ライフサイエンスコーパス: cyclic-di-GMP

1 & Microbe, Laventie et al. (2019) describe a cyclic-di-GMP-dependent pathway used by the opportunisti

2 c phosphodiesterases, while CgsB displayed a cyclic-di-GMP synthase phenotype.

3 more, DRaCALA can detect the expression of a cyclic-di-GMP (cdiGMP)-binding protein in whole-cell lys

4 yticus strain previously shown to accumulate cyclic-di-GMP and in vitro using phosphodiesterase activ

5 dA encodes a cyclic bis(3',5')guanylic acid (cyclic di-GMP)-forming enzyme with an unusual GGDEF moti

6 as a cue for surface adhesion and activates cyclic-di-GMP signaling.

7 on the presence of the allosteric activator cyclic-di-GMP, but is independent of lipid-linked reacta

8 bound domains from riboswitches for adenine, cyclic di-GMP, and glycine.

9 Next, we showed that mucosal adjuvant cyclic di-GMP differentiated lung moDCs into Bcl6(+) mat

10 by inhibiting biofilm formation and altering cyclic di-GMP signaling.

11 Cyclic di-AMP (c-di-AMP) and cyclic di-GMP (c-di-GMP) are signaling molecules that pl

12 olysaccharide (biofilm matrix component) and cyclic di-GMP (biofilm-regulatory molecule) were detecte

13 effector that directly links cyclic GMP and cyclic di-GMP signalling.

14 esent a model for the roles of magnesium and cyclic di-GMP in the control of motility of V. fischeri.

15 , AMP, phosphoadenylyl adenosine (pApA), and cyclic di-GMP (c-di-GMP).

16 ental conditions are quorum sensing (QS) and cyclic di-GMP (c-di-GMP) signaling, respectively.

17 by quorum sensing, two-component systems and cyclic di-GMP signalling.

18 this recent work: tRNA(Phe), the adenine and cyclic-di-GMP riboswitches, and 5S rRNA.

19 ut not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA,

20 indicating that the impact of magnesium and cyclic-di-GMP primarily acts following transcription.

21 ents by the use of second messengers such as cyclic di-GMP (c-di-GMP).

22 jority of homologs associated with bacterial cyclic di-GMP signaling.

23 Finally, bacterial cyclic-di-GMP induces an alternative active STING confor

24 sults reveal an important connection between cyclic-di-GMP, B. burgdorferi motility and Lyme disease

25 This protein was found to bind cyclic-di-GMP (c-di-GMP) and regulate type 3 fimbrial ex

26 , we show that GacB is inhibited directly by cyclic di-GMP, which provides evidence for cross-regulat

27 As the plzR promoter is induced by cyclic di-GMP, PlzR might play a role in coupling T4P fu

28 olysaccharides, as well as its activation by cyclic-di-GMP.

29 ng and the motile-sessile switch mediated by cyclic-di-GMP-by two domains that sense, respond to, and

30 and its synthesis is likewise stimulated by cyclic-di-GMP.

31 re demonstrated: OpaR increases the cellular cyclic di-GMP (c-di-GMP) level, positively controls chit

32 biofilm formation and motility by degrading cyclic-di-GMP, is upregulated in the WT strain but not i

33 une activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP), and DNA viruses.

34 ll three loss-of-function mutations enhanced cyclic-di-GMP-mediated bacterial biofilm formation in th

35 binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C) throu

36 esigned RNA-based fluorescent biosensors for cyclic di-GMP and cyclic AMP-GMP by fusing the Spinach a

37 dition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of

38 cyclases, suggesting an inhibitory role for cyclic di-GMP.

39 swimming pattern, indicating a function for cyclic-di-GMP in regulating B. burgdorferi motility.

40 se (PTS(Ntr)) system, as being important for cyclic-di-GMP production and for biofilm formation.

41 resolves unexpected tertiary proximities for cyclic-di-GMP, glycine, and adenosylcobalamin riboswitch

42 pecies, the results are broadly relevant for cyclic-di-GMP- and HAMP domain-regulated transmembrane s

43 in mice, demonstrating an important role for cyclic-di-GMP in B. burgdorferi infection.

44 results reveal a previously unknown role for cyclic-di-GMP in type 3 fimbrial production.

45 ism involved in Y. pestis biofilm formation, cyclic-di-GMP signaling, is also widespread in bacteria;

46 0.054 microM, confirming it is a functional cyclic-di-GMP phosphodiesterase.

47 Bacterial bis-(3'-5') cyclic GMP (cyclic di-GMP [c-di-GMP]) serves as a second messenger a

48 However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake

49 BB0363 specifically hydrolyzed cyclic-di-GMP with a K(m) of 0.054 microM, confirming it

50 EAL domain protein that binds and hydrolyzes cyclic di-GMP (c-di-GMP).

51 that respond to theophylline, hypoxanthine, cyclic-di-GMP, and folinic acid from libraries of ~22,70

52 The activity of XC_0249 in cyclic di-GMP synthesis was enhanced by addition of cycl

53 omologous to EAL domain proteins involved in cyclic-di-GMP regulation, appears to act at a step after

54 These domains are canonically involved in cyclic-di-GMP signaling processes, but S. aureus is not

55 be elicited by bacterial products, including cyclic di-GMP.

56 ding global regulators, leading to increased cyclic di-GMP levels and elevated biofilm production.

57 carrying genes known to alter intracellular cyclic-di-GMP pools in Vibrio parahaemolyticus revealed

58 result of the accumulation of intracellular cyclic-di-GMP.

59 gellin production, and reduces intracellular cyclic-di-GMP levels, thereby priming aflagellated biofi

60 regulation of CsrB/C decay does not involve cyclic di-GMP metabolism.

61 g proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting

62 is regulated by the inner membrane-localized cyclic-di-GMP receptor LapD via direct protein-protein i

63 rocesses, but S. aureus is not known to make cyclic-di-GMP.

64 nts for the feedback between mechanosensors, cyclic-di-GMP signaling, and production of adhesive poly

65 Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling system, synthesized b

66 The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and

67 The second messenger cyclic di-GMP (c-di-GMP) controls the transition between

68 The bacterial second messenger cyclic di-GMP (c-di-GMP) has emerged as a prominent medi

69 The second messenger cyclic di-GMP (c-di-GMP) is a nearly ubiquitous intracel

70 Signaling through the second messenger cyclic di-GMP (c-di-GMP) is central to the life cycle of

71 many bacterial species, the second messenger cyclic di-GMP (c-di-GMP) negatively regulates flagellar

72 In Vibrio cholerae, the second messenger cyclic di-GMP (c-di-GMP) positively regulates biofilm fo

73 eria employ the prokaryotic second messenger cyclic di-GMP (c-di-GMP) to coordinate responses to shif

74 p1 is the production of the second messenger cyclic di-GMP (c-di-GMP), which is indispensable for B.

75 ll-cycle initiation via the second messenger cyclic di-GMP (c-di-GMP).

76 -styles is regulated by the second messenger cyclic di-GMP (c-di-GMP).

77 The universal second messenger cyclic di-GMP (cdG) is involved in the regulation of a d

78 two-component systems, the second messenger cyclic di-GMP and direct interactions of photoreceptors

79 w the universal eubacterial second messenger cyclic di-GMP impacts the production of T6SS toxins and

80 DNA, RNA, and the bacterial second messenger cyclic-di-GMP (c-di-GMP).

81 The bacterial second messenger cyclic-di-GMP is a widespread, prominent effector of lif

82 asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulat

83 d by the Lap system and the second messenger cyclic-di-GMP.

84 y bacterial species, the secondary messenger cyclic-di-GMP mediates switching between planktonic phas

85 r production of the intracellular messenger, cyclic-di-GMP.

86 tics are controlled by the second messenger, cyclic-di-GMP, which is upregulated on surface contact.

87 work suggests that the secondary messenger, cyclic-di-GMP, promotes biofilm formation.

88 ferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is

89 he site of cyclic GMP binding that modulates cyclic di-GMP synthesis.

90 The second-messenger molecule cyclic di-GMP (c-di-GMP) and quorum sensing (QS) are imp

91 The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile

92 vels of the intracellular signaling molecule cyclic di-GMP (c-di-GMP) due to loss of BifA, a c-di-GMP

93 The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bact

94 vels of the intracellular signaling molecule cyclic di-GMP (c-di-GMP).

95 d synthesis of the second messenger molecule cyclic-di-GMP.

96 The intracellular signaling molecule cyclic-di-GMP (c-di-GMP) has been shown to influence sur

97 modulating levels of the signaling molecule cyclic-di-GMP, coregulate swarming motility and biofilm

98 The intracellular signaling molecule, cyclic-di-GMP (c-di-GMP), has been shown to influence ba

99 d in cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) metabolism.

100 ff state, acquisition requires activation of cyclic di-GMP (c-di-GMP) synthesis by the Hk1/Rrp1 TCS;

101 at this process coincides with alteration of cyclic di-GMP (c-di-GMP) levels.

102 rp mutant, showing the connection between of cyclic di-GMP and cAMP signaling in V. cholerae.

103 at modulate the synthesis and degradation of cyclic di-GMP (cdGMP).

104 erties and increased intracellular levels of cyclic di-GMP (c-di-GMP).

105 s aeruginosa is known to require a number of cyclic di-GMP (c-di-GMP)-degrading phosphodiesterases (P

106 We assayed for the production of cyclic di-GMP using two-dimensional thin-layer chromatog

107 esses genes responsible for the synthesis of cyclic di-GMP, an activator of PGA production.

108 te that HmsT is involved in the synthesis of cyclic di-GMP.

109 A variety of cyclic di-GMP regulons are revealed, including some ribo

110 and thereby the corresponding activation of cyclic-di-GMP signaling, can be adjusted both by varying

111 y, a Trp quenching study revealed binding of cyclic-di-GMP with FlrC(C) Excess cyclic-di-GMP represse

112 promotes an enzymatic process independent of cyclic-di-GMP signaling, revealing a new function for th

113 High cytoplasmic levels of cyclic-di-GMP activate the transmembrane receptor LapD t

114 dpA, which decreases intracellular levels of cyclic-di-GMP to induce MSHA pilus retraction.

115 llular signaling by modulating the levels of cyclic-di-GMP, and the virulence factors tolC and pglA r

116 to monitor apparent alteration in levels of cyclic-di-GMP, both BpdA and BpdB displayed a phenotype

117 erential expression of various regulators of cyclic-di-GMP, a secondary signaling molecule that media

118 To investigate the role of cyclic-di-GMP in B. melitensis, all 11 predicted cyclic-

119 c mechanisms, such as the unexpected role of cyclic-di-GMP in host sensitivity to phage N4, and more

120 ave been found to carry out the last step of cyclic-di-GMP (c-di-GMP) degradation, that is, pGpG to G

121 Valentini and Filloux focus on cyclic di-GMP, while Kavanaugh and Horswill discuss the

122 lase and phosphodiesterase domains acting on cyclic-di-GMP.

123 cyclic diguanosine 3',5'-(cyclic)phosphate (cyclic di-GMP) and mediated by the action of several GGD

124 ic-di-GMP in B. melitensis, all 11 predicted cyclic-di-GMP-metabolizing proteins were separately dele

125 hown to be diguanylate cyclases that produce cyclic di-GMP (cdiG), a second messenger that modulates

126 sponds to growth on agar surfaces to produce cyclic-di-GMP, which stimulates biofilm formation.

127 nosa Wsp signal transduction system produces cyclic-di-GMP (c-di-GMP), an intracellular messenger tha

128 overned by DgcB (GGDEF enzyme) that produces cyclic-di-GMP in response to an unknown stimulus.

129 xtent to which bb0419 or any of the putative cyclic-di-GMP metabolizing genes impact B. burgdorferi m

130 response regulators, HnoB and HnoD, regulate cyclic-di-GMP levels and influence biofilm formation.

131 unique life history strategies by regulating cyclic-di-GMP levels, global transcriptional responses,

132 sis and degradation of the nucleotide signal cyclic di-GMP (c-di-GMP) in many bacteria.

133 nown that intracellular levels of the signal cyclic-di-GMP increase upon surface adhesion and that th

134 terically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological c

135 We found that cyclic di-GMP in many bacterial species is sensed by a r

136 Paul et al. in Molecular Cell, now show that cyclic di-GMP also regulates flagellar motor speed throu

137 We have previously shown that cyclic di-GMP (c-di-GMP [c-diguanylate]) is a novel smal

138 Here, we show that cyclic-di-GMP-AMP (cGAMP) synthase (cGAS) is the primary

139 ly, we demonstrate, for the first time, that cyclic-di-GMP may play a role in mediating catabolite re

140 The cyclic di-GMP (c-di-GMP) second messenger represents a s

141 motor speed through interactions between the cyclic di-GMP binding protein YcgR and the motor protein

142 The RetS/LadS/Gac/Rsm network and the cyclic-di-GMP (c-di-GMP) signaling pathways are both cen

143 he other end inserted at a GTGTC site of the cyclic-di-GMP phosphodiesterase A (PDEA) gene (BMEII1009

144 Three of these cyclic-di-GMP-metabolizing proteins were found to alter

145 turn stimulates cellulose production through cyclic di-GMP (c-di-GMP).

146 imeric scaffold that selectively responds to cyclic di-GMP synthesized by a neighbouring cGAS/DncV-li

147 scent biosensors that respond selectively to cyclic di-GMP, an intracellular bacterial second messeng

148 We established that WarA binds to cyclic-di-GMP, which potentiates its methyltransferase a

149 tion, we show that the protein levels of two cyclic di-GMP (c-di-GMP) diguanylate cyclases (DGCs), Gc

150 The universal cyclic-di-GMP second messenger is instrumental in the sw

151 As was employed to assess binding of the Vc2 cyclic-di-GMP riboswitch to its ligand.

152 ation of flagella in Brucella melitensis via cyclic-di-GMP.

153 tside-in signal that is reinforced only when cyclic-di-GMP levels increase.

154 However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a

155 A mechanism by which cyclic-di-GMP influences motility and infection is propo

156 migrated with an R(f) value consistent with cyclic di-GMP that was not produced by strains carrying

157 d BpdB displayed a phenotype consistent with cyclic-di-GMP-specific phosphodiesterases, while CgsB di