ライフサイエンスコーパス: cyclic GMP-AMP

1 uires dimerization, which is induced by 2'3' cyclic GMP-AMP (cGAMP) produced by the cGAMP synthase in

2 minimize intracellular accumulation of 2'3'-cyclic GMP-AMP (2'3'-cGAMP) to further avoid downstream

3 ed the production of macrophage-derived 2'3'-cyclic GMP-AMP (cGAMP) and epithelial-derived IL-18.

4 xhibited increased TB disease, cGAS and 2'3'-cyclic GMP-AMP (cGAMP) expression, and type I IFN produc

5 cyclic GMP-AMP synthase, which produces 2'3'-cyclic GMP-AMP (cGAMP) that binds to and activates stimu

6 verse physiological contexts, including 2'3'-cyclic GMP-AMP (cGAMP) transport and downstream stimulat

7 Ab and TH responses than the mammalian 2'3'-cyclic GMP-AMP (cGAMP), and generated better protection

8 through binding the cyclic dinucleotide 2'3'-cyclic GMP-AMP (cGAMP), produced by the DNA sensor cycli

9 with low nanomolar activity to inhibit 2'3'-cyclic GMP-AMP (cGAMP)-induced STING activation and rele

10 e immune cyclic GMP-AMP synthase (cGAS)-2'3'-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (S

11 A, cGAS generates the second messenger 2',3'-cyclic GMP-AMP (cGAMP) that directly binds to and activa

12 e cyclic dinucleotide second messenger 2',3'-cyclic GMP-AMP (cGAMP)(1-4).

13 izes the dinucleotide second messenger 2',3'-cyclic GMP-AMP (cGAMP), which binds to the endoplasmic r

14 lso required for the inhibition of the 2',3'-cyclic GMP-AMP (cGAMP)-dependent immune responses during

15 vating cyclic dinucleotides 3',3'- and 2',3'-cyclic GMP-AMP (cGAMP).

16 stal structures of Acb1 in complex with 3'3'-cyclic GMP-AMP define a mechanism of metal-independent h

17 3',3'-cyclic GMP-AMP (cGAMP) is the third cyclic dinucleotide

18 2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activa

19 Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported

20 d metastasis by dampening extracellular 2'3'-cyclic-GMP-AMP (cGAMP)-STING-mediated antitumoral immuni

21 n contrast to the natural STING ligand 2',3'-cyclic-GMP-AMP (cGAMP), PC7A stimulates the prolonged pr

22 Composed of a cyclic GMP-AMP synthase (cGAS) and CBASS-associated prot

23 validation also revealed the activation of a cyclic GMP-AMP synthase (cGAS)-dependent type I interfer

24 that is responsible for the activation of a cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

25 Wang et al. now report on a cyclic GMP-AMP adjuvant, the natural stimulator of inter

26 endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response an

27 Mitotic errors can activate cyclic GMP-AMP synthase (cGAS) and induce type I interfe

28 l DNA release into the cytosol and activated cyclic GMP-AMP Synthase-Stimulator of interferon genes (

29 tosol of human monocytes binds and activates cyclic GMP-AMP synthase (cGAS).

30 ytosolic mitochondrial DNA (mtDNA) activates cyclic GMP-AMP synthase-stimulator of interferon genes (

31 1 (ENPP1), which hydrolyzes STING-activating cyclic GMP-AMP (cGAMP), is a safer and more effective ST

32 ble to bind c-di-AMP and with lower affinity cyclic GMP-AMP (3'3'-cGAMP) but not c-di-GMP or 2'3'-cGA

33 particles (MPs) to deliver the STING agonist cyclic GMP-AMP (cGAMP) which achieved >10x dose-sparing

34 neered exosomes to deliver the STING agonist cyclic GMP-AMP (iExo(STINGa)), to exploit their favorabl

35 y a stimulator of IFN genes (STING) agonist, cyclic GMP-AMP (cGAMP), because together they synergize

36 odulators, notably lysophosphatidic acid and cyclic GMP-AMP (cGAMP).

37 us reduces the rate of enzyme activation and cyclic GMP-AMP synthesis.

38 CIN), leading to a tumor cell-autonomous and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

39 and type III CRISPR systems in bacteria and cyclic GMP-AMP synthase-stimulator of interferon genes (

40 or 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2

41 Additionally, we determined that STING and cyclic GMP-AMP synthase (cGAS) are important to engage t

42 ryotic Toll/interleukin-1 receptor (TIR) and cyclic GMP-AMP synthase (cGAS) immunity, we discover sev

43 ng pathways, toll-like receptor 9 (TLR9) and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

44 n immunity, targets of immunotherapy such as cyclic GMP-AMP synthase (cGAS) or PD-L1 can crosstalk wi

45 osolic nucleic acid sensor pathways, such as cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

46 future autoimmune therapies.Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucle

47 is caused not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chr

48 phosphate-adenosine monophosphate (cGAMP) by cyclic GMP-AMP synthase (cGAS).

49 robial infections and is quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection

50 Detection of viral DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defenc

51 Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon

52 Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formatio

53 increased interferon signaling, mediated by cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

54 evel of mRNA upregulation to DAI/ZBP1, or by cyclic GMP-AMP synthase (cGAS), despite its presence in

55 clic GMP-AMP, a second messenger produced by cyclic GMP-AMP synthase (cGAS) as well as RNA ligands an

56 cluding cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic

57 adenosine monophosphate (cGAMP), produced by cyclic GMP-AMP synthase (cGAS), stimulates the productio

58 During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to the production

59 n translates the sensing of cytosolic DNA by cyclic-GMP-AMP synthase (cGAS) into an inflammatory resp

60 mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contri

61 The canonical cyclic GMP-AMP synthase/stimulator of interferon genes i

62 e diffusible cyclic dinucleotide 2'3'-cGAMP (cyclic GMP-AMP), which subsequently binds to the adaptor

63 nzyme that catalyzes the synthesis of cGAMP (cyclic GMP-AMP), a critical second messenger along the r

64 ry from cytoplasm of chromatin-binding cGAS (cyclic GMP-AMP synthase).

65 fter detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity

66 sed DNA damage, and recruitment of the cGAS (cyclic GMP-AMP synthase) to the nuclear membrane and mic

67 Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon

68 The cGAS-cyclic GMP-AMP (cGAMP)-stimulator of IFN genes (STING) p

69 asome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS).

70 of cytosolic DNA-sensing pathway comprising cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of

71 cal modulatory role for PARP9 in DNA damage, cyclic GMP-AMP synthase (cGAS) expression, and type I IF

72 terplay among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (

73 ses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I i

74 Upon binding double-stranded DNA, cyclic GMP-AMP synthase synthesizes a cyclic dinucleotid

75 are key in the pathogenesis of PD and drives cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

76 Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to indu

77 during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and ant

78 The evolutionary conserved enzyme cyclic GMP-AMP synthase (cGAS) is one of the most recent

79 The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in i

80 w DNA-activated pathway involving the enzyme cyclic GMP-AMP synthase (cGAS) was described and potenti

81 and DNA bridges also stained positively for cyclic GMP-AMP synthase.

82 nt studies have also revealed a key role for cyclic GMP-AMP synthase (cGAS) in STING activation.

83 been shown to bind cytosolic DNA to generate cyclic GMP-AMP, which binds to the signaling adaptor sti

84 cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide

85 Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger tr

86 Here, we identify cyclic GMP-AMP synthase (cGAS) and interferon-inducible

87 y, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for

88 ade since the discovery of the innate immune cyclic GMP-AMP synthase (cGAS)-2'3'-cyclic GMP-AMP (cGAM

89 lear transcription and via the innate immune cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

90 Mice genetically deficient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3,

91 Several dinucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-

92 s a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synt

93 e immune responses upon infection, including cyclic GMP-AMP synthase (cGAS) signaling that results in

94 posed to activate the ISD pathway, including cyclic GMP-AMP synthase (cGAS).

95 PARP and ATR inhibitors also induced cyclic GMP-AMP synthase/stimulator of interferon genes (

96 chondrial DNA soiling of the cytosol induced cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

97 In fact, CP-N competitively inhibits cyclic GMP-AMP production by both full-length cGAS and C

98 gnaling in SAMHD1-knockout (KO) monocytes is cyclic GMP-AMP synthase (cGAS)-dependent.

99 Here we reveal that mice lacking cyclic GMP-AMP synthase (cGAS)-stimulator of IFN genes (

100 tment with DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP).

101 n to produce the nucleotide second messenger cyclic GMP-AMP (cGAMP), which initiates stimulator of in

102 (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).

103 mpetitive inhibition of the second messenger cyclic GMP-AMP production.

104 signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of in

105 ough the production of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimul

106 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP) in vitro from adenosine tripho

107 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates

108 We used mouse cyclic GMP-AMP synthase and bacterial dinucleotide synth

109 effects on two major sensors of DNA, namely cyclic GMP-AMP synthase (cGAS) and TLR9.

110 ING pathway: this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation

111 e immune responses through the activation of cyclic GMP-AMP synthase (cGAS) and production of the cyc

112 erferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

113 Here, we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive resi

114 antigen cross-presentation and activation of cyclic GMP-AMP synthase-stimulator of interferon genes (

115 s active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces c

116 Here, we report the discovery of a class of cyclic GMP-AMP synthase inhibitors identified by a high-

117 rferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct re

118 studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (c

119 mical analyses showed enhanced generation of cyclic GMP-AMP, STING aggregation, and TANK-binding kina

120 a-associated herpesvirus (KSHV) inhibitor of cyclic GMP-AMP synthase (cGAS) (KicGAS) encoded by ORF52

121 have compromised expression or repression of cyclic GMP-AMP (cGAMP) synthase (cGAS), which prevents e

122 These findings indicate a key role of cyclic GMP-AMP synthase for the initiation of self-DNA-i

123 toward understanding the biological roles of cyclic GMP-AMP synthase and can serve as a molecular sca

124 onuclei formation and activates signaling of cyclic GMP-AMP synthase-stimulator of interferon genes (

125 onships and we present crystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibi

126 AS is activated to catalyse the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ATP(3).

127 It catalyses the synthesis of cyclic GMP-AMP (cGAMP)(9-12), which stimulates the induc

128 is activated and catalyzes the synthesis of cyclic GMP-AMP (cGAMP), which induces potent antimicrobi

129 ded DNA (dsDNA) to catalyze the synthesis of cyclic GMP-AMP (cGAMP), which serves as the secondary me

130 -cyclic dinucleotides (2'3'CDNs) with use of cyclic GMP-AMP synthases (cGAS) from human, mouse, and c

131 IFN expression depended on cyclic GMP-AMP synthase (cGAS) and RIG-I-like receptors'

132 cyte-intrinsic responses to ERVs depended on cyclic GMP-AMP synthase (cGAS)/stimulator of interferon

133 , retinoic acid-inducible gene I (RIG-I), or cyclic GMP-AMP synthase-STING.

134 animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)(4,5), which leads to the expressi

135 lso show expression of the antiviral protein cyclic GMP-AMP synthase (cGAS) in neuronal SH-SY5Y cells

136 ndent of the cytosolic nucleic acid receptor cyclic GMP-AMP (cGAMP) synthase (cGAS), but cGAS neverth

137 infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the secon

138 In humans, the innate immune receptor cyclic GMP-AMP synthase (cGAS) detects viral infection t

139 the cytoplasmic pattern recognition receptor cyclic GMP-AMP synthase (cGAS), thereby stimulating immu

140 y the cytosolic pattern recognition receptor cyclic GMP-AMP synthase (cGAS), which initiates a signal

141 calize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS).

142 ository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS).

143 y, particularly for the DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signal

144 ell receptor and the innate immune receptors cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

145 One of several upstream receptors, cyclic GMP-AMP synthase, binds to cytosolic DNA and gene

146 atures of necroptosis; self-DNA recognition; cyclic GMP-AMP synthase/stimulator of IFN genes activati

147 acter sulfurreducens, specifically regulates cyclic GMP-AMP (3',3'-cGAMP) levels in vivo to stimulate

148 pase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta

149 ed as a crucial regulator of the DNA-sensing cyclic GMP-AMP synthase (cGAS)-STING pathway, and this s

150 The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) mediated sensing

151 leotides that are produced by the DNA sensor cyclic GMP-AMP (cGAMP) synthase or by invading bacteria(

152 n of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) produces the se

153 S2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation

154 The DNA sensor cyclic GMP-AMP synthase (cGAS) has been shown to bind cy

155 The major cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) has emerged as a key medi

156 The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiv

157 The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antivira

158 timulates the RNA sensor MDA5 and DNA sensor cyclic GMP-AMP synthase (cGAS) to boost type I interfero

159 tigated the roles of the putative DNA sensor cyclic GMP-AMP synthase (cGas), as well as the downstrea

160 ytosolic dsDNA, mainly by the key DNA sensor cyclic GMP-AMP synthase (cGAS), leads to the synthesis o

161 GMP-AMP (cGAMP), produced by the DNA sensor cyclic GMP-AMP synthase (cGAS), which is important for t

162 ustering highlights the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) as

163 rom activation of the cytoplasmic DNA sensor cyclic GMP-AMP synthase by a nucleic acid substrate of T

164 demonstrate that knocking out the DNA sensor cyclic GMP-AMP synthase completely abrogates spontaneous

165 ene (encoding an inhibitor of the DNA sensor cyclic GMP-AMP synthase, cGAS) and expression of two mem

166 nded DNA (dsDNA), the cytosolic dsDNA sensor cyclic GMP-AMP synthase (cGAS) synthesizes the diffusibl

167 upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP synthase (cGAS), the innate immune adapto

168 rantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of I

169 tructures activated the innate immune sensor cyclic GMP-AMP synthase (cGAS) and induced type I IFN pr

170 The cytosolic innate immune sensor cyclic GMP-AMP synthase-stimulator of interferon genes (

171 s a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS), which catalyzes

172 The innate immune sensor cyclic-GMP-AMP synthase (cGAS), an enzyme that plays a c

173 recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in pro

174 data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-indu

175 We report that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activati

176 The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the stimulator of IF

177 mechanism requiring the nucleic acid sensors cyclic GMP-AMP synthase (cGAS), stimulator of interferon

178 racellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon ga

179 TBI increased expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon gen

180 ecruited and activated 2 major DNA sensors - cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2

181 y, we report that the cytosolic DNA sensors, cyclic GMP-AMP synthase (cGAS) and Ifi204, are both requ

182 e immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interfer

183 r patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes)

184 n in innate immunity: the animal cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes)

185 chromatin fragments activate the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes)

186 eins potently interfere with the cGAS-STING (cyclic GMP-AMP synthetase-stimulator of interferon genes

187 cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMU

188 These data demonstrate that cyclic GMP-AMP produced in infected cGAS(+)STING(-) cell

189 It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an importan

190 ral pathway, recent work has implicated that cyclic GMP-AMP-synthase-Stimulator of Interferon Genes (

191 The cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

192 The cyclic GMP-AMP synthase (cGAS)-cGAMP-STING pathway plays

193 The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

194 The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

195 The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

196 The cyclic GMP-AMP synthase-Stimulator of Interferon Genes (

197 The cyclic GMP-AMP synthase-stimulator of interferon genes (

198 The cyclic GMP-AMP synthase-stimulator of interferon genes (

199 The cyclic GMP-AMP synthase-stimulator of the IFN genes (cGA

200 The cyclic GMP-AMP synthase-stimulator of the interferon gen

201 The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/ST

202 The cyclic GMP-AMP synthase/stimulator of interferon genes (

203 ieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious p

204 enic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

205 that deletion of mutant Trp53 activated the cyclic GMP-AMP Synthase-Stimulator of Interferon Genes p

206 of extrachromosomal DNA, which activated the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/ST

207 HRD also activates the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

208 triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

209 ent an effective strategy for activating the cyclic GMP-AMP synthase-STING pathway in future clinical

210 st multiple sclerosis and psoriasis, and the cyclic GMP-AMP synthase/stimulator of interferon genes (

211 es simplex virus 1 (HSV-1) triggers both the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

212 inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP) synthase (cGAS).

213 into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN gen

214 increased genomic instability, elevated the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon

215 ein 1 (PQBP1) as an adapter required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response

216 context of promoting antitumor immunity, the cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/ST

217 c dinucleotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

218 unological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.

219 lammation are attenuated in mice lacking the cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon

220 ochondrial DNA (mtDNA) and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

221 , recruitment of cGAS, and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

222 s cytosolic DNA to prevent activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

223 sol, where it triggers the activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

224 events are associated with activation of the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon

225 ted with activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) in

226 in part via inhibiting the activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (

227 caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-T

228 high-throughput screen for inhibitors of the cyclic GMP-AMP synthase/stimulator of interferon genes p

229 of IFN genes (STING), a key component of the cyclic GMP-AMP synthase/STING pathway, is crucial for nu

230 N)beta production, which is dependent on the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon

231 d brain through a mechanism dependent on the cyclic GMP-AMP synthase/stimulator of interferon genes (

232 epigenetic silencing of either STING or the cyclic GMP-AMP synthase, which generates STING-activatin

233 th in immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pat

234 sponse, in the present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (

235 ntle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of int

236 forms for the delivery of IIMs targeting the cyclic GMP-AMP synthase-stimulator of interferon genes p

237 ating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

238 is thought to require signaling through the cyclic GMP-AMP synthase (cGAS)-STING pathway and subsequ

239 unction, and inflammatory cytokines, via the cyclic GMP-AMP synthase-STING and STAT3 signaling pathwa

240 diated dsRNA sensing in conjunction with the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon

241 cleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of do

242 terferons and inflammatory cytokines through cyclic GMP-AMP synthase, which produces 2'3'-cyclic GMP-

243 acid-inducible gene I (RIG-I) in response to cyclic GMP-AMP, a second messenger produced by cyclic GM

244 sponses to human CMV that are dependent upon cyclic GMP-AMP synthase (cGAS), STING, and interferon re

245 ere triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon re