ライフサイエンスコーパス: cyclin-dependent kinase 9

1 putative GRIP1 kinases, casein kinase 2 and cyclin-dependent kinase 9.

2 Inhibition of both cyclin-dependent kinase 9 activity and viral DNA replica

3 anscription factor b, P-TEFb, is composed of cyclin-dependent kinase 9 and a regulatory cyclin (T1/T2

4 on elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1 or T2, is requir

5 on elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1, stimulates the

6 general transcription factor IIB (TFIIB) and cyclin-dependent kinase 9 are upregulated during hypertr

7 factor b (P-TEFb), a complex containing the cyclin-dependent kinase 9 (CDK-9) and cyclin T1 subunits

8 Consisting of cyclin dependent kinase 9 (Cdk9) and cyclin T1, P-TEFb p

9 We identify cyclin dependent kinase 9 (CDK9) as a novel binding part

10 vels in primary MEPs, specific inhibition of cyclin dependent kinase 9 (CDK9) in MEPs leads to both d

11 metry was applied to measure the dynamics of cyclin dependent kinase 9 (CDK9) interactomes during tra

12 ranscriptional elongation complex containing cyclin dependent kinase-9 (CDK9; a kinase necessary for

13 Cyclin-dependent kinase 9 (CDK9) and CDK12 have each bee

14 on elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 (CDK9) and cyclin T, is a glob

15 ion factor b (P-TEFb) complexes, composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1 or T2, ar

16 n elongation factor b (P-TEFb), comprised of cyclin-dependent kinase 9 (CDK9) and cyclins T1 (CycT1)

17 This important factor is a heterodimer of cyclin-dependent kinase 9 (Cdk9) and one of four cyclin

18 Cyclin-dependent kinase 9 (CDK9) and serine-2-phosphoryl

19 defined Myc-driven HCC model, we identified cyclin-dependent kinase 9 (Cdk9) as required for disease

20 ICP22 binds the cyclin-dependent kinase 9 (cdk9) but not cdk7, and this

21 infection enhances the activated fraction of cyclin-dependent kinase 9 (CDK9) by promoting its associ

22 is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation

23 lated cyclins T1, T2a, and T2b interact with cyclin-dependent kinase 9 (CDK9) forming multiple nuclea

24 rgeting transcription via regulators such as cyclin-dependent kinase 9 (CDK9) has potential as a ther

25 We found that SIRT2 deacetylates cyclin-dependent kinase 9 (CDK9) in a type I IFN-depende

26 Previously, two regions phosphorylated by cyclin-dependent kinase 9 (CDK9) in elongation factor SP

27 The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phospory

28 Cyclin-dependent kinase 9 (Cdk9) inhibition liberated hn

29 In particular, we focused on the cyclin-dependent kinase 9 (CDK9) inhibitor, FIT-039, whi

30 Importantly, we demonstrated that cyclin-dependent kinase 9 (CDK9) inhibitors rapidly down

31 Cyclin-dependent kinase 9 (cdk9) is a multifunctional ki

32 Cyclin-dependent kinase 9 (CDK9) is a novel prognostic m

33 we examine the role of the Tat/TAR-specified cyclin-dependent kinase 9 (CDK9) kinase activity in regu

34 cleolytic subunit of Integrator, INTS11, and cyclin-dependent kinase 9 (CDK9) maintain directionality

35 f cyclin T1 and concomitant stabilization of cyclin-dependent kinase 9 (CDK9) may facilitate producti

36 phosphorylation of elongation factor Spt5 by cyclin-dependent kinase 9 (Cdk9) occur during transcript

37 t of an IL-6-inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) on gamma-FBG expression

38 Mechanistically, BRD4 is required for cyclin-dependent kinase 9 (CDK9) recruitment and phospho

39 HMBA triggered cyclin-dependent kinase 9 (CDK9) recruitment to the LTR,

40 ress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for

41 a heterodimer of a cyclin-dependent kinase, cyclin-dependent kinase 9 (Cdk9), and one of four cyclin

42 ofactors of HIV-1 Tat, cyclin T1 (CycT1) and cyclin-dependent kinase 9 (CDK9), are required for LTR-d

43 ted at the mammal-specific threonine 1032 by cyclin-dependent kinase 9 (CDK9), dynamically moves alon

44 ding Ras GTPase-activating protein (RasGAP), cyclin-dependent kinase 9 (Cdk9), fibronectin, and Ras h

45 factor b (P-TEFb), containing cyclin T1 and cyclin-dependent kinase 9 (CDK9), interacts with the hum

46 several components of transcription such as cyclin-dependent kinase 9 (cdk9), localize at these site

47 RMC5 and Pol II requires the transcriptional cyclin-dependent kinase 9 (CDK9), supporting a phospho-d

48 and the enhancer regions, and inhibition of cyclin-dependent kinase 9 (CDK9), that regulates these e

49 Cyclin-dependent kinase 9 (CDK9), the catalytic componen

50 We found that cyclin-dependent kinase 9 (Cdk9), the catalytic subunit

51 on and led to higher enzymatic activities of cyclin-dependent kinase 9 (CDK9), which serves as a tran

52 s 9 (H3K9ac) and 56 (H3K56ac), activation of cyclin-dependent kinase 9 (CDK9)-that phosphorylates NEL

53 ive to flavopiridol, a specific inhibitor of cyclin-dependent kinase 9 (Cdk9).

54 complex proteins, bromodomain 4 (Brd4), and cyclin-dependent kinase 9 (CDK9).

55 TEFb, a complex containing cyclin T1 and the cyclin-dependent kinase 9 (Cdk9).

56 or b (P-TEFb) contains cyclin T1 (CycT1) and cyclin-dependent kinase 9 (Cdk9).

57 in T and the previously cloned small subunit cyclin-dependent kinase 9 (CDK9).

58 omain containing 4 (BRD4) with NF-kappaB and cyclin-dependent kinase 9 (CDK9).

59 tivated by HIV-1 Tat protein, which recruits cyclin-dependent kinase 9 (CDK9)/cyclin T1 and other hos

60 ster orthologs of the vertebrate PITSLRE and cyclin-dependent kinase-9 (CDK9) kinases, as Hh regulato

61 horylated at an N-terminal serine cluster by cyclin-dependent kinase-9 (CDK9), which is recruited int

62 he role of an isoform of the multifunctional cyclin-dependent kinase 9, CDK9-55, in DNA repair, by ge

63 longation factor b (P-TEFb), consisting of a cyclin-dependent kinase 9-cyclin T heterodimer, stimulat

64 anscriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positiv

65 II transcriptional elongation factor P-TEFb (cyclin-dependent kinase 9/cyclin T) is a cellular protei

66 Cyclin-dependent kinase 9/cyclin T, the protein kinase h

67 y, we found that Thr 4 was phosphorylated by cyclin-dependent kinase 9 in cells and dephosphorylated

68 We thus identified 2 cyclin-dependent kinase 9 inhibitors, alvocidib and dina

69 pression of HIV-1 transcription by selective cyclin-dependent kinase-9 inhibitors may be a useful the

70 roscovitine, newly identified inhibitors of cyclin-dependent kinase-9, markedly decrease HIV-1 promo

71 e inhibitors of the transcription regulating cyclin-dependent kinase 9 on the development and progres

72 h the diapause-like adaptation by inhibiting cyclin-dependent kinase 9 represent potential therapeuti

73 (P-TEFb) is composed of cyclins T1 or T2 and cyclin-dependent kinase 9 that regulate the elongation p

74 either by expression of a dominant-negative cyclin-dependent kinase 9 transgene or through the use o

75 hat in a cohort of 46 patients with HB, high cyclin-dependent kinase 9 tumor expression was significa

76 FF4-CHD as a substrate for the P-TEFb kinase cyclin-dependent kinase 9, which triggers release of pol