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1 her understand the mechanism of this [3 + 2]-cycloaddition reaction.
2 enantioselective triple cascade 1,3-dipolar cycloaddition reaction.
3 G-II through a copper-catalysed azide-alkyne cycloaddition reaction.
4 socyanides to nitrile N-oxides via a [3 + 1] cycloaddition reaction.
5 o our knowledge, of an enzymatic 1,3-dipolar cycloaddition reaction.
6 en enol ether systems can participate in the cycloaddition reaction.
7 quence over the alternate hetero-Diels-Alder cycloaddition reaction.
8 an unsaturated aldehyde-allene for a [2 + 2] cycloaddition reaction.
9 an effective catalyst for the Huisgen [3+2] cycloaddition reaction.
10 ed using the copper-catalyzed sydnone-alkyne cycloaddition reaction.
11 hesis of bicyclic adduct through Diels-Alder cycloaddition reaction.
12 itable motifs for the intermolecular [2 + 2] cycloaddition reaction.
13 y through a copper(I)-catalyzed azide-alkyne cycloaddition reaction.
14 methane, a C-C or N-C coupling, and a formal cycloaddition reaction.
15 cation via the copper-catalyzed azide-alkyne cycloaddition reaction.
16 solely committed to the catalysis of a [4+2] cycloaddition reaction.
17 olymerization and azide-alkyne [3+2] Huisgen cycloaddition reaction.
18 eration of the copper-catalyzed azide-alkyne cycloaddition reaction.
19 ted for its ability to promote a Diels-Alder cycloaddition reaction.
20 omplexes using the CuI-mediated azide-alkyne cycloaddition reaction.
21 no[2,3,4- ij]isoquinolines through a [4 + 2]-cycloaddition reaction.
22 atalysis of the copper-mediated azide-alkyne cycloaddition reaction.
23 of two new C-N bonds via the formal [3 + 2] cycloaddition reaction.
24 hemistry involving a 4-hydroxycoumarin 4 + 1 cycloaddition reaction.
25 ising the overall efficiency or scope of the cycloaddition reaction.
26 bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction.
27 BO-NOTA) via copper-free Huisgen-1,3-dipolar cycloaddition reaction.
28 for subsequent copper-catalyzed azide-alkyne cycloaddition reactions.
29 t of its reactivity in Michael, radical, and cycloaddition reactions.
30 embered anionic heterocycles in formal [2+2] cycloaddition reactions.
31 n, ylide formation, Wolff rearrangement, and cycloaddition reactions.
32 s employing Michael addition and Diels-Alder cycloaddition reactions.
33 o be used in tandem with other bioorthogonal cycloaddition reactions.
34 ly prepared by enantioselective formal [3+2] cycloaddition reactions.
35 etrazine inverse electron demand Diels-Alder cycloaddition reactions.
36 insertion, and [2 + 2], [3 + 2], and [4 + 2] cycloaddition reactions.
37 ioselectivities in nucleophilic addition and cycloaddition reactions.
38 ve as substrates for SN2, SN2', and aldehyde cycloaddition reactions.
39 preformed 5-membered rings, based mainly on cycloaddition reactions.
40 ic questions regarding ketene-alkene [2 + 2] cycloaddition reactions.
41 which is faster than recent strain-promoted cycloaddition reactions.
42 versatility in both Diels-Alder and dipolar cycloaddition reactions.
43 gration of propargylic esters in a number of cycloaddition reactions.
44 talytic activity for copper sulfate mediated cycloaddition reactions.
45 s hitherto unknown during phosphine-promoted cycloaddition reactions.
46 substitution, thiol addition, or 1,3-dipolar cycloaddition reactions.
47 eactions afford cycloheptadienes via [4 + 3] cycloaddition reactions.
48 sm of both inter- and intramolecular [2 + 2] cycloaddition reactions.
49 reactivity of pentafulvenes in a plethora of cycloaddition reactions.
50 eactions, and intermolecular [2 + 2 + 1 + 1] cycloaddition reactions.
51 upramolecular catalysis for copper-catalyzed cycloaddition reactions.
52 products of synthetic and biosynthetic [4+2] cycloaddition reactions.
53 ving as electron-rich dienophiles in [4 + 2] cycloaddition reactions.
54 DM2 RNA dysfunction by a Huisgen 1,3-dipolar cycloaddition reaction, a variant of click chemistry.
55 serve as conduits to three-component [4 + 2] cycloaddition reactions accessing structurally and stere
57 mines participate in this novel hetero-[5+2] cycloaddition reaction and the cycloadducts can be readi
58 pha,beta-unsaturated ketone to undergo [1+4] cycloaddition reactions and afford [Cp*(IXy)(H)2 RuSn(ka
59 rated in this fashion are highly reactive in cycloaddition reactions and display a scope of reactivit
61 ly regio- and stereoselective intramolecular cycloaddition reactions and organometallic additions to
63 ous types of organic reactions, ranging from cycloaddition reactions and sigmatropic rearrangements t
64 of independent (nontethered) bis-1,3-dipolar cycloaddition reactions and the characterization of 5 ne
65 (ii) the thermal stability toward the retro-cycloaddition reaction, and (iii) the effect of changing
66 more fully understand the mechanism of this cycloaddition reaction, and to guide efforts to extend i
67 dition reactions, intermolecular [2 + 2 + 2] cycloaddition reactions, and intermolecular [2 + 2 + 1 +
68 s are important intermediates in 1,3-dipolar cycloaddition reactions, and they are also known to unde
71 pha-Hydroxy-gamma-pyrone-based oxidopyrylium cycloaddition reactions are useful methods for accessing
72 itution and the participation of corroles in cycloaddition reactions as 2pi or 4pi components (coveri
73 und at 0 degrees C resulted in a retro [4+2] cycloaddition reaction, as observed by gel permeation ch
74 Baylis-Hillman, imino-ene, Mannich-type, and cycloaddition reactions, as well as hydrogenation and re
77 fied TNA nucleosides (2'-NH2-TNA) based on a cycloaddition reaction between a glycal and an azodicarb
78 ates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equi
80 esized through a ruthenium-catalyzed [2+2+2] cycloaddition reaction between a propargylic alcohol and
81 and led to the discovery of a Paterno-Buchi cycloaddition reaction between acetone and an angular me
83 ted monolayers were formed through a Huisgen cycloaddition reaction between an alpha-helical peptide
84 pyridyl-modified nucleotides, accelerates a cycloaddition reaction between anthracene and maleimide
87 Cl(4) was found to catalyze a formal [3 + 2] cycloaddition reaction between C(3)-substituted indoles
88 e of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and tetraphenylcy
91 perimental and computational studies for the cycloaddition reaction between N-(3-pyridyl)aldimines an
92 crystal by a photochemically induced [4 + 4] cycloaddition reaction between neighboring monomers in w
94 eloped the first intermolecular hetero-[5+2] cycloaddition reaction between oxidopyrylium ylides and
95 cular dynamics simulations indicate that the cycloaddition reaction between ozone and trans-isoprene
96 Theory indicates that a pi2 + pi2 + sigma2 cycloaddition reaction between SO3 and HCOOH is a plausi
97 the photo- and cobalt-catalyzed [2 + 2 + 2] cycloaddition reaction between the corresponding naphthy
98 al resolution in cells via a Cu(I)-catalyzed cycloaddition reaction between the terminal alkyne group
99 It is found that the AlCl3-catalyzed [4 + 2]-cycloaddition reaction between these dienes and N-methyl
100 id synthesis utilized a novel hetero-[2 + 2]-cycloaddition reaction between two aryl ynol ethers to y
101 th 1 and 2 are effective catalysts for [3+2] cycloaddition reactions between alkynes and azides (i.e.
103 copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridin
104 (F)CF2CF2-)(PPh2Me) in the first examples of cycloaddition reactions between perfluoroalkenes and met
106 also susceptible to nucleophilic attacks and cycloaddition reactions by and with the phosphorus ylide
107 e first general method for catalysis of such cycloaddition reactions by using solvent hydrogen bondin
108 hree-step sequence involving the Diels-Alder cycloaddition reaction can be employed as advanced inter
109 cular, we show that the azide-alkyne Huisgen cycloaddition reaction catalyzed by copper(I) is fully c
110 reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethylaluminum chl
111 zetidinone and a variety of diynes undergo a cycloaddition reaction catalyzed by Ni/IPr to give dihyd
112 5-shift precursor, a copper-mediated dipolar cycloaddition reaction ("click") with azide partners is
118 s show why the catalytic, asymmetric (4 + 3)-cycloaddition reaction developed in the Harmata laborato
119 performing Sonogashira coupling and Huisgen cycloaddition reactions directly to the CTV core for the
120 several constrained agonists generated by a cycloaddition reaction displayed high selectivity (223-
122 to CuPRT via a Cu(I)-catalyzed azide-alkyne cycloaddition reaction failed as a result of dethreading
123 -membered ring trans-alkenes underwent [4+2] cycloaddition reactions faster than a trans-cyclooctene.
124 ed in good yields presumably through [4 + 2] cycloaddition reactions followed by hydrogen migrations.
125 echanistic insights into the thermal [3 + 2] cycloaddition reaction for such substrates, they were al
128 les are found to proceed through retro-(3+2)-cycloaddition reactions, generating the experimentally r
129 metal-free highly diastereoselctive [3 + 2] cycloaddition reaction has been developed between N-phen
130 derivatives by tandem beta-azidation/[3 + 2] cycloaddition reaction has been developed under mild con
131 the boron substituted cycloadducts of those cycloaddition reactions have been used in cross coupling
132 able linker via Cu(I)-catalyzed azide-alkyne cycloaddition reaction; (iii) enrichment of the biotin-t
134 the power of the intramolecular hetero [4+2] cycloaddition reaction in the total synthesis of complex
137 nd bio-orthogonal reactions are dominated by cycloaddition reactions in general and 1,3-dipolar cyclo
138 onventional chemical approaches to achieving cycloaddition reactions in synthesis and uncover enantio
139 tions, other intermolecular and transannular cycloaddition reactions included intermolecular Pauson-K
140 on-metal-free applications of arynes include cycloaddition reactions, insertion reactions and multico
141 product was assembled rapidly via a [4 + 3] cycloaddition reaction-inspired strategy, and the tertia
142 Pauson-Khand reactions, transannular [4 + 2] cycloaddition reactions, intermolecular [2 + 2 + 2] cycl
143 f the transition-metal-catalyzed [2 + 2 + 2] cycloaddition reaction involving all kinds of unsaturate
145 een successfully synthesized through [4 + 2] cycloaddition reaction involving in situ arynes as dieno
147 ies of multicomponent [4 + 2]/[3 + 2] domino cycloaddition reactions involving nitroindole derivative
149 lytic processes proceed via stepwise [4 + 2] cycloaddition reactions involving three steps, which are
151 plets (ca. 5 mum diameter) and find that the cycloaddition reaction is accelerated even further (by a
154 We find that the precursor of this [2 + 2] cycloaddition reaction is the singlet doubly pi(2)pi*(2)
155 tution pattern governs both dimerization and cycloaddition reactions is of fundamental interest to pr
156 o form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chem
158 exes are employed as catalysts for a [4 + 2] cycloaddition reaction leading to alkylidenecyclohexenes
159 lves at room temperature via a retro-[2 + 2]-cycloaddition reaction, leading to an original NHC-stabi
160 polarophiles in a 1,3-dipolar intramolecular cycloaddition reaction, leading to the corresponding iso
161 dipoles and to tune their reactivity toward cycloaddition reactions makes mesoionics an attractive o
162 yield through a chelator-accelerated one-pot cycloaddition reaction mediated by copper(I) catalysis.
164 f the in situ protein-templated azide-alkyne cycloaddition reaction occurring at a localized, sequest
165 repared by a one-pot three-component [3 + 2] cycloaddition reaction of (E)-3-arylidene-1-phenyl-pyrro
166 derivatives through the dearomative (4 + 3) cycloaddition reaction of 2-vinylindoles or 4H-furo[3,2-
167 or the formation of C(60) involves a [2 + 2] cycloaddition reaction of a cyclopolyyne to form a tetra
168 The technique illustrated here involves a cycloaddition reaction of a lactone with the in situ-gen
169 a Ru- or Rh-catalyzed [5 + 2] intramolecular cycloaddition reaction of an alkyne and a vinylcycloprop
170 The key step is an intramolecular [3 + 2]-cycloaddition reaction of an in situ generated azomethin
175 ion, transphosphorylation, and a 1,3-dipolar cycloaddition reaction of diazoalkylphosphonates in a pe
176 ure, we found that the rate constant for the cycloaddition reaction of DIFBO with an azide exceeds th
177 ater, is a regioselective hetero-Diels-Alder cycloaddition reaction of enol ethers to 4-phosphinyl or
181 s the formal inverse electron demand [4 + 2] cycloaddition reaction of in situ-generated cationic ary
183 iiodide ions, which collectively mediate the cycloaddition reaction of organic azide and terminal alk
187 A regioselective dearomative aza-(3 + 2) cycloaddition reaction of substituted indoles with alpha
188 thesized as crystalline solids via a [1 + 2] cycloaddition reaction of the aluminum(I) complex HC[(CM
190 of the reaction sequence included a [3 + 2] cycloaddition reaction of unsaturated vicinal dicarboxyl
191 as accomplished through mono- and bis[3 + 2]-cycloaddition reactions of (2E,4E)-ethyl 5-(phenylsulfon
194 ffolds is presented, which exploits multiple cycloaddition reactions of a carbohydrate-derived nitron
195 selectivity to triplet excited-state [2 + 2] cycloaddition reactions of alkenes photocatalyzed by the
197 an be achieved for either [4 + 2] or [4 + 3] cycloaddition reactions of allene-dienes catalyzed by go
199 y 1,4-disubstituted 1,2,3-triazole using the cycloaddition reactions of an appropriately functionaliz
201 ONHC(6)H(3)( (i)Pr)(2))) were applied in the cycloaddition reactions of aziridines with carbon dioxid
204 ino esters are formed catalytically by [3+2] cycloaddition reactions of enecarbamates with electrophi
207 , synthesis of small-ring compounds, (2 + 2) cycloaddition reactions of halogenated ethylenes, assist
208 udies include the development and use of the cycloaddition reactions of heterocyclic azadienes (1,2,4
216 ficient and stereoselective Pt(IV)-catalyzed cycloaddition reactions of the corresponding quinone met
217 catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of the synthesized spiro-cyclopr
219 cation of intramolecular 1,3-dipolar nitrone cycloaddition reaction on carbohydrate-derived precursor
220 ent complexation is much more favorable than cycloaddition reactions on interior bonds of graphene.
221 and 2 do not undergo heat- or light-induced cycloaddition reactions or Friedel-Crafts acylations.
222 rs for the biosynthetic relevance of [4 + 2] cycloaddition reactions, other cycloadditions have recei
224 On the basis of the strain-promoted [3 + 2] cycloaddition reaction performed at ambient temperature,
226 ve synthetic steroid, by using a 1,3-dipolar cycloaddition reaction (Prato's protocol) results in the
227 lectivity was observed in the intramolecular cycloaddition reaction producing 5 to 7-membered rings.
228 sess the viability of nitrone-alkene (3 + 2) cycloaddition reactions proposed to occur during the bio
233 s the transition-metal-catalyzed [2 + 2 + 2] cycloaddition reaction, since it permits the formation o
234 s and 1,4,2-dioxazolidines revealed that the cycloaddition reaction takes place through a concerted m
235 we report an unprecedented overall 4pi + 2pi cycloaddition reaction that generates a different, highl
236 , the result is a sequential [5 + 2]/[4 + 2] cycloaddition reaction that provides sp(3)-rich products
237 des have proven to be versatile reagents for cycloaddition reactions that allow highly efficient cons
238 idized to Cu(I) , catalyzes the azide-alkyne cycloaddition reactions that result in the efficient syn
239 n other transformations, such as 1,3-dipolar cycloaddition reactions, that provide these products.
240 A DFT study explains the polar nature of the cycloaddition reaction, the observed reactivity and sugg
242 ymers, which are generated via retro-[4 + 2] cycloaddition reactions, the first-order kinetic coeffic
243 spite the widespread use of copper-catalyzed cycloaddition reactions, the mechanism of these processe
245 ed as an isomer formed via an internal 2 + 2 cycloaddition reaction; the triplet lifetime (8.4 +/- 0.
247 .1]-5-undecen-9-one; and (iii) a Diels-Alder cycloaddition reaction to construct the third ring found
248 we report the use of the Huisgen 1,3-dipolar cycloaddition reaction to generate triazole-stapled BCL9
249 ped by an alkene dipolarophile via a [2 + 3] cycloaddition reaction to give the corresponding isooxaz
250 plication of the ruthenium-catalyzed [2+2+2] cycloaddition reaction to highly substituted indene syst
253 ntioselective azomethine ylide (1,3)-dipolar cycloaddition reaction to set the absolute and relative
254 tions via a UV-irradiation-initiated [2 + 2] cycloaddition reaction to yield the corresponding cyclob
255 ites-that react pairwise through 1,3-dipolar cycloaddition reactions to create a network of four leng
256 n regio- and stereo-selective intramolecular cycloaddition reactions to give adducts, for example, 15
257 The regio- and stereoselective control of cycloaddition reactions to polyconjugated systems has be
258 also underwent strain-promoted alkyne-azido cycloaddition reactions to provide access to fluorescent
259 zido fluorophore, via copper catalyzed [3+2] cycloaddition reactions, to produce the corresponding tr
260 e use of tandem, cobalt-mediated [2 + 2 + 2] cycloaddition reactions, two synthetic routes have been
261 binary behavior: undergoing a retro-[4 + 2] cycloaddition reaction under high load to form a surface
262 hat underwent exquisite intramolecular [4+2] cycloaddition reactions under thermal conditions to prov
264 ggering of the metal-free azide to acetylene cycloaddition reaction was achieved by masking the tripl
265 isoxazoline complex as the catalyst, a [3+3]-cycloaddition reaction was achieved with excellent yield
267 oles formed via strain-promoted azide-alkyne cycloaddition reactions was investigated by density func
268 Brummond-Chen thermal intramolecular (2 + 2)-cycloaddition reactions were examined using density func
271 C) and featured a novel [2 + 2] photoinduced cycloaddition reaction which occurred with complete regi
272 onjugated aromatic system would be broken by cycloaddition reactions, which are therefore rarely appl
273 Cu(I) significantly accelerate azide-alkyne cycloaddition reactions while Bipy-containing SCPNs liga
274 functionalized by the four reagents through cycloaddition reactions, while the interior regions cann
275 can be visualized "on chip" by a 1,3-dipolar cycloaddition reaction with an alkynyl-modified dye.
276 cially available amide base and trapped in a cycloaddition reaction with furan in moderate to good yi
277 alyzed dearomative trimethylenemethane [3+2] cycloaddition reaction with simple nitroarene substrates
278 ooctene as the activator leads to a complete cycloaddition reaction with the antibody-drug conjugate
280 hat were subsequently subjected to a dipolar cycloaddition reaction with trimethylsilyl amino esters.
281 y reported asymmetric Diels-Alder and Ficini cycloaddition reactions with 2,3-disubstituted butadiene
282 reversible, recognition-mediated 1,3-dipolar cycloaddition reactions with a stoppering maleimide grou
287 s have been sought as substrates for Cu-free cycloaddition reactions with azides in biological system
288 )-ligated dirhodium carboxylates for [3 + 3]-cycloaddition reactions with both acyclic and cyclic nit
289 roenamines and their use in Zn(II)-catalyzed cycloaddition reactions with commercial alpha,beta-unsat
290 eners to carbonyl compounds, undergo [2 + 2] cycloaddition reactions with different alkynes to genera
292 nters can be generated via completed (3 + 2) cycloaddition reactions with full regio- and diastereoco
293 ntities via N-chlorosulfonylisocyanate (CSI) cycloaddition reactions with functionalized alkenes; pre
294 rans linked by a rigid tether undergo tandem cycloaddition reactions with high stereoselectivity.
295 prepared in situ, is exemplified by dipolar cycloaddition reactions with nitrones to give highly sub
296 o react readily in [n + 2] (n = 6, 4, 2 + 2) cycloaddition reactions with norbornadiene and quadricyc
297 uranoside were also subjected to 1,3-dipolar cycloaddition reactions with six azidopyranosides under
298 shown to undergo characteristic ketene [2+2] cycloaddition reactions with tethered alkenes and extern
299 of products through irreversible 1,3-dipolar cycloaddition reactions with the four nitrones present i
300 ognition site can participate in 1,3-dipolar cycloaddition reactions with two maleimides that differ