ライフサイエンスコーパス: cyclase

1 imulation of G(i) and inhibition of adenylyl cyclase.

2 by a bicarbonate-dependent soluble adenylate cyclase.

3 venting the inhibitory binding of RD3 to the cyclase.

4 core and increased the RD3 affinity for the cyclase.

5 chaperone machinery and by soluble guanylyl cyclase.

6 ynthase or the NO receptor soluble guanylate cyclase.

7 le effectively suppressed RD3 binding to the cyclase.

8 eports that CO2 directly stimulates adenylyl cyclase.

9 ncoupled respiration downstream of adenylate cyclase.

10 from beta-adrenergic receptors to adenylate cyclase.

11 ued by pharmacological blockade of adenylate cyclase.

12 otein responsible for activation of adenylyl cyclase.

13 talytic activation of transmembrane guanylyl cyclases.

14 PS) and activating Ca(2+) regulated adenylyl cyclases.

15 P-gated cation channels and distal guanylate cyclases.

16 ly understood family of fungal meroterpenoid cyclases.

17 ought to be specifically coupled to adenylyl cyclases.

18 of this new family of non-canonical, terpene cyclases.

19 sium (Mg(2+))-binding motif found in terpene cyclases.

20 hat is mediated by Ca(2+)-sensitive adenylyl cyclases.

21 onserved among the greater family of terpene cyclases.

22 ncy of calcium input is filtered by adenylyl cyclase 1 and phosphodiesterases in this pathway such th

23 letion of cGMP by deleting retinal guanylate cyclase 1 or inhibition of PKG using chemical inhibitors

24 Nitric Oxide Synthase 3 [NOS3] and Guanylate Cyclase 1, Soluble, Alpha 3 [GUCY1A3]) with a range of h

25 mes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

26 Three SNPs within adenylate cyclase 2 (ADCY2) showed the same direction of the inter

27 this was specifically dependent on adenylyl cyclase 5 (AC5) activity.

28 ynthesis is catalysed by the enzyme adenylyl cyclase 5 (AC5), which is itself regulated by the stimul

29 y, the fecal bacterial community of adenylyl cyclase 5 knock-out (AC5KO, n = 7) mice or their wild-ty

30 the corresponding mutated enzymes, adenylyl cyclase-5 and retinal guanylyl cyclase-1.

31 intestinal epithelial cell-specific adenylyl cyclase 6 (AC6) knockout mice to study its role in CT-in

32 ly unrecognized connection between adenylate cyclase 6 (AC6), a cilia signaling mediator, and the aut

33 Here, we report that adenylate cyclase 6 (AC6), a highly abundant AC isoform in airway

34 ubule-derived, PC1-knock-out cells, adenylyl cyclase 6 and 3 (AC6 and -3) are both expressed.

35 meric G-protein subunit G(s) alpha, adenylyl cyclase 6, and activation of the cAMP-regulated protein

36 Binding of Ca(2+)-activated adenylyl cyclase 8 (AC8) to the N-terminus of ORAI1 positions AC8

37 However, both inhibition of adenylate cyclase A (ACA) with SQ22536 and incubation of a tempera

38 ylate (c-di-GMP), synthesized by diguanylate cyclase A (DgcA), induces stalk formation.

39 Endogenous pGC-A (particulate guanylyl cyclase A receptor) activators were reported to preserve

40 t that the catalytic activity of the terpene cyclases AaTPS and FgGS can be switched from cyclase to

41 We identify an oxidosqualene cyclase able to produce the potential 30-carbon triterpe

42 ibitors, SSRIs) treatment increased adenylyl cyclase (AC) and BDNF gene expression in LCLs.

43 CyaA bears an N-terminal adenylyl cyclase (AC) domain linked to a pore-forming RTX cytolys

44 ough the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenosine dipho

45 Adenylate cyclase (AC) is an attractive candidate as a putative AE

46 Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory mechanism

47 phas) inhibitor and an inhibitor of adenylyl cyclase (AC) prevented stimulating effects of OLA.

48 ceptor response was not mediated by adenylyl cyclase (AC)/cyclic nucleotide-gated (CNG) channels or b

49 ll occurred in mutants lacking the adenylate cyclases ACG or ACR, or the cAMP phosphodiesterase RegA.

50 main clustering of Ca(2+)-sensitive adenylyl cyclases (ACs) drives oscillations of local cAMP levels

51 he presence of at least 15 distinct adenylyl cyclases (ACs).

52 , with ADCYAP1 (encoding pituitary adenylate cyclase activating peptide, PACAP) being the most strong

53 n shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate P

54 Pituitary adenylate cyclase activating polypeptide (PACAP, gene Adcyap1) is

55 The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in the bed nu

56 ology with the mammalian pituitary adenylate cyclase-activating peptide (PACAP).

57 of peptide and Gs-bound pituitary adenylate cyclase-activating peptide, PAC1 receptor, and corticotr

58 stress response system, pituitary adenylate cyclase-activating polypeptide (PACAP), and its cognate

59 The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a pot

60 The guanylyl cyclase-activating protein, GCAP1, activates photorecept

61 tGC) activation via calcium-sensing guanylyl cyclase-activating proteins (GCAP), and RD3 truncation c

62 from degeneration by competing with guanylyl cyclase-activating proteins (GCAPs), which are calcium s

63 and suppresses RetGC activation by guanylyl cyclase-activating proteins (GCAPs).

64 ects of both nitric oxide-sensitive guanylyl cyclase activation and inhibition of the cGMP-degrading

65 mpetition with GCAPs that inhibits premature cyclase activation in the inner segment.

66 and NOS stimulation and subsequent guanylyl cyclase activation that probably occurred in pericytes.

67 stress fibres were mimicked by the adenylyl cyclase activator forskolin and prevented by inhibitors

68 Furthermore, treatment with the adenylyl cyclase activator forskolin diminishes cytosolic localiz

69 We show that the guanylate cyclase activator, riociguat, a novel treatment for PAH,

70 The guanylate cyclase activator, riociguat, enhanced current through W

71 n Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodiesterase inhibitors, and mo

72 inase that has in vitro kinase and guanylate cyclase activities.

73 knockout of the ANP receptor with guanylate cyclase activity (betaGC-A-KO).

74 whereas in Arabidopsis, OsWAKL21.2 guanylate cyclase activity activates these responses.

75 ples to G(i/o) proteins to inhibit adenylate cyclase activity and typically induces downstream signal

76 In summary, the loss or gain of guanylate cyclase activity for these NPR1 allelic variants could e

77 is based on the reconstitution of adenylate cyclase activity from a split enzyme.

78 osphorylation of NPR2 decreases its guanylyl cyclase activity in growth plate chondrocytes in living

79 Therefore, the guanylate cyclase activity of BRI1 is modulated by the kinase whil

80 t studies have revealed that the nucleotidyl cyclase activity of ExoY is stimulated by actin filament

81 N-terminal sensor domain in sGC enhances the cyclase activity of the C-terminal catalytic domain.

82 Rv0891c had very low adenylyl cyclase activity so it could represent a pseudoenzyme.

83 ty, consistent with ATP stimulating guanylyl cyclase activity through an allosteric, phosphorylation-

84 icles (LVs), whereas NKH477-induced adenylyl cyclase activity was equivalent to WT.

85 4 recombinant protein also revealed guanylyl cyclase activity, as inferred by sequence analysis.

86 of interest because the product of adenylyl cyclase activity, cAMP, is relevant to cilia-related dis

87 ic spines within the PKDs increased guanylyl cyclase activity, increased sensitivity to natriuretic p

88 agonist-induced G protein coupling, adenylyl cyclase activity, receptor internalization and desensiti

89 ses, such as protein synthesis and adenylate cyclase activity, through protein-protein interactions.

90 dissociation acts as an 'off-switch' for the cyclase activity.

91 w ATP binding to the PKD influenced guanylyl cyclase activity.

92 nsistent with the impairment of Mg-proto MME cyclase activity.

93 ved motifs required for farnesyl diphosphate cyclase activity.

94 indirectly, via actin-activated nucleotidyl cyclase activity.

95 of heme insertion into apo-sGCbeta and with cyclase activity; and (iii) apo-sGCbeta mutants possessi

96 In the MB, Rutabaga (Rut) adenylate cyclase acts as a coincidence detector during associativ

97 t, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to

98 Cs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cA

99 pha, a fusion protein composed of a guanylyl cyclase and a phospholipid transporter domain.

100 oligoA (cOA) synthesized by Cas10 polymerase-cyclase and allosterically activates the effector, typic

101 as G-proteins and via activation of adenylyl cyclase and cAMP-dependent protein kinase, but some alte

102 y be a link between the catalytic state of a cyclase and its physical contact with an effector.

103 e negative regulation by Galphai of adenylyl cyclase and its production of cAMP, independent of alter

104 n turn regulates the activity of diguanylate cyclase and phosphodiesterase domains acting on cyclic-d

105 ential through PAR(2) Inhibitors of adenylyl cyclase and protein kinase A (PKA) prevented the effects

106 c OR14I1 peptide and inhibitors of adenylate cyclase and protein kinase A (PKA) signaling.

107 ng, and CB1-mediated inhibition of adenylate cyclase and protein kinase A activity.

108 llular targeting of cAMP-generating adenylyl cyclases and processes regulated by their compartmentali

109 emical biology, focusing mainly on terpenoid cyclases and related prenyltransferases for which X-ray

110 lation and inactivation of the NPR2 guanylyl cyclase, and cGMP hydrolysis is increased by activation

111 Rv0891c has sequence similarity to adenylyl cyclases, and Rv0890c harbors the NB-ARC-TPR-HTH domains

112 the PI3 kinase/Akt/PKB pathway and guanylyl cyclases, AprA does not induce actin polymerization or i

113 ugation, whereas other class III nucleotidyl cyclases are functional dimers.

114 e-integral and soluble adenylyl and guanylyl cyclases, are central components in a wide range of sign

115 The role of the terpenoid cyclase as a template for catalysis is paramount to its

116 ovel NIT-domain containing soluble guanylate cyclases as putative NO/nitrite/nitrate sensors.

117 ng microfluidics-assisted TIRF, we show that Cyclase-associated protein (CAP) and Cofilin synergize t

118 inhibition," whereby a complex consisting of cyclase-associated protein (CAP) bound to lysine-acetyla

119 re we show that the putative actin regulator cyclase-associated protein (CAP) is present in two diffe

120 x of lysine-acetylated actin (KAc-actin) and cyclase-associated protein (CAP).

121 Cyclase-associated protein 1 (CAP1) is a conserved actin

122 n of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transforming pr

123 complex between lysine-acetylated actin and cyclase-associated protein inhibits the formin INF2 by e

124 Cyclase-associated proteins (CAP) are a family of actin

125 d the WT GCAP1, but failed to decelerate the cyclase at the Ca(2+) concentrations characteristic of d

126 m through conditional disruption of adenylyl cyclase beta (ACbeta) and its downstream effector, cAMP-

127 through the introgression of a lycopene beta-cyclase (beta-Cyc) allele from a Solanum galapagense bac

128 Swapping cyclases between cyanobacteria and purple phototrophic b

129 inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these t

130 cAMP signaling, the photo-activated adenylyl cyclase bPAC and the light-activated phosphodiesterase L

131 ein consisting of a light-activated adenylyl cyclase (bPAC) and luciferase (nLuc).

132 vasodilation, which is dependent on guanylyl cyclase but not prostaglandins.

133 t, as well as nitric oxide (NO) and guanylyl cyclase, but not prostaglandin dependent.

134 (Ad5) combination regimen targeting guanylyl cyclase C (GUCY2C), a receptor expressed by intestinal m

135 We observed that the adenylyl cyclase-cAMP-protein kinase A axis is involved in HCAR1

136 egress by activating the Galpha(s)/adenylyl cyclase/cAMP pathway.

137 anding how a cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a

138 ive kinase and also encapsulates a guanylate cyclase catalytic centre.

139 Terpenoid cyclases catalyze the most complex chemical reactions in

140 eld esterifications and in the sesquiterpene cyclase-catalyzed synthesis of sesquiterpenes from farne

141 In nature, terpene cyclases comprise the foundation of molecular biodiversi

142 tablishing a catalytically competent dimeric cyclase conformation.

143 A guanylate cyclase construct containing the juxta-membrane and kina

144 (PSY) and chromoplast-specific lycopene beta-cyclase (CYCB) alleles.

145 synthase 1, nitric oxide, soluble guanylate cyclase, cyclic GMP (cGMP), and PKG.

146 The failure of cells lacking adenylyl cyclase (cyr1Delta) to form hyphae has suggested that cA

147 Ankmy2 binds to multiple adenylyl cyclases, determining their maturation and trafficking t

148 ions of the development-specific diguanylate cyclases (DGCs) CdgB and CdgC, and the c-di-GMP phosphod

149 of two cyclic di-GMP (c-di-GMP) diguanylate cyclases (DGCs), GcpA and GcpL, are repressed by Hfq.

150 The role of this region in cyclase dimerization has been a subject of debate.

151 c-producing Streptomyces use the diadenylate cyclase DisA to synthesize the nucleotide second messeng

152 e corresponding regions of human nucleotidyl cyclases disrupt the normal helical domain structure.

153 domain (which degrades viral DNA)(1,2) and a cyclase domain (which synthesizes cyclic oligoadenylates

154 onsisting of an N-terminal putative adenylyl cyclase domain fused to a nucleotide-binding adaptor sha

155 urther, target RNA recognition activates the cyclase domain of Cas10, resulting in the synthesis of c

156 systems detect foreign RNA and activate the cyclase domain of the Cas10 subunit, generating cyclic o

157 of the C-terminal cGMP-synthesizing guanylyl cyclase domain.

158 ng a type I rhodopsin domain with a guanylyl cyclase domain.

159 receptors containing intracellular guanylyl cyclase domains, such as GC-A and GC-B, also known as Np

160 res are produced in nature by type I terpene cyclase enzymes from one single substrate.

161 This reaction is catalyzed by two unrelated cyclase enzymes using different chemistries.

162 The promiscuous nucleotidyl cyclase, exoenzyme Y (ExoY), is one of the most common e

163 for other members of the larger nucleotidyl cyclase family.

164 f the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF) domain from the cyanobacteriochrome P

165 here it is less likely to couple to adenylyl cyclase for cAMP production.

166 study, we tested five bacterial diguanylate cyclases from the Gram-negative bacterium Salmonella Ent

167 RhoGC is a rhodopsin (Rho)-guanylyl cyclase (GC) gene fusion molecule that is central to zoo

168 ) is critical in the regulation of guanylate cyclase (GC) signaling and photoreceptor cell survival.

169 ripherin/rds; however, the retinal guanylate cyclases GC1 and GC2 were severely affected in the Reep6

170 hosphodiesterase (PDE6) and retinal guanylyl cyclases (GCs), and mutations in genes that disrupt cGMP

171 ensory receptor, the receptor-type guanylate cyclase GCY-9, to cilia in chemosensory neurons of the n

172 ses the endogenous mycobacterial diadenylate cyclase gene and releases high levels of the STING agoni

173 occus aureus strain deleted for the c-di-AMP cyclase gene dacA is unable to survive in rich medium un

174 rotein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> neuritogenic cAMP sensor-Rapgef2 --

175 rotein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response element-bindi

176 ough mutations within this region in various cyclases have been linked to genetic diseases, the molec

177 of additional standalone [Formula: see text]-cyclases have been reported as potential Diels-Alderases

178 tica eudoraenol synthase is an oxidosqualene cyclase homologous to bacterial lanosterol synthases and

179 3 repressors and early depletion of adenylyl cyclase III in neuroepithelial cilia, implicating defici

180 a monocytogenes CdaA is the sole diadenylate cyclase in L. monocytogenes, making this enzyme an attra

181 of dopamine and depend on soluble guanylate cyclase in postsynaptic Kenyon cells.

182 AcsF is the cyclase in Rvi.

183 re unable to identify a functional adenylate cyclase in S. aureus and only detected 2',3'-cAMP but no

184 concentrations decline, and decelerates the cyclase in the dark, when Ca(2+) concentrations rise.

185 gray, nor a super-sensitization of adenylyl cyclase in the striatum, which are hallmarks of opioid n

186 with the RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-bromo-cyclic A

187 The role of adenylyl cyclases in ciliary function has been of interest becaus

188 nce for a mechanistic link between disparate cyclases in thiopeptide biosynthesis.

189 erated a duodecuple mutant of 12 diguanylate cyclases in V. cholerae.

190 ase while cGMP, the product of the guanylate cyclase, in turn inhibits BRI1 kinase activity.

191 Several dinucleotide cyclases, including cyclic GMP-AMP synthase, and their i

192 Nucleotidyl cyclases, including membrane-integral and soluble adenyl

193 sferase activity discovered in other terpene cyclases indicates that this cryptic function is broadly

194 that signals primarily through the adenylyl cyclase-inhibiting heterotrimeric G protein G(i).

195 Transmembrane adenylyl cyclase inhibition had no effect on the SOCE-induced ris

196 nal assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and beta-arres

197 . up to 245-fold, reduced the IC(50) for the cyclase inhibition.

198 Here we showed that adenylyl cyclase inhibitor 2',5'-dideoxyadenosine and PKA inhibit

199 the CFTR inhibitor CFTR_inh172, the adenylyl cyclase inhibitor MDL 12330A, and the protein kinase A a

200 ut was significantly inhibited by the adenyl cyclase inhibitor MDL12330A or the PKA inhibitor H89, bu

201 SAN4825, an ADP-ribosyl cyclase inhibitor that reduces cADPR and NAADP synthesis

202 ed by kappaOR signaling through the adenylyl cyclase-inhibitory family of Gi protein.

203 Activation of adenylyl cyclase is necessary and sufficient for down-regulation

204 Because adenylate cyclase is only functional in the cytoplasm, both protei

205 acking one of the two NO-sensitive guanylate cyclase isoforms [NO-GC1 knockout (KO) or NO-GC2 KO].

206 of the nine different transmembrane adenylyl cyclase isoforms that generate the cAMP signal in the cy

207 pecies A28L phytochrome-activated diguanylyl cyclase (IsPadC)) and characteristic differences in phot

208 ame this toxicity by developing an adenylate cyclase-knockout E. coli cell line.

209 rast, in Lycopodium clavatum, two sequential cyclases, LcLCC and LcLCD, are required to produce alpha

210 erent protein families including unknown and cyclase-like proteins.

211 as dependent on the Rutabaga type I adenylyl cyclase, linking cAMP-dependent plasticity to behavioral

212 carbon skeleton of 1 suggests a rare terpene cyclase machinery, exemplifying the chemical diversity i

213 nd dysfunction using Npr1 (encoding guanylyl cyclase/natriuretic peptide receptor-A, GC-A/NPRA) gene-

214 nNOS and its receptor, guanylate cyclase (NO-GC), are expressed in somata of T-stellate c

215 activates the NO-sensitive soluble guanylate cyclase (NO-GC, sGC) and triggers intracellular signalin

216 thological differentiation via the guanylate cyclase NPR2 (natriuretic peptide receptor 2) and not th

217 L-NNA, and an inhibitor of soluble guanylyl cyclase, ODQ, greatly enhanced colonic contractions.

218 ) deletion, LI-1, and inhibitors of adenylyl cyclase or protein kinase A (PKA) prevented the effects

219 ith specific targets (e.g. soluble guanylate cyclase) or through the generation of secondary species,

220 Oxidosqualene cyclases (OSCs) catalyze the first committed step in tri

221 triterpenoids are generated by oxidosqualene cyclases (OSCs).

222 tome analysis of the roots, an oxidosqualene cyclase, OsONS1, was identified that produces alpha-onoc

223 covalently linked physiological diguanylate cyclase output module in which asymmetry might play a ro

224 tions of the canonical G protein -> adenylyl cyclase pathway that is initiated by G-protein-coupled r

225 require the PI3 kinase/Akt/PKB and guanylyl cyclase pathways to induce chemorepulsion.

226 Furthermore, we find that adenylate cyclase, PKA, CaMKII, and release of Ca(2+) from intrace

227 helial tropism and the role of the adenylate cyclase/PKA/AKT-mediated signaling pathway in HCMV infec

228 th a decrease in the sensitivity of adenylyl cyclase production of cAMP to inhibitory Galphai protein

229 sterase 5 or stimulators of soluble guanylyl cyclase rapidly enhanced multiple proteasome activities

230 ling pyrophosphate initiated class I terpene cyclase reaction chemistry.

231 ral ligands for cell membrane-bound guanylyl cyclase receptors that mediate the effects of natriureti

232 Here we show that AdrA, a diguanylate cyclase regulated by AmrZ participates in this signaling

233 strongly dominated the Ca(2+) sensitivity of cyclase regulation by GCAP1 in RetGC1 heterodimer produc

234 gelatinosus, whereas alphaproteobacterial cyclases require a newly discovered protein that we term

235 degeneration by preventing retinal guanylyl cyclase (RetGC) activation via calcium-sensing guanylyl

236 1, activates photoreceptor membrane guanylyl cyclase (RetGC) in the light, when free Ca(2+) concentra

237 es accumulation of retinal membrane guanylyl cyclase (RetGC) in the photoreceptor outer segment and s

238 the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of bl

239 ensor proteins for retinal membrane guanylyl cyclase (RetGC).

240 ensive study of all currently annotated Stig cyclases, revealing that these proteins can assemble int

241 KinD from Bacillus subtilis and diguanylate cyclase rpHK1S-Z16 from Rhodopseudomonas palustris, enha

242 HCO(3)(-)-sensitive enzyme, soluble adenylyl cyclase (sAC), links Ca(2+) influx in human coronary art

243 l results), NO-independent soluble guanylate cyclase (sGC) activation, or enhancement of sGC sensitiv

244 to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are

245 itric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellula

246 Soluble guanylate cyclase (sGC) catalyzes the conversion of guanosine trip

247 Stimulators of soluble guanylate cyclase (sGC) enhance NO signaling; have been shown prec

248 The enzyme soluble guanylyl cyclase (sGC) is a heterodimer composed of an alpha subu

249 Soluble guanylyl cyclase (sGC) is a key component of NO-cGMP signaling in

250 Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO)

251 Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (

252 Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a hig

253 The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduc

254 lpha1 and beta1 subunits of soluble guanylyl cyclase (sGC) was directly and specifically regulated by

255 plexes with NMDA receptors, soluble guanylyl cyclase (sGC), and PSD95.

256 cells that had a functional soluble guanylyl cyclase (sGC)-cGMP signaling pathway and was diminished

257 c oxide (NO)-NO-sensitive (soluble) guanylyl cyclase (sGC)-cyclic guanosine monophosphate (cGMP) path

258 rs (beta(3)-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messeng

259 e NMDA receptors (NMDA-Rs), soluble guanylyl cyclase (sGC, the NO receptor), and PSD95 (a protein tha

260 oproteomic findings in lycopene beta/epsilon cyclase showed that carotenoid levels are affected by TO

261 dings indicate that cilia-dependent adenylyl cyclase signaling represses the Hedgehog pathway and pro

262 alternative strategies to activate adenylate cyclase signalling in multiple cancer types.

263 on (G(s)) or inhibition (G(i/o)) of adenylyl cyclase, stimulation of potassium channel currents (G(i)

264 g patients with HFpEF, the soluble guanylate cyclase stimulator praliciguat, compared with placebo, d

265 f vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and r

266 status, and vericiguat, a soluble guanylate cyclase stimulator, reduces heart failure hospitalizatio

267 and safety of a novel oral soluble guanylate cyclase stimulator, vericiguat, on quality of life and e

268 being evaluated, including soluble guanylate cyclase stimulators, phosphodiesterase type 5 inhibitors

269 or (beta2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex

270 Here, I review key advances in terpenoid cyclase structural and chemical biology, focusing mainly

271 rom marine algae that repurposes the terpene cyclase structural fold for the N-prenylation of glutami

272 ge, they are distinct from all other terpene cyclases, suggesting a very distant ancestor to the larg

273 The rutabaga-adenylyl cyclase synthesizes cAMP in a Ca(2+)/calmodulin-dependen

274 pressor of the Hedgehog pathway via adenylyl cyclase targeting.

275 is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleos

276 l signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behavior

277 tructurally distinct from ubiquitous terpene cyclases that, instead, assemble terpenes via intramolec

278 les and fischerindoles is controlled by Stig cyclases through a three-step cascade involving Cope rea

279 cGMP is relayed from the receptor guanylate cyclase to a cGMP-gated channel that serves as a perfect

280 ategy that uses a photoactivatable adenylate cyclase to achieve real-time regulation of cAMP and the

281 cyclases AaTPS and FgGS can be switched from cyclase to aromatic prenyltransferase at basic pH to gen

282 Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenesis.

283 unctional coupling of Galpha(s) and adenylyl cyclase to increase intracellular cyclic adenosine monop

284 ivated C-Raf reduces sensitivity of adenylyl cyclase to opioids in nonexcitable HEK293 cells, whereas

285 afts, couples less effectively with adenylyl cyclase to produce cAMP, and this is reversed by antidep

286 s, while in turn, calcium activates adenylyl cyclases to produce more cAMP-PKA signaling.

287 Adenylate cyclase toxin (ACT) is a critical factor in establishing

288 ssis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host cells to a

289 activities of Bordetella pertussis adenylate cyclase toxin (CyaA), Escherichia coli alpha-hemolysin (

290 he finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONCLUSIONThe

291 The Bordetella adenylate cyclase toxin-hemolysin (CyaA) and the alpha-hemolysin (

292 The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in immun

293 to the full-length membrane-bound guanylate cyclase type 1.

294 nzyme is inactive in the absence of adenylyl cyclase type 6 (ADCY6).

295 Adenylyl cyclase type 9 (AC9) is found tightly associated with th

296 O species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to me

297 Inhibition of adenylyl cyclase with SQ 22,536 restored BLT1(-/-) BMN apoptosis,

298 to different regions on the target guanylate cyclase with submicromolar affinity (apparent KD-values

299 cobacteria harbor a unique class of adenylyl cyclases with a complex domain organization consisting o

300 ng GCAP1-regulated Ca(2+) sensitivity of the cyclase within the physiological range of intracellular