ライフサイエンスコーパス: cyclin-dependent protein kinase

1 ts with p34cdc2, the catalytic domain of the cyclin-dependent protein kinase.

2 drives cell-cycle transitions by activating cyclin-dependent protein kinases.

3 gulate the cell division cycle by activating cyclin-dependent protein kinases.

4 which functions as a universal inhibitor of cyclin-dependent protein kinases.

5 Cyclins are the regulatory subunits of cyclin-dependent protein kinases.

6 site has similarities with that of inactive cyclin-dependent protein kinases.

7 rtical release is disrupted in a hypomorphic cyclin-dependent protein kinase 1 (cdk-1) mutant and tha

8 Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme req

9 In eukaryotes, cyclin B-bound cyclin-dependent protein kinase 1 promotes mitotic entry

10 cell cycle is regulated by the action of the cyclin dependent protein kinase 2 (CDK2) in association

11 sterone receptors (PR) are phosphorylated by cyclin-dependent protein kinase 2 (CDK2) at multiple sit

12 Three other kinases [cyclin-dependent protein kinase 2 (CDK2), phosphorylase

13 ut not mutant) specifically disrupted an E2F-cyclin-dependent protein kinase 2-p107 DNA binding compl

14 ssion of proliferating cell nuclear antigen, cyclin-dependent protein kinase 4, cell division cycle 2

15 t the cell-cycle entry program by activating cyclin-dependent protein kinase 4/6 (CDK4/6).

16 phorylation of phosphodiesterase-4 (PDE4) by cyclin-dependent protein kinase 5 (Cdk5) facilitated cAM

17 Cyclin-dependent protein kinase 5 (cdk5), a member of th

18 known Pgammas preserve a consensus motif for cyclin-dependent protein kinase 5 (Cdk5), a protein kina

19 ed levels of p25 and p35, both activators of cyclin-dependent protein kinase 5 (CDK5), enhanced calpa

20 Egr-1 silencing does not affect levels of cyclin-dependent protein kinase 5 (Cdk5), glycogen synth

21 ated with increased levels of tau oligomers, cyclin-dependent protein kinase 5 activators p35 and p25

22 ty of p35, a neuronal protein that activates cyclin-dependent protein kinase 5 through complex format

23 ylation by cAMP-dependent protein kinase and cyclin-dependent protein kinase-5.

24 K are related to Ime2p in budding yeast, and cyclin-dependent protein kinase-activating kinase Cak1p

25 arrested by mating pheromone show a loss of cyclin-dependent protein kinase activity caused by trans

26 f XlORC was affected by inhibitors of either cyclin-dependent protein kinase activity or DNA synthesi

27 T, a potential phosphorylation site for both cyclin-dependent protein kinase and mitogen-activated-pr

28 p21Sdi1/WAF1/Cip1 inhibits cyclin-dependent protein kinases and cell proliferation.

29 bited by olomoucine, which potently inhibits cyclin-dependent protein kinases, and contained an appro

30 Cyclin-dependent protein kinases are among the key regul

31 The cyclin-dependent protein kinases are important targets i

32 entified BUR2, a cyclin for the Bur1/2 (BUR) cyclin-dependent protein kinase, as a specific regulator

33 The association of G(1) cyclins and Cdc28/cyclin-dependent protein kinase catalyzes the cell cycle

34 show that deletion of PHO85, which encodes a cyclin-dependent protein kinase, causes reduced transcri

35 In this article we consider the role of the cyclin-dependent protein kinase cdc2 in regulating progr

36 A specific amino acid substitution in the cyclin-dependent protein kinase Cdc28 was found to cause

37 Cdc6 interacts with the critical cell cycle, cyclin-dependent protein kinase Cdc28.

38 horylation, most likely by the budding yeast cyclin-dependent protein kinase, Cdc28.

39 d with the increased levels of cyclin D3 and cyclin-dependent protein kinase (cdk) 6.

40 In Saccharomyces cerevisiae, PHO85 encodes a cyclin-dependent protein kinase (Cdk) catalytic subunit

41 roteins, including members of the cyclin and cyclin-dependent protein kinase (Cdk) families, and the

42 n about the posttranslational control of the cyclin-dependent protein kinase (CDK) inhibitor p21.

43 y oscillation of an engineered monomolecular cyclin-dependent protein kinase (CDK) module lacking muc

44 Ctk1 is a Saccharomyces cerevisiae cyclin-dependent protein kinase (CDK) that assembles wit

45 In Saccharomyces cerevisiae, PHO85 encodes a cyclin-dependent protein kinase (Cdk) with multiple role

46 species in vivo is dependent upon the Cdc28 cyclin-dependent protein kinase (CDK), which can directl

47 otic cell cycle requires the activation of a cyclin-dependent protein kinase (CDK).

48 e eukaryotic cell cycle are regulated by the cyclin-dependent protein kinases (CDK).

49 ase and requires phosphorylation by the G(1) cyclin-dependent protein kinase (cdk1).

50 e AMPA glutamate receptor subunit GluR2, the cyclin-dependent protein kinase Cdk5, and the transcript

51 activated protein kinases (MAPK) and by the cyclin-dependent protein kinase Cdk7.

52 Phosphorylation of CTD is mediated by the cyclin-dependent protein kinases Cdk7 and Cdk9, whereas

53 cently been shown to associate with a unique cyclin dependent protein kinase (cdk8) and it has been p

54 Cyclin dependent protein kinases (CDKs) have become attr

55 EE1 regulates the cell cycle by inactivating cyclin dependent protein kinases (CDKs) via phosphorylat

56 of proteins whose functions are regulated by cyclin dependent protein kinases (Cdks).

57 karyotes is governed by a complex network of cyclin-dependent protein kinases (CDKs) and auxiliary pr

58 Cyclin E is a regulator of cyclin-dependent protein kinases (Cdks) and is involved

59 is regulated at every stage by a network of cyclin-dependent protein kinases (CDKs) and protein phos

60 Cyclin-dependent protein kinases (Cdks) are key regulato

61 Remarkably, combined PIN1 and cyclin-dependent protein kinases (CDKs) inhibition creat

62 The activation of cyclin-dependent protein kinases (Cdks) is dependent upo

63 Activating phosphorylation of cyclin-dependent protein kinases (CDKs) is necessary for

64 The activity of cyclin-dependent protein kinases (cdks) is physiological

65 Cyclin-dependent protein kinases (Cdks) play a key role

66 Complete activation of most cyclin-dependent protein kinases (CDKs) requires phospho

67 l division cycle is regulated by a family of cyclin-dependent protein kinases (CDKs) that are functio

68 n mRNA and protein expression of cyclins and cyclin-dependent protein kinases (cdks), activity of cdk

69 sion through the cell cycle is controlled by cyclin-dependent protein kinases (Cdks), but the mechani

70 In addition, the inhibitor of cyclin-dependent protein kinases (CDKs), p16INK4a, whose

71 aryotes emphasize the periodic activation of cyclin-dependent protein kinases (CDKs), recent experime

72 itogen-activated protein kinases (MAPKs) and cyclin-dependent protein kinases (CDKs), respectively.

73 ere the first identified binding partners of cyclin-dependent protein kinases (cdks), their cell cycl

74 hoice between repair pathways is governed by cyclin-dependent protein kinases (CDKs), with a major si

75 tively regulates cell division by activating cyclin-dependent protein kinases (CDKs).

76 tions in eukaryotes through association with cyclin-dependent protein kinases (CDKs).

77 The Drosophila melanogaster cyclin-dependent protein kinase complex CycD/Cdk4 stimul

78 The Drosophila cyclin-dependent protein kinase complex Cyclin D/Cdk4 in

79 e the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essentia

80 ne H3 (H3K4), which included components of a cyclin-dependent protein kinase (Ctk complex) that phosp

81 RB is phosphorylated by cyclin-dependent protein kinase during cell cycle progre

82 tation group B (XPB) and D (XPD) genes and a cyclin-dependent protein kinase encoded by the CDK7 gene

83 in-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase family, which has been f

84 ase was not GSK3 but instead a member of the cyclin-dependent protein kinase family.

85 phosphorylation of Cdh1 by Cdc28, the major cyclin-dependent protein kinase in budding yeast.

86 n and is accompanied by up-regulation of the cyclin-dependent protein kinase inhibitor p21(CIP1).

87 by an increase in protein expression of the cyclin-dependent protein kinase inhibitor p21(WAF1/Cip1)

88 on, which alters the conserved sequence, the cyclin-dependent protein kinase inhibitor Sic1, an SCF(C

89 ion of the Ace2 transcription factor and the cyclin-dependent protein kinase inhibitor Sic1.

90 orylation of T320 of PP-1 was reduced by the cyclin-dependent protein kinase inhibitor, olomoucine, a

91 Phosphorylation of RB, which is catalyzed by cyclin-dependent protein kinases, inhibits all three pro

92 iation is prompted during G(1) phase by Cln3/cyclin-dependent protein kinase-mediated transcriptional

93 nds to the consensus target sequence for the cyclin-dependent protein kinase p34(cdc2).

94 (state III), whereas phosphorylation by the cyclin-dependent protein kinase Pcl10p/Pho85p decreased

95 The cyclin-dependent protein kinase Pho85 is a known negativ

96 The cyclin-dependent protein kinase, Pho85, in conjunction w

97 ressed Cdc6 protein that is dependent on the cyclin-dependent protein kinase phosphorylation sites on

98 dent kinase G (CDKG) gene defines a clade of cyclin-dependent protein kinases related to CDK10 and CD

99 e loss of Bur2, a component of the Bur1/Bur2 cyclin-dependent protein kinase, results in a decrease i

100 protein kinase systems, the S-phase-specific cyclin-dependent protein kinases (S-CDKs) and the Dbf4-C

101 Pho85p is a cyclin-dependent protein kinase that antagonizes SNF1 co

102 of proteins, are the regulatory subunits of cyclin-dependent protein kinase that are essential activ

103 otein kinase (Cak1) is itself a Cdc2-related cyclin-dependent protein kinase that associates with cyc

104 These results reveal that the same cyclin-dependent protein kinase that initiates mitosis i

105 ic and regulatory subunits, respectively, of cyclin-dependent protein kinases that control progressio

106 Cks proteins are essential components of the cyclin-dependent protein kinases that regulate mitosis i