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1 IIb, but show higher levels of FcgammaRII in cynomolgus monkey.
2 gG1 antibody to oxidized LDL (anti-oxLDL) in cynomolgus monkey.
3 n promising oral bioavailability in rats and cynomolgus monkey.
4 em closely homologous to that of humans, the cynomolgus monkey.
5 s high oral bioavailability in rat, dog, and cynomolgus monkey.
6 inding, and radiation dosimetry in a healthy cynomolgus monkey.
7 A PET study was performed on a cynomolgus monkey.
8 erated and confirmed to be cross-reactive to cynomolgus monkey.
9 netic/pharmacodynamic study was conducted in cynomolgus monkeys.
10 hippocampal IRS-1pSer and JNK activation in cynomolgus monkeys.
11 d both blood and bone marrow plasma cells in cynomolgus monkeys.
12 tic cleavage of FGF21 identified in mice and cynomolgus monkeys.
13 ghtly higher than typical IgG1 antibodies in cynomolgus monkeys.
14 e, and selectively reduce LDL-cholesterol in cynomolgus monkeys.
15 labeled material) to two male and two female cynomolgus monkeys.
16 us-sensitive, CD155 transgenic (tg) mice and cynomolgus monkeys.
17 e, after accounting for total volume, in the cynomolgus monkeys.
18 f total volume were determined in rhesus and cynomolgus monkeys.
19 heavy drinking within the inferior olive of cynomolgus monkeys.
20 ogenitor, CAT6001, in a single-dose study in cynomolgus monkeys.
21 rior cingulate cortex (ACC; Area 24) of male cynomolgus monkeys.
22 f PMNs from the bone marrow of both mice and cynomolgus monkeys.
23 nd pharmacokinetic analysis was performed in cynomolgus monkeys.
24 e different serum pools from male and female cynomolgus monkeys.
25 surgically menopausal young and middle-aged cynomolgus monkeys.
26 properties of 12p were assessed in rats and Cynomolgus monkeys.
27 tive primer and probe sets ever reported for cynomolgus monkeys.
28 one marrow transplant recipients of same sex cynomolgus monkeys.
29 g agent and evaluated as PET radioligands in cynomolgus monkeys.
30 d chimerism and renal allograft tolerance in cynomolgus monkeys.
31 mg/kg of LY2886721, a BACE1 inhibitor, in 2 cynomolgus monkeys.
32 s, and DST effectively prevents rejection in cynomolgus monkeys.
33 ian parvovirus (SPV) was first isolated from cynomolgus monkeys.
34 OP) changes in conscious ocular hypertensive cynomolgus monkeys.
35 < 0.001) lowered IOP in ocular hypertensive cynomolgus monkeys.
36 the corresponding biological consequences in cynomolgus monkeys.
37 reaction-mismatched, ABO blood group-matched cynomolgus monkeys.
38 fusion) was performed in one eye each of two cynomolgus monkeys.
39 oxyalaninyl phosphoramidate was evaluated in Cynomolgus monkeys.
40 travitreal (ITV) or intravenous (IV) dose in cynomolgus monkeys.
41 rials of (225)Ac; there are no CD33 sites in cynomolgus monkeys.
42 efrontal and parietal cortex of adult female cynomolgus monkeys.
43 atured good oral bioavailability in mice and cynomolgus monkeys.
44 in vivo by administration of LymphoStat-B to cynomolgus monkeys.
45 mouse model, L(EV) was also tested in three cynomolgus monkeys.
46 fas ligand in blood samples from rhesus and cynomolgus monkeys.
47 f ACAT activity, was significantly higher in cynomolgus monkeys.
48 ntrathecal administration of rituximab using cynomolgus monkeys.
49 b/CD18 prevents progression of AKI to CKD in cynomolgus monkeys.
50 n of B cells and bone marrow plasma cells in cynomolgus monkeys.
51 ow background after intravenous injection in cynomolgus monkeys.
52 n stimulated gene (ISG) response in mice and cynomolgus monkeys.
53 bies virus-based EBOV vaccine, in rhesus and cynomolgus monkeys.
54 poor pharmacokinetic profile in both rat and cynomolgus monkeys.
55 to identify recently derived retrocopies in cynomolgus monkeys.
56 increased circulating intact FGF21 levels in cynomolgus monkeys.
57 retrocopies, all of which are polymorphic in cynomolgus monkeys.
58 ing strength of cocaine in group-housed male cynomolgus monkeys.
59 erapeutic target for autoimmune diseases, in cynomolgus monkeys.
60 d reduces fever after sublethal challenge in cynomolgus monkeys.
61 administration to lipopolysaccharide-treated cynomolgus monkeys.
62 electrocardiogram parameters in telemetrized cynomolgus monkeys.
63 al mice, mice transgenic for human FcRn, and cynomolgus monkeys.
64 inding protein 2 (MECP2), in both rhesus and cynomolgus monkeys.
65 r cell-mediated killing assay and in vivo in cynomolgus monkeys.
66 tal, 10 PET measurements were conducted on 5 cynomolgus monkeys.
67 I and demonstrated to modulate serum iron in cynomolgus monkeys.
68 on in livers of mice, rats, and dogs but not cynomolgus monkeys.
69 optic nerve margin in the right eyes of four cynomolgus monkeys.
71 e target tissues, liver, and adipose, and in cynomolgus monkeys a 10 mg/kg oral dose reduced cortisol
73 ant 3-fold increase of ACAT2 protein mass in cynomolgus monkeys, a much greater increase than was fou
75 diet periods, liver biopsies were taken from cynomolgus monkeys, a species highly responsive to dieta
76 s, exemplified by compound 52, in an in vivo cynomolgus monkey acute adrenocorticotropic hormone (ACT
79 n and thrombus detection was investigated in cynomolgus monkeys after insertion of a roughened cathet
80 ifferentiated from the wild-type antibody in cynomolgus monkeys after intravenous administration.
81 n addition, R-13bhad good plasma exposure in cynomolgus monkeys after oral administration, with a C(m
83 nduced ex-vivo platelet aggregation assay in cynomolgus monkeys after oral administration; this activ
84 accine to demonstrate complete protection of cynomolgus monkeys against a homologous MARV challenge.
85 lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (
86 264RAD cross-reacts with human, mouse and cynomolgus monkey alphavbeta6, and inhibits binding to a
87 nt anterograde and retrograde tracers in the cynomolgus monkey and found that all PMC areas are inter
89 ed (>100-fold) stability over 1 or 5, with a cynomolgus monkey and human in vitro plasma half-life of
90 omolgus monkey of those derivatives with low cynomolgus monkey and human intrinsic clearance gave 2',
91 flammatory cytokine induction pathway in the cynomolgus monkey and humans, but not observed systemica
92 and intravenous administration of NgR1-Fc to cynomolgus monkey and to rat are without evident toxicit
93 to 10,000-fold for CYP1A1 in vivo in rat and cynomolgus monkey and up to 45-fold for CYP1A1 and CYP1A
94 f NiV (Malaysia, Bangladesh) was assessed in cynomolgus monkeys and compared with henipavirus-infecte
95 r experience with severe sepsis in two young cynomolgus monkeys and five pigs that were subjected to
96 ormed 305 ovarian stimulations in 128 female cynomolgus monkeys and found that ovarian stimulation ca
97 gulation of the AOX promoter by PPARalpha in cynomolgus monkeys and humans and suggest that this mode
98 of (11)C-Lu AE92686 in the striatum of both cynomolgus monkeys and humans were evaluated by the simp
102 anslate to a pharmacokinetic benefit in both cynomolgus monkeys and mice when constructed on a differ
103 ed the same strategy, with modifications, to cynomolgus monkeys and most recently to renal transplant
104 erapy functionality of SiGdNP were tested in cynomolgus monkeys and pancreatic tumor-bearing mice mod
105 ound 6 had minimal effect on HDL-C levels in cynomolgus monkeys and showed human cadaver skin permeab
106 ntion of acute kidney allograft rejection in cynomolgus monkeys and synergizes with cyclosporine and/
107 ibose (ADPR) and ADP in colonic muscles from cynomolgus monkeys and wild-type (CD38(+/+)) and CD38(-/
108 the pharmacokinetic study of a mAb dosed in cynomolgus monkey, and the results were compared with th
109 olving NK cells, mediate XmAb5574 potency in cynomolgus monkeys, and that enhancing these mechanisms
110 PMNs to LukGH was similar between humans and cynomolgus monkeys, and was greater than that of rabbits
115 bust and sustained anticoagulant activity in cynomolgus monkeys as assessed by activated partial thro
116 nge in resistance significantly increased in cynomolgus monkeys as total volume perfused increased (0
117 d higher titers of toxin-neutralizing Abs in cynomolgus monkeys at 2 wk compared with animals immuniz
121 d 8 has good oral bioavailability in rat and cynomolgus monkey, attractive overall preclinical proper
123 kGH was administered to mice, rabbits, and a cynomolgus monkey by subcutaneous or intradermal injecti
124 tional to Delta n(RNFL)) was measured in two cynomolgus monkeys by enhanced polarization-sensitive op
126 ribution of (125)I-AMG 386 was determined in cynomolgus monkeys by whole-body autoradiography and rad
129 on of 1 mg/kg of body weight fully protected cynomolgus monkeys challenged with aerosolized anthrax s
130 barrier in archival formalin-fixed lungs of cynomolgus monkeys challenged with the fully virulent B.
131 ddition, we investigated the left MD in four cynomolgus monkeys chronically exposed to haloperidol an
134 d chimerism and renal allograft tolerance in cynomolgus monkeys, cyclophosphamide (CP) and total body
135 ements were performed on ex vivo lenses from cynomolgus monkeys (cyno: n = 120; age, 2.7-14.3 years),
136 cine and human therapeutic Ab development in cynomolgus monkeys (cynos) are influenced by immune resp
137 ic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to
138 in whole blood isolated from untransplanted cynomolgus monkeys (cynos), in vivo in blood from untran
139 inally, we validated these rodent studies in cynomolgus monkeys, demonstrating that a single 10-Gy do
140 way-derived cells from Ascaris suum-allergic cynomolgus monkeys did not produce appreciable TNF-alpha
141 mouse models of human lymphoma and in normal cynomolgus monkeys disclosed that low doses of veltuzuma
143 ng data on pancreas weight and histology, in Cynomolgus monkeys dosed with two different human glucag
144 alyzed 15 pairs of pregnant and non-pregnant cynomolgus monkeys, each pair of which received embryos
145 its a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50 0.12 mg/kg) and in DIO mice.
146 lture system that enabled the development of cynomolgus monkey embryos in vitro for up to 20 days.
147 o three target sites across 11 genes/loci in cynomolgus monkey embryos using CRISPR-based cytidine- a
150 ic nerve head (ONH) and overlying vessels in cynomolgus monkey eyes were imaged with a fundus camera
152 lecules and their SEFL variants to human and cynomolgus monkey FcgammaRs were evaluated using flow cy
153 tely 40-fold increase in binding affinity to cynomolgus monkey FcRn (C-FcRn) at pH 6.0, with maintena
154 esteryl ester concentrations were highest in cynomolgus monkeys fed cholesterol, despite the fact tha
156 t tetravalent formulations were evaluated in cynomolgus monkeys following a single-dose subcutaneous
157 everal cases of symptomatic SPV infection in cynomolgus monkeys following heart transplantation.
159 ng and cross-species comparisons with mouse, cynomolgus monkey gastrulae, and post-implantation human
160 compounds from each series in rat, dog, and cynomolgus monkey has led to the identification of 22 (C
161 ults for human IgG2 and IgG4 obtained in the cynomolgus monkey have to be cautiously interpreted, whe
163 ld prolonged half-life in mice, rabbits, and cynomolgus monkeys; however, the prolongation was less p
164 nd effector functions, whereas, in contrast, cynomolgus monkey IgG2 and IgG4 display strong effector
166 of B cells prior to heart transplantation in cynomolgus monkeys, in addition to conventional posttran
167 odels required dosing every 48 h, studies in cynomolgus monkeys indicate that less frequent dosing ma
168 -MS/MS assay for quantification of human and cynomolgus monkey interleukin 21 (IL-21) was developed,
171 est that depressive behavior in adult female cynomolgus monkeys is similar to that observed in humans
175 arried out metabolic stability studies using cynomolgus monkey liver and intestinal S9 fractions.
176 ve state in a non-human primate species, the cynomolgus monkey (Macaca fascicularis), in a realistic
178 ntia tsutsugamushi (Kp r56) was evaluated in cynomolgus monkeys (Macaca fascicularis) for immunogenic
180 injections in the lateral divisions of MD in cynomolgus monkeys (Macaca fascicularis) to assess the r
182 SEARCH DESIGN AND At baseline, 32 male adult cynomolgus monkeys (Macaca fascicularis) were randomized
183 isms of spread, we infected groups of 5 or 6 cynomolgus monkeys (Macaca fascicularis) with either a w
190 1/2) and the lack of target cell antigens in cynomolgus monkeys may increase toxicity compared with h
192 t/CRISPR-associated nuclease 9 to generate a cynomolgus monkey model by disrupting SHANK3 at exons 6
194 el of fatal tuberculosis and the established cynomolgus monkey model to design an immuno-chemotherape
197 ge average: 41 +/- 17 years; range: 6-7) and cynomolgus monkey (n = 19; age average: 7.7 +/- 1.8 year
199 receptor availability was assessed in female cynomolgus monkeys (n = 16) with positron emission tomog
205 istered to healthy mice by oral gavage or to cynomolgus monkeys (nonhuman primates) by colonic spray
206 the utility of preclinical species, rats and cynomolgus monkeys [nonhuman primates (NHPs)], to predic
208 pharmacokinetic profile in the rat, dog, and cynomolgus monkey of those derivatives with low cynomolg
209 dation of a humanized monoclonal antibody in cynomolgus monkeys over a time period of 12 weeks after
210 important pathogen in surgically manipulated cynomolgus monkeys, particularly with immune compromise.
212 totoxicity in vitro against Daudi cells with cynomolgus monkey peripheral blood mononuclear cells, an
213 e performed in rats (organ distribution) and cynomolgus monkeys (PET/CT imaging) to determine the GLP
215 antibody-dependent monocyte phagocytosis of cynomolgus monkey platelets, and cynomolgus platelet act
216 fusion model of thrombomodulin activation in cynomolgus monkeys, previous intravenous infusion of pha
217 isplacement experiment of [(123)I]ZIENT in a cynomolgus monkey, radioactivity was reduced by 39% in t
218 ure perfusion in one eye of 22 rhesus and 17 cynomolgus monkeys (ranging in age, respectively, from 4
219 given to rhesus macaques on days 42 and 225; cynomolgus monkeys received a booster with either PA or
223 secondary lymphoid organs, and the graft in cynomolgus monkey recipients of heterotopic cardiac allo
225 d in a retrospective analysis on 20 selected cynomolgus monkey recipients of renal xenografts transge
226 uence of alemtuzumab (i) on ex vivo-expanded cynomolgus monkey regulatory T cells (Treg) generated fo
231 al administration of R-13b to castrated male cynomolgus monkeys resulted in a significant decrease in
233 rations by dietary cholesterol, seen only in cynomolgus monkeys, resulted in higher ACAT2 protein lev
234 man (h)FcRn transgenic mice and threefold in cynomolgus monkeys retain efficacy at longer dosing inte
235 say was developed and qualified in human and cynomolgus monkey serum and tissues with a lower limit o
236 antibody and those derived from proteins in cynomolgus monkey serum with either d(2)- or d(0)-formal
238 and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelop
241 ging with [(18)F]9-[(18)F]11 in anesthetized cynomolgus monkeys showed high uptake in the putamen wit
242 ic studies in human FcRn transgenic mice and cynomolgus monkeys showed that multiple variants with in
243 ety pharmacology studies with bevacizumab in cynomolgus monkeys showed that this agent is generally w
244 ation of 11 in conscious ocular hypertensive cynomolgus monkeys showed this compound to be efficaciou
245 Administration of bardoxolone methyl to cynomolgus monkeys significantly decreased the protein e
246 er tissues of primates, we gave adult female cynomolgus monkeys six times the human-equivalent dose o
247 However, IL-21 levels were quantified in cynomolgus monkey spleen and colon tissue and normal and
248 idly induce anovulation in a third of female cynomolgus monkeys (stress-sensitive; SS); a third will
249 pproximately 2-fold decrease in clearance in cynomolgus monkey, supporting the notion that modest inc
251 it is tolerated at higher doses in rats and cynomolgus monkeys than the same conjugate prepared by c
252 ime profile after oral administration in the cynomolgus monkey that showed a very low peak-to-trough
253 , we evaluated T and B cell alloresponses in cynomolgus monkeys that had received combined kidney/bon
255 ed hamsters, human CETP transgenic mice, and cynomolgus monkeys, the in vivo efficacy of 12 for raisi
256 HF, we examined tissues of 21 EBOV-infected cynomolgus monkeys throughout time, and also evaluated E
257 acokinetics of two human IgG1 Fc variants in cynomolgus monkey to further clarify the affinity-pharma
258 Heterotopic cardiac allograft outcomes in cynomolgus monkeys treated with a CD154 inhibitor, IDEC-
260 hed streptozotocin-induced diabetic juvenile cynomolgus monkeys underwent transplantation intraportal
261 ST101 were studied in 3xTg-AD mice and young cynomolgus monkeys using a combination of biochemical an
262 e the biological outcome of BAFF blockade in cynomolgus monkeys using a soluble fusion protein consis
263 swine were transplanted into the spleens of cynomolgus monkeys using conventional immunosuppression
264 development of allergic lung inflammation in cynomolgus monkeys using gene expression profiling and t
265 short tandem repeat profiling methodology to cynomolgus monkeys using two human specific alleles, TPO
273 sign in which 31 ovariectomized adult female cynomolgus monkeys were divided into social groups of th
286 cy and was bioavailable in the rat, dog, and cynomolgus monkey when administered orally as a solution
288 was advanced into a pharmacodynamic model in cynomolgus monkeys, where it inhibited adipose 11beta-HS
289 age, obtained from young adult and old adult cynomolgus monkeys, which develop age-related, naturally
290 FKB8488A induced marked weight loss in obese cynomolgus monkeys while elevating serum adiponectin and
291 unodeficiency virus SHIV(89.6P) challenge of cynomolgus monkeys, while native, inactivated, or vector
292 plasma from chimpanzees; gorillas; bonobos; cynomolgus monkeys; wild-type, apoE(-/-), LDLR(-/-), and
296 hibits airway tryptase in Ascaris-sensitized cynomolgus monkeys with favorable pharmacokinetics.
299 study evaluates the brain of a rhesus and 11 cynomolgus monkeys with Nissl staining and immunohistoch