ライフサイエンスコーパス: cyclic GMP

1 uires dimerization, which is induced by 2'3' cyclic GMP-AMP (cGAMP) produced by the cGAMP synthase in

2 e cyclic dinucleotide second messenger 2',3'-cyclic GMP-AMP (cGAMP)(1-4).

3 lso required for the inhibition of the 2',3'-cyclic GMP-AMP (cGAMP)-dependent immune responses during

4 cyclic GMP-AMP synthase, which produces 2'3'-cyclic GMP-AMP (cGAMP) that binds to and activates stimu

5 Ab and TH responses than the mammalian 2'3'-cyclic GMP-AMP (cGAMP), and generated better protection

6 3',3'-cyclic GMP-AMP (cGAMP) is the third cyclic dinucleotide

7 2'3'-cyclic-GMP-AMP (cGAMP) is a second messenger that activa

8 Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter exported

9 Bacterial bis-(3'-5') cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second

10 A cyclic GMP analog, 8-bromo-cyclic GMP, increased endogen

11 LY-83583 (10 microM; F(2,18)=3.46; P<0.01; a cyclic GMP lowering agent), there is no effect of ODQ (a

12 ANP, as determined by Western analysis and a cyclic GMP assay.

13 of the secondary messenger cyclic GMP and a cyclic GMP-activated Ca(2+)-conducting channel in the Pe

14 nd mitochondrial OXPHOS gene expression in a cyclic GMP-dependent manner.

15 regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synt

16 Wang et al. now report on a cyclic GMP-AMP adjuvant, the natural stimulator of inter

17 feeding by antagonizing signalling through a cyclic GMP-gated ion channel encoded by tax-2 and tax-4.

18 endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent type I IFN response an

19 tosol of human monocytes binds and activates cyclic GMP-AMP synthase (cGAS).

20 ble to bind c-di-AMP and with lower affinity cyclic GMP-AMP (3'3'-cGAMP) but not c-di-GMP or 2'3'-cGA

21 Ca(2+), InsP3, InsP4, GTPgammaS, cyclic AMP, cyclic GMP, ATP, and ADP) activated 3-pS channels in ins

22 ate cyclase-activating proteins 1 and 2, and cyclic GMP phosphodiesterase were undetectable, although

23 identified endothelin-2, interleukin-6, and cyclic GMP-dependent protein kinase II as novel targets

24 odulators, notably lysophosphatidic acid and cyclic GMP-AMP (cGAMP).

25 iminished agonist-induced Akt activation and cyclic GMP production.

26 inase activity and restored NOS activity and cyclic GMP levels in O vessels to those of Y.

27 creased in O rings, whereas NOS activity and cyclic GMP levels were decreased.

28 hosphotriester derivatives of cyclic AMP and cyclic GMP are described, where the additional group on

29 hippocampus that breaks down cyclic AMP and cyclic GMP.

30 in intracellular concentrations of Ca2+ and cyclic GMP in response to activation of the Wnt/Frizzled

31 odiesterases (PDEs), by hydrolyzing cAMP and cyclic GMP, regulate the amplitude, duration, and compar

32 or 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2

33 significant increase in GTN denitration and cyclic GMP accumulation, whereas mitochondrial overexpre

34 undles Rac1, Rac2, cyclic AMP-dependent, and cyclic GMP-dependent protein kinases in close proximity

35 lase (GC), which synthesizes cyclic GMP, and cyclic GMP-dependent protein kinase (PKG).

36 C, cyclic AMP-dependent protein kinase, and cyclic GMP-dependent protein kinase were not capable of

37 lic AMP-dependent protein kinase A (PKA) and cyclic GMP-dependent protein kinase I (PKGI), induces th

38 Additionally, we determined that STING and cyclic GMP-AMP synthase (cGAS) are important to engage t

39 osolic nucleic acid sensor pathways, such as cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

40 future autoimmune therapies.Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucle

41 eased activation of eNOS and NO bioactivity (cyclic GMP).

42 The isolated cNMP domain of XC_0249 bound cyclic GMP and a structure-function analysis, directed b

43 Similar to diazoxide, exposure to 8-Br-cyclic GMP antagonized the PGE(2)-induced increase in ex

44 The effects of 8-Br-cyclic GMP could be reversed by exposure to glibenclamid

45 ion of sensory neurons were affected by 8-Br-cyclic GMP.

46 of soluble guanylyl cyclase because 8-bromo-cyclic GMP activated PI3 kinase and the soluble guanylyl

47 ormylmethionylleucylphenylalanine or 8-bromo-cyclic GMP activates either cyclic AMP-dependent or cycl

48 d by protein kinase G activated with 8-bromo-cyclic GMP and by a high (*)NO flux ( approximately 112

49 se (LY83583) or protein kinase G (Rp-8-bromo-cyclic GMP or KT5823), the response to ATP was restored.

50 ctive catalytic subunit of PKG-I, or 8-bromo-cyclic GMP stimulated RGS translocation.

51 A cyclic GMP analog, 8-bromo-cyclic GMP, increased endogenous AChR aggregation in emb

52 ormylmethionylleucylphenylalanine or 8-bromo-cyclic GMP.

53 oprusside) or the cyclic GMP analog, 8-bromo-cyclic GMP.

54 Cyclic AMP is not involved, but cyclic GMP is a likely candidate since the protein kinas

55 Furthermore, eNOS bioactivity assayed by cyclic GMP levels was significantly reduced by CRP.

56 is caused not by telomere shortening, but by cyclic GMP-AMP synthase (cGAS) recognizing cytosolic chr

57 ly comes under a further level of control by cyclic GMP-dependent protein kinase and that its activat

58 robial infections and is quickly detected by cyclic GMP-AMP synthase (cGAS) to elicit anti-infection

59 Detection of viral DNA by cyclic GMP-AMP synthase (cGAS) is a first line of defenc

60 Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formatio

61 ophase arrest in the oocyte is maintained by cyclic GMP from the surrounding granulosa cells that dif

62 evel of mRNA upregulation to DAI/ZBP1, or by cyclic GMP-AMP synthase (cGAS), despite its presence in

63 clic GMP-AMP, a second messenger produced by cyclic GMP-AMP synthase (cGAS) as well as RNA ligands an

64 The channel also can be regulated by cyclic GMP.

65 Cellular signaling by cyclic GMP (cGMP) regulates MMP-9 dynamics in various ce

66 ls its effect is enhanced synergistically by cyclic GMP (cGMP) through an unknown mechanism.

67 mtDNA was recognized by cyclic-GMP-AMP synthase (cGAS) in the DC cytosol, contri

68 ry from cytoplasm of chromatin-binding cGAS (cyclic GMP-AMP synthase).

69 Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon

70 e RhoA/Rho-kinase and nitric oxide (NO)/cGMP/cyclic GMP-dependent kinase (cGKI) pathways, myosin ligh

71 d with T. gondii with 8-(4-chlorophenylthio)-cyclic GMP (CPT-cGMP), a membrane-permeable, nonhydrolyz

72 asome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS).

73 of cytosolic DNA-sensing pathway comprising cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of

74 iesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the parasite, but the mechan

75 1, nitric oxide, soluble guanylate cyclase, cyclic GMP (cGMP), and PKG.

76 nerally acts is the soluble guanylyl cyclase-cyclic GMP (sGC-cGMP) pathway.

77 ated through Ca2+-dependent guanylyl cyclase-cyclic GMP-protein kinase G signaling pathway.

78 Activation of the guanylyl cyclase-cyclic GMP-protein-kinase-G system with nitroprusside or

79 GUC2B]; gene name NPR2) produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligand,

80 terplay among the DNA damage response (DDR), cyclic GMP-AMP synthase-stimulator of interferon genes (

81 (1) It controls the hormonally dependent cyclic GMP production in the kidney and the adrenal glan

82 ses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I i

83 Upon binding double-stranded DNA, cyclic GMP-AMP synthase synthesizes a cyclic dinucleotid

84 photon-activated rhodopsin with the effector cyclic GMP phosophodiesterase (PDE) in the vertebrate ph

85 ures of a full-length Caenorhabditis elegans cyclic GMP-activated channel TAX-4, reconstituted in lip

86 PRKG1 encodes cyclic GMP-dependent protein kinase 1, which is involved

87 Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to indu

88 during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and ant

89 ta42 reduced endothelial NO synthase (eNOS), cyclic GMP (cGMP), and protein kinase G (PKG) activity i

90 The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in i

91 w DNA-activated pathway involving the enzyme cyclic GMP-AMP synthase (cGAS) was described and potenti

92 ind or stimulate the target/effector enzyme (cyclic GMP phosphodiesterase).

93 e series targeting the Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG).

94 that a functional KH domain is essential for cyclic GMP production.

95 nucleotidyl cyclase domain, is required for cyclic GMP synthesis.

96 nt studies have also revealed a key role for cyclic GMP-AMP synthase (cGAS) in STING activation.

97 We show here that K-Ras is a substrate for cyclic GMP-dependent protein kinases (PKGs).

98 gnal amplifier that operates downstream from cyclic GMP-gated cation channels and distal guanylate cy

99 eath (dnd1) mutant, which lacks a functional cyclic GMP-activated cell membrane Ca(2+)-conducting cha

100 yclase (GC), we investigated the role of GC, cyclic GMP (cGMP), and cGMP-activated protein kinase (PK

101 been shown to bind cytosolic DNA to generate cyclic GMP-AMP, which binds to the signaling adaptor sti

102 ular localization but is unable to hydrolyze cyclic GMP (cGMP).

103 erase type 5A (PDE5A) selectively hydrolyzes cyclic GMP.

104 Recent studies identified cyclic GMP-AMP (cGAMP) as a metazoan second messenger tr

105 Here, we identify cyclic GMP-AMP synthase (cGAS) and interferon-inducible

106 y, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for

107 tial expression and down-regulation of IFNs, cyclic GMP, and nuclear factor kappa B isoforms.

108 Purified XC_0250 was active in cyclic GMP synthesis in vitro.

109 ansfer (FRET) imaging reveals the changes in cyclic GMP in response to Wnt5a predominate about the ce

110 Mice genetically deficient in cyclic GMP-AMP synthase (cGAS), its adaptor STING, IRF3,

111 ole of the GC kinase homology (KH) domain in cyclic GMP production by GC1, the major cyclase in photo

112 stimulation decrease and, thereby, a drop in cyclic GMP concentration and membrane voltage.

113 rt suggests that a BR-dependent elevation in cyclic GMP may be involved in the Ca(2+) signaling casca

114 data are consistent with a role for FHOD1 in cyclic GMP-dependent inhibition of VSMC stress fiber for

115 es, namely channel noise and fluctuations in cyclic GMP.

116 em of Manduca sexta undergoes an increase in cyclic GMP (cGMP) when exposed to the insect peptide ecl

117 wo PKGI isozymes, PKGIalpha and PKGIbeta, in cyclic GMP-mediated inhibition of [Ca2+]i in VSMCs are u

118 GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)-regulated cyclic nucleotide phosphodie

119 o downstream signaling components, including cyclic GMP.

120 Several dinucleotide cyclases, including cyclic GMP-AMP synthase, and their involvement in STING-

121 onsible for ETEC-induced diarrhea, including cyclic GMP (cGMP) produced by GUCY2C, activation of cGMP

122 posed to activate the ISD pathway, including cyclic GMP-AMP synthase (cGAS).

123 noic acid and docosahexaenoic acid increased cyclic GMP levels and blocked cardiac fibroblast transfo

124 n and vasodilation, which acts by increasing cyclic GMP (cGMP) levels in VSMC, thereby activating cGM

125 lary collecting duct linking two independent cyclic GMP-generating signal transduction systems involv

126 ed derivative OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhi

127 ith the concomitant decline in intracellular cyclic GMP levels appears to account for a significant p

128 increased their expression of intracellular cyclic GMP (cGMP) when treated with ST and their express

129 Elevation of intracellular cyclic GMP either by inhibition of cyclic GMP phosphodie

130 Real-time analysis of intracellular cyclic GMP using the Cygnet2 biosensor revealed p38 to a

131 NO-ASA had no effect on intracellular cyclic GMP concentrations.

132 g induces apoptosis by a mechanism involving cyclic GMP (cGMP) phosphodiesterase inhibition, sustaine

133 share a phototransduction pathway involving cyclic GMP.

134 tment with DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP).

135 on with a novel effector that directly links cyclic GMP and cyclic di-GMP signalling.

136 Thus FGF signaling lowers cyclic GMP production in the growth plate, which counter

137 osteric transition responsible for the major cyclic GMP-dependent physiological effects of NO.

138 eloping an in vivo imaging system to measure cyclic GMP production in intact tibia, we show that FGF-

139 The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like be

140 O signal into the classical second messenger cyclic GMP (cGMP).

141 (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).

142 mpetitive inhibition of the second messenger cyclic GMP-AMP production.

143 into the production of the second messenger cyclic GMP.

144 cell-specific generation of second-messenger cyclic GMP in the retinal neurons.

145 h the involvement of the secondary messenger cyclic GMP and a cyclic GMP-activated Ca(2+)-conducting

146 s the concentration of the second messenger, cyclic GMP (cGMP), causing closure of cGMP-sensitive cha

147 signals by synthesis of a second messenger, cyclic GMP-AMP (cGAMP), which activates stimulator of in

148 ough the production of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimul

149 elerates production of the second messenger, cyclic GMP.

150 in to generate the odorant second messenger, cyclic GMP.

151 levels of the nitric oxide second messenger, cyclic GMP.

152 s stimulated at least fivefold by 1.0 microM cyclic GMP, but was not stimulated by cAMP or by 8-pCPT-

153 Cyclic guanosine 3',5'-monophosphate (cyclic GMP) is a second messenger whose role in bacteria

154 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP) in vitro from adenosine tripho

155 osine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates

156 ion of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in buffered media.

157 myocytes, which constitutively produced more cyclic GMP, detected with a new transgenic FRET sensor.

158 t be dephosphorylated and thus produces more cyclic GMP.

159 The findings provide evidence for a new cyclic GMP transduction system in synaptic layers and th

160 verexpression had increased S-nitrosylation, cyclic GMP, NO formation, and were protected from postin

161 sphoinositide 3-kinase-Akt-nitric oxide (NO)-cyclic GMP pathway and also provide an explanation why L

162 ced acute antinociception might involve a NO-cyclic GMP-protein kinase G-ATP-sensitive potassium (K(A

163 ciception might be due to activation of a NO-cyclic GMP-protein kinase G-K(ATP) channel pathway.

164 Moreover, METH induced the accumulation of cyclic GMP and activated caspase-3 in approximately 18%

165 second messenger induces the accumulation of cyclic GMP and activated caspase-3 in some striatal neur

166 ypoxia triggers NO-dependent accumulation of cyclic GMP and translocation of cytoplasmic GFP-Relish (

167 f cells with LPS resulted in accumulation of cyclic GMP.

168 ING pathway: this involves the activation of cyclic GMP-AMP (cGMP-AMP) synthase (cGAS) and generation

169 e immune responses through the activation of cyclic GMP-AMP synthase (cGAS) and production of the cyc

170 erferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS) and stimulator of interfe

171 antigen cross-presentation and activation of cyclic GMP-AMP synthase-stimulator of interferon genes (

172 tone by elevation of cGMP and activation of cyclic GMP-dependent protein kinase (PKG).

173 di-GMP synthesis was enhanced by addition of cyclic GMP.

174 he application of a cell permeable analog of cyclic GMP (8-bromo-cGMP; 0.01-1000 microM) is without e

175 tion of SGC alpha-subunit (SGCalpha), and of cyclic GMP (cGMP) after exposure to an NO donor.

176 s active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces c

177 Here, we report the discovery of a class of cyclic GMP-AMP synthase inhibitors identified by a high-

178 guanylate cyclase activation, generation of cyclic GMP (cGMP), and activation of cGMP-dependent prot

179 dulated Ca(2+) signal into the generation of cyclic GMP, in vivo, exists as a homodimer, the two subu

180 mical analyses showed enhanced generation of cyclic GMP-AMP, STING aggregation, and TANK-binding kina

181 acellular cyclic GMP either by inhibition of cyclic GMP phosphodiesterase or by addition of 8-bromocy

182 KT5823, an inhibitor of cyclic GMP-dependent protein kinase (PKG) reversed the R

183 vation of a fibroblast is an interruption of cyclic GMP production from this receptor.

184 iosensor revealed p38 to act at the level of cyclic GMP, upstream of the mobilization of intracellula

185 oxide (NO) signaling involves modulation of cyclic GMP (cGMP) levels through activation of the solub

186 n was examined in the absence or presence of cyclic GMP in human coronary VSMC cells (Co403).

187 0 function, the ANP-stimulated production of cyclic GMP was inhibited.

188 ular relaxation by stimulating production of cyclic GMP, which activates type I cGMP-dependent protei

189 anylate cyclase and subsequent production of cyclic GMP.

190 uanylyl cyclase domain for the production of cyclic GMP.

191 ior work has established the central role of cyclic GMP (cGMP) from the granulosa cells in maintainin

192 These findings indicate a key role of cyclic GMP-AMP synthase for the initiation of self-DNA-i

193 Here we investigate the role of cyclic GMP-dependent protein kinase (PKG) in the contrac

194 toward understanding the biological roles of cyclic GMP-AMP synthase and can serve as a molecular sca

195 ight and apical and basolateral secretion of cyclic GMP (cGMP) under baseline, unstimulated condition

196 f the holo-complex, demonstrated the site of cyclic GMP binding that modulates cyclic di-GMP synthesi

197 onships and we present crystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibi

198 C1 and GC2) are responsible for synthesis of cyclic GMP in rods and cones, but their individual contr

199 AS is activated to catalyse the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ATP(3).

200 It catalyses the synthesis of cyclic GMP-AMP (cGAMP)(9-12), which stimulates the induc

201 -cyclic dinucleotides (2'3'CDNs) with use of cyclic GMP-AMP synthases (cGAS) from human, mouse, and c

202 in degradation of the intracellular pool of cyclic-GMP (cGMP).

203 The production of cyclic-GMP and cAMP, and the activation of the MAP kinas

204 t catalytic domain of suPDE5 hydrolyzes only cyclic GMP (cGMP) and the activity is pH-dependent.

205 GMP activates either cyclic AMP-dependent or cyclic GMP-dependent protein kinase, respectively, outsi

206 we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length

207 tin polymerization, mediated by nitric oxide-cyclic GMP signaling leading to inhibition of RhoA.

208 ition of VSMC activation by the nitric oxide/cyclic GMP pathway.

209 herapeutic agents targeting the nitric oxide/cyclic GMP signaling pathway have successfully treated p

210 stem with nitroprusside or membrane-permeant cyclic GMP analogs mimicked the proexocytotic effect of

211 , the second messenger of phototransduction, cyclic GMP, is rapidly degraded and must be replenished

212 The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential

213 tabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were s

214 lase (R-GC) signaling molecules that produce cyclic GMP (cGMP) and stimulate the cystic fibrosis tran

215 c oxide inhibitors and mimicked by prolonged cyclic GMP elevation.

216 lso show expression of the antiviral protein cyclic GMP-AMP synthase (cGAS) in neuronal SH-SY5Y cells

217 act independently of the classic NO radical/cyclic GMP pathway to increase CFTR expression and matur

218 ration, activating guanylyl cyclase, raising cyclic GMP concentration, opening cyclic nucleotide-gate

219 ndent of the cytosolic nucleic acid receptor cyclic GMP-AMP (cGAMP) synthase (cGAS), but cGAS neverth

220 infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the secon

221 ository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS).

222 y, particularly for the DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signal

223 One of several upstream receptors, cyclic GMP-AMP synthase, binds to cytosolic DNA and gene

224 acter sulfurreducens, specifically regulates cyclic GMP-AMP (3',3'-cGAMP) levels in vivo to stimulate

225 cteristics by mutagenesis of PDE5, a related cyclic GMP-specific, cGMP-binding PDE.

226 pase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-beta

227 acilitate the stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme.

228 n the gene encoding the alpha subunit of rod cyclic GMP phosphodiesterase (PDE6A), and a null mutatio

229 The parasite's cyclic GMP (cGMP)-dependent protein kinase (PKG) is esse

230 The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) mediated sensing

231 n of microbial DNA, the cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) produces the se

232 S2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for lysosomal degradation

233 The DNA sensor cyclic GMP-AMP synthase (cGAS) has been shown to bind cy

234 tigated the roles of the putative DNA sensor cyclic GMP-AMP synthase (cGas), as well as the downstrea

235 ytosolic dsDNA, mainly by the key DNA sensor cyclic GMP-AMP synthase (cGAS), leads to the synthesis o

236 ustering highlights the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) as

237 rom activation of the cytoplasmic DNA sensor cyclic GMP-AMP synthase by a nucleic acid substrate of T

238 demonstrate that knocking out the DNA sensor cyclic GMP-AMP synthase completely abrogates spontaneous

239 upon the double-stranded DNA (dsDNA) sensor cyclic GMP-AMP synthase (cGAS), the innate immune adapto

240 s a danger signal detected by the DNA sensor cyclic-GMP-AMP (cGAMP) synthase (cGAS), which catalyzes

241 recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in pro

242 data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-indu

243 We report that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activati

244 The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the stimulator of IF

245 racellular sensors including the DNA sensors cyclic GMP-AMP (cGAMP) synthase (cGAS) and interferon ga

246 TBI increased expression of DNA sensors cyclic GMP-AMP synthase and stimulator of interferon gen

247 y, we report that the cytosolic DNA sensors, cyclic GMP-AMP synthase (cGAS) and Ifi204, are both requ

248 e immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interfer

249 chromatin fragments activate the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes)

250 t response can be corrected by supplementing cyclic GMP.

251 cGAS synthesizes cyclic GMP-AMP (cGAMP), which binds to the adaptor STIMU

252 re guanylate cyclase (GC), which synthesizes cyclic GMP, and cyclic GMP-dependent protein kinase (PKG

253 Recently, targeting cyclic-GMP specific phosphodiesterase-5 (PDE5) has attra

254 These data demonstrate that cyclic GMP-AMP produced in infected cGAS(+)STING(-) cell

255 It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an importan

256 protein and substrate in VSMCs and show that cyclic GMP negatively regulates the FHOD1-PKGI interacti

257 The cyclic GMP analogue 8-bromo-cGMP rescues a sensory defec

258 The cyclic GMP-AMP synthase (cGAS)-cGAMP-STING pathway plays

259 The cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/ST

260 The cyclic GMP-dependent kinase (PKG) is an important mediat

261 The cyclic GMP-gated cationic channels of vertebrate photore

262 ieres syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious p

263 enic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

264 triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

265 sducin alpha subunit (Galpha(T).GTP) and the cyclic GMP (cGMP) phosphodiesterase 6 (PDE6), which stim

266 es simplex virus 1 (HSV-1) triggers both the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

267 into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN gen

268 h its specific cellular target/effector, the cyclic GMP phosphodiesterase (PDE).

269 c dinucleotides are second messengers in the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

270 unological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway.

271 f multiple signaling cascades, including the cyclic GMP-dependent PKG pathway.

272 mutant produces insufficient amounts of the cyclic GMP needed to drive the machinery of phototransdu

273 Activation of the cyclic GMP phosphodiesterase (PDE6) by transducin is the

274 Here, we describe a crystalline form of the cyclic GMP phosphodiesterases/adenylyl cyclase/FhlA (GAF

275 e is a central transduction component of the cyclic GMP signaling pathway.

276 , recruitment of cGAS, and activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon

277 ted with activation of the stimulator of the cyclic GMP-AMP synthase interferon genes (cGAS-STING) in

278 caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-T

279 high-throughput screen for inhibitors of the cyclic GMP-AMP synthase/stimulator of interferon genes p

280 xO1a directly activates transcription of the cyclic GMP-dependent protein kinase I (cGKI) gene and wh

281 lear translocation through activation of the cyclic GMP/protein kinase G pathway in cardiac fibroblas

282 mine NONOate or sodium nitroprusside) or the cyclic GMP analog, 8-bromo-cyclic GMP.

283 epigenetic silencing of either STING or the cyclic GMP-AMP synthase, which generates STING-activatin

284 tide receptors, NPR-A and NPR-B, raising the cyclic GMP (cGMP) levels.

285 ual signal terminating transition state, the cyclic GMP phosphodiesterase (PDE6) inhibitory gamma-sub

286 *) linker mutants were able to stimulate the cyclic GMP phosphodiesterase.

287 sponse, in the present study, we studied the cyclic GMP-AMP synthase-stimulator of interferon genes (

288 ntle this sensing mechanism by targeting the cyclic GMP-AMP synthase (cGAS) and the stimulator of int

289 is thought to require signaling through the cyclic GMP-AMP synthase (cGAS)-STING pathway and subsequ

290 cleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of do

291 terferons and inflammatory cytokines through cyclic GMP-AMP synthase, which produces 2'3'-cyclic GMP-

292 ion and exerting signaling primarily through cyclic GMP production, offer a new perspective on the pa

293 e, we report that the ratio of cyclic AMP to cyclic GMP activities sets the polarity of netrin-1-indu

294 acid-inducible gene I (RIG-I) in response to cyclic GMP-AMP, a second messenger produced by cyclic GM

295 In contrast to the transducin-cyclic GMP phosphodiesterase pathway found in vertebrate

296 sponses to human CMV that are dependent upon cyclic GMP-AMP synthase (cGAS), STING, and interferon re

297 important role antagonizing the vasodilatory cyclic GMP system.

298 ere triggered by tumor-cell-derived DNA, via cyclic-GMP-AMP synthase (cGAS), STING, and interferon re

299 dings describe a regulatory pathway in which cyclic GMP regulates virulence and biofilm formation thr

300 The non-canonical Wnt/cyclic GMP/Ca(2+)/NF-AT pathway operates via Frizzled-2,