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1 Wittig reactions, a new, efficient access to cyclic 1,3-dienyl boronic esters has been developed via
3 activity and in the generation of riboflavin cyclic 4',5'-phosphate (cyclic FMN) through an FMN lyase
4 lpha inhibitory protein Galpha(o1) to reduce cyclic adenosine monophosphate (cAMP) levels in mice and
5 ns in the GNAS gene, which encodes the 3',5'-cyclic adenosine monophosphate (cAMP) pathway-associated
6 DE4B), FTO augmented second messenger 3', 5'-cyclic adenosine monophosphate (cAMP) signaling and supp
8 s of the regulatory subunit (PRKAR1A) of the cyclic adenosine monophosphate (cAMP)-dependent protein
10 ted the ability of RvD5n-3 DPA to upregulate cyclic adenosine monophosphate, phagocytosis of bacteria
12 vation of a diverse set of readily available cyclic alcohols for the remote and site-specific arylati
14 ]Rh(COD), that can catalytically hydrogenate cyclic alkenes such as 1,5-cyclooctadiene and cis-cycloo
17 adical cation, [(CAAC)(2)Be](+*) (2) [CAAC = cyclic (alkyl)(amino)carbene], prepared by oxidation of
19 ed cyclic organic molecules, such as arynes, cyclic alkynes and cyclic allenes, have intrigued chemis
20 sults reveal reactivity that is available to cyclic allenes beyond the traditional cycloadditions and
21 olecules, such as arynes, cyclic alkynes and cyclic allenes, have intrigued chemists for more than a
22 lononitriles (YMs) react with amines to form cyclic amidines and that the starting linear YMs are non
26 A series of copper(I) complexes bearing a cyclic (amino)(aryl)carbene (CAArC) ligand with various
28 report that the ubiquitous second messenger cyclic AMP (cAMP) is an activator of the Hypr GGDEF enzy
29 ensitivity of beta-cells to the elevation of cyclic AMP (cAMP) levels and reduced proliferation of be
30 tion stability assay, and protein-misfolding cyclic amplification, we monitored the conformational an
31 ations in the Au(I)-catalyzed cyclization of cyclic and acyclic acetals of alkynylaldehydes that lead
33 hich can hydrolytically interconvert between cyclic and acyclic forms, alone or in the presence of gl
35 of the C=C bond migration position, in both cyclic and acyclic systems, to furnish disubstituted and
37 tigated by ultraviolet-visible spectroscopy, cyclic and square wave voltammetry, and density function
38 e- or quinidine-promoted methanolysis of the cyclic anhydride (+/-)-10, leading to chromatographicall
40 y in nature highlights the vital role that a cyclic architecture can play in imparting valuable physi
41 edominant tautomeric structure for the major cyclic ASA derivative, confirming the importance of intr
43 report application of a previously disclosed cyclic carbamate P1 linker which provided improved oral
44 e intramolecular C-H oxygenations to provide cyclic carbonates, hydroxylated carbamates, or 1,2-diols
45 documented fault valving behavior, that is, cyclic changes in pressure and unsteady fluid migration
46 ocks, whose components cooperate to generate cyclic changes in their own abundance and activity, with
48 munoglobulin G, antinuclear antibodies, anti-cyclic citrullinated peptide antibodies, rheumatoid fact
49 unoglobulin G, antinuclear antibody, or anti-cyclic citrullinated peptide antibody levels were found.
51 gated nanohoops allow studying the effect of cyclic conjugation and bending on the incorporated pai-s
52 mechanical state of cardiomyocytes, and that cyclic contractile activity of cardiomyocytes accelerate
55 ptor binding and revealed that the pan-group cyclic CSPs exhibit a chimeric hydrophobic patch conform
58 In this study, we report the development of cyclic derivatives of the immunomodulatory and antibiofi
59 DncV-like nucleotidyltransferase synthesizes cyclic di- or tri-nucleotide second messengers in respon
61 , we show that GacB is inhibited directly by cyclic di-GMP, which provides evidence for cross-regulat
62 c mechanisms, such as the unexpected role of cyclic-di-GMP in host sensitivity to phage N4, and more
63 binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C) throu
64 y, a Trp quenching study revealed binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP represse
67 on a Au(111) surface through coadsorption of cyclic dialanine with Cu-adatoms under Ultra-High Vacuum
68 s article, we investigated the I(2)-promoted cyclic dialkyl ether formation from 6-membered oxanickel
71 ive DOC of SASFs with a range of dipoles and cyclic dienes, we report a diverse click-library of 173
73 es the synthesis of the cell-cycle regulator cyclic diguanylate monophosphate (c-di-GMP) through chan
74 regulated by the bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) by pos
75 ot only to monomers (SARS-CoV-2) but also to cyclic dimers (Newcastle disease, Lyme disease), trimers
77 l or bacterial infection in mammalian cells, cyclic dinucleotide activation of STING induces interfer
78 sensor cGAS catalyzes the production of the cyclic dinucleotide cGAMP, resulting in type I interfero
79 A sensor that catalyses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the i
80 s and prevented explanation of the origin of cyclic dinucleotide signalling in mammalian innate immun
84 receptor in human cells that senses foreign cyclic dinucleotides that are released during bacterial
90 Herein we report the design and synthesis of cyclic dominant negative competence-stimulating peptide
94 o thermoneutral (TN; 20 degrees C; n = 7) or cyclic elevated temperature conditions (ET; 28 to 33 deg
95 nds can be easily controlled using different cyclic enals and enones or by altering the length of the
96 thod for the deprotection of Co-complexes of cyclic enediynes using tetrabutylammonium fluoride in an
97 -opening metathesis polymerization (ROMP) of cyclic enol ethers, because the resulting electron-rich
99 In the presence of Lewis acid salts, the cyclic ether, dioxolane (DOL), is known to undergo ring-
100 rated one equiv of carbon monoxide to give a cyclic five-membered P(=O)-CH(2)-B compound, the product
104 r targeted screening analysis of ASA and its cyclic forms using capillary electrophoresis-electrospra
105 , yielding an equilibrium with the resulting cyclic forms, which can predominate under different anal
106 tions drive morphogenetic processes, but how cyclic frequencies and amplitudes of contractions are tu
108 have implicated several human orthologues of cyclic genes that are associated with the mouse segmenta
110 ta42 reduced endothelial NO synthase (eNOS), cyclic GMP (cGMP), and protein kinase G (PKG) activity i
111 Here, we describe a crystalline form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF
112 tin polymerization, mediated by nitric oxide-cyclic GMP signaling leading to inhibition of RhoA.
114 ough the production of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimul
115 during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and ant
116 into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN gen
119 is caused not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chr
121 TBI increased expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon gen
122 ted with activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) in
123 Several dinucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-
124 terplay among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (
125 sponse, in the present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (
126 ses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I i
127 ent production of the second messenger 3',5'-cyclic guanosine monophosphate (cGMP) have been shown to
131 Phosphodiesterase-5 inhibitors and other cyclic guanosine monophosphate signaling activators work
132 chromatin without linker histone stimulates cyclic guanosine monophosphate-adenosine monophosphate (
133 PS)-biomimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (
134 observed an altered distribution of nuclear cyclic guanosine monophosphate-adenosine monophosphate s
135 he conversion of guanosine triphosphate into cyclic guanosine-3',5'-monophosphate, a key second messe
136 of David catenane, derived from a hexameric cyclic helicate, is 2 orders of magnitude more potent in
138 lite of cyanobacteria (blue-green algae) and cyclic heptapeptide cyanotoxin, are one of the main mari
140 ng perylene diimides (PDIs) as components in cyclic host systems for the noncovalent recognition of f
142 eatures, the instrument allows multiple pass cyclic ion mobility separation, with concomitant increas
144 A structure-activity relationship of the cyclic lipopeptide vaccine showed successful induction o
147 be generated by minimal augmentations to the cyclic mechanism even when these augmentations involved
148 lass of multisite modification circuits: the cyclic mechanism, which corresponds to the same ordering
149 f their membranes by adjusting the number of cyclic moieties within the cores of their glycerol dibip
152 ditions, delta-acetoxy allenoates react with cyclic N-sulfonyl imines (sulfamidate imines/sulfonyl im
153 ial and temporal smoothness and consistency, cyclic nature of cardiac motion, and better adherence to
154 d, a transannular Mannich-type reaction of a cyclic nitrone to stitch the C4 and C13 together, and a
155 he discovery of eight new proline-containing cyclic nonribosomal peptides, which we have given the tr
156 erse certain biological properties of linear/cyclic nucleic acids, and enable antibody-level targetin
157 clic nucleotide-gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electr
158 ivity between multiple binding events in the cyclic nucleotide binding domains of HCN pacemaker chann
159 perazines in the case of proteins and 2', 3'-cyclic nucleotide monophosphates in the case of RNA.
163 Our findings highlight the crucial role of cyclic nucleotide signalling in the conflict between vir
164 nhanced transmission may arise from impaired cyclic nucleotide signalling, resulting from compromised
165 dent gating is mediated by the intracellular cyclic nucleotide-binding domain (CNBD) connected to the
166 studies implicate both Brugia osm-9 and the cyclic nucleotide-gated (CNG) channel subunit tax-4 in l
168 currents of both hyperpolarization-activated cyclic nucleotide-gated (HCN) and small conductance calc
169 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4) locus of the mouse ge
170 rted for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so
171 sms proposed for hyperpolarization-activated cyclic nucleotide-gated channels(5), and may represent a
174 CNG channels open upon direct binding of cyclic nucleotides (cAMP and/or cGMP), but the allosteri
175 hlighted the importance of acutely regulated cyclic nucleotides and their effectors in the control of
176 ar effectors, compartmentalized signaling of cyclic nucleotides confers specificity to extracellular
178 cleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, reducing the s
179 hodiesterases (PDEs), through degradation of cyclic nucleotides, play critical roles in cardiovascula
182 e show that, for a range of solid tumours, a cyclic octapeptide labelled with a near-infrared dye sel
184 new anti-CRISPR (Acr) that degrades cA(4), a cyclic oligo-adenylate second messenger produced during
185 SPR-Cas systems, where the CARF domain binds cyclic oligoA (cOA) synthesized by Cas10 polymerase-cycl
188 gnition, type III CRISPR-Cas systems produce cyclic-oligoadenylate second messengers that activate do
193 oach has been applied for 2nd and 3rd series cyclic oligomers, using the closest structural-similar 1
194 d bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti-phage signaling system
195 were found to proceed through highly ordered cyclic or bicyclic transition states, leading to remarka
197 ((CH(3) )(2) As)(8) ] (Pd(16) ) comprises a cyclic palladium-oxo unit capped by eight dimethylarsina
202 um levels of TNF-alpha and anticitrullinated cyclic peptide Abs, along with terminal phalanx bone des
204 n and lays the ground for the development of cyclic peptide inhibitors of a vital HIV-1 RNA-protein i
205 tural and affinity analyses, we designed two cyclic peptide mimics of the TAR-binding beta2-beta3 loo
208 e HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.
209 Here, we present the discovery of a 16-mer cyclic peptide that binds to Cdc42 with nanomolar affini
211 timization from library screening produced a cyclic peptide with ~100-fold improved activity over the
212 ores functionalized by the side chain of the cyclic peptide, suggesting a general method to form func
215 ological interest, e.g. for the synthesis of cyclic peptides for drug design or for protein engineeri
218 he results suggest that mRNA display-derived cyclic peptides may be useful in challenging protein cry
219 roach makes use of a reactive linker to form cyclic peptides on the phage surface while simultaneousl
221 lationships have been extensively studied in cyclic peptides whose backbones are cyclized from head t
222 get-binding or pharmacokinetic properties of cyclic peptides, it is frequently necessary to "fine-tun
223 under confinement will not only improve the cyclic performance of photochromic molecules, but may al
224 nionic perfluoroalkane sulfonamides (FASAs), cyclic PFAS (PFEtCHxS), per- and polyfluoroalkyl ether a
225 in present in several enzymes that hydrolyze cyclic phosphate bonds on different substrates, includin
226 be evaluated and describe two new series of cyclic phosphate prodrugs of PPA capable of regenerating
227 NMR samples, we found substantial amounts of cyclic phosphates in X. autotrophicus, suggesting that i
230 Although methods for preparing well-defined cyclic polymers have only been available since 1980, the
231 been used to prepare a fully pai-conjugated cyclic porphyrin octamer, composed of both beta,meso,bet
232 sient intermediates, the thioimidate and the cyclic precursor of the thiazoline product, and determin
238 d that the kinetics and electron flux of the cyclic redox reaction are key to the layer-to-tunnel str
239 a novel electrochemical method to mimic the cyclic redox reactions occurring over long geological ti
240 e ridges turn into conical teeth and undergo cyclic replacement, while those added labially achieve a
241 ions identify the lowering of hysteresis and cyclic reversibility of the transformation as enabling c
245 as been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant
246 of several commercially available linear and cyclic siloxanes (molecular weight 162-410 g/mol) as PIS
250 could be gained including the observation of cyclic structures (MALDI), E/Z isomerism from maleic to
252 ed from simple aliphatic alcohols to complex cyclic systems and highly substituted sugar derivatives.
253 , the main results of structural analysis on cyclic systems as well as on beta- and gamma-peptides ar
254 ataricus type III-D CRISPR complex generates cyclic tetra-adenylate (cA(4)), activating the ribonucle
255 lpha-amino group on the sn-2 ester to form a cyclic tetrahedral intermediate that then collapses to p
256 since 1980, the extensive utilization of the cyclic topology in nature highlights the vital role that
259 of 6-aminouracils as stable alpha,beta-diEWG cyclic vinylogous amides for the efficient synthesis of
260 ngement of alpha,beta-unsaturated enals with cyclic vinylogous amides under oxidative conditions gene
261 ial was detectable in 10 s by multicomponent cyclic voltammetric (CV) analysis on unmodified glassy c
262 ectrodes in the array show highly consistent cyclic voltammetric signals in Au surface cleaning exper
265 for 5-HT sensing studies; conducted through cyclic voltammetry (CV) and square wave voltammetry (SWV
267 rystal X-ray diffraction, UV/Vis absorption, cyclic voltammetry (CV), electron paramagnetic resonance
271 nistic insight based on DFT data, as well as cyclic voltammetry and NMR spectroscopy, suggests that a
275 We paired this model with in vivo fast scan cyclic voltammetry in freely moving rats to test for dif
276 dopamine release was measured with fast-scan cyclic voltammetry in isolated adult Drosophila brains.
277 and organic acid sites are in agreement with cyclic voltammetry measurements for a series of GCC acid
279 roviding an explanation for the absence of a cyclic voltammetry peak corresponding to PCET at this ac
281 Solution electron-transfer experiments and cyclic voltammetry show that the cage anodically shifts
282 n reduction in 0.1 M NBu(4)PF(6)/CH(2)Cl(2), cyclic voltammetry studies indicate a 1.8 x 10(5) increa
284 HMBC spectroscopy, absorption spectroscopy, cyclic voltammetry, and density functional theory (DFT)
285 zed them using scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectr
286 ques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectr
287 es of the new hybrids were also evaluated by cyclic voltammetry, both systems exhibit three quasi-rev
288 se a combination of chemogenetics, fast scan cyclic voltammetry, pharmacology, biochemistry, and coca
289 The modified electrode was evaluated by cyclic voltammetry, scanning electronic microscopy (SEM)
290 h sensor types was investigated by employing cyclic voltammetry, square wave voltammetry, atomic forc
292 is substantiated by UV/vis spectroscopy and cyclic voltammetry, which demonstrate these cyclophanes
293 s studied on a glassy carbon electrode using cyclic voltammetry, while glassy carbon paste electrode
299 g spontaneous adenosine events, as adenosine cyclic voltammograms have a primary oxidation at 1.3 V a
300 The electrochemical cell provides local cyclic voltammograms with a nanoscale spatial resolution