ライフサイエンスコーパス: cultured cell

1 e lipolytic effect of GH in humans, mice and cultured cells.

2 lity of research results obtained from human cultured cells.

3 itro and transactivate SOX reporter genes in cultured cells.

4 back inhibition in Notch signaling assays in cultured cells.

5 n condensation in nuclear organelles of live cultured cells.

6 n of HOP did not disrupt CT activity against cultured cells.

7 s retained full sensitivity to ganetespib in cultured cells.

8 me in both the aerobically and anaerobically cultured cells.

9 n of histone methylation in a range of human cultured cells.

10 hat seen in studies of purified proteins and cultured cells.

11 they have proved challenging to propagate in cultured cells.

12 of fluorescence-labeled biomolecules inside cultured cells.

13 hould produce equivalent immunopeptidomes as cultured cells.

14 understanding of supplementation studies in cultured cells.

15 o creating viable synthetic embryos by using cultured cells.

16 wild-type viruses following transfection of cultured cells.

17 infections have focused on BV infections of cultured cells.

18 sis in both Drosophila tissues and mammalian cultured cells.

19 usually use either freshly isolated cells or cultured cells.

20 complex in individual blastocysts but not in cultured cells.

21 C2) signaling in an AMPK-dependent manner in cultured cells.

22 unted DAPLE--mediated apical constriction of cultured cells.

23 ts Nf1 RasGAP activity in vivo as it does in cultured cells.

24 re is much lower in human neurons than other cultured cells.

25 ects MKK and NLRP1B cleavage in vitro and in cultured cells.

26 ,000-fold MECP2 up-regulation from the Xi in cultured cells.

27 a general RNA-processing factor in yeast and cultured cells.

28 y compound glycosylation and growth phase of cultured cells.

29 rate of diversification can be controlled in cultured cells.

30 protein and lipid delivery to nascent NR in cultured cells.

31 netic, genomic or other biological assays in cultured cells.

32 -1 in vitro and inhibits MOAP-1 stability in cultured cells.

33 egy of serial passage in nonhost animals and cultured cells.

34 en used to transfer constructs directly into cultured cells.

35 mes modulates the length of primary cilia in cultured cells.

36 e most potent ones were not acutely toxic to cultured cells.

37 pplying complex dynamic mechanical forces to cultured cells.

38 ies of the PSP extracts were investigated in cultured cells.

39 docin through cis- and trans-associations in cultured cells.

40 processing of pri-mir-30c-1 in vitro and in cultured cells.

41 orylation and an increase in Abeta levels in cultured cells.

42 ructures containing the small GTPase Rab8 in cultured cells.

43 lpha MAPK-induced BACE1 protein reduction in cultured cells.

44 nd stoichiometry in rat liver microsomes and cultured cells.

45 ently tagged clathrin coat components within cultured cells.

46 racellular vimentin and keratin filaments in cultured cells.

47 o 0.9 Hz after stimulation with 30 mM KCl in cultured cells.

48 pecific approach used to model resistance in cultured cells.

49 y of bioengineering anticoagulant heparin in cultured cells.

50 er capacity to neutralize virus infection in cultured cells.

51 arly markers of adipocyte differentiation in cultured cells.

52 in real-time without the need for relocating cultured cells.

53 lism and those necessary for biosynthesis in cultured cells.

54 centrations of Ac(4)ManNAz and DBCO-Cy5.5 in cultured cells.

55 ellular rRNA expression and proliferation of cultured cells.

56 of a 24-kDa C-terminal Nogo-A fragment from cultured cells.

57 rough modulation of an observed phenotype in cultured cells.

58 e differentiation of adipocyte precursors in cultured cells.

59 ction TRPC6 channel variants is cytotoxic in cultured cells.

60 study the cortisol response in >6,000 single cultured cells.

61 ia (PML) nuclear bodies in breast cancer and cultured cells.

62 ues(4,5) and induces double-strand breaks in cultured cells(3).

63 alkyne conjugates were profiled directly in cultured cells, achieving thiol saturation in a few minu

64 ized the performance of the new NIR GECIs in cultured cells, acute mouse brain slices, and Caenorhabd

65 In cultured cells after a period of serum deprivation, trea

66 FBS-cultured cells also showed higher MsgA and NanA activity

67 A55 or C2 have altered cytopathic effects in cultured cells and altered pathology in vivo Previous st

68 AV to study viral infection dynamics in both cultured cells and animal models of viral infection.

69 ction of monogenic neuromuscular diseases in cultured cells and animal models.

70 With demonstrated utility in both cultured cells and animals, this mRNA delivery technolog

71 By using a live transcription assay in cultured cells and by depleting actin-rich processes in

72 cell oxygen-consumption-rate measurements of cultured cells and by imaging intratumoral metabolic het

73 The protocol is applicable to cultured cells and can potentially also be adapted to pr

74 th DNA activates damage repair mechanisms in cultured cells and causes DNA strand breakage and an inc

75 to achieve efficient cell rearrangements of cultured cells and during embryonic development.

76 t StcE digests cancer-associated mucins from cultured cells and from ascites fluid derived from patie

77 obtained from plasma and viral outgrowth of cultured cells and from proviral DNA were amplified by P

78 dichlorophenes potently inhibit NAPE-PLD in cultured cells and have significant selectivity for NAPE

79 e exhibiting Cl-13 wild-type-like fitness in cultured cells and immunocompromised mice.

80 e show that they exhibit robust signaling in cultured cells and in an acute brain slice preparation.

81 hondrial and nuclear translocation of p53 in cultured cells and in APP/PS1 mice.

82 so (i) gained greater replication ability in cultured cells and in chicken embryos as well as (ii) in

83 2O3 exposure increased MTHFD1 SUMOylation in cultured cells and in in vitro SUMOylation reactions, an

84 substantially increases NAD(+)/NADH ratio in cultured cells and in liver and no induction of apoptoti

85 e to elevated beta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prol

86 d and cofractionated with gamma-secretase in cultured cells and in mouse and human brain.

87 egulation and prostate cancer progression in cultured cells and in mouse models of prostate epitheliu

88 Experiments in cultured cells and in osteoclasts derived from both mous

89 In cultured cells and in samples from patients, HEV produce

90 lating variants defective for replication in cultured cells and in spotted fever pathogenesis.

91 press the GR transcriptional network both in cultured cells and in the mouse liver.

92 surements of their impact on PC synthesis in cultured cells and in tissues with a stringent requireme

93 In cultured cells and in transgenic mice, deficiency in end

94 its efficacy in blocking HCV replication in cultured cells and in treatment of patients with HCV inf

95 sphorylated downstream of AngII signaling in cultured cells and in vitro by PKC and PKA.

96 nscriptionally regulated by SKP2 in vitro in cultured cells and in vivo in mouse models.

97 dented telomere-specific DDR inactivation in cultured cells and in vivo in mouse tissues.

98 pon light-induced CRY2-CIB1 dimerization, in cultured cells and in vivo in rodent brain.

99 tely assess and quantify senescence, both in cultured cells and in vivo.

100 broadly localized to the plasma membrane of cultured cells and intact blood vessels in the inner ret

101 out diminishing WNT-potentiating activity in cultured cells and intestinal organoids.

102 onitoring histone-acetylation levels in both cultured cells and living organisms based on the ratio o

103 exons were essential for the growth of both cultured cells and lung adenocarcinoma xenografts, while

104 can be quantified by expressing the motor in cultured cells and measuring tubulin fluorescence levels

105 affinity and IL-33 antagonistic activity in cultured cells and mice.

106 the mitochondrial oxygen consumption rate of cultured cells and mice.

107 ase II (Pol II) transcription termination in cultured cells and mice.

108 nd identification of sialoglycoproteins from cultured cells and model organisms.

109 e distinct loci on different chromosomes, in cultured cells and mouse embryos alike.

110 Using cultured cells and mouse skeletal muscle, we show that T

111 of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be c

112 We applied this method to both cultured cells and mouse tissues to investigate changes

113 hundreds of ADP-ribosylated proteins in both cultured cells and mouse tissues.

114 roved for cancer treatment reduced growth of cultured cells and mouse tumors in a time-of-day-specifi

115 Eya-So transcriptional output in vivo and in cultured cells and on meta analysis of their chromatin o

116 device successfully captures NO evolution in cultured cells and organs, with results comparable to th

117 pproximately 7-kDa cytoplasmic C terminus in cultured cells and purified from Escherichia coli The al

118 n of SUCLG2 suppressed NE differentiation in cultured cells and reduced prostate tumor growth in a xe

119 er rates of chromosome segregation errors in cultured cells and suppressed shot-induced mitotic arres

120 We use different types of animal tissues and cultured cells and test the performance of the method un

121 orylate ICAP1 at Ser-10 both in vitro and in cultured cells and that active PAK4 inhibits ICAP1 nucle

122 diates aggregation of otherwise non-adherent cultured cells and that loss of Ihog activity disrupts w

123 ed JNK-c-Jun activity in SMA mouse and human cultured cells and tissues.

124 of EVs into biologic fluids is a hallmark of cultured cells and tumors, their payload and biologic ac

125 Here, using cultured cells and two animal models, we demonstrate tha

126 about RNR regulation comes from studies with cultured cells and with purified proteins.

127 protective against mitochondrial toxicity in cultured cells and zebrafish models.

128 0.3 Hz, respectively, for adrenal slices and cultured cells) and increased up to 0.9 Hz after stimula

129 ibe key findings in human postmortem brains, cultured cells, and animal models of disease that suppor

130 planar tissue including rodent brain slices, cultured cells, and brain regions with laminar structure

131 mutations affect SARM1 apoptotic activity in cultured cells, and in this way identified critical olig

132 C and CE in lipid extracts from human serum, cultured cells, and mouse liver.

133 died and was examined using human specimens, cultured cells, and mouse model systems.

134 dolosa induced a robust cytokine response in cultured cells, and this effect was dependent on the fla

135 phaDKRC transgene was designed, validated in cultured cells, and used to make transgenic mice.

136 In cultured cells, androgen suppressed the expression of th

137 and expand Ag-specific memory B cells; these cultured cells are highly effective in presenting Ag to

138 es, but differences in CA between tumors and cultured cells are uncharacterized.

139 istance to glutamate-induced cytotoxicity in cultured cells as well as increased carbon tetrachloride

140 cells, optimized the protocol for suspension cultured cells, as this is the industrial practice for C

141 In cultured cells, AS69 reduced the self-interaction of [Fo

142 In cultured cells, BIRFLU displayed growth kinetics compara

143 Experiments in cultured cells, brain slices, and in living mice demonst

144 ffected the kinetics of VEEV accumulation in cultured cells but strongly inhibited its pathogenesis i

145 NPLA3 and CGI-58 resulted in LD depletion in cultured cells, but expression of PNPLA3 alone did not.

146 Stx1a is more toxic to cultured cells, but Stx2 subtypes are more potent in ani

147 tes similarly to the wild-type (WT) virus in cultured cells, but the DUBmut virus activates an IFN re

148 cit insulin-like signaling by mutant INSR in cultured cells, but whether this translates into meaning

149 RNA and lipids in single organelles of live cultured cells by biomolecular component analysis using

150 ation of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to

151 e show that PIM1 is modified in vitro and in cultured cells by the Small ubiquitin-like modifier (SUM

152 In cultured cells, CHCHD10 knockdown results in OPA1-mitofi

153 Experiments in cultured cells confirmed the link between TRAF3 and NF-k

154 y more embedded ribonucleotides than that of cultured cells, consistent with the high ratio of ribonu

155 t displayed altered substrate specificity in cultured cells, consistent with the idea that SUMOylatio

156 mal aggregation in NHFs-cultured cells, MWFs-cultured cells contain more and bigger lysosomal accumul

157 The cultured cells contained HPV-16, formed colonies in soft

158 old signal amplification in diverse samples (cultured cells, cryosections, formalin-fixed paraffin-em

159 ansgenic Drosophila, providing evidence that cultured cell cytoneme analysis is predictive of in vivo

160 Here, we introduce a fixation method whereby cultured cell cytonemes can be preserved for imaging stu

161 e novel missense NOTCH1 and DLL4 variants in cultured cells demonstrate reduced signalling activity,

162 For example, SARS-CoV infection of cultured cells depends on endosomal acid pH-dependent pr

163 e screen did not affect circadian rhythms in cultured cells derived from luminescent reporter embryos

164 Here, we show that knockout of GSAP in cultured cells directly reduces gamma-secretase activity

165 The integration profile of AAV-465lambda in cultured cells display both full-length and fragmented A

166 hat conclusions based on studies of Doc2b in cultured cells do not necessarily generalize to mature s

167 hromosome could be selectively eliminated in cultured cells, embryos, and tissues in vivo.

168 ntitative assessments of target occupancy in cultured cells, emphasizing generalizable methodologies

169 D), are inhibited in c9ALS/FTD brains and in cultured cells expressing either of two arginine-rich di

170 Cultured cells expressing VopA were also impaired in the

171 In cultured cells, expression of both the mutant SDR9C7 pro

172 MATAL LINEAGE) in the simplifying context of cultured cell filaments and in protoplasts before and du

173 We demonstrate that cultured cells form multiple nanotubes that mediate inte

174 Cultured cells from both diseases have similar sensitivi

175 th animal models of fibrous dysplasia and in cultured cells from individuals with MAS but not in huma

176 demonstrate that EVs containing CysC protect cultured cells from starvation-induced death.

177 In mice lacking CPEB1 and in cultured cells from which CPEB has been depleted, random

178 In cultured cells, Fucci(CA) produced a sharp triple color-

179 MiDs in a time- and dose-dependent manner in cultured cells grown ex vivo or in vivo.

180 Genetic engineering of model organisms and cultured cells has for decades provided important insigh

181 aithfully recapitulates human disease; thus, cultured cells have been used to model Shigella pathogen

182 Biochemical analyses and studies in cultured cells have identified a large number of protein

183 Studies in cultured cells have reported that zinc stimulates the en

184 Consistent with the results in cultured cells, hepatic levels of Insig-2 mRNA were enha

185 of p-c-Jun levels in SMA compared to control cultured cells, human or mouse spinal cord tissues, or m

186 RAMP consists of coexpressing in cultured cells (i) an organellar protein fused to the st

187 10 change during C. trachomatis infection of cultured cells in a manner dependent on both host and pa

188 We cultured cells in uniform conditions and profiled genome

189 organization and dynamics are controlled in cultured cells in vitro However, our understanding of mi

190 ng machines have been studied extensively in cultured cells; in contrast, remarkably little is known

191 requirements to achieve lytic replication in cultured cells included (i) either in vitro cultures of

192 Experiments performed on cultured cells indicated that Doc2 proteins promote spon

193 ce for deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DN

194 The retention of bioenergetic defects in cultured cells indicates that there is a genetic or epig

195 , ruzasvir, velpatasvir, and pibrentasvir in cultured cells infected with HCV recombinants expressing

196 In cultured cells, infectivity and cytokine induction were

197 CPC also targeted CSE in cultured cells, inhibiting transsulfuration flux by 80-9

198 has been to determine why VZV, when grown in cultured cells, invariably is more cell associated and h

199 encephalitis in mice, and its replication in cultured cells is inhibited by the zinc finger antiviral

200 The application of mechanical forces to cultured cells is often performed using specialized syst

201 icroscopy (SMLM), while well established for cultured cells, is not yet fully compatible with tissue-

202 Overexpression of CK1epsilon in cultured cells led to increased tau phosphorylation at m

203 In cultured cells, LHK15 did not react with K15 deficient N

204 tween MTCBP-1 and MT1-MMP expression both in cultured cell lines and human pancreatic tumors.

205 We used mouse models, cultured cell lines and patient-derived xenografts to de

206 Cultured cell lines are the workhorse of cancer research

207 Cultured cell lines are widely used for research in the

208 nthetic yeast centromeric plasmids (YCps) to cultured cell lines at rates similar to that of 12 kb YC

209 studying the effect of anti-cancer drugs in cultured cell lines by monitoring phosphatidylserine tra

210 nts make multiplex genetic assays in diverse cultured cell lines easier, cheaper and more effective,

211 Cultured cell lines infected with HCMV show induction of

212 We found that in cultured cell lines, FAM92A colocalizes with Cby1 at the

213 Using cultured cell lines, gastric biopsy specimens, primary c

214 sed chromatin organization studies have used cultured cell lines, limiting their generalizability.

215 Using cultured cell lines, primary neurons, and organotypic br

216 or 16,698 single cells from a combination of cultured cell lines, primate frontal cortex tissue and t

217 These effects are observed in 3D-cultured cell lines, tumor organoids, chemoresistant xen

218 ariations in cell-cycle requirements between cultured cell lines, we generated knockouts across cell

219 rter plasmids into Huh7, BNL-1ME, and HEK293 cultured cell lines.

220 sion in mice, in human kidney tissue, and in cultured cell lines.

221 In cultured cells, mitotic delays resulting from centrosome

222 Using a cultured cell model of erythroid differentiation, deplet

223 Herein, we describe cultured cell model systems and common assays that have

224 m Hydra to humans, with reference to ex vivo-cultured cell models of pluripotency when appropriate.

225 ate partners interacted both in vitro and in cultured cell models.

226 lticellular spheroids as a 3D cell model and cultured cell monolayers as a 2D cell model.

227 iled-coil containing protein 3) signaling in cultured cells more effectively than either BGJ398 or ga

228 tochondrialand lysosomal aggregation in NHFs-cultured cells, MWFs-cultured cells contain more and big

229 and the basal body in different tissues and cultured cells of Drosophila melanogaster, highlighting

230 e conformation capture (Hi-C) generated from cultured cells of nine individuals with developmental di

231 cellular matrix (ECM) scaffolds derived from cultured cells or natural tissues exhibit superior bioco

232 In cultured cells, overexpressed Smad3 is sufficient to ind

233 Functional analysis in cultured cells overexpressing FLAG-tagged wild-type or m

234 ased the incidence of inclusion formation in cultured cells overexpressing P23H rod opsin, and increa

235 In cultured cells, overexpression of VPS4A mutants caused e

236 tial for binding to beta-Catenin in vitro In cultured cells, phosphorylation of specific serine resid

237 jectories and equilibrium convergence of the cultured cell population.

238 also show that association rates measured in cultured cells predict the extent of internalization of

239 s capable of interaction with poly(A) RNA in cultured cells, primarily mediated by the N-terminal reg

240 formin and a constitutive stress response in cultured cells, primary patient cells, and Drosophila ne

241 In cultured cells, Rbpr2 localized to membranes and promote

242 lantable electrode arrays capable of housing cultured cells, referred to as biohybrid implants.

243 Cultured cells require the actions of growth factors to

244 Whether laboratory-cultured cells retain a similar generative capacity rema

245 iption (TPRT) and mobilized efficiently in a cultured cell retrotransposition assay.

246 Previous studies in cultured cells (Schumacher et al., 2015) revealed that U

247 HSV infection in these cultured cells shows the properties expected for a laten

248 on of desthiobiotin-functionalized probes to cultured cells simplified enrichment and elution to enab

249 Here, we report that in SPECC1L-knockdown cultured cells, staining of canonical adherens junction

250 amount of total TGFbeta stored in the ECM of cultured cells, suggesting that the MAGPs compete with t

251 elta39) exhibited decreased viral fitness in cultured cells, suggesting the feasibility of using this

252 d from host cells in response to bacteria in cultured cell systems and in the intestine in vivo Uric

253 This is observed in cultured cell systems, as well as in clinical trials in

254 In cultured cells, tacrolimus inhibited dephosphorylation o

255 In cultured cells, TBK1 associates with and activates mTORC

256 In cultured cells, the compound can block the interaction o

257 In human cultured cells, the compounds inhibit phosphorylation-de

258 nd enhances spontaneous cationic currents in cultured cells, the first C-terminal mutant to do so.

259 In cultured cells, the loss of S-sulfhydration impaired int

260 In cultured cells, the mutations reduced the DNA binding af

261 s by analyzing LZA element function in human cultured cells; the LZA element-mediated transcriptional

262 In cultured cells, this capacity is tightly aligned to phos

263 t Pik3ca induces centrosome amplification in cultured cells (through a pathway involving AKT, ROCK an

264 science as well as clinical studies such as cultured cells, tissue homogenates, and serum.

265 In cultured cells, TMG promoted sequestration of the cap-bi

266 increasingly intact biological systems, from cultured cells to acute brain slices to behaving mice.

267 ss such mechanisms, we subjected transformed cultured cells to chronic circadian desynchrony (CCD), m

268 Importantly, the responses by cultured cells to density signals also uncover key mecha

269 Here we used cultured cells to examine the coordinated regulation of

270 for the fast isolation of mitochondria from cultured cells to generate MITO-Tag Mice.

271 lain elevated CA in vivo because exposure of cultured cells to hypoxia or mimicking hypoxia pharmacol

272 4me3) and H3K36me3 after a brief exposure of cultured cells to hypoxia predict the cell's transcripti

273 translating systems-biology approaches from cultured cells to living organisms.

274 B induction in Drosophila animal tissues and cultured cells to more deeply interrogate the impact of

275 oncentrations of F10 over serial passages in cultured cells to select for escape mutations.

276 In cultured cells, treatment with sunitinib and erlotinib,

277 Oleate treatment of cultured cells triggered CCTalpha translocation to the n

278 L types in a highly disease-relevant primary cultured cell type and provide novel insights into their

279 ted coincreases of NEAT1 and paraspeckles in cultured cells under paraquat (PQ)-induced oxidative str

280 and assessed the functions of strumpellin in cultured cells using both overexpression and RNA interfe

281 sociated AAA+ ATPase VPS4 on EV release from cultured cells using two methods for EV recovery, differ

282 extracellular matrix proteins from normally cultured cells was 1.1 mmol/mol tyrosine and decreased s

283 Inhibitor efficacy in cultured cells was studied using a human mammary epithel

284 Using cultured cells, we previously showed that sterols trigge

285 To understand this phenomenon in cultured cells, we used a system that combines flow cyto

286 Cultured cells were treated or not with sodium iodoaceta

287 Cultured cells were treated with short interfering RNA (

288 latory activity of GPC6 was also observed in cultured cells, where this GPC increased the binding of

289 uptake and beta-oxidation were increased in cultured cells, whereas adipose tissue morphology, gluco

290 describes how to identify the active RBPs in cultured cells, whereas this Protocol Extension also ena

291 ectron battery by stimulating a monolayer of cultured cells, which fluoresces a calcium ion wave at a

292 nfection activated the RIPK3-MLKL pathway in cultured cells, which resulted in suppression of intrace

293 odal monitoring and localized control of the cultured cells, which thereby allows minimizing operatio

294 iently attenuated, and grow to high titer in cultured cells, while retaining high immunogenicity.

295 ssional phagocytosis was studied by staining cultured cells with live-cell staining dyes or by staini

296 Treatment of cultured cells with SBI-797812 increases intracellular N

297 DNA aptamers capable of homing to nuclei of cultured cells without transfection agents or viral tran

298 lian homologue Afadin plays similar roles in cultured cells, working in parallel with ZO-1 proteins,

299 ools for the efficient delivery of mRNA into cultured cells would advance many areas of research, and

300 acologic modulation of IRE1alpha and PERK in cultured cells, xenograft, and spontaneous genetic (RIP-

301 Serum starvation stimulates cilia growth in cultured cells, yet serum factors associated with ciliog