ライフサイエンスコーパス: cyclic ADP-ribose

1 of the effects of intracellular dialysis of cyclic ADP ribose.

2 rolene, but not by ruthenium red, heparin or cyclic ADP-Ribose.

3 from that of inositol-1,4,5-trisphosphate or cyclic ADP-ribose.

4 s dependent on Ca++ mobilization mediated by cyclic ADP-ribose.

5 to that of a global messenger, like IP(3) or cyclic ADP-ribose.

6 of the cyclic ADP ribose antagonists 8-amino-cyclic ADP ribose (10-100 microM) and 8-bromo-cyclic ADP

7 yclic ADP ribose (10-100 microM) and 8-bromo-cyclic ADP ribose (100-1000 microM) reduced this inhibit

8 8-NH(2) cyclic ADP-ribose (20 microm) inhibits the action of cho

9 The cyclic ADP ribose antagonist 8-bromo-cyclic ADP ribose (30 mum) had no effect on either phase

10 However, when cyclic ADP ribose (5 microM) was applied directly to the

11 lay elevated NAD(+) concentrations and lower cyclic ADP-ribose, a known product of SARM1-dependent NA

12 at catalyzes the synthesis and hydrolysis of cyclic ADP-ribose, a recently identified Ca2+ mobilizing

13 These results indicate that cyclic ADP ribose acts on a specific intracellular site

14 11) but still did in the presence of 8-bromo cyclic ADP-ribose, an antagonist of cyclic ADP-ribose (c

15 ximal inhibition concentrations for 8-amino- cyclic ADP ribose and 8-bromo-cyclic ADP ribose were aro

16 , by inositol-1,4,5-trisphosphate (InsP(3)), cyclic ADP ribose and nicotinic acid adenine dinucleotid

17 joined by two other Ca-releasing messengers, cyclic ADP ribose and nicotinic acid adenine dinucleotid

18 The role of cyclic ADP ribose and ryanodine receptors in the inhibit

19 mbinant CD38 catalyzes the formation of both cyclic ADP-ribose and ADP-ribose products from NAD+ and

20 a(2+) messengers by cyclizing NAD to produce cyclic ADP-ribose and exchanging nicotinic acid with the

21 or be metabolized by ecto-enzymes to produce cyclic ADP-ribose and nicotinic acid adenine dinucleotid

22 We show that IP(3), cyclic ADP-ribose and nicotinic acid adenine dinucleotid

23 n CD38 catalyzes the conversion of NAD(+) to cyclic ADP-ribose and to ADP-ribose via a common covalen

24 s the interaction of inositol trisphosphate, cyclic ADP ribose, and nicotinic acid adenine dinucleoti

25 l chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of i

26 ble of producing the potent second messenger cyclic ADP-ribose, and SLO and SPN act synergistically t

27 The cyclic ADP ribose antagonist 8-bromo-cyclic ADP ribose (

28 Application, via the patch pipette, of the cyclic ADP ribose antagonists 8-amino-cyclic ADP ribose

29 Neither of the cyclic ADP ribose antagonists altered the amplitude of I

30 Cyclic ADP ribose (cADPR) has been shown to trigger Ca2+

31 Cyclic ADP ribose (cADPR) is a Ca(2+)-mobilizing intrace

32 Cyclic ADP ribose (cADPR) is a calcium-mobilizing metabo

33 A induces production of the second-messenger cyclic ADP ribose (cADPR), which controls release of int

34 Two signaling molecules, cGMP and cyclic ADP ribose (cADPR), which function downstream of

35 volved in gene silencing regulation, and for cyclic ADP ribose (cADPR)-dependent Ca(2+) signaling.

36 cts pulmonary arteries in part by increasing cyclic ADP-ribose (cADPR) accumulation in the smooth mus

37 NAADP, inositol trisphosphate (IP3) and cyclic ADP-ribose (cADPR) all mobilized Ca2+ from intern

38 nodine receptors (RyR), the second messenger cyclic ADP-ribose (cADPR) also accelerates the activity

39 ectoenzyme CD38 catalyzes the production of cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from its

40 m nicotinamide adenine dinucleotide (NAD) to cyclic ADP-ribose (cADPR) and from cADPR to ADP-ribose (

41 Cyclic ADP-ribose (cADPR) and hydrogen peroxide (H2O2) c

42 at the two Ca2+-mobilizing second messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine din

43 olved in metabolizing two Ca(2+) messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine din

44 sis and metabolism of two Ca(2+) messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine din

45 Cyclic ADP-ribose (cADPR) and nicotinic acid adenine din

46 NAD(+) acts partially via cyclic ADP-ribose (cADPR) and subsequent release of Ca(2

47 d adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca(2+)-mobilizing messenge

48 We previously demonstrated that cyclic ADP-ribose (cADPR) elicits Ca2+ release in airway

49 onal ectoenzyme, catalyzing the synthesis of cyclic ADP-ribose (cADPR) from NAD+ and the hydrolysis o

50 Cyclic ADP-ribose (cADPR) has been shown to act as a pot

51 Cyclic ADP-ribose (cADPr) has been shown to release intr

52 Cyclic ADP-ribose (cADPR) has recently been proposed as

53 ging to the bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose (cADPr) hydrolase family regulate dive

54 s potent as inositol trisphosphate (IP3) and cyclic ADP-ribose (cADPR) in mobilizing intracellular Ca

55 Analogues of cyclic ADP-ribose (cADPR) incorporating a methylenebisph

56 Cyclic ADP-ribose (cADPR) induces intracellular Ca2+ ([C

57 Cyclic ADP-ribose (cADPR) is a Ca(2+)-mobilizing cyclic

58 Cyclic ADP-ribose (cADPR) is a calcium mobilization mess

59 Cyclic ADP-ribose (cADPR) is a potentially important int

60 Cyclic ADP-ribose (cADPR) is a universal calcium messeng

61 Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous dese

62 ctural features needed for antagonism at the cyclic ADP-ribose (cADPR) receptor are unclear.

63 8-bromo cyclic ADP-ribose, an antagonist of cyclic ADP-ribose (cADPR) signaling at RyR (S2/S1=0.48+/

64 bose (8Br-cADPr), a competitive inhibitor of cyclic ADP-ribose (cADPr) signaling that partially relie

65 Cyclic ADP-ribose (cADPR) was identified as a signaling

66 Cyclic ADP-ribose (cADPR) was previously shown to activa

67 hat catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca(2+) messenger molecule r

68 nctional enzyme responsible for metabolizing cyclic ADP-ribose (cADPR), a Ca(2+) messenger.

69 Recent evidence shows that cyclic ADP-ribose (cADPr), an endogenous activator of th

70 Cyclic ADP-ribose (cADPR), an intracellular second messe

71 f RD29A-GUS and KIN2-GUS in response to ABA, cyclic ADP-ribose (cADPR), and Ca2+.

72 uces the calcium-mobilizing second messenger cyclic ADP-ribose (cADPR), CD157, a sister protein of CD

73 CD38, an ectoenzyme that converts NAD(+) to cyclic ADP-ribose (cADPr), may play a role in cytokine-i

74 ysiological processes that produce peroxide, cyclic ADP-ribose (cADPR), nicotinamide adenine dinucleo

75 ecently discovered Ca2+-releasing messenger, cyclic ADP-ribose (cADPR), which activates ryanodine rec

76 receptor is the nucleotide second messenger cyclic ADP-ribose (cADPR), which is generated by an ecto

77 aling pathway involving the second messenger cyclic ADP-ribose (cADPR).

78 as by inositol 1,4,5-trisphosphate (IP3) and cyclic ADP-ribose (cADPR).

79 AD+, to the Ca2+-releasing second messenger, cyclic ADP-ribose (cADPr).

80 o intracellular second messengers: IP(3) and cyclic ADP-ribose (cADPR).

81 NAD+ to the Ca2+-releasing second messenger cyclic ADP-ribose (cADPr).

82 CD38, catalyzes the cyclization of NAD(+) to cyclic ADP-ribose (cADPr).

83 Methylenebisphosphonate cyclic ADP-ribose (cADPR[CH(2)]) and methylenebisphospho

84 sis of a general calcium messenger molecule, cyclic ADP-ribose(cADPR).

85 Furthermore, we show that cyclic ADP-ribose can directly induce intracellular Ca++

86 InsP(3) and cyclic ADP ribose cause the release of Ca(2+) from sarco

87 gnaling mechanisms in each cell type, namely cyclic ADP-ribose-dependent Ca2+ mobilization from the s

88 rom that of inositol-1,4,5-trisphosphate- or cyclic ADP-ribose-elicited Ca2+ release.

89 aging showed that following the Ca2+ influx, cyclic ADP-ribose enhanced the spatial spread of the Ca2

90 Cyclic ADP-ribose enhanced the total cytoplasmic Ca2+ le

91 d hepatocytes showed that both ryanodine and cyclic ADP-ribose evoked a slow Ca2+ leak from intracell

92 synthesis of the calcium mobilizing molecule cyclic ADP-ribose from NAD.

93 inic acid adenine dinucleotide phosphate and cyclic ADP-ribose has been further defined.

94 These powerful actions suggest a role for cyclic ADP-ribose in the functional coupling of neuronal

95 , is postulated to be an important source of cyclic ADP-ribose in vivo.

96 ndent on phospholipase C (inhibited by ) and cyclic ADP-ribose (inhibited by nicotinamide).

97 Cyclic ADP-ribose is believed to be an important calcium

98 es at the single channel level indicate that cyclic ADP ribose may not act directly on the M-channels

99 ctoenzyme that produces the paracrine factor cyclic ADP ribose-mediates the effects of calorie restri

100 that inositol 1,4,5-trisphosphate (IP3) and cyclic ADP-ribose mobilize Ca2+ from the sarcoplasmic re

101 We can detect no requirement for cyclic ADP ribose, NAADP-dependent lysosomal Ca2+ releas

102 sphosphate, intracellular messengers include cyclic ADP ribose, nicotinic acid adenine dinucleotide p

103 Neither cyclic ADP-ribose nor inositol 1,4,5-trisphosphate showe

104 are different from those activated by either cyclic ADP-ribose or inositol 1,4,5-trisphosphate (IP3).

105 + through a mechanism totally independent of cyclic ADP-ribose or inositol trisphosphate.

106 The effects of submaximal doses of IP3 or cyclic ADP-ribose plus palmitoyl-CoA were additive.

107 ferent but converging pathway with NAADP and cyclic ADP-ribose receptors.

108 an local, an effect mediated specifically by cyclic ADP-ribose receptors.

109 gradient in either inositol trisphosphate or cyclic ADP-ribose, respectively.

110 AADP but not inositol 1,4,5-trisphosphate or cyclic ADP-ribose resulted in self-inactivation.

111 croM ryanodine, which suggests that the CD38/cyclic ADP-ribose/RyR pathway is not a primary mechanism

112 lcium-dependent mechanism involving CD38 and cyclic ADP ribose signalling.

113 Paneth cells in the ISC niche secrete cyclic ADP ribose that triggers SIRT1 activity and mTORC

114 er, unlike previously established effects of cyclic ADP ribose, the ryanodine receptor is not require

115 GRGDSP treatment increased cyclic ADP-ribose, the endogenous activator of ryanodine

116 The pyridine nucleotide, cyclic ADP-ribose, thought to be an endogenous modulator

117 ADP-ribose products from NAD+ and hydrolyzes cyclic ADP-ribose to ADP-ribose.

118 s were also induced by cyclic GMP (cGMP) and cyclic ADP-ribose, two molecules that can serve as secon

119 Accordingly, cyclic ADP ribose was very effective in mobilizing Ca2+

120 s for 8-amino- cyclic ADP ribose and 8-bromo-cyclic ADP ribose were around 40 microM and 1 mM, respec

121 in human cells (UDP-mannose, ADP-ribose, and cyclic ADP-ribose) which can be prevented by disruption