery technolog

73 By using a live transcription assay in cultured cells and by depleting actin-rich processes in

74 cell oxygen-consumption-rate measurements of cultured cells and by imaging intratumoral metabolic het

75 The protocol is applicable to cultured cells and can potentially also be adapted to pr

76 th DNA activates damage repair mechanisms in cultured cells and causes DNA strand breakage and an inc

77 to achieve efficient cell rearrangements of cultured cells and during embryonic development.

78 t StcE digests cancer-associated mucins from cultured cells and from ascites fluid derived from patie

79 obtained from plasma and viral outgrowth of cultured cells and from proviral DNA were amplified by P

80 dichlorophenes potently inhibit NAPE-PLD in cultured cells and have significant selectivity for NAPE

81 e show that they exhibit robust signaling in cultured cells and in an acute brain slice preparation.

82 hondrial and nuclear translocation of p53 in cultured cells and in APP/PS1 mice.

83 so (i) gained greater replication ability in cultured cells and in chicken embryos as well as (ii) in

84 2O3 exposure increased MTHFD1 SUMOylation in cultured cells and in in vitro SUMOylation reactions, an

85 substantially increases NAD(+)/NADH ratio in cultured cells and in liver and no induction of apoptoti

86 d and cofractionated with gamma-secretase in cultured cells and in mouse and human brain.

87 egulation and prostate cancer progression in cultured cells and in mouse models of prostate epitheliu

88 Experiments in cultured cells and in osteoclasts derived from both mous

89 In cultured cells and in samples from patients, HEV produce

90 lating variants defective for replication in cultured cells and in spotted fever pathogenesis.

91 press the GR transcriptional network both in cultured cells and in the mouse liver.

92 surements of their impact on PC synthesis in cultured cells and in tissues with a stringent requireme

93 In cultured cells and in transgenic mice, deficiency in end

94 its efficacy in blocking HCV replication in cultured cells and in treatment of patients with HCV inf

95 sphorylated downstream of AngII signaling in cultured cells and in vitro by PKC and PKA.

96 nscriptionally regulated by SKP2 in vitro in cultured cells and in vivo in mouse models.

97 dented telomere-specific DDR inactivation in cultured cells and in vivo in mouse tissues.

98 pon light-induced CRY2-CIB1 dimerization, in cultured cells and in vivo in rodent brain.

99 tely assess and quantify senescence, both in cultured cells and in vivo.

100 broadly localized to the plasma membrane of cultured cells and intact blood vessels in the inner ret

101 out diminishing WNT-potentiating activity in cultured cells and intestinal organoids.

102 onitoring histone-acetylation levels in both cultured cells and living organisms based on the ratio o

103 exons were essential for the growth of both cultured cells and lung adenocarcinoma xenografts, while

104 can be quantified by expressing the motor in cultured cells and measuring tubulin fluorescence levels

105 affinity and IL-33 antagonistic activity in cultured cells and mice.

106 the mitochondrial oxygen consumption rate of cultured cells and mice.

107 ase II (Pol II) transcription termination in cultured cells and mice.

108 nd identification of sialoglycoproteins from cultured cells and model organisms.

109 e distinct loci on different chromosomes, in cultured cells and mouse embryos alike.

110 Using cultured cells and mouse skeletal muscle, we show that T

111 of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be c

112 We applied this method to both cultured cells and mouse tissues to investigate changes

113 hundreds of ADP-ribosylated proteins in both cultured cells and mouse tissues.

114 roved for cancer treatment reduced growth of cultured cells and mouse tumors in a time-of-day-specifi

115 Eya-So transcriptional output in vivo and in cultured cells and on meta analysis of their chromatin o

116 device successfully captures NO evolution in cultured cells and organs, with results comparable to th

117 pproximately 7-kDa cytoplasmic C terminus in cultured cells and purified from Escherichia coli The al

118 n of SUCLG2 suppressed NE differentiation in cultured cells and reduced prostate tumor growth in a xe

119 er rates of chromosome segregation errors in cultured cells and suppressed shot-induced mitotic arres

120 orylate ICAP1 at Ser-10 both in vitro and in cultured cells and that active PAK4 inhibits ICAP1 nucle

121 diates aggregation of otherwise non-adherent cultured cells and that loss of Ihog activity disrupts w

122 ed JNK-c-Jun activity in SMA mouse and human cultured cells and tissues.

123 of EVs into biologic fluids is a hallmark of cultured cells and tumors, their payload and biologic ac

124 Here, using cultured cells and two animal models, we demonstrate tha

125 about RNR regulation comes from studies with cultured cells and with purified proteins.

126 ibe key findings in human postmortem brains, cultured cells, and animal models of disease that suppor

127 planar tissue including rodent brain slices, cultured cells, and brain regions with laminar structure

128 mutations affect SARM1 apoptotic activity in cultured cells, and in this way identified critical olig

129 C and CE in lipid extracts from human serum, cultured cells, and mouse liver.

130 died and was examined using human specimens, cultured cells, and mouse model systems.

131 dolosa induced a robust cytokine response in cultured cells, and this effect was dependent on the fla

132 phaDKRC transgene was designed, validated in cultured cells, and used to make transgenic mice.

133 In cultured cells, androgen suppressed the expression of th

134 es, but differences in CA between tumors and cultured cells are uncharacterized.

135 istance to glutamate-induced cytotoxicity in cultured cells as well as increased carbon tetrachloride

136 cells, optimized the protocol for suspension cultured cells, as this is the industrial practice for C

137 In cultured cells, AS69 reduced the self-interaction of [Fo

138 mechanodynamics of epithelial monolayers by culturing cells at an air-liquid interface.

139 Here, we have developed a novel co-culture cell-based high throughput assay system to ident

140 In cultured cells, BIRFLU displayed growth kinetics compara

141 Experiments in cultured cells, brain slices, and in living mice demonst

142 ffected the kinetics of VEEV accumulation in cultured cells but strongly inhibited its pathogenesis i

143 NPLA3 and CGI-58 resulted in LD depletion in cultured cells, but expression of PNPLA3 alone did not.

144 Stx1a is more toxic to cultured cells, but Stx2 subtypes are more potent in ani

145 tes similarly to the wild-type (WT) virus in cultured cells, but the DUBmut virus activates an IFN re

146 cit insulin-like signaling by mutant INSR in cultured cells, but whether this translates into meaning

147 RNA and lipids in single organelles of live cultured cells by biomolecular component analysis using

148 ation of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to

149 e show that PIM1 is modified in vitro and in cultured cells by the Small ubiquitin-like modifier (SUM

150 In cultured cells, CHCHD10 knockdown results in OPA1-mitofi

151 Experiments in cultured cells confirmed the link between TRAF3 and NF-k

152 y more embedded ribonucleotides than that of cultured cells, consistent with the high ratio of ribonu

153 t displayed altered substrate specificity in cultured cells, consistent with the idea that SUMOylatio

154 The cultured cells contained HPV-16, formed colonies in soft

155 old signal amplification in diverse samples (cultured cells, cryosections, formalin-fixed paraffin-em

156 ansgenic Drosophila, providing evidence that cultured cell cytoneme analysis is predictive of in vivo

157 Here, we introduce a fixation method whereby cultured cell cytonemes can be preserved for imaging stu

158 e novel missense NOTCH1 and DLL4 variants in cultured cells demonstrate reduced signalling activity,

159 For example, SARS-CoV infection of cultured cells depends on endosomal acid pH-dependent pr

160 e screen did not affect circadian rhythms in cultured cells derived from luminescent reporter embryos

161 Here, we show that knockout of GSAP in cultured cells directly reduces gamma-secretase activity

162 The integration profile of AAV-465lambda in cultured cells display both full-length and fragmented A

163 hat conclusions based on studies of Doc2b in cultured cells do not necessarily generalize to mature s

164 hromosome could be selectively eliminated in cultured cells, embryos, and tissues in vivo.

165 ntitative assessments of target occupancy in cultured cells, emphasizing generalizable methodologies

166 D), are inhibited in c9ALS/FTD brains and in cultured cells expressing either of two arginine-rich di

167 Cultured cells expressing VopA were also impaired in the

168 MATAL LINEAGE) in the simplifying context of cultured cell filaments and in protoplasts before and du

169 We demonstrate that cultured cells form multiple nanotubes that mediate inte

170 ion of multiple WNT-related genes in primary culture cells from ampullary adenocarcinoma, but SFRP1 e

171 th animal models of fibrous dysplasia and in cultured cells from individuals with MAS but not in huma

172 demonstrate that EVs containing CysC protect cultured cells from starvation-induced death.

173 In cultured cells, Fucci(CA) produced a sharp triple color-

174 MiDs in a time- and dose-dependent manner in cultured cells grown ex vivo or in vivo.

175 Genetic engineering of model organisms and cultured cells has for decades provided important insigh

176 Human tissue culture cells have long been a staple of molecular and c

177 aithfully recapitulates human disease; thus, cultured cells have been used to model Shigella pathogen

178 Biochemical analyses and studies in cultured cells have identified a large number of protein

179 Studies in cultured cells have reported that zinc stimulates the en

180 r distributions when overexpressed in tissue culture cells (HEK293), and can induce the formation of

181 Consistent with the results in cultured cells, hepatic levels of Insig-2 mRNA were enha

182 of p-c-Jun levels in SMA compared to control cultured cells, human or mouse spinal cord tissues, or m

183 RAMP consists of coexpressing in cultured cells (i) an organellar protein fused to the st

184 10 change during C. trachomatis infection of cultured cells in a manner dependent on both host and pa

185 We cultured cells in uniform conditions and profiled genome

186 organization and dynamics are controlled in cultured cells in vitro However, our understanding of mi

187 In this study, we demonstrate that culturing cells in different physical environments, stif

188 We first established a protocol that enables culturing cells in our microfluidic platform and that ca

189 These effects can be recovered by culturing cells in the presence of a ROS quencher or in

190 ng machines have been studied extensively in cultured cells; in contrast, remarkably little is known

191 requirements to achieve lytic replication in cultured cells included (i) either in vitro cultures of

192 Experiments performed on cultured cells indicated that Doc2 proteins promote spon

193 ce for deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DN

194 The retention of bioenergetic defects in cultured cells indicates that there is a genetic or epig

195 causes altered IL-6 induction both in tissue culture cells induced by LPS treatment in vitro as well

196 , ruzasvir, velpatasvir, and pibrentasvir in cultured cells infected with HCV recombinants expressing

197 In cultured cells, infectivity and cytokine induction were

198 CPC also targeted CSE in cultured cells, inhibiting transsulfuration flux by 80-9

199 has been to determine why VZV, when grown in cultured cells, invariably is more cell associated and h

200 The application of mechanical forces to cultured cells is often performed using specialized syst

201 icroscopy (SMLM), while well established for cultured cells, is not yet fully compatible with tissue-

202 Overexpression of CK1epsilon in cultured cells led to increased tau phosphorylation at m

203 In cultured cells, LHK15 did not react with K15 deficient N

204 tween MTCBP-1 and MT1-MMP expression both in cultured cell lines and human pancreatic tumors.

205 We used mouse models, cultured cell lines and patient-derived xenografts to de

206 Cultured cell lines are the workhorse of cancer research

207 Cultured cell lines are widely used for research in the

208 nthetic yeast centromeric plasmids (YCps) to cultured cell lines at rates similar to that of 12 kb YC

209 studying the effect of anti-cancer drugs in cultured cell lines by monitoring phosphatidylserine tra

210 nts make multiplex genetic assays in diverse cultured cell lines easier, cheaper and more effective,

211 Cultured cell lines infected with HCMV show induction of

212 We found that in cultured cell lines, FAM92A colocalizes with Cby1 at the

213 Using cultured cell lines, gastric biopsy specimens, primary c

214 sed chromatin organization studies have used cultured cell lines, limiting their generalizability.

215 Using cultured cell lines, primary neurons, and organotypic br

216 or 16,698 single cells from a combination of cultured cell lines, primate frontal cortex tissue and t

217 These effects are observed in 3D-cultured cell lines, tumor organoids, chemoresistant xen

218 ariations in cell-cycle requirements between cultured cell lines, we generated knockouts across cell

219 rter plasmids into Huh7, BNL-1ME, and HEK293 cultured cell lines.

220 sion in mice, in human kidney tissue, and in cultured cell lines.

221 In long-term cultures, cells maintain their morphology, form capillar

222 In cultured cells, mitotic delays resulting from centrosome

223 Using a cultured cell model of erythroid differentiation, deplet

224 Herein, we describe cultured cell model systems and common assays that have

225 m Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate.

226 ate partners interacted both in vitro and in cultured cell models.

227 lticellular spheroids as a 3D cell model and cultured cell monolayers as a 2D cell model.

228 iled-coil containing protein 3) signaling in cultured cells more effectively than either BGJ398 or ga

229 and the basal body in different tissues and cultured cells of Drosophila melanogaster, highlighting

230 e conformation capture (Hi-C) generated from cultured cells of nine individuals with developmental di

231 cellular matrix (ECM) scaffolds derived from cultured cells or natural tissues exhibit superior bioco

232 In cultured cells, overexpressed Smad3 is sufficient to ind

233 Functional analysis in cultured cells overexpressing FLAG-tagged wild-type or m

234 ased the incidence of inclusion formation in cultured cells overexpressing P23H rod opsin, and increa

235 In cultured cells, overexpression of VPS4A mutants caused e

236 tial for binding to beta-Catenin in vitro In cultured cells, phosphorylation of specific serine resid

237 jectories and equilibrium convergence of the cultured cell population.

238 also show that association rates measured in cultured cells predict the extent of internalization of

239 s capable of interaction with poly(A) RNA in cultured cells, primarily mediated by the N-terminal reg

240 formin and a constitutive stress response in cultured cells, primary patient cells, and Drosophila ne

241 In cultured cells, Rbpr2 localized to membranes and promote

242 lantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants.

243 Whether laboratory-cultured cells retain a similar generative capacity rema

244 iption (TPRT) and mobilized efficiently in a cultured cell retrotransposition assay.

245 Previous studies in cultured cells (Schumacher et al., 2015) revealed that U

246 HSV infection in these cultured cells shows the properties expected for a laten

247 on of desthiobiotin-functionalized probes to cultured cells simplified enrichment and elution to enab

248 t morphogenesis of stem explants, and in BY2 cultures cell size was reduced.

249 amount of total TGFbeta stored in the ECM of cultured cells, suggesting that the MAGPs compete with t

250 elta39) exhibited decreased viral fitness in cultured cells, suggesting the feasibility of using this

251 d from host cells in response to bacteria in cultured cell systems and in the intestine in vivo Uric

252 In cultured cells, TBK1 associates with and activates mTORC

253 In cultured cells, the compound can block the interaction o

254 In human cultured cells, the compounds inhibit phosphorylation-de

255 nd enhances spontaneous cationic currents in cultured cells, the first C-terminal mutant to do so.

256 In cultured cells, the loss of S-sulfhydration impaired int

257 In cultured cells, the mutations reduced the DNA binding af

258 s by analyzing LZA element function in human cultured cells; the LZA element-mediated transcriptional

259 In cultured cells, this capacity is tightly aligned to phos

260 t Pik3ca induces centrosome amplification in cultured cells (through a pathway involving AKT, ROCK an

261 science as well as clinical studies such as cultured cells, tissue homogenates, and serum.

262 In cultured cells, TMG promoted sequestration of the cap-bi

263 increasingly intact biological systems, from cultured cells to acute brain slices to behaving mice.

264 ss such mechanisms, we subjected transformed cultured cells to chronic circadian desynchrony (CCD), m

265 Importantly, the responses by cultured cells to density signals also uncover key mecha

266 Here we used cultured cells to examine the coordinated regulation of

267 for the fast isolation of mitochondria from cultured cells to generate MITO-Tag Mice.

268 lain elevated CA in vivo because exposure of cultured cells to hypoxia or mimicking hypoxia pharmacol

269 4me3) and H3K36me3 after a brief exposure of cultured cells to hypoxia predict the cell's transcripti

270 translating systems-biology approaches from cultured cells to living organisms.

271 B induction in Drosophila animal tissues and cultured cells to more deeply interrogate the impact of

272 oncentrations of F10 over serial passages in cultured cells to select for escape mutations.

273 In cultured cells, treatment with sunitinib and erlotinib,

274 Oleate treatment of cultured cells triggered CCTalpha translocation to the n

275 L types in a highly disease-relevant primary cultured cell type and provide novel insights into their

276 ted coincreases of NEAT1 and paraspeckles in cultured cells under paraquat (PQ)-induced oxidative str

277 ken together, these results demonstrate that culturing cells under hyperoxic conditions reduces their

278 and assessed the functions of strumpellin in cultured cells using both overexpression and RNA interfe

279 sociated AAA+ ATPase VPS4 on EV release from cultured cells using two methods for EV recovery, differ

280 extracellular matrix proteins from normally cultured cells was 1.1 mmol/mol tyrosine and decreased s

281 Inhibitor efficacy in cultured cells was studied using a human mammary epithel

282 Using cultured cells, we previously showed that sterols trigge

283 To understand this phenomenon in cultured cells, we used a system that combines flow cyto

284 Cultured cells were treated or not with sodium iodoaceta

285 Cultured cells were treated with short interfering RNA (

286 latory activity of GPC6 was also observed in cultured cells, where this GPC increased the binding of

287 nge at the frequency of 5% in primary tissue culture cells, whereas higher levels were seen in severa

288 uptake and beta-oxidation were increased in cultured cells, whereas adipose tissue morphology, gluco

289 describes how to identify the active RBPs in cultured cells, whereas this Protocol Extension also ena

290 ectron battery by stimulating a monolayer of cultured cells, which fluoresces a calcium ion wave at a

291 nfection activated the RIPK3-MLKL pathway in cultured cells, which resulted in suppression of intrace

292 odal monitoring and localized control of the cultured cells, which thereby allows minimizing operatio

293 iently attenuated, and grow to high titer in cultured cells, while retaining high immunogenicity.

294 ssional phagocytosis was studied by staining cultured cells with live-cell staining dyes or by staini

295 Treatment of cultured cells with SBI-797812 increases intracellular N

296 DNA aptamers capable of homing to nuclei of cultured cells without transfection agents or viral tran

297 lian homologue Afadin plays similar roles in cultured cells, working in parallel with ZO-1 proteins,

298 ools for the efficient delivery of mRNA into cultured cells would advance many areas of research, and

299 acologic modulation of IRE1alpha and PERK in cultured cells, xenograft, and spontaneous genetic (RIP-

300 Serum starvation stimulates cilia growth in cultured cells, yet serum factors associated with ciliog