ライフサイエンスコーパス: cyanate

1 nts of OSCN(-) (hypothiocyanite) and OCN(-) (cyanate).

2 healthy subjects was induced with potassium cyanate.

3 dation and preventing the formation of toxic cyanate.

4 roxidase activity was not affected by sodium cyanate.

5 ministration of 100, 200 or 300 mg/kg sodium cyanate.

6 zide or other weak acids such as formate and cyanate.

7 ')-cyanated 2-aryl-2H-indazoles 3a-j, (C-2')-cyanated 1-aryl-1H-indazoles 4a-j [distal], or C-3 cyana

8 bond formation method that results in (C-2')-cyanated 2-aryl-2H-indazoles 3a-j, (C-2')-cyanated 1-ary

9 ed 1-aryl-1H-indazoles 4a-j [distal], or C-3 cyanated 2-aryl-2H-indazoles 5a-i [proximal] products in

10 hesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as antica

11 bserved product groups: (1) carboxylates and cyanate; (2) formate, amide and CO(2).

12 Sodium cyanate, a neurotoxic chemical in rodents, primates and

13 Cyanate, a reactive electrophilic species in equilibrium

14 Cyanate, a reactive species in equilibrium with urea, ca

15 ar rates of nitrite production from urea and cyanate additions, which often persisted even when ammon

16 bered cobaltacycle that then reacts with the cyanating agent.

17 bered cobaltacycle that then reacts with the cyanating agent.

18 lled release of glycolonitrile as the active cyanating agent.

19 irect access to carbon-labeled electrophilic cyanating agents suitable for both radioactive (14)C and

20 It has the capacity to utilize urea and cyanate and a mixotrophic lifestyle.

21 ; but rather (3) that urea, via breakdown to cyanate and ammonium ions, may cause cell stress because

22 r ring by treatment with beta-ethoxyacryloyl cyanate and cyclization to form the uracil ring.

23 ep involves a carbamylation reaction between cyanate and the nascent alpha amino group resulting from

24 On the other hand, the use of iso(thio)cyanates and arylcarbodiimides led to non-rearranged o-f

25 bstituent groups R in heteroatom-substituted cyanates and thiocyanates RX-YCN and the isomeric isocya

26 ilyl azide or isocyanate or potassium azide, cyanate, and bromide) to yield unstable hypervalent iodi

27 and ions, notably carbon monoxide, cyanide, cyanate, and hydrogen sulfide, are potent inhibitors of

28 pe involve the HOMO of a nearly linear (thio)cyanate anion and the LUMO of the acyl cation, in partic

29 ditions demonstrate that insoluble inorganic cyanate anion is activated by bromide displacement on a

30 -), is the heaviest group 16 congener of the cyanate anion, [OCN](-).

31 containing analogues of the thio- and seleno-cyanate anions, PCSe(-) , AsCS(-) , and AsCSe(-) , as we

32 these results, we hypothesize that urea and cyanate are substrates for ammonia-oxidizing Thaumarchae

33 that marine Thaumarchaeota can use urea and cyanate as both an energy and N source.

34 isolates have been shown to utilize urea and cyanate as energy and N sources through intracellular co

35 A range of substrates has furnished cyanated azaindoles in good to excellent yields under th

36 odynamic potential--EPR spectra confirm that cyanate binds selectively to C(red2).

37 lternative sources of ammonia, such as urea, cyanate, biuret, triuret and nitriles.

38 Gulf of Mexico, Thaumarchaeota use urea and cyanate both directly and indirectly as energy and N sou

39 mposition, forming an equilibrium mixture of cyanate (CNO(-)) and the reactive electrophile isocyanat

40 during its facile reaction with CO to form a cyanate complex, demonstrating the nucleophilic reactivi

41 Their dependencies on pH and azide or cyanate concentrations are consistent with both earlier

42 hronic urea overload significantly increases cyanate concentrations in patients with ESKD, leading to

43 ing reactions with dialkynes, while the (iso)cyanate-containing polymers reacted with diamines to aff

44 hydrolysis product, cyanoacetaldehyde), with cyanate, cyanogen, or urea.

45 Sodium cyanate depleted GSH levels in all regions of mouse brai

46 action of cysteine sulfhydryls with residual cyanate derived from urea.

47 marchaeota incorporated ammonium-, urea- and cyanate-derived N at significantly higher rates than mos

48 KC8 reduction of 3 resulted in cyanate dissociation to give [U(Tren(TIPS))] (4) and KNC

49 litates a direct thiocyanate conversion into cyanate, elemental sulfur, and two reducing equivalents

50 100 hours, highlighting the benefits of the cyanated end group and the synthetic approach.

51 llustrated using agarose supports containing cyanate ester, N-hydroxy-succinimide, and epoxy function

52 ve and quantitatively dominant mechanism for cyanate formation and protein carbamylation at sites of

53 combination of NMR and IR spectroscopy, and cyanate formation was further confirmed by performing a

54 grating R group and the neighboring iso(thio)cyanate function.

55 ous amino ester hydrochlorides and potassium cyanate in a planetary ball-mill is described.

56 to generate V(N[t-Bu]Ar)(3) (1-V) and sodium cyanate in an isolated yield of 77%.

57 plications on the presence of magnesium (iso)cyanates in the ISM and the chemical model for the dust

58 tissue GSH/GSSG ratios, likely results from cyanate-induced inhibition of glutathione reductase acti

59 rovide a direct source of isocyanic acid and cyanate ion (NCO(-)) to humans at levels that have recog

60 active intermediates, such as free radicals, cyanate ions, and isocyanic acid, which can form cross-l

61 (3) Cyanate is a strong inhibitor of CO(2) reduction but inh

62 of aryl chlorides and triflates with sodium cyanate is reported.

63 scopy, fluorescence from fluorescein isothio-cyanate-labeled FN-oligonucleotides was detected in reti

64 ximately thiocyanate approximately nitrate < cyanate < azide < fluoride << cyanide.

65 Cyanate modification of the lysines in model alpha-helix

66 , is chemically masked with an electrophilic cyanate motif in order to construct a fluorescent probe

67 nsfer from inorganic azide ([Bu(4)N][N(3)]), cyanate (Na[NCO]), and phosphonate (Na(dioxane)(2.5)[PCO

68 ation of C(sp(2))-H nucleophiles with sodium cyanate (NaOCN) is reported.

69 The molecular and cellular mechanisms of cyanate neurotoxicity are not understood.

70 The results of this study suggest that cyanate neurotoxicity, and perhaps cassava-associated ne

71 Recent studies suggest that cyanate (OCN(-)) is a potentially important source of re

72 addition to N3(-), thiocyanate ((-)SCN) and cyanate ((-)OCN) anions were also studied.

73 avity (e.g.: fluoride, F(-); cyanide, CN(-); cyanate, OCN(-); thiocyanate, SCN(-); and nitrate, NO(3)

74 This study investigates the effect of sodium cyanate on glutathione (GSH) homeostasis in rodent brain

75 aeota in the ocean directly utilize urea and cyanate or rely on co-occurring microorganisms to break

76 Addition of the weakly acidic anions azide, cyanate, or formate accelerates the decay of the O inter

77 . pasteurianum was activated by thiocyanate, cyanate, or sulfhydryl compounds; inhibited by sulfite,

78 demonstrated by transforming the synthesized cyanated product into numerous other functional groups,

79 Acyl-, alkoxycarbonyl-, and carbamoyl cyanates R-CO-OCN are predicted to be in some cases isol

80 ing N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent in the presence of AgOTf and NaOAc in

81 d, using nontoxic potassium thiocyanate as a cyanating reagent in the presence of silica sulfuric aci

82 Employing the electrophilic cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide

83 repare aryl nitriles by using a carbon-bound cyanating reagent which undergoes cross-coupling with th

84 substituted 1,3-dienes and an electrophilic cyanating reagent with high regio and stereocontrol.

85 om aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN

86 sily accessible and environmentally friendly cyanating reagent, NCTS.

87 g with reactants such as carbonyl compounds, cyanating reagents, aminating reagents, halogenating rea

88 ion to give [U(Tren(TIPS))] (4) and KNCO, or cyanate retention in [U(Tren(TIPS))(NCO)][K(B15C5)2] (5,

89 The strategy is based on a [3,3]-allyl cyanate sigmatropic rearrangement from enantioenriched g

90 f 2-phenylpyridine derivatives and potassium cyanate through C-H bond functionalization in the presen

91 zes the bicarbonate-dependent degradation of cyanate to produce ammonia and carbon dioxide, and ammon

92 -allenyl rearrangement, conversion of benzyl cyanates to o-isocyanatotoluenes, and conversion of N-cy

93 is based on enzymatic kinetic resolution and cyanate-to-isocyanate rearrangement as key steps.

94 The key step is stereospecific allyl cyanate-to-isocyanate rearrangement, which proceeds with

95 The key step is allyl cyanate-to-isocyanate rearrangement.

96 ha-tertiary allylamines via stereocontrolled cyanate-to-isocyanate sigmatropic rearrangement reaction

97 ming conventional C-N bonds via irreversible cyanate trimerization to forming the C-O bonds through r

98 H2CH2NSiiPr3)3) with CO gave the uranium(IV) cyanate [U(Tren(TIPS))(NCO)] (3).

99 ic Ni(3+) active sites, thus augmenting the "cyanate" UOR pathway.

100 le for the conversion of azide to nitride to cyanate using 4, NaN3 and CO is presented.

101 dizing communities(7-10), but no evidence of cyanate utilization exists for marine ammonia oxidizers.

102 Therefore, we tested cyanate utilization in Nitrosopumilus maritimus, which a

103 o lacks a canonical cyanase, and showed that cyanate was oxidized to nitrite.

104 d is met by the organic-N compounds urea and cyanate, while AOA mainly assimilate ammonium.

105 The reaction of sodium cyanate with benzo[ b]quinolizinium substrates at room t

106 Reaction of cyanate with the alpha-amino group of hemoglobin (HbOCN)