ライフサイエンスコーパス: cyano

1 ps, including keto, imino, ester, ether, and cyano.

2 blockade with D3R antagonist trans-N-4-2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethylcyclohexy

3 p unexpectedly found that N-[(1r,4r)-4-[2-(7-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexy

4 g as C-C-S building blocks produce 5-amino-4-cyano-1,2,3-thiadiazoles exclusively.

5 ne (E-1), (Z)-1-cyano-1,3-butadiene (Z-1), 4-cyano-1,2-butadiene (2), and 2-cyano-1,3-butadiene (3).

6 ve synthesis was developed to generate (E)-1-cyano-1,3-butadiene (1) (10:1 E/Z) via tandem S(N)2 and

7 the E2' reactions leading to (E)- and (Z)-1-cyano-1,3-butadiene (1) were analyzed by density functio

8 iene (Z-1), 4-cyano-1,2-butadiene (2), and 2-cyano-1,3-butadiene (3).

9 yields and isolated as pure compounds: (E)-1-cyano-1,3-butadiene (E-1), (Z)-1-cyano-1,3-butadiene (Z-

10 unds: (E)-1-cyano-1,3-butadiene (E-1), (Z)-1-cyano-1,3-butadiene (Z-1), 4-cyano-1,2-butadiene (2), an

11 example: The reported 1.643 A C-C bond in 5-cyano-1,3-dehydroadamantane was redetermined and "only"

12 ute for the construction of functionalized 2-cyano-1,4-diketones has been established from the nucleo

13 Now, a series of six novel 6-amino-5-cyano-1,4-disubstituted-2(1H)-pyrimidinones 5a-5f and tw

14 molecular Pauson-Khand reactions of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched

15 -tolyl-2(1H)-pyrimidinone (5b) and 6-amino-5-cyano-1-(naphthalen-1-yl)-4-p-tolyl-2(1H)-pyrimidinone (

16 2-Cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[2-(phenylsulfanyl

17 alternative synthetic approach toward ( S)-4-cyano-1-aminoindane as a chiral key intermediate for oza

18 ading to the desired key intermediate ( S)-4-cyano-1-aminoindane in satisfactory yield and with excel

19 mation of the 4-carboxy-indanone into ( S)-4-cyano-1-aminoindane then represents the key step for int

20 ean-1,12-dien-30-oate (CF3DODA-Me) contain 2-cyano-1-en-3-one and 2-trifluoromethyl-1-en-3-one moieti

21 The rotational barriers of 6-amino-5-cyano-1-o-tolyl-4-p-tolyl-2(1H)-pyrimidinone (5b) and 6-

22 nished 2,2'-bipyrroles as well as 5,5'-bis(5-cyano-1-pyrrolines), depending on the reaction condition

23 (+)-2-Cyano-1-{[trans-(1S,3S)-3-(1H-imidazol-4-yl)cyclopentyl]

24 bromo(7,8), phosphonate(9), enediyne(10,11), cyano(12), diazo(13), alkene(14) and alkyne(15-17) group

25 denosine analogs in this class identified 1'-cyano-2'-C-methyl 4-aza-7,9-dideaza adenosine as a poten

26 GS-6620, a phosphoramidate derivative of 1'-cyano-2'-C-methyl-4-aza-7,9-dideazaadenosine C-nucleosid

27 The nucleoside analog 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosyl-cytosine

28 able to sugar-protected 6-cyanouridine and 6-cyano-2'-deoxyuridine without the protection at the N(3)

29 The enols of 4-cyano-2,2,6,6-tetramethyl-3,5-heptanedione and of nitrom

30 ase of compound 2a and 3,4-trans-1-benzoyl-4-cyano-2,3-(6-bromotetrahydroisoquinoline)tetrahydropyraz

31 l % catalyst to afford 3,4-trans-1-benzoyl-4-cyano-2,3-(tetrahydroisoquinoline)tetrahydropyrazole (2a

32 R,4S)-1 affords (+)-(2R,3R)-2-carbomethoxy-3-cyano-2,3-diphenyl-butane 2 with two adjacent stereogeni

33 t bacterial abundance, metabolic activity (5-cyano-2,3-ditolyl tetrazolium chloride (CTC+) cells), an

34 In contrast to the other epithionitriles, 1-cyano-2,3-epithiopropane is highly reactive.

35 Here, we characterized the reactivity of 1-cyano-2,3-epithiopropane under aqueous heat treatment co

36 The epithionitriles, 1-cyano-2,3-epithiopropane, in particular, and 1-cyano-3,4

37 o-alpha-cyanocinnamic acid (ClCCA) and alpha-cyano-2,4-difluorocinnamic acid (DiFCCA) matrixes.

38 hexasubstituted (+)-(2R,4S)-2-carbomethoxy-4-cyano-2,4-diphenyl-3-pentanone 1.

39 Ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino)acetate (o-Nosyl

40 Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY

41 Most importantly, byproducts Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] and 4-nitrobenzenesulfoni

42 oate (4a and 17) and (E)- and (Z)-diethyl (1-cyano-2-heptenyl)phosphate (21a and 21b) with organocupr

43 ((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283), reveal striking conf

44 oswitch 2, luminophore 3) was treated with 2-cyano-2-phenylpropanoic acid (4) as a chemical fuel, pro

45 ne are triggered by the decarboxylation of 2-cyano-2-phenylpropanoic acid and detected by the oscilla

46 atalyst conditions using n-Bu4NBr afforded 2-cyano-2-siloxyvinylallenes via a tandem process that inv

47 abolic stability afforded N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-s

48 on of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A1

49 2-Substituted 1,4-benzodioxanes, such as 2-cyano-, 2-methoxycarbonyl-, 2-aminocarbonyl-, and 2-form

50 penoids such as bardoxolone methyl (methyl-2-cyano 3,12-dioxooleano-1,9-dien-28-oate; CDDO-Me) (4) ar

51 Compound 21 [N-(4'-cyano-3'-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonam

52 y related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate [bardoxolone-meth

53 In addition, 2-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-ethyl a

54 iterpenoids, bardoxolone methyl (BARD) and 2-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-ethyl a

55 the non-steroidal anti-inflammatory drug, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid-ethyl am

56 ministration of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-C28-methyl ester (CD

57 Our previous work demonstrates that the 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and i

58 ap1 expression or by the reactive compound 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid methyl ester

59 The triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid (CDDO) and i

60 extensively used octocrylene (2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, OCT) was frequently fou

61 we have demonstrated that N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-

62 gs to those of the related epithionitriles 1-cyano-3,4-epithiobutane and 1-cyano-4,5-epithiopentane.

63 ano-2,3-epithiopropane, in particular, and 1-cyano-3,4-epithiobutane, are important, but yet underest

64 Focused library development of our lead 2-cyano-3-(1-(3-(dimethylamino)propyl)-2-methyl-1H-indol-3

65 Compound 18 [( E)-2-Cyano-3-(2,4-dichlorophenyl)but-2-enamide] induced the h

66 naling [aurintricarboxylic acid (ATA), (E)-2-cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenami

67 ent with the JAK/STAT inhibitor AG490 [(E)-2-cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenami

68 f the new molecules, compounds 2-75 [4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-th

69 xoheptyl)benzamide] and 1005 [(E)-3-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-th

70 activation of Nrf2 by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9 (11)-dien-28-oyl]imidazole l

71 ive allosteric modulation [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl

72 d the concentration of generated (R)-ethyl-4-cyano-3-hydroxybutyrate ((R)-CHCN).

73 h as isopropylidenemalononitrile and ethyl 2-cyano-3-methyl-2-butenoate underwent the phospha-Michael

74 derived from [Ir(cod)Cl]2, allyl acetate, 4-cyano-3-nitro-benzoic acid, and (R)-MeO-BIPHEP catalyzes

75 m C,O-benzoate derived from allyl acetate, 4-cyano-3-nitrobenzoic acid and (S)-SEGPHOS delivers produ

76 atalyst (R)-I derived from [Ir(cod)Cl](2), 4-cyano-3-nitrobenzoic acid, (R)-SEGPHOS, and allyl acetat

77 complex (S)-I derived from [Ir(cod)Cl](2), 4-cyano-3-nitrobenzoic acid, allyl acetate, and (S)-SEGPHO

78 ecific janus kinase 2 (JAK2) inhibitor alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG-490) and the

79 s observed, including direct comparison of 3-cyano-, 3-nitro-, and 3-phenyl-substituted BF2 formazana

80 Mitsunobu chemistry afforded 6-cyano (35) and 6-azido (36) analogues of GlcN-(Cbz), and

81 ginal coumarin dyes has been replaced by the cyano(4-nitrophenyl)methylene moiety.

82 he magnetic field-aligned nematic phase of 4-cyano-4'-n-pentylbiphenyl (5CB) at 295 K.

83 In this system, 4-cyano-4'-pentyl biphenyl (5CB) was doped with a sulfur-

84 at room temperature for TDI(2) aligned in 4-cyano-4'-pentylbiphenyl (5CB), a nematic liquid crystal.

85 tudied in the nematic liquid crystal (NLC) 4-cyano-4'-pentylbiphenyl (5CB): Both point and ring topol

86 cterizing the orientations of nematic LCs (4-cyano-4'-pentylbiphenyl and TL205 (a mixture of mesogens

87 e interface between air and the nematic LC 4-cyano-4'-pentylbiphenyl create quadrupolar distortions i

88 ecules such as squalane, polyisoprene, and 4-cyano-4'-pentylbiphenyl into a nanocrystal suspension, t

89 aces of thermotropic liquid crystals (LCs; 4-cyano-4'-pentylbiphenyl) triggers spatially localized (m

90 tron-withdrawing group, 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF), with a tri

91 ctron-accepting group 2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF).

92 thionitriles 1-cyano-3,4-epithiobutane and 1-cyano-4,5-epithiopentane.

93 Starting from the previously identified 3-cyano-4,6-diphenyl-pyridines, we chemically modified thi

94 d with the RAFT chain transfer agent (CTA) 4-cyano-4-(ethylsulfanylthiocarbonylsulfanyl) pentanoic ac

95 previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring clos

96 elective androgen receptor modulator, (S)-(7-cyano-4-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydrocyclopent

97 In contrast, 4-cyano-4-biphenylcarboxylic acid (CBCA) is calculated to

98 h various polysaccharide/protein ratios by 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP)

99 ation curves of standard peptides with alpha-cyano-4-hdydroxycinnamic acid as a matrix.

100 in culture using the MCT-4 inhibitor, alpha-cyano-4-hydroxy-cinnamic acid (CHCA), a cinnamon derivat

101 th PR(4)(+) cations and ferulate (FA), alpha-cyano-4-hydroxycinnamate (CHCA), and 2,5-dihydroxybenzoa

102 r of mitochondrial pyruvate transport, alpha-cyano-4-hydroxycinnamate.

103 er to the pyruvate transport inhibitor alpha-cyano-4-hydroxycinnamate.

104 sulation of an anticancer therapeutic, alpha-cyano-4-hydroxycinnamic acid (alpha-CHC), and subsequent

105 did two other commonly used matrixes, alpha-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxyben

106 on to its well-established predecessor alpha-cyano-4-hydroxycinnamic acid (CHCA) is significantly dep

107 Two ILs derived from alpha-cyano-4-hydroxycinnamic acid (CHCA) were synthesized and

108 nzoic acid (DHB), sinapinic acid (SA), alpha-cyano-4-hydroxycinnamic acid (CHCA), 2,6-dihydroxyacetph

109 nzoic acid (DHB), 4-nitroaniline (NA), alpha-cyano-4-hydroxycinnamic acid (CHCA), and sinapic acid (S

110 spectrometry (MS) bacteria profiling, alpha-cyano-4-hydroxycinnamic acid (CHCA), sinapinic acid (SA)

111 s, 2,5-dihydroxybenzoic acid (DHB) and alpha-cyano-4-hydroxycinnamic acid (CHCA).

112 D(4)-alpha-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthe

113 es 2,5-dihydroxybenzoic acid (DHB) and alpha-cyano-4-hydroxycinnamic acid (HCCA) as well as five halo

114 5-dihydroxybenzoic acid + pyridine and alpha-cyano-4-hydroxycinnamic acid + butylamine) were investig

115 Comparisons with other UV matrixes (alpha-cyano-4-hydroxycinnamic acid and sinapinic acid) and ion

116 ation of TBA (tributylamine) and CHCA (alpha-Cyano-4-hydroxycinnamic acid) as extraction solvent.

117 DHB (2,5-dihydroxybenzoic acid), CHCA (alpha-cyano-4-hydroxycinnamic acid), and 2-mercaptobenzothiazo

118 mparison to classical matrices such as alpha-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid,

119 imination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform

120 -2(1H)-pyrimidinones 5a-5f and two 6-amino-5-cyano-4-p-tolyl-1-substituted-2(1H)-pyrimidinethiones 6a

121 N-(2-((3-Cyano-5,7-dimethylquinolin-2-yl)amino)ethyl)-3-methoxybe

122 was obtained with the fluorescent substrate cyano(6-methoxy-naphthalen-2-yl)methyl glycidyl carbonat

123 N-{trans-3-[(5-Cyano-6-methylpyridin-2-yl)oxy]-2,2,4,4-tetramethylcyclo

124 he utility of our approach, we synthesized 2-cyano-7-(N,N-diethylamino)pyrene (3), a pyrene analogue

125 es of 3 are compared to those of DMABN and 2-cyano-7-(N,N-dimethylamino)-4,5,9,10-tetrahydropyrene, a

126 xy-7-amido-7-deazaguanine (dADG), 2'-deoxy-7-cyano-7-deazaguanine (dPreQ(0)) and 2'-deoxy-7- aminomet

127 yzes the reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ(0)) to 7-aminomethyl-7-deazag

128 nine (CDG) into its corresponding nitrile, 7-cyano-7-deazaguanine (preQ0 ).

129 In nature, QueF converts 7-cyano-7-deazaguanine (preQ0) into 7-aminomethyl-7-deazag

130 glycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis and DNA metabolis

131 ne modification enzyme, together with four 7-cyano-7-deazaguanine synthesis genes.

132 rmation of the native substrates NADPH and 7-cyano-7-deazaguanine.

133 ystematic structural modifications to the (8-cyano-7-hydroxyquinolin-2-yl)methyl (CyHQ) chromophore t

134 otorearrangement reaction promoted by the (8-cyano-7-hydroxyquinolin-2-yl)methyl (CyHQ) photoremovabl

135 ting Plk1 with a small molecule inhibitor (5-Cyano-7-nitro-2-(benzothiazolo-N-oxide)-carboxamide) or

136 ody, and the glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dion abolishes evoked MGF r

137 cid (AP-5) and AMPA/KA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) acted on RGCs

138 onal EPSPs as well as a local injection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and (2R)-amino

139 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a partial ago

140 ly reduced by the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whereas this

141 preparations, blockade of this region with 6-cyano-7-nitroquinoxaline-2,3-dione and (2R)-amino-5-phos

142 ven extremely low efficacy ligands such as 6-cyano-7-nitroquinoxaline-2,3-dione can produce a full lo

143 nase (BTK), we serendipitously discover that cyano-acrylamide-based reversible covalent chemistry can

144 ed an endovascular embolization with N-butyl-cyano-acrylate (NBCA) glue.

145 rform an endovascular treatment with N-butyl-cyano-acrylate (NBCA) glue.

146 The cyano adducts were characterized by UV-vis, EPR, and END

147 cade reaction of ene-yne substrates carrying cyano/aldehyde group is described.

148 enerated carbon-palladium bond to a tethered cyano/aldehyde group.

149 ion onto alkyne, followed by 1,2-addition to cyano/aldehyde, providing a convenient synthesis of both

150 teroaryl group at the beta-position of alpha-cyano aliphatic acids for the first time.

151 ryl-, silyl-, and alkyl-capped alkynyl alpha-cyano alkanone systems to the corresponding highly funct

152 In addition, the alpha-cyano-alpha-ketocyclopropane products are demonstrated t

153 lyzed arylation of C(sp(3))-H bonds in alpha-cyano-alpha-methyl aliphatic amides is achieved in the p

154 protocol for the synthesis of arylated alpha-cyano amides.

155 nds to form channels that are decorated with cyano and amide groups.

156 ain multiple functionalities, such as amino, cyano and boronate groups, that are ubiquitous in medici

157 energy surfaces (PESs) for the reactions of cyano and ethynyl radicals with styrene and N-methyleneb

158 the highest potencies were achieved for the cyano and hydroxyiminomethyl substituents, with TPI valu

159 arboxamido, trimethylammonium as well as the cyano and methoxy moieties with interesting inhibitory a

160 Cyano and thiocyano groups have received attention as IR

161 oups, such as the ester, aryl ketone, nitro, cyano, and amide functions.

162 ctionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups.

163 ve groups like alkyl and aryl esters, amide, cyano, and the carbon-carbon double bond survive the rea

164 and substituted with methyl, dimethylamino, cyano, and vinyl substituents were examined with the B3L

165 an alternative structural difference between cyano- and iodocuprates, which is in agreement with the

166 f both similar and different reactivities of cyano- and iodocuprates.

167 d even simple nucleophiles, such as azido or cyano anions, react with unexpected stereo- or regiosele

168 NH and methyl, alkyl, aralkyl, vinyl, cyano, aryl and N-heteroaryl, acyl, carbamoyl, alkoxycar

169 ron-withdrawing groups (EWGs) like nitro and cyano at the phenyl ring, leading to absorption in the g

170 ematic variation of the number and nature of cyano-based acceptor TCNE and TCNQ units on the photophy

171 f MPC by the pharmacological inhibitor alpha-cyano-beta-(1-phenylindol-3-yl)-acrylate (UK5099) result

172 of the metastable photomagnetic phase in the cyano-bridged 3D network Cs(2)Cu(7)[Mo(CN)(8)](4).

173 Herein, two trinuclear cyano-bridged bimetallic donor-acceptor ensembles, Fe(II

174 8)] magnetic system gives two enantiomorphic cyano-bridged chains, {[Co(II)((S,S)-iPr-Pybox)(MeOH)](3

175 The paramagnetic cyano-bridged complex PhB((t)BuIm)(3)Fe-NC-Mo(N(t)BuAr)(

176 The nonphotomagnetic cyano-bridged Fe(II)-Nb(IV) coordination polymer {[Fe(II

177 and in the construction of high-dimensional cyano-bridged materials exhibiting higher ordering tempe

178 metalated nitrile nucleophile species (alpha-cyano carbanion analogues), is a key step of the mechani

179 Aromatic cyano, chloro, and bromo functionalities are tolerated b

180 ovalent silicon atom, i.e. shifting from the cyano (CN) to the silicon nitride (SiN) radical, has a d

181 we also explored the aurophilic anchor group cyano (CN), amino (NH2), thiol (SH), and 4-pyridyl (PY).

182 the same X(2)Sigma(+) electronic structure - cyano (CN), boron monoxide (BO), silicon nitride (SiN),

183 fically incorporated carbon-deuterium (C-D), cyano (CN), thiocyanate (SCN), and azide (N3) "transpare

184 three-periodic (framework) p, d, and f metal cyano complexes or cyanometallates, i.e. coordination co

185 5-Cyano compounds are especially potent and selective rat

186 um salts was obtained from the corresponding cyano compounds or nitriles by reaction with anhydrous H

187 These cyano-containing precursors are analogues of the triyne

188 diazo ester in the process, leading to alpha-cyano cycloprop(en)ylcarboxylates in high yields and ste

189 d also highly substituted anilines including cyano derivatives.

190 ives allowed the alternative use of an alpha-cyano diazo ester in the process, leading to alpha-cyano

191 phonates was developed by employing an alpha-cyano diazophosphonate and Rh(2)(S-IBAZ)(4) as chiral ca

192 Here, we describe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group,

193 nes, functionalized with ester, keto, nitro, cyano etc.

194 of oxygen and subsequent deprotection of the cyano ethyl phosphoester afforded the target compounds i

195 In comparison with the isoelectronic cyano-ethylene system, the cyanoethylene (C(2)H(3)CN) is

196 electfluor-mediated coupling of the BPin and cyano functionalities to annulate a new five-membered ri

197 ans with both a tetra-substituted carbon and cyano functionality are accessed by the newly developed

198 The strong electron-withdrawing cyano functionality enables DCNBT-IDT with n-type charac

199 roved the structural equivalence of iodo and cyano Gilman cuprates and their subsequential intermedia

200 rporation of alkyl copper in iodo but not in cyano Gilman cuprates during the reaction.

201 onger electron withdrawing groups (triflate, cyano) give oligomers for which misfolded states are und

202 ion of a hydrophobic substituent next to the cyano group and aminoquinoline methylation considerably

203 A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to

204 e, the replacement of the carbon atom in the cyano group by an isovalent silicon atom has a pronounce

205 scribe an analogue of dZ (cyano-dZ) having a cyano group instead of a nitro group, including its synt

206 triple bond]N) fluorescence is high when the cyano group is hydrogen bonded and low when it is not.

207 Hydrogen bonding to the cyano group is known to play a major role in modulating

208 Replacement of the iminium motif by a cyano group is well tolerated and gives an additional de

209 Introducing an electron-deficient p-cyano group on the B-phenyl substituent creates a twiste

210 lectivity are mediated by the binding of the cyano group to a new auxiliary pocket in nNOS.

211 ich then undergo smooth cycloaddition with a cyano group to generate the desired fused 1,2,3-triazole

212 rated that C-H bonds can be activated by the cyano group under high pressure, but at room temperature

213 formed by combining the electron-withdrawing cyano group with thiophene or benzothiadiazole units.

214 dynes (from 1,3-diynes containing a tethered cyano group) or 2,3-pyridynes (from 1-cyanoethyne deriva

215 , a(u), b(1g), and b(2u), all located at the cyano group) with pi*-orbitals of the ring systems.

216 By changing the dimethylamino with the cyano group, a dendrimeric molecule can change from a hy

217 of TO is replaced by an electron withdrawing cyano group, which was expected to decrease the suscepti

218 eraction observed in this study was with the cyano group.

219 e ring opening, the unusual migration of the cyano group.

220 eactive azadienophiles including unactivated cyano groups and heterosubstituted imine derivatives suc

221 n of the peptide/protein upon removal of the cyano groups from the derived bisthiocyanate.

222 observation that NHC-boryl radicals abstract cyano groups from various organic nitriles has been parl

223 ine 5 to a dinitrile 7, 8, or 9 with the two cyano groups in 1,3 or 1,4 distance.

224 rformance is further enhanced by introducing cyano groups to the CoPc molecule.

225 s that are activated by electron-withdrawing cyano groups.

226 and N-chains with terminal ester, ketone, or cyano groups.

227 ther, dimethylamino, trifluoromethyl, ester, cyano, halide, hydroxyl, and silyl functionalities compa

228 A wide variety of functional groups (nitro, cyano, halo, alkyl, amido, and thioether) was tolerated,

229 peridine derivatives with electron-deficient cyano(hetero)arenes.

230 ) ) coupling method using boronic esters and cyano heteroarenes under flow conditions.

231 monocarboxylate transporter (MCT) inhibitor cyano-hydroxycinnamic acid (CHC).

232 amino-group(s) directly linked to a pulling cyano, imino, or phosphoimino group, as well as those in

233 s) and increases the basicity of the pulling cyano, imino, or phosphoimino group.

234 dition of both the CN and OTf groups of aryl(cyano)iodonium triflates to alkynes is described.

235 de range of functional groups such as ester, cyano, keto, and nitro.

236 1-(SS) and 1-(RR) are paramagnets with cyano-mediated Co(II)-W(V) magnetic couplings that lead

237 or, 5-chloro-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxybenzamide ("ZT-1a

238 nd unpaired electron to the nitrogens of the cyano moieties and also, notably, to the silicon atoms o

239 r (SET) that is uniform from 4-methoxy- to 4-cyano-N,N-dimethylanilines.

240 r the mGluR5 positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) or CDPPB.

241 ed, as both the systemic administration of 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)

242 ors (mGluR5) positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB)

243 Pharmacological treatments with 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, a posit

244 port the first derivatization reagent, (E)-2-cyano-N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-

245 We have developed [(11)C]CPPC [5-cyano-N-(4-(4-[(11)C]methylpiperazin-1-yl)-2-(piperidin-

246 3; 3, X = H; 4, X = Br) photosensitized by 3-cyano-N-methylquinolinium perchlorate (3-CN-NMQ(+)) has

247 ion of the parent sulfoxides sensitized by 3-cyano-N-methylquinolinium perchlorate (3-CN-NMQ(+)ClO4(-

248 using bis(pinacolato)diboron (B2Pin2) and N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as reag

249 n of bis(pinacolato)diboron (B2 pin2 ) and N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) to a br

250 loying the electrophilic cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) as the cyano

251 ough N-directed ortho C-H activation using N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent

252 of alkenylboronic acids with delta- or gamma-cyano-N-tosylhydrazones.

253 Substitution with hydroxy, cyano, nitro, acetamido, and fluoro led to high inhibito

254 at 70 degrees C with bromoarenes containing cyano, nitro, ester, keto, fluoro, enolizable hydrogen,

255 of the amino acid, such as trifluoromethyl, cyano, nitro, ferrocenyl, boronato, or azido.

256 anophenyl is adopted to replace the stronger cyano one to construct blue emitters with multiple donor

257 )12, cyanocycloheptatetraene 13, and finally cyano(phenyl)carbene (3)14 as evaluated by IR spectrosco

258 irst dimension ((1)D), and five (C18, amide, cyano, phenyl and PFP) in the second dimension ((2)D) we

259 The FTLSs indicate that p-cyano phenylalanine incorporated at two positions is eng

260 he same linear dependence is observed with p-cyano phenylalanine, cyanylated cysteine, or cyanylated

261 his goal, isotopically labeled p-((13)C(15)N-cyano)phenylalanine was synthesized, site-selectively in

262 hing vibration of an unnatural amino acid, p-cyano-phenylalanine, to directly probe how TMAO affects

263 o[b,d]pyr an-3-yl]-2-methyl-propanoic acid 3-cyano-propyl ester (AM7438), showed picomolar affinity f

264 oal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structur

265 f an aryl sulfone as a replacement for the 3-cyano pyridyl group.

266 Silicon nitride (SiN) and the cyano radical (CN) are isoelectronic; however, their che

267 ompared to the isoelectronic reaction of the cyano radical (CN) with acetylene, the replacement of th

268 nitrogen atom to the acetylene molecule, the cyano radical adds barrierlessly with the carbon atom fo

269 double bond of ethylene; in comparison, the cyano radical adds via its carbon atom.

270 ons of ethylene with silicon nitride and the cyano radical, the silaisonitrile over the silanitrile a

271 s and also the distinct differences with the cyano radical-ethylene system.

272 he elementary reactions of ethynyl (CCH) and cyano radicals (CN) with unsaturated hydrocarbons.

273 Cyano radicals and excited carbon monoxide molecules in

274 bundant vinyl cyanide and its radical or via cyano radicals reacting with 1,3-butadiene.

275 -N-phenyl-p-toluenesulfonamide (NCTS) as the cyano source, efficient decarboxylative cyanation chemis

276 te [2](2-) to be an unusual high-spin Co(II)-cyano species (S = 3/2), while IR, EXAFS, and EPR spectr

277 alculations identify the thiophene units and cyano substituents at the vinylene linkage as active sit

278 ton affinity of the parent molecule, and the cyano substituents increased its hydride affinity.

279 Functionalization of tetracene with cyano substituents yields a more stable chromophore with

280 eveloped due to ICT in the moderately stable cyano substituted enolate intermediate.

281 considerable range of Z- or E-di-substituted cyano-substituted alkenes or their corresponding tri-sub

282 tones and aldehydes that rapidly couple with cyano-substituted aryl rings at the carbonyl beta-positi

283 vatives RNC: under heating conditions gave a cyano-substituted boronium [L2PhBCN]BF4 5 and a 2-borany

284 and B-H hydride donors transfer hydride to a cyano-substituted carbon of DDQ is supported by quantum-

285 Here, we focus on thiacloprid, a widely used cyano-substituted neonicotinoid thought to be less toxic

286 Cyano-substituted neonicotinoids (acetamiprid, thiaclopr

287 We now report the synthesis of sulfonyl- and cyano-substituted oxacycles via intramolecular reaction

288 ,beta-unsaturated alpha-cyanoketones gives 5-cyano-substituted pyrimidines.

289 The key step involves a cyano-substituted TMM cycloaddition, which proceeds in n

290 work, benzannulation together with terminal cyano-substitution was demonstrated to be an efficient a

291 Furthermore, chloro, fluoro, or cyano substitutions on the 4- and 6-positions of the ind

292 iotin was attached to the surface in a mixed cyano-terminated silane monolayer.

293 (iii) A web service, the CYANO-VECTOR assembly portal, which was built to organiz

294 atility in the mechanism by which it removes cyano versus alkyl ligands in cobalamin.

295 ial discussion about a special reactivity of cyano- versus iodocuprates concentrated on the existence

296 bearing various substituents (chloro, bromo, cyano, vinyl, phenyl, carbethoxy, nitro, etc.) followed

297 nking reaction is possible via ligation of a cyano-vinyl carbazole nucleoside with an opposite thymin

298 V2 (E(g) =2.2 eV) are compared with those of cyano-vinylene-linked 2D-CN-PPQV1 (E(g) =2.4 eV) produce

299 nalities such as chloro, bromo, hydroxy, and cyano were also amenable to the developed reaction.

300 ons of four pyridinium salts (4-phenyl and 4-cyano with N-methoxy and N-ethoxy substituents) led to a