ライフサイエンスコーパス: cyclopiazonic acid

1 sceptibility to unrelated inhibitors such as cyclopiazonic acid.

2 rcoplasmic reticulum (SR) with ryanodine and cyclopiazonic acid.

3 e L263E mutation is also more susceptible to cyclopiazonic acid.

4 luorescein isothiocyanate, thapsigargin, and cyclopiazonic acid.

5 tiated Ca2+ entry with low concentrations of cyclopiazonic acid.

6 plasmic reticulum (ER) sequestration blocker cyclopiazonic acid.

7 shed by cotreatment with the SERCA inhibitor cyclopiazonic acid.

8 ically dimethylallylates cAATrp to form beta-cyclopiazonic acid.

9 an twofold after depletion by treatment with cyclopiazonic acid.

10 ic acid; m/z 357/210 and 357/191 for (13)C20-cyclopiazonic acid.

11 nodine, 0.1 microM thapsigargin or 10 microM cyclopiazonic acid.

12 cells treated with a SR Ca2+-pump inhibitor, cyclopiazonic acid.

13 of endoplasmic reticulum Ca(2+)-ATPase pump, cyclopiazonic acid.

14 Both thapsigargin (1 microM) and cyclopiazonic acid (1 microM), compounds that deplete al

15 eter) but is inhibited by vanadate (1 mM) or cyclopiazonic acid (1 microM).

16 Similar hyperpolarization was evoked with cyclopiazonic acid (10 microM, an inhibitor of sarcoplas

17 Cyclopiazonic acid (10-30 microM CPA), an inhibitor of t

18 STICS were also blocked by cyclopiazonic acid, 2-aminoethoxydiphenyl borate (2-APB)

19 Cyclopiazonic acid (20 microM; an inhibitor of sarcoplas

20 Caffeine (10 mM), ryanodine (10 microM), cyclopiazonic acid (30 microM) or CCCP (10 microM) had n

21 d by treatment with ryanodine (1 microM) and cyclopiazonic acid (30 microM).

22 /endoplasmic reticulum Ca2+-ATPase inhibitor cyclopiazonic acid (30 mum) was also applied during the

23 Cyclopiazonic acid (5 microM) did not affect the holding

24 lum Ca2+ release with Ca2+-ATPase inhibitors cyclopiazonic acid (5 microM) or thapsigargin (5 microM)

25 (5 micromol/L), ryanodine (5 micromol/L), or cyclopiazonic acid (5 micromol/L) in Ca2+-containing or

26 Cyclopiazonic acid, a blocker of animal sarcoplasmic/end

27 , a selective blocker of Ca2+ release and by cyclopiazonic acid, a blocker of Ca2+ sequestration into

28 r application of thapsigargin, ryanodine, or cyclopiazonic acid, a hypoxic challenge produced no furt

29 entry (SOCE) by passive store depletion with cyclopiazonic acid, a reversible blocker of sarco-endopl

30 Cyclopiazonic acid, a specific blocker of animal sarcopl

31 pletion of intracellular Ca(2+) stores using cyclopiazonic acid abolished SAH-induced eHACSs and rest

32 evious depletion of the ER calcium stores by cyclopiazonic acid abolished the HP-induced calcium leve

33 f the sarcoplasmic reticulum Ca2+ pump (with cyclopiazonic acid) abolished Ca2+ oscillations in all c

34 Inhibition of the SR by cyclopiazonic acid also caused a more vigorous increase

35 The SERCA2a inhibitors thapsigargin and cyclopiazonic acid also completely prevented cross-linki

36 on of endoplasmic reticular Ca2+ uptake with cyclopiazonic acid also had little effect on stimulation

37 2+ stores by perifusion with thapsigargin or cyclopiazonic acid also reduced DAP amplitudes by approx

38 Cyclopiazonic acid (an inhibitor of the calcium pump in

39 lowed in the presence of either ryanodine or cyclopiazonic acid (an inhibitor of the SR Ca2+-ATPase).

40 Ca(2+), depletion of ER Ca(2+) stores using cyclopiazonic acid, an ER Ca(2+)-ATPase inhibitor, and c

41 ent increase in [Ca2+]in that was blocked by cyclopiazonic acid, an inhibitor of endoplasmic reticulu

42 ined by a short treatment with 2.5-10 microm cyclopiazonic acid, an inhibitor of the sarco/endoplasmi

43 Two structurally distinct SERCA inhibitors, cyclopiazonic acid and 2,5-di-[t-butyl]-1,4-hydroquinone

44 Cyclopiazonic acid and graded changes in phospholamban p

45 ere ablated by inhibiting Ca(2+) stores with cyclopiazonic acid and reduced by inhibiting Ca(2+) infl

46 Other cells exposed to cyclopiazonic acid and ryanodine to inhibit SR Ca2+ re-u

47 nodine receptors (Ryanodine) and SERCA pump (cyclopiazonic acid and thapsigargin) abolished Ca(2+) tr

48 ndoplasmic reticulum Ca(2+)-ATPase inhibitor cyclopiazonic acid and was attenuated by pre-incubation

49 Cells were exposed to cyclopiazonic acid and zero extracellular Na+ and Ca2+ t

50 y to inhibitors (vanadate, thapsigargin, and cyclopiazonic acid) and affinity for substrates (MgATP a

51 m Ca2+-transporting ATPase (SERCA; 10 microM cyclopiazonic acid) and/or sarcolemmal Na+-Ca2+ exchange

52 y used SERCA1a inhibitors thapsigargin (Tg), cyclopiazonic acid, and 2,5-di-tert-butylhydroquinone.

53 ,N',N'-tetraacetic acid acetoxymethyl ester, cyclopiazonic acid, and N,N,N',N'-tetrakis(2-pyridylmeth

54 doplasmic reticulum Ca2+ pump (thapsigargin, cyclopiazonic acid, and tert-butylhydroquinone), and pro

55 ndoplasmic reticulum calcium ATPase (SERCA), cyclopiazonic acid, and thapsigargin (1) selectively enh

56 2+ from a store sensitive to thapsigargin or cyclopiazonic acid, but not sensitive to heparin.

57 Cyclopiazonic acid, but not thapsigargin, blocked this p

58 Depleting intracellular Ca(2+) stores with cyclopiazonic acid completely blocked both the outward c

59 (caffeine) and SR calcium-ATPase inhibitor (cyclopiazonic acid), consistent with studies suggesting

60 Two other SERCA inhibitors, BHQ and cyclopiazonic acid CPA, were similarly toxic, although a

61 Inhibition of SERCA with cyclopiazonic acid (CPA) abolished these differences bet

62 intracellular Ca(2+) store-depleting agents cyclopiazonic acid (CPA) and 1,2-bis-(2-aminophenoxy)eth

63 racteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM.

64 currents evoked by the Ca2+-ATPase inhibitor cyclopiazonic acid (CPA) by about 3-fold at -80 mV.

65 ry cultured mouse PASMCs loaded with fura-2, cyclopiazonic acid (CPA) caused a transient followed by

66 We extend the latter hypothesis employing cyclopiazonic acid (CPA) challenge, which similarly incr

67 in slices, we found that SERCA inhibition by cyclopiazonic acid (CPA) decreased evoked [DA](o) in the

68 smic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillati

69 For the determination of cyclopiazonic acid (CPA) in food and feed samples a simp

70 to NO were inhibited by thapsigargin (TG) or cyclopiazonic acid (CPA) indicating the involvement of s

71 Cyclopiazonic acid (CPA) induced an outward, but not an

72 The neurotoxin alpha-cyclopiazonic acid (CPA) is an emerging mycotoxin produc

73 Inhibition of the SR Ca2+ pump with cyclopiazonic acid (CPA) markedly reduced the spontaneou

74 Cyclopiazonic acid (CPA) pretreatment abolished Ca(2+) t

75 (2+) in living normal rat kidney cells using cyclopiazonic acid (CPA) resulted in the extreme expansi

76 2-Aminoethoxydiphenylborate, caffeine, cyclopiazonic acid (CPA), 2,5-di-(t-butyl)-1,4-hydroquin

77 Ca2+ by inhibiting the SR Ca2+-ATPase (with cyclopiazonic acid (CPA), 20 microM) resulted in an enha

78 The fungal neurotoxin alpha-cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+

79 The fungal neurotoxin alpha-cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca2+-

80 ed skeletal muscle cells were depleted using cyclopiazonic acid (CPA), a reversible inhibitor of Ca2+

81 A slow decline of tension was produced by cyclopiazonic acid (CPA), a sarcoplasmic reticulum Ca2+

82 ion following stimulation in the presence of cyclopiazonic acid (CPA), a sarcoplasmic reticulum Ca2+-

83 Cyclopiazonic acid (CPA), an endoplasmic reticulum (ER)

84 ted sarcoplasmic reticulum Ca2+ pumping with cyclopiazonic acid (CPA), an inhibitor of the sarco(endo

85 We have investigated the effect of cyclopiazonic acid (CPA), an inhibitor of the sarcoplasm

86 c/endoplasmic reticulum Ca(2+)-ATPase pumps, cyclopiazonic acid (CPA), and thapsigargin (Thg).

87 Application of cyclopiazonic acid (CPA), which depletes internal Ca2+ s

88 Cyclopiazonic acid (CPA)-induced whole-cell SOC currents

89 solates produced aflatoxins B and G, but not cyclopiazonic acid (CPA).

90 tion, we inhibited the SR Ca(2+)-ATPase with cyclopiazonic acid (CPA).

91 (mycotoxins), including the neurotoxin alpha-cyclopiazonic acid (CPA).

92 RMSAs with 100 nM thapsigargin or 10 microM cyclopiazonic acid (CPA).

93 by depletion of internal Ca(2+) stores with cyclopiazonic acid (CPA).

94 mitant administration of the SERCA inhibitor cyclopiazonic acid (CPA).

95 ng application of the SR Ca2+ pump inhibitor cyclopiazonic acid (CPA).

96 pretreatment with the SR Ca2+ pump inhibitor cyclopiazonic acid (CPA).

97 sarcoplasmic reticulum (SR) Ca2+-ATPase with cyclopiazonic acid (CPA).

98 eceptors (RyRs), or thapsigargin (500 nM) or cyclopiazonic acid (CPA, 10 microM), to inhibit the SR C

99 s were not measured, DSI was not affected by cyclopiazonic acid (CPA, 20-40 microM), a blocker of Ca2

100 Inhibition of SR Ca2+ uptake with cyclopiazonic acid (CPA, 30 microM) slowed but did not s

101 t isoprenaline reduced the current evoked by cyclopiazonic acid (CPA, sarcoplasmic/endoplasmic reticu

102 or low-dose caffeine (to stimulate CICR) or cyclopiazonic acid (CPA; to slow SR refilling).

103 Inhibition of SR Ca(2+) pump by cyclopiazonic acid dose-dependently suppressed spontaneo

104 Cyclopiazonic acid had no further effect when added to c

105 2+)](SR), whereas inhibition of SERCA (3 muM cyclopiazonic acid) had the opposite effect.

106 Application of cyclopiazonic acid in the presence of carbachol further

107 iated Ca(2+) entry after S/ER unloading with cyclopiazonic acid (in Ca(2+)-free medium).

108 The calcium agonists A23187 and cyclopiazonic acid increased [Ca(2+)](c) levels.

109 Cyclopiazonic acid increased Mn2+ influx with physiologi

110 Cyclopiazonic acid increased the rate of [Ca2+]i rise fo

111 Thapsigargin and cyclopiazonic acid (inhibitors of the sarcoplasmic Ca(2+

112 Treatment with thapsigargin or cyclopiazonic acid, inhibitors of the sarco-endoplasmic

113 tions were used: m/z 337/196 and 337/182 for cyclopiazonic acid; m/z 357/210 and 357/191 for (13)C20-

114 Ca(2+) transients were abolished by cyclopiazonic acid or caffeine but were unaffected by te

115 Depletion of stores with cyclopiazonic acid or carbachol also activates capacitat

116 Blockade of SMOCs with cyclopiazonic acid or ryanodine converted the irregular

117 2+ uptake by the sarcoplasmic reticulum with cyclopiazonic acid or thapsigargin did not prevent accel

118 ic/endoplasmic reticulum calcium ATPase with cyclopiazonic acid or thapsigargin), Ca(2+) waves ceased

119 s against ER stress induced by thapsigargin, cyclopiazonic acid, palmitate, insulin overexpression, a

120 (3 nm) pre-incubation also augmented 10 muM cyclopiazonic acid plus 10 mm caffeine-evoked release of

121 With a somewhat higher concentration of cyclopiazonic acid, PMA had no effect on calcium entry.

122 to Ca(2+) mobilizers such as thapsigargin or cyclopiazonic acid primes the releasable pool of vasopre

123 RCA blockers thapsigargin, thapsigargicin or cyclopiazonic acid rapidly activated ICRAC in low buffer

124 ompounds, including caffeine, ryanodine, and cyclopiazonic acid, reduce inhibitory junction potential

125 In addition, thapsigargin, ryanodine, and cyclopiazonic acid reduced action potential-evoked Ca2+

126 Washout of the reversible inhibitor cyclopiazonic acid restored the ability to induce LTD.

127 ER by exposure to the ER Ca2+ pump inhibitor cyclopiazonic acid resulted in a delayed activation of C

128 oxic challenge, thapsigargin, ryanodine, and cyclopiazonic acid resulted in a significant increase in

129 of the response to several concentrations of cyclopiazonic acid revealed that Ca2+ influx that regula

130 c levels) is achieved by a thapsigargin (and cyclopiazonic acid)-sensitive Ca2+-pump in cooperation w

131 ly Ca(2+)-free solution containing 10 microM cyclopiazonic acid, simultaneous 10(-6) M ET-1 and extra

132 taroxime accelerated and its inhibition with cyclopiazonic acid slowed TAUlocal significantly more in

133 Cyclopiazonic acid slowed the recovery of NCTs (from a t

134 litation was abolished by both ryanodine and cyclopiazonic acid suggesting a role for release from in

135 Blockade of Ca(2+)-release from ICS by cyclopiazonic acid, thapsigargin, or ryanodine blocked L

136 l smooth muscle hyperpolarizations evoked by cyclopiazonic acid were depressed by the gap junction in

137 tors of the SR calcium ATPase (thapsigargin, cyclopiazonic acid) were without effect on arterial wall

138 or Na+ but is abolished by thapsigargin and cyclopiazonic acid, which are specific inhibitors of the

139 (an inhibitor of IP8 formation) or 10 microM cyclopiazonic acid, which depletes intracellular Ca2+ st

140 Thapsigargin and cyclopiazonic acid, which mobilize Ca(2+) from intracell

141 confirmed by inhibiting SR Ca2+ ATPase with cyclopiazonic acid, which slowed Ca2+ removal more in co

142 Responses to cyclopiazonic acid, which stimulates endothelium-depende