ライフサイエンスコーパス: cyclophilin A

1 APDH and LDH) but not others (e.g. Hsp90 and cyclophilin A).

2 te of its primary cyclophilin enzyme ligand, cyclophilin A.

3 tion with the retinoblastoma protein but not cyclophilin A.

4 iciently in the presence of normal levels of cyclophilin A.

5 ncoding the prototypical cyclophilin protein cyclophilin A.

6 ied CD147 as the main signaling receptor for cyclophilin A.

7 l cis-trans isomerization catalyzed by human cyclophilin A.

8 disrupting the association of caveolin-1 and cyclophilin A.

9 sed immunophilin proteins such as FKBP12 and cyclophilin A.

10 ed for interaction with the cellular protein cyclophilin A.

11 s: annexin II, cyclophilin 40, caveolin, and cyclophilin A.

12 59, were considered as candidate targets for cyclophilin A.

13 t not by cyclosporin A, a drug that binds to cyclophilin A.

14 ells, H9 cells express greater quantities of cyclophilin A.

15 und crystal form and as a complex with human cyclophilin A.

16 apsid (residues 1-151) in complex with human cyclophilin A.

17 f high PF74 concentrations was attenuated by cyclophilin A.

18 on other isomerases such as Pin4, FKBP12, or cyclophilin A.

19 merization outpowers the holding activity of cyclophilin A.

20 The binding site for cyclophilin A, a cellular rotamase that is packaged into

21 lpha-actin, a smooth muscle cell marker, and cyclophilin A, a control gene.

22 sets, the top ranked gene was PPIA, encoding cyclophilin A, a druggable target using cyclosporine.

23 Cyclophilin A, a known ligand of BSG, competitively redu

24 inhibition of HIV infection by SUN2 involves cyclophilin A, a protein that binds the HIV capsid and d

25 Here, we characterize ECD in Cyclophilin A, a well-studied peptidyl-prolyl cis-trans

26 Surprisingly, a number of cyclophilin A active-site mutants previously assumed to

27 the finding that Gag mutants with decreased cyclophilin A affinity are dead in Jurkat cells but capa

28 The A224E Gag mutant has no effect on cyclophilin A affinity but renders HIV-1 replication cyc

29 oviruses encoding Gag mutants with decreased cyclophilin A affinity exhibit attenuated infectivity, a

30 ession in cis of a Gag mutant that decreases cyclophilin A-affinity.

31 EMENT We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-i

32 Cyclophilin A, also known as peptidylprolyl cis-/trans-i

33 ether, these data provide evidence that both cyclophilin A and B interact with CYDV-RPV, and these in

34 east mutants lacking the CsA target proteins cyclophilin A and calcineurin.

35 These results indicate that cyclophilin A and Ess1 function in parallel pathways and

36 interact with the peptidyl-propyl isomerases cyclophilin A and FK506-binding protein (FKBP12), respec

37 neurin inhibitors, such as the cyclosporin A-cyclophilin A and FK506-FKBP12 complexes, regulate this

38 iae, CsA and FK506 bind to the immunophilins cyclophilin A and FKBP12 and the resulting complexes inh

39 yclosporin A and tacrolimus binding proteins cyclophilin A and FKBP12 were also expressed by keratino

40 s of C2-C12 cells express similar amounts of cyclophilin A and FKBP12, immunophilins known to be intr

41 irus type 1 (HIV-1) Gag polyprotein binds to cyclophilin A and incorporates this cellular peptidyl pr

42 equired for proper interaction with the host cyclophilin A and influences its peptidyl-prolyl cis/tra

43 e cis-bound and trans-bound conformations of cyclophilin A and its substrate as the enzymatic reactio

44 ive HIV-1 capsid mutants P90A (defective for cyclophilin A and Nup358 recruitment) and N74D (defectiv

45 domain cyclophilins, including the mammalian cyclophilin A and plant Roc1 and Roc2, which are ortholo

46 RIM5alpha is altered by interactions between cyclophilin A and the HIV-1 capsid.

47 cation of this putative factor-binding site, cyclophilin A and the restricting factor(s) cooperated t

48 nsity collected from crystals of the enzymes cyclophilin A and trypsin.

49 ntified in this proof of principle work were cyclophilin A and UDP-glucose-4-epimerase, both of which

50 h a combination of the two being optimal for cyclophilins A and B.

51 not CrkI, associates with the immunophilins, cyclophilin A, and 12-kDa FK506-binding protein, in rest

52 olin, heat-shock protein 56, cyclophilin 40, cyclophilin A, and cholesterol.

53 h caveolin-1, i.e. FK506-binding protein 52, cyclophilin A, and cyclophilin 40, were not necessary fo

54 ve expression of alpha-actin, alpha-tubulin, cyclophilin A, and proliferating cell nuclear antigen (P

55 ive of these proteins as gp96, HSP70, HSP90, cyclophilin-A, and FKBP18.

56 Moreover, cyclophilin A, another cellular protein that binds to HI

57 Since Nef and cyclophilin A appear to act in similar ways on postentry

58 he viral protein Nef and the cellular factor cyclophilin A are both required for full infectivity of

59 and its interaction with the human chaperone cyclophilin A are both targets for highly potent and pro

60 laboratory has shown that human recombinant cyclophilins A, B, and C have sequence homology with the

61 We report here that cyclophilin A becomes essential when Ess1 function is co

62 lt demonstrates that capsid dimerization and cyclophilin A binding are not thermodynamically coupled

63 infectivity of virions with mutations in the cyclophilin A binding loop of Gag.

64 he inner face of the viral matrix and at the Cyclophilin A binding loop of the capsid.

65 , including the N-terminal beta-hairpin, the cyclophilin A binding loop, the inter-domain linker, seg

66 n though these residues are distant from the cyclophilin A binding loop.

67 lso evolved amino acid changes in the capsid cyclophilin A binding loop.

68 but mutants that recapitulate the effect of Cyclophilin A binding on capsid conformation and dynamic

69 lpha-helices 4 and 5 of CA, analogous to the cyclophilin A-binding loop of human immunodeficiency vir

70 A change in the cyclophilin A-binding loop of the HIV-1 capsid decreased

71 tants that were altered near the base of the cyclophilin A-binding loop of the N-terminal capsid doma

72 within a nuclear localization signal in the cyclophilin A-binding loop, is critical for engaging the

73 regions, including the NTD beta-hairpin, the cyclophilin A-binding loop, residues in the hexamer cent

74 -1 replication in transformed cells requires cyclophilin A but is dependent on other interactions in

75 utant) resulted in a channel unresponsive to cyclophilin A but with pore properties similar to the wi

76 , in contrast to HCV, HAV does not depend on cyclophilin A, but rather on adenosine-triphosphate-bind

77 We found that mRNAs encoding for cyclophilin A, c-myc binding protein 1, the heat shock p

78 That Gag's functional dependence on cyclophilin A can be differentiated genetically from its

79 n of cis-trans isomerization of the free and cyclophilin A-catalyzed process.

80 Among these proteins, annexin A4, cyclophilin A, cathepsin D, galectin-1, 14-3-3zeta, alph

81 One such cDNA shows homology to cyclophilins, a class of immunophilins with a peptidyl-p

82 cule-1, macrophage scavenger receptor-1, and cyclophilin A compared with controls 3 days after arteri

83 The crystal structure of human recombinant cyclophilin A complexed with a substrate of succinyl-Ala

84 The structures of cyclophilin A complexed with dipeptides of Ser-Pro, His-

85 Reduced cyclophilin A content resulting in decreased binding of

86 Cyclophilin A contributes to aortopathy induced by postn

87 ed a network of protein vibrations in enzyme cyclophilin A, coupled to its catalytic activity of pept

88 on of a non-G-protein substrate of TTS-ExoS, cyclophilin A (CpA), a peptidyl-prolyl isomerase (PPIase

89 The peptidyl-prolyl isomerase (PPIase) cyclophilin A (Cpr1p) is conserved from eubacteria to ma

90 Cyclophilin A (Cpr1p) was identified as a cytosolic prot

91 wo immunophilin-immunosuppressant complexes, cyclophilin A-cyclosporin A (CyPA-CsA) and FKBP-FK506.

92 ith the CaN autoinhibitory peptide (CaP) and cyclophilin A/cyclosporin A (CyPA/CsA) using each peptid

93 Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are prese

94 Cyclophilin A (CyP A), a cellular chaperone with cis-tra

95 d in a pi-stacking interaction with Arg55 of cyclophilin A (Cyp A), and the m-Tyr residue was displac

96 Although cyclophilin A (CyP-A) is a relatively abundant small imm

97 or the first time that the chaperone protein cyclophilin A (CyPA) acts as a Ca(2+) modulator in plate

98 Extracellular cyclophilin A (CyPA) and CyPB have been well described a

99 Cyclophilin A (CyPA) and its peptidyl-prolyl isomerase (

100 eens on two model protein systems, including cyclophilin A (CypA) and the minor allele variant of hum

101 newly synthesized HIV-1 capsid with cellular cyclophilin A (CYPA) and the subsequent activation of th

102 Since Nef and cyclophilin A (CyPA) appear to act in similar ways on po

103 tures of apo-CA hexamers and in complex with cyclophilin A (CypA) at near-atomic resolutions.

104 , as well as a nearby histidine (H87) in the cyclophilin A (CypA) binding loop.

105 ere, we demonstrate that substitution of the cyclophilin A (CyPA) binding region in the capsid of an

106 Cyclophilin A (CypA) binding to viral capsid protects HI

107 The peptidyl-prolyl isomerase cyclophilin A (CypA) binds a proline-rich loop on the su

108 The host cell protein cyclophilin A (CypA) binds to CA of human immunodeficien

109 ns of the cellular peptidyl-prolyl isomerase cyclophilin A (CyPA) by the Gag polyprotein.

110 Remarkably, in Owl monkeys (omk), a cyclophilin A (CypA) cDNA has been transposed into the T

111 rly restriction mediated by TRIMCyp, a TRIM5-cyclophilin A (CypA) chimera resulting from a CypA retro

112 e viral Nef protein and the cellular protein cyclophilin A (CyPA) during virus assembly.

113 The peptidyl-prolyl isomerase cyclophilin A (CypA) embraces an exposed, proline-rich l

114 een CsA resistance and reduced dependency on cyclophilin A (CyPA) for replication was identified.

115 type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication.

116 ity in the active site of the dynamic enzyme cyclophilin A (CypA) has been previously linked to its c

117 More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated i

118 Of 15 known human cyclophilins, cyclophilin A (CypA) has been the focus of investigation

119 Cyclophilin A (CypA) has interacted with the CA of lenti

120 tiprotein complex in which HCV NS5A and host cyclophilin A (CypA) have been shown to be present toget

121 gp120 envelope protein and virion-associated cyclophilin A (CypA) have been shown to directly interac

122 e dynamics of the prolyl cis-trans isomerase cyclophilin A (CypA) in its substrate-free state and dur

123 ssion of small interfering RNA for targeting cyclophilin A (CypA) in p19 cells lose their potential f

124 nt study proposes a novel mode of action for cyclophilin A (CypA) in the HIV-1 life cycle.

125 The peptidyl-prolyl isomerase cyclophilin A (CypA) increases the kinetics by which hum

126 PO3, addition of the CA-binding host protein cyclophilin A (CypA) inhibited HIV-1 uncoating and reduc

127 lex, the maedi-visna virus (MVV) Vif hijacks cyclophilin A (CypA) instead.

128 The host cell factor cyclophilin A (CypA) interacts directly with the HIV-1 c

129 Packaging of cyclophilin A (CypA) into HIV-1 virions is essential for

130 lyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the f

131 Cyclophilin A (CyPA) is a 20-kDa chaperone protein secre

132 tudies conducted in cell lines indicate that cyclophilin A (CypA) is a component of HIV type 1 (HIV-1

133 Cyclophilin A (CypA) is a member of a family of cellular

134 Cyclophilin A (CypA) is a peptidyl-prolyl isomerase that

135 Previously we demonstrated that cyclophilin A (CyPA) is a secreted oxidative stress-indu

136 We previously demonstrated that cyclophilin A (CyPA) is an essential cofactor for HCV in

137 Cyclophilin A (CypA) is an intracellular protein that is

138 HIV-1 Gag protein interaction with cyclophilin A (CypA) is critical for viral fitness.

139 interaction with the human prolyl isomerase cyclophilin A (CypA) is essential for viral RNA replicat

140 that the prolyl cis-trans isomerase (PPIase) cyclophilin A (CypA) is hijacked by Listeria at membrane

141 Cyclophilin A (CypA) is necessary for effective human im

142 Cyclophilin A (CypA) is required for viral replication,

143 Cyclophilin A (CyPA) is specifically incorporated into t

144 s of restriction mediated by owl monkey TRIM-cyclophilin A (CypA) or human TRIM5alpha.

145 residues Val86-Arg97 that contain the human cyclophilin A (CypA) packaging signal have (15)N heteron

146 Recent studies showed that cyclophilin A (CypA) promotes NF-kappaB/p65 nuclear tran

147 Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity t

148 for the binding of cyclosporin A (CsA) to a cyclophilin A (CypA) sample in which the protein was a c

149 Peptidyl prolyl cis/trans isomerase cyclophilin A (CypA) serves as a cellular receptor for t

150 Herein, we identify a novel Cyclophilin A (CypA) small molecule inhibitor (HL001) th

151 ng tripartite motif-containing 5 (TRIM5) and cyclophilin A (CypA) that potently blocks HIV-1 infectio

152 The binding of cyclophilin A (CypA) to the human immunodeficiency virus

153 enhanced by binding of the host cell protein cyclophilin A (CypA) to the viral capsid protein (CA).

154 We found that cyclophilin A (CypA) was excluded from wild-type SIV par

155 Cyclophilin A (CypA) was recently reported to be overexp

156 CA interactions with both CPSF6 and cyclophilin A (CypA) were essential for the unique dose-

157 Also, virion incorporation of cyclophilin A (CypA), a cellular peptidyl-prolyl isomera

158 The host protein cyclophilin A (CypA), a cis-trans prolyl isomerase, in s

159 Cyclophilin A (CypA), a cytoplasmic, human immunodeficie

160 ivity to restriction factors is modulated by cyclophilin A (CypA), a host cell protein that binds the

161 tion was greatly reduced both by antibody to cyclophilin A (CyPA), a known mediator of inflammation i

162 Here we demonstrate that cyclophilin A (CyPA), a member of the immunophilin famil

163 Cyclophilin A (CyPA), a ubiquitously distributed intrace

164 rised of ubiquitin, ribonuclease A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (

165 ncluding ubiquitin, ribonuclease A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (

166 5 recognized a 20-kDa protein, identified as cyclophilin A (CypA), and CypA was present on the surfac

167 The cytoplasmic subtype of cyclophilin, cyclophilin A (CyPA), appears to be required for functio

168 e, using chemical inhibition or silencing of cyclophilin A (CypA), as well as CA mutant viruses, we i

169 riments showing that overexpressed wild-type cyclophilin A (CyPA), but not CyPA with a rotamase activ

170 on of the capsid with host cell factors like cyclophilin A (CypA), can influence the efficiency of re

171 rly part of the viral lifecycle by utilising cyclophilin A (CypA), cleavage and polyadenylation speci

172 ice lacking the essential cellular co-factor cyclophilin A (CypA), HCV RNA replication is markedly di

173 ding mice with ablation and/or inhibition of cyclophilin A (CypA), here we show that expression of AP

174 olecular dynamics simulations to study human cyclophilin A (CypA), in order to understand the role of

175 denylation specificity factor 6 (CPSF6), and cyclophilin A (CypA), indicating that the observed loss

176 The founding member of the family, cyclophilin A (CyPA), is an abundant, ubiquitously expre

177 on with the human peptidyl prolyl isomerase, cyclophilin A (CypA), that results in packaging of CypA

178 cellular peptidyl-prolyl cis-trans isomerase cyclophilin A (CyPA), the cytosolic receptor for the imm

179 y incorporates the peptidyl prolyl isomerase cyclophilin A (CyPA), the cytosolic receptor for the imm

180 tigated the effects of the host cell protein cyclophilin A (CypA), which binds to HIV-1 CA, on HIV-1

181 ort that the peptidyl-prolyl isomerase (PPI) cyclophilin A (CypA), which is implicated in the regulat

182 t residues H(219), I(223), and M(228) in the cyclophilin A (CypA)-binding loop in B57(+) individuals

183 on specific factor 6 (CPSF6), as well as the cyclophilin A (CypA)-binding loop mutation P90A, all inc

184 5A, which encompasses residues implicated in cyclophilin A (CypA)-dependent HCV RNA replication.

185 V-1 capsid (CA) interaction with target cell cyclophilin A (CypA).

186 eta1 stimulation via robust up-regulation of cyclophilin A (CypA).

187 nd orthologs of essential host factors, like cyclophilin A (CypA).

188 ortant interaction with the cellular protein cyclophilin A (CypA).

189 ecessary and sufficient for CD147 binding to cyclophilin A (CypA).

190 its CA is not bound to the cellular protein cyclophilin A (CypA).

191 to analyze the catalytic mechanism of human cyclophilin A (CypA).

192 by the peptidyl prolyl isomerase activity of cyclophilin A (CypA).

193 pendent upon CA interacting with host factor cyclophilin A (CypA).

194 that functions by targeting a host protein, cyclophilin A (CypA).

195 ency virus type 1 (HIV-1) CA binding protein cyclophilin A (CypA).

196 ng Fv1NtD fused to the HIV-1 binding protein Cyclophilin A (CypA).

197 us (HCV) requires host cell factors, such as cyclophilin A (CypA).

198 red with wild-type controls through secreted cyclophilin A (CypA).

199 ted by the cellular peptidylprolyl isomerase cyclophilin A (CyPA).

200 ng substates of the human proline isomerase, cyclophilin A (CYPA, also known as PPIA).

201 Cyclophilin A (CypA, encoded by Ppia) is highly expresse

202 Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase

203 Cyclophilin A (CyPA; encoded by Ppia) is a ubiquitously

204 46 in TRIMCyp (or residues 66 and 143 in the cyclophilin A [CypA] domain) confer restriction specific

205 addition of cyclosporine A or infection of a cyclophilin A-deficient cell line.

206 scattering measurements on a dynamic enzyme, cyclophilin A, demonstrating that these experiments are

207 V-2 or SIV Nef would have a direct effect on cyclophilin A dependence.

208 We also found that purified cyclophilin A destabilizes in vitro-assembled HIV-1 CA-N

209 We show that cyclophilin A displays rich dynamics following a tempera

210 ent conformational properties, rhodanese and cyclophilin A, during binding and encapsulation by GroEL

211 ss1 conditional and null mutations, and that cyclophilin A enzymatic activity is required for suppres

212 Further evidence that increased cyclophilin A expression in H9 cells is of functional re

213 and that infectivity is finely tuned by host cyclophilin A expression levels.

214 Our results suggest that TNPO3 and cyclophilin A facilitate HIV-1 infection by coordinating

215 Nef are able to compensate for the need for cyclophilin A for full infectivity and that amino acids

216 type 1 (HIV-1) Gag and the cellular protein cyclophilin A form an essential complex in the virion co

217 protein processing, and the upregulation of cyclophilin A further support the notion that C. neoform

218 ontained two- to threefold reduced ratios of cyclophilin A:Gag protein as compared with untreated vir

219 )) or by the product of the owl monkey TRIM5-cyclophilin A gene fusion (TRIMCyp).

220 roximately 61 % sequence identity with human cyclophilin A (hCyPA) and the structures are similar, co

221 r surface of recombinant human hexahistidine cyclophilin A (His-CypA) is described.

222 In this study, a human cyclophilin A homologue, TvCyclophilin 1 (TvCyP1), was i

223 Cyclophilin A immunoreactivity was undetectable in glial

224 hat only the trans cis form of AAPF binds to cyclophilin A implies that cyclophilin A predominantly c

225 only the cis form of the substrate bound to cyclophilin A in a stoichiometry of 1:1.

226 fort, evidence of developmental functions of cyclophilin A in non-plant systems has remained obscure.

227 ction between CD147 and another cyclophilin, cyclophilin A, in solution.

228 Disruption of cyclophilin A incorporation, either by gag mutations or

229 In addition, cyclophilin A increased Crk SH3 domain-binding guanine-n

230 nnel had been opened by PKA phosphorylation, cyclophilin A increased the open probability of wild-typ

231 3-Rpd3 histone deacetylase complex, and that cyclophilin A increases and Ess1 decreases disruption of

232 us to identify a third cyclophilin protein, cyclophilin A, interacting directly or in complex with p

233 Disruption of the HIV-1 CA-cyclophilin A interaction caused a minimal increase in t

234 Disruption of the HIV-1 CA-cyclophilin A interaction inhibits Lv1 restriction in so

235 The observation that disruption of the Gag-cyclophilin A interaction rescues A224E mutant replicati

236 hat indirectly targets NS5A by blocking NS5A/cyclophilin A interaction.

237 ye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by

238 A-NS5A interactions but does not affect NS5A-cyclophilin A interactions.

239 unodeficiency virus (SIV) do not incorporate cyclophilin A into virions or need it for full infectivi

240 Cyclophilin A is a conserved peptidyl-prolyl cis-trans i

241 Cyclophilin A is a small, soluble protein which binds th

242 Cyclophilin A is a tractable model system to study using

243 or a simian lentivirus that does not recruit cyclophilin A is also stimulated by these drugs.

244 ntiated genetically from its ability to bind cyclophilin A is further demonstrated by the rescue of a

245 the more expanded and unstructured denatured cyclophilin A is not encapsulated but is expelled into s

246 f cyclophilin A with hensin, suggesting that cyclophilin A is the PPIase that mediates the polymeriza

247 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously

248 A sixth suppressor, cyclophilin A, is a member of a distinct family of PPIas

249 cyclosporin A (CsA), an inhibitory ligand of cyclophilin A, is a widely used immunosuppressive drug,

250 dentity with the central conserved region of cyclophilin A, is evolutionarily conserved by Southern b

251 Other notables include cyclophilin-A, keratin, GAPDH, and cytochrome c.

252 sponsible for the alteration of phenotype in cyclophilin A knockdown (CypA-KD) P19 cells, we observed

253 Roc2, which are orthologs of the yeast Cpr1p cyclophilin, a known inhibitor of TBSV replication in ye

254 ellular ligands for cyclosporine include the cyclophilins, a large family of phylogenetically conserv

255 Cyclophilin A localizes within the F-actin of these stru

256 Catalysis of proline isomerization by cyclophilin A lowers the energy barrier for alpha-synucl

257 with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in

258 particularly activation of a proinflammatory cyclophilin A-mediated pathway in brain vascular pericyt

259 r findings support a model in which Ess1 and cyclophilin A modulate the activity of the Sin3-Rpd3 com

260 Suppression by a panel of cyclophilin A mutants correlated with PPIase activity, c

261 the effect of the peptidyl-prolyl isomerase, cyclophilin A, on the CFTR channel.

262 We show here that cyclophilin A, one of the most common PPIases, provides

263 Mutations in a tomato (Solanum lycopersicum) cyclophilin A ortholog, DIAGEOTROPICA (DGT), have been s

264 rated by the rescue of a mutation precluding cyclophilin A packaging by a mutation conferring cyclosp

265 We also report that cyclophilin A packaging is severely reduced in W23A and

266 We show that cyclophilin, a peptidyl-prolyl isomerase secreted from T

267 ses (tau(1), tau(2), tau(3)) to catalysis by cyclophilin, a peptidyl-prolyl isomerase.

268 inhibits virion infectivity, indicating that cyclophilin A plays an essential role in the HIV-1 life

269 phosphorylation during transcription of the cyclophilin A (PPIA), glyceraldehyde-3-phosphate dehydro

270 wn, including kallikrein-7 (KLK7; 2.2-fold), cyclophilin A (PPIA; 0.9-fold), and cofilin-1 (CFL1, 1.3

271 Employing the cyclophilin A PPIase together with its biologically rele

272 of AAPF binds to cyclophilin A implies that cyclophilin A predominantly catalyzes the trans to cis i

273 n binding interaction of Cyclosporine A with cyclophilin A protein in a yeast cell lysate is successf

274 ic effects of CsA are mediated by the 18-kDa cyclophilin A protein.

275 hat the Gly89-Pro90 dipeptide is the primary cyclophilin A recognition motif, with Pro85, Val86, His8

276 s macrophage migration inhibitory factor and cyclophilin A, respectively.

277 s were found and identified, namely enolase, cyclophilin-A, ribosomal protein L13 and actin-1.

278 The resulting larger quantity of cyclophilin A shown to be packaged into virions produced

279 Other host factors, such as cyclophilin A, stabilize the HIV-1 capsid and are requir

280 infectivity imposes narrow constraints upon cyclophilin A stoichiometry in virions and that infectiv

281 We also show that overexpression of cyclophilin A suppresses ess1 conditional and null mutat

282 variants, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), are attractive candidates owing to

283 orthologs, rhesus TRIM5alpha (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restricto

284 o binds the human peptidyl prolyl isomerase, cyclophilin A, thereby packaging the enzyme into the vir

285 A content resulting in decreased binding of cyclophilin A to Gag could account, in part, for the obs

286 The recruitment of cyclophilin A to GTP-bound Ras blocks its interaction wi

287 was promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclospo

288 as well as literature values for uncomplexed cyclophilin A, to theoretical predictions using a combin

289 The expression levels of alpha-actin and cyclophilin A varied little during the course of develop

290 UP153 depletion, as was wild-type HIV-1 when cyclophilin A was depleted simultaneously or when infect

291 teins was confirmed by Western blotting, and cyclophilin A was localized to the tumor cells by immuno

292 Cyclophilin A was produced and secreted into the media t

293 During catalytic action of the enzyme cyclophilin A, we detect conformational fluctuations of

294 lar to that of the peptidyl-prolyl isomerase cyclophilin A, we probed purified virions with antibodie

295 aturation, virus infectivity, and binding to cyclophilin A, whereas the subtype B portion of RT was l

296 nal domains on TRIM5alpha (SPRY) or TRIMCyp (cyclophilin A), which interact weakly with capsids.

297 ntiviral effect is mediated by inhibition of cyclophilin A, which is an essential host factor in the

298 at Pro-222 decreases virion incorporation of cyclophilin A, while mutation at Pro-231 abolishes infec

299 sing disparity is the weaker interactions of cyclophilin A with a transiently formed GroEL-GroES comp

300 onstant expression levels of alpha-actin and cyclophilin A with development, suggest that these are u

301 fied the direct CsA-sensitive interaction of cyclophilin A with hensin, suggesting that cyclophilin A

302 We have obtained HDX data for the complex of cyclophilin A with the immunosuppressant cyclosporin A.