ライフサイエンスコーパス: cyclin-dependent kinase 1

1 ycle regulatory proteins cyclin B1 and CDK1 (cyclin-dependent kinase 1).

2 fingerprint analysis identified it as cdc2 (cyclin-dependent kinase 1).

3 ed to uninfected cells, have lower levels of cyclin-dependent kinase 1.

4 mulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.

5 he drug Roscovitine, a specific inhibitor of cyclin-dependent kinases 1, 2, 5, 7, and 9, we have show

6 Roscovitine, a potent inhibitor of cyclin-dependent kinases 1, 2, and 5, has recently been

7 bers, seven are pro-proliferation molecules: cyclin-dependent kinase-1, -2, -4, and -6 and cyclins A,

8 tein kinase kinase, ribosomal S6 kinase, and cyclin-dependent kinase 1/2 in combination with Bcl-XL i

9 phosphorylation and inhibition of cdc25B, a cyclin dependent kinase 1-activating phosphatase, and is

10 tus begins before M phase, is independent of cyclin-dependent kinase 1 activation, and requires MEK s

11 1 (MCPH1) exists as 2 isoforms that regulate cyclin-dependent kinase-1 activation and chromosome cond

12 Cyclin-dependent kinase 1 activity also was found to reg

13 cle arrest in association with inhibition of cyclin-dependent kinase 1 activity and hyperphosphorylat

14 were competent for actin cable assembly, and cyclin-dependent kinase 1 activity was indispensible.

15 In contrast, cyclin-dependent kinase 1 activity, cyclin B1 protein, a

16 sistance that correlated with suppression of cyclin-dependent kinase-1 activity.

17 el sensitivity that correlated with enhanced cyclin-dependent kinase-1 activity.

18 G(2)/M transition due to the decreased CDK1 (cyclin-dependent kinase 1) activity and upregulated p21,

19 hase; reduced levels of cyclin B1, cyclin A, cyclin dependent kinases 1 and 2; and increased p21(Cip1

20 ionally, we identify PNKP as a substrate for cyclin-dependent kinase 1 and 2 (CDK1/2), which phosphor

21 uration promoting factor (MPF), a complex of cyclin-dependent kinase 1 and cyclin B, drives oocyte ma

22 s G(2) arrest and represses the synthesis of cyclin-dependent kinase 1 and cyclin B1, two proteins re

23 inase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry.

24 cycle regulators and proliferation markers (cyclin-dependent kinase 1 and proliferating cell nuclear

25 F-L-Leu and celecoxib each reduced the cyclin-dependent kinase 1 and proliferating cell nuclear

26 d in all tissues by combined treatment where cyclin-dependent kinase 1 and proliferating cell nuclear

27 of retinoblastoma protein and activation of cyclin-dependent kinases 1 and 2 and promoted cell cycle

28 d) and ATR (ATM and Rad3-related) and by the cyclin-dependent kinases 1 and 2.

29 activity of several kinases, including CDK1 (cyclin-dependent kinase 1) and protein kinase C (PKC), h

30 and repression of G2/M regulators cyclin B1, cyclin-dependent kinase 1, and cyclin A indicated a G2/e

31 o on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, and dephosphorylated by the p

32 c regulatory proteins reveals that cyclin B, cyclin-dependent kinase 1, and the Ancdc14 phosphatase f

33 n a pool of inactive "pre-MPF" consisting of cyclin-dependent kinase 1 bound to B-type cyclins, of wh

34 netic stability, is governed by the cyclin B/Cyclin dependent kinase 1 (Cdc2) complex.

35 on of human CaP cells via an inactivation of cyclin-dependent kinase 1 (Cdc2)/cyclin B 1-mediated mit

36 ed with increased Tyr(15) phosphorylation of cyclin-dependent kinase 1 (Cdk 1) and inhibition of Cdk

37 Both drugs inhibit cyclin-dependent kinase 1 (cdk-1) and cdk-2 (required fo

38 We identify cyclin-dependent kinase 1 (Cdk-1) as a critical upstream

39 inds to a phosphoepitope generated by either cyclin dependent kinase 1 (Cdk1) (non-self-priming) or P

40 mportant in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4

41 yclin A2, cyclin E, cyclin B1, cyclin F, and cyclin dependent kinase-1 (Cdk1) genes and diminished pr

42 We identify cyclin-dependent kinase 1 (cdk1 [cdc2]) and glycogen syn

43 SAMHD1 contains a target motif for cyclin-dependent kinase 1 (cdk1) ((592)TPQK(595)), and c

44 under physiological conditions, we show how cyclin-dependent kinase 1 (CDK1) activates the APC/C thr

45 nse that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 (CDK1) activation.

46 ng interphase that corresponded with delayed cyclin-dependent kinase 1 (CDK1) activation.

47 it, which is regulated by degradation of the cyclin-dependent kinase 1 (Cdk1) activator, cyclin B.

48 n mitotic cells was associated with the high cyclin-dependent kinase 1 (CDK1) activities.

49 Cyclin-dependent kinase 1 (Cdk1) activity rises and fall

50 725) demonstrate that the down-regulation of cyclin-dependent kinase 1 (Cdk1) activity triggers the o

51 effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage re

52 These changes are driven by cyclin-dependent kinase 1 (CDK1) activity, yet how cytop

53 p31(comet) in a process that is regulated by cyclin-dependent kinase 1 (CDK1) activity.

54 hat YTHDF2 protein stability is dependent on cyclin-dependent kinase 1 (CDK1) activity.

55 ntially promote actin cable assembly through cyclin-dependent kinase 1 (Cdk1) activity.

56 This hyperpolarization was dependent on cyclin-dependent kinase 1 (CDK1) activity.

57 We demonstrate that dCK interacts with cyclin-dependent kinase 1 (Cdk1) after IR and that the i

58 Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promo

59 a physically and functionally interacts with cyclin-dependent kinase 1 (Cdk1) and Cdk2.

60 n of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs i

61 iven by the activities of two major kinases, cyclin-dependent kinase 1 (Cdk1) and mitogen-activated p

62 mitotic entry initiated by the activities of Cyclin-dependent kinase 1 (CDK1) and Polo-like kinase 1

63 rodimer undergoes mitotic phosphorylation by cyclin-dependent kinase 1 (Cdk1) at a single site, p27 T

64 Cyclin B activates cyclin-dependent kinase 1 (CDK1) at mitosis, but conflic

65 ba is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) at Ser(119) and Ser(175

66 Ezh2 is phosphorylated by cyclin-dependent kinase 1 (CDK1) at threonine residues 3

67 Phosphorylation by Cyclin-dependent kinase 1 (CDK1) at two conserved sites

68 sister chromatid disjunction and inactivates cyclin-dependent kinase 1 (Cdk1) causing mitotic exit.

69 Mitotic entry is controlled by the cyclin B-cyclin-dependent kinase 1 (Cdk1) complex, and the inhibi

70 Cyclin-dependent kinase 1 (Cdk1) controls cell prolifera

71 e show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interaction

72 Cyclin-dependent kinase 1 (CDK1) drives cell division an

73 The cyclin-dependent kinase 1 (Cdk1) drives cell division.

74 PKR is phosphorylated by cyclin-dependent kinase 1 (CDK1) during anti-tubulin tre

75 l4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug

76 Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cy

77 Activation of cyclin-dependent kinase 1 (Cdk1) has been linked to cell

78 t study sheds light on two distinct roles of cyclin-dependent kinase 1 (CDK1) in promoting polarized

79 Here we report that cyclin-dependent kinase 1 (Cdk1) inhibition can induce b

80 Upon mitotic enrichment using the cyclin-dependent kinase 1 (CDK1) inhibitor RO-3306.

81 nd the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(5

82 Cyclin-dependent kinase 1 (CDK1) inhibitory phosphorylat

83 tase promotes entry into mitosis by removing cyclin-dependent kinase 1 (Cdk1) inhibitory phosphorylat

84 Cyclin-dependent kinase 1 (Cdk1) initiates mitosis and l

85 Cyclin-dependent kinase 1 (Cdk1) is an archetypical kina

86 Cyclin-dependent kinase 1 (Cdk1) is required for initiat

87 Cyclin-dependent kinase 1 (Cdk1) is the primary upstream

88 Cyclin-dependent kinase 1 (Cdk1) is thought to trigger c

89 Cyclin-dependent kinase 1 (Cdk1) kinase dephosphorylatio

90 Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphoryla

91 promote checkpoint recovery independently of cyclin-dependent kinase 1 (Cdk1) or Plx1 (Xenopus polo-l

92 Here, we discovered that the cyclin-dependent kinase 1 (CDK1) pathway is also affecte

93 We found that cyclin-dependent kinase 1 (CDK1) phosphorylated a threon

94 Cyclin-dependent kinase 1 (Cdk1) phosphorylates BRCA1, a

95 Here, we demonstrate that cyclin-dependent kinase 1 (Cdk1) phosphorylates septin 9

96 phorylated in mitosis and that inhibition of cyclin-dependent kinase 1 (CDK1) prevented MLK3 phosphor

97 failure to remove inhibitory phosphate from cyclin-dependent kinase 1 (Cdk1) prevents entry into mit

98 Downregulation of cyclin A2 and cyclin-dependent kinase 1 (CDK1) recapitulated this phen

99 kinase (Aurora A)/Polo-like kinase 1 (PLK1)/cyclin-dependent kinase 1 (CDK1) signaling pathway was t

100 Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphoryl

101 During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR an

102 Furthermore, decreased levels of Cyclin-dependent kinase 1 (Cdk1), a kinase partner of Cy

103 osphorylated at T341 most likely by Cyclin B/Cyclin-dependent kinase 1 (Cdk1), and then dephosphoryla

104 The activity of the cyclin-dependent kinase 1 (Cdk1), Cdc28, inhibits the tr

105 (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and

106 s involved in mitotic progression, including cyclin-dependent kinase 1 (Cdk1), cyclin B2, and their t

107 ence of STING led to premature activation of cyclin-dependent kinase 1 (CDK1), early onset to S-phase

108 In eukaryotic cells, cyclin-dependent kinase 1 (CDK1), in combination with ei

109 The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry

110 Phosphorylation of Thr92 by cyclin-dependent kinase 1 (CDK1)-cyclin B1 initiates deg

111 Mitotic activation of Gwl requires both cyclin-dependent kinase 1 (CDK1)-dependent phosphorylati

112 Here we demonstrate that the cyclin-dependent kinase 1 (Cdk1)-dependent phosphorylati

113 -box domain (PBD) of Plk1 and is enhanced by cyclin-dependent kinase 1 (Cdk1)-mediated phosphorylatio

114 Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylatio

115 s inhibited during prophase and metaphase by cyclin-dependent kinase 1 (CDK1)-mediated phosphorylatio

116 ed in large part by a switch from mTORC1- to cyclin-dependent kinase 1 (CDK1)-mediated regulation.

117 eolysis of cyclin B, a regulatory subunit of cyclin-dependent kinase 1 (Cdk1).

118 mitosis by phosphorylating and inactivating cyclin-dependent kinase 1 (Cdk1).

119 posttranslational stabilization of the G2/M cyclin-dependent kinase 1 (CDK1).

120 transition because of impaired activation of cyclin-dependent kinase 1 (Cdk1).

121 elayed activation of Aurora A, Aurora B, and cyclin-dependent kinase 1 (CDK1).

122 on at serine 81 is stimulated by the mitotic cyclin-dependent kinase 1 (CDK1).

123 at KDM5B is phosphorylated at Ser1456 by the cyclin-dependent kinase 1 (CDK1).

124 ynthesis of cyclins, which bind and activate cyclin-dependent kinase 1 (Cdk1).

125 to mitosis by phosphorylating and inhibiting cyclin-dependent kinase 1 (Cdk1).

126 Wild-type Cdc6 but not Cdc6-TV binds cyclin-dependent kinase 1 (Cdk1).

127 olymerase alpha (polalpha) and controlled by cyclin-dependent kinase 1 (CDK1).

128 tosis in eukaryotes requires the activity of cyclin-dependent kinase 1 (Cdk1).

129 CDC25C activity and, consequentially, higher cyclin-dependent kinase 1 (CDK1)/cyclin B activity, and

130 In this report, evidence is presented that cyclin-dependent kinase 1 (CDK1)/cyclin B catalyzes mito

131 ccurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/cyclin B rather than th

132 Here, we identified a metabolic function of cyclin-dependent kinase 1 (CDK1)/cyclin B1-the activatio

133 orylated at Ser 29 (S29) specifically by the cyclin-dependent kinase 1 (cdk1)/cyclinB complex, primar

134 osphorylation of hundreds of proteins by the cyclin-dependent kinase 1 (Cdk1):cyclin B (CycB) complex

135 that Ser1232 in eIF4G1 is phosphorylated by cyclin-dependent kinase 1 (Cdk1):cyclin B during mitosis

136 Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using pall

137 Cyclin-dependent kinase-1 (CDK1) is a key regulator of t

138 ondria, in which it binds to, and activates, cyclin-dependent kinase-1 (Cdk1).

139 Resumption of meiosis requires activation of cyclin-dependent kinase-1 (CDK1, p34cdc2), one component

140 Rad53, was required to both maintain active cyclin-dependent kinase 1, Cdk1(Cdc28), and prevent anap

141 roduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinas

142 urchin zygotes arrested in S phase, whether cyclin-dependent kinase 1-cyclin B (Cdk1-B) activity rem

143 We have shown previously that the cyclin-dependent kinase 1/cyclin B (cdk1/CyB or cdc2/CyB

144 Phospho-mimetic mutation of known cyclin-dependent kinase 1/cyclin B sites, all of which a

145 This activates cyclin-dependent kinase 1/cyclin B1 (CDK1/CYCB1) to dire

146 in the G(2)/M phase, and there was increased cyclin-dependent kinase 1/cyclin B1 activity.

147 an cells by signaling that is independent of cyclin-dependent kinase 1/cyclin B1 down-regulation.

148 osed that inhibition of the G(2)/M regulator cyclin-dependent kinase 1 decreases BMP (bone morphogene

149 L chromatin retention, which was reversed by cyclin-dependent kinase 1-dependent phosphorylation of t

150 both MCPH1 isoforms are phosphorylated in a cyclin-dependent kinase-1-dependent manner in mitosis an

151 osphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin

152 Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte gro

153 We apply nanoSPLITS to cyclin-dependent kinase 1 inhibited cells and found phos

154 ,3 -b] pyridine), which were shown to act as cyclin-dependent kinase 1 inhibitors, consistently reduc

155 to down-regulation of cyclin B1, cdc25c, and cyclin-dependent kinase 1 levels.

156 emonstrated that O-GlcNAcylation antagonizes cyclin-dependent kinase 1-mediated phosphorylation and p

157 Knockdown of cyclin E or cyclin-dependent kinase 1, or overexpression of fizzy-re

158 NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and ki

159 In vitro assays showed that cyclin-dependent kinase 1 phosphorylates hamartin at thr

160 Hamartin with alanine mutations in the three cyclin-dependent kinase 1 phosphorylation sites increase

161 inhibition with decreased phosphorylation of cyclin-dependent kinase 1 staining by immunohistochemist

162 SNP rs2456778, which maps to CDK1 ('cyclin-dependent kinase 1'), was associated with cocaine