ライフサイエンスコーパス: cysteine

1 bolites that are derived from the amino acid cysteine.

2 cal cysteine residues to form S-(2-succinyl)-cysteine.

3 er effect on antioxidant capacity than added cysteine.

4 cyP causes the accumulation of cytoplasmic l-cysteine.

5 itutively reduce cystine to the more soluble cysteine.

6 e moieties capable of covalent reaction with cysteine.

7 important molecules, such as the amino acid cysteine.

8 inues into cells that are already sated with cysteine.

9 sting of 91 amino acids with eight conserved cysteines.

10 oxide reduction involving three redox-active cysteines.

11 These data indicate that redox regulation of Cysteine 147 of mouse STING, which is equivalent to Cyst

12 e 147 of mouse STING, which is equivalent to Cysteine 148 of human STING, controls interferon product

13 y acquired revertant mutations that restored cysteine 181.

14 elective SRC covalent inhibitor by targeting cysteine 277 on the P-loop of SRC.

15 that lowered peroxynitrite levels prevented cysteine 36 oxidation of AKAP150 and rescued endothelial

16 idation of the regulatory protein AKAP150 at cysteine 36, to impair AKAP150-TRPV4 channel signaling a

17 ctin filaments with N-1-pyrene conjugated to cysteine 374 and either ADP (3.2 angstrom) or ADP-phosph

18 e (alphaCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondri

19 Biological sensing of cysteine, a disease biomarker and carcinoembryonic antig

20 recombinant proteins and metal transport and cysteine accessibility assays, we demonstrate that two p

21 ith the topology obtained by the substituted cysteine accessibility method and revealed that the acti

22 tive site in a partially oxidized state form cysteine adducts that induce an open-to-closed conformat

23 These probes offer advantages over existing cysteine alkylation reagents, including accelerated reac

24 NOTCH1 expression, and the use of N-acetyl-L-cysteine altered NOTCH1 expression, suggesting that this

25 Here, cysteine aminoethylation using 2-bromoethylamine was app

26 ling pathways, as the antioxidant N-acetyl-l-cysteine and a Syk inhibitor differentially blocked heme

27 directly introduced onto the thiol group of cysteine and can be used for copper-catalyzed alkyne-azi

28 hesized that S. aureus acquires host-derived cysteine and cystine as sources of nutrient sulfur durin

29 ration of cyst(e)inase, a drug that depletes cysteine and cystine, demonstrating a translatable means

30 f soy lecithin, salt, and reducing agents (l-cysteine and glutathione).

31 sulfide, preferentially via condensation of cysteine and homocysteine.

32 transfer ability of the metal separately by cysteine and hydrolyzed zinc(II), and synergistically by

33 study examined the ability of l-arginine, l-cysteine and l-methionine, to inhibit postharvest senesc

34 nzymatically S-acylate and N-acylate protein cysteine and lysine residues, respectively.

35 ntaining metabolites such as glutathione and cysteine and reduced proteins such as insulin and imaged

36 Despite binding similarly to PKM2, how cysteine and serine differentially regulate this enzyme

37 ired growth in the absence of the amino acid cysteine and that gigC regulates the expression of sever

38 We find that several highly conserved cysteines and an Ala306-Phe307-Arg308 motif of human ALA

39 ling between the dynamics of the active-site cysteines and of the cap loop which modulates the associ

40 sulforaphane cysteine, sulforaphane N-acetyl cysteine) and indole metabolites (ascorbigen and methoxy

41 as highly active with l-cysteine, N-acetyl-l-cysteine, and allyl mercaptan.

42 al variants of DIDS suggested that intrinsic cysteine, and not lysine, reactivity was important for a

43 Sulfate, cysteine, and some sulfur-containing secondary metabolit

44 Leucine, proline, cysteine, and tryptophan concentrations were not influen

45 rmanent Michael adducts with eight different cysteines, and acyl adducts with lysine and several tyro

46 s form a disulfide bond; when reduced, these cysteines are available to bind Fe(3+)-heme.

47 sG1D) and amino acid metabolism (methionine, cysteine/arginine metabolism) in sucrose medium.

48 employing silver nanoparticles modified with cysteine as the chiral inducer, polydiacetylene (PDA) wi

49 lemented with cystine, cysteine, or N-acetyl cysteine as the sole sulfur source.

50 ion and use of cystine, the oxidized form of cysteine, as a source of cellular sulfur.

51 teins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).

52 Besides a role in cysteine biosynthesis, TgCBS can also efficiently produc

53 rotein, likely through its regulation of the cysteine biosynthetic pathway, plays a key role in the v

54 enes involved in the sulfur assimilation and cysteine biosynthetic pathways.

55 Sulfur compound, methionine and cysteine biosynthetic processes were identified as signi

56 s a need to identify new moieties capable of cysteine bond formation that are differentiated from com

57 y stimulated by apo FliY, more strongly by d-cysteine-bound FliY, and maximally by l-cysteine- or l-c

58 previously identified and harnessed a unique cysteine (C55) in the groove of anti-apoptotic BFL-1 to

59 nucleophilicity and modification of a nearby cysteine (C665), thereby stabilizing the loop in an acti

60 e of CTAB capped TiO(2), MoS(2)@TiO(2) and L-Cysteine capped MoS(2)@TiO(2) as 12.6, 11.7 and 10.2 nm,

61 irreversible inhibitors (E-64 derivative) of cysteine cathepsins (CCs) as trapping agents to increase

62 ied as an anti-greening strategy, given that cysteine-CGA conjugates are colorless.

63 (2020) show that defective vacuole-mediated cysteine compartmentalization in aging yeast leads to ir

64 n was promoted at higher pH and inhibited as cysteine concentration increased.

65 carbohydrate linker- and cyanobenzothiazole-cysteine condensation reaction-based small molecule scaf

66 ally selective and irreversible scaffold for cysteine conjugation.

67 he alkylated thiol-containing and UV-reduced cysteine-containing peptides to be identified by a nonta

68 gation by undergoing reaction with a second, cysteine-containing protein.

69 such as alliin and N-gamma-glutamyl-S-allyl cysteine, could notably be detected in lower amounts in

70 d Eu(III)-labeled streptavidin donor and the cysteine-coupled AlexaFluor 680 acceptor dye is observed

71 ls in MdfA, reconstituted in nanodiscs, with cysteine cross-linking of natively expressed membrane-em

72 vements of the LBDs that might be trapped by cysteine cross-links and metal bridges.

73 [CTGF], secreted protein, acidic and rich in cysteine), crosslinking genes/enzymes (lysyl oxidase, ly

74 r to function poorly for epitopes containing cysteine (Cys) residues, which can oxidize and form disu

75 s glutathione (GSH), homocysteine (Hcy), and cysteine (Cys), coexist in biological systems with diver

76 we report the development of MFH290, a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13.

77 th a CYP24A1 isoform 2 lacking the catalytic cysteine (Cys-462), suggesting that CYP24A1's oncogenic

78 ction, which is then resolved by a conserved cysteine, Cys-66, or by the nonconserved residue Cys-127

79 2 Mpro in the close proximity to a conserved cysteine (Cys44), which is hyper-reactive according to t

80 of the purified Escherichia coli YecSC-FliY cysteine/cystine import system.

81 l-cystine and its subsequent reduction to l-cysteine depleted both NADPH and GSH pools, thereby allo

82 Cysteine depletion or iron supplementation restores mito

83 ered to undergo a substitution reaction with cysteine derivatives.

84 athway, the pyridoxal 5'-phosphate-dependent cysteine desulfurase enzyme IscS provides sulfur to the

85 des a significant catalytic advantage over a cysteine disulfide.

86 cult, leading to focus on the C-terminal six cysteine domain (6C) with the use of fusion proteins to

87 xidative post-translational modifications of cysteines during inflammation and aging, no systematic c

88 of lysines or more site-specific labeling of cysteines, each with attendant challenges.

89 r of cytoplasmic cystine, as opposed to an l-cysteine exporter, and further elucidate a link between

90 combination of the two through the known Zn-cysteine finger redox trap effect.

91 histidine to facilitate endosomal escape and cysteine for stability and controlled cargo release.

92 his trial-and-error process often results in cysteine-free proteins with reduced activity or stabilit

93 ed to as cysteine synthase (CS), synthesizes cysteine from O-acetyl serine (OAS) and sulfur in bacter

94 ase, the CydDC complex, shuttles excessive l-cysteine from the cytoplasm to the periplasm, thereby ma

95 ings are notable because SLC7A11 codes for a cysteine-glutamate anti-porter regulating levels of the

96 quently, cysteine nitrile is not stable, and cysteine has been proposed to be a product of evolution,

97 een 6-hydroxy-2-cyanobenzothiazole (CBT) and cysteine has been shown for various applications such as

98 al methods and the KLR models both show that cysteine has the lowest propensity for hinge-bending reg

99 Acid ceramidase (AC) is a cysteine hydrolase that plays a crucial role in the meta

100 chondria and show that elevated non-vacuolar cysteine impairs mitochondrial respiration by limiting i

101 hus, MFSD12 is an essential component of the cysteine importer for melanosomes and lysosomes.

102 ntioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice

103 ition of RHO-1, which depends on a conserved cysteine in its nucleotide binding site (C20).

104 ere designed to covalently target a reactive cysteine in the binding site of Her2 and were further op

105 TEAD inhibitors, which covalently target the cysteine in the central pocket, block the interaction wi

106 a sulfur atom bridging the SQOR active site cysteines in a trisulfide configuration.

107 against excessive oxidation of the catalytic cysteines in Cd-MsrB through intra- and intermolecular d

108 Our results indicate that the cysteines in OGG1 fall into four functional categories:

109 Here, we present a global map of cysteines in primary human T cells that are susceptible

110 our understanding of electrophile-sensitive cysteines in the human immune proteome remains limited.

111 rmal levels of cystine-the oxidized dimer of cysteine-in melanosomes, and to produce cysteinyldopas,

112 Concentration-dependent cysteine inhibition of CGA-lysine greening was attribute

113 scal loop (D2), a region that contains seven cysteines involved in intra- and intermolecular disulfid

114 acetyl-S-(4-hydroxy-2-methyl-2-buten-1-yl)-l-cysteine (IPM3) in participants (>=3 year old) from the

115 The simulations also predicted that cysteine is a quantitatively-significant sulfane sulfur

116 Among amino acids, we find that cysteine is most toxic for mitochondria and show that el

117 l-cysteine is the source of all bacterial sulfurous biomol

118 xture was separately further modified with l-cysteine (l-Cys) and l-serine (l-Ser).

119 a general methodology to rationally engineer cysteine-less proteins.

120 or is allowed to bind to either histidine or cysteine ligands, within a single artificial protein.

121 tious viral particle, specifically the viral cysteine-like protease, might also be potent immunogens.

122 e assessed endogenous proteomic responses to cysteine limitation in Mycobacterium smegmatis using mas

123 Furthermore, a conformationally preserved "cysteine lock"-Trp116(23.50) was identified.

124 Cysteine locks DndCDE-FeS to the modification site with

125 ound that the X-Pro amide bonds in the inter-cysteine loop are rigidly constrained to cis conformatio

126 by cystathionine beta-synthase duplication, cysteine lyase neofunctionalization and cysteic acid dec

127 In vascular endothelial cells, cysteine metabolism by the cystathionine gamma lyase (CS

128 duced from either H(2) S oxidation or from L-cysteine metabolism.

129 ion and nucleation of autophagic vesicles by cysteine modification of conserved autophagy proteins in

130 These compounds are thought to act by cysteine modification to alter the functions of immune-r

131 presence of two computationally selected and cysteine modified epitopes of neuron specific enolase (N

132 ing strategy is reported by employing double-cysteine-modified peptides as the templates and adsorbin

133 We demonstrate the detection concept with cysteine modifying S-nitrosylation and ADP-ribosylation

134 otentially applicable to investigate various cysteine-modifying enzymes in a high throughput compatib

135 The developed antibody-free assay for cysteine-modifying enzymes provides a detection platform

136 The ShK-like1 peptide has a ShKT cysteine motif, is lethal for fish larvae and packaged i

137 However, the cytoplasmic level of l-cysteine must be tightly regulated due to its propensity

138 We incorporated a cysteine mutation in the cavity located above the putati

139 We then transposed the cysteine mutation to the native receptor, to demonstrate

140 ered and characterized reoviruses containing cysteine mutations that cross-link sigma1 monomers in no

141 however, the enzyme was highly active with l-cysteine, N-acetyl-l-cysteine, and allyl mercaptan.

142 si-NOX2 and antioxidant N-acetyl cysteine (NAC) reversed si-TTP-induced cell apoptosis.

143 We report a novel conjugation of N-terminal cysteines (NCys) that proceeds with fast kinetics and ex

144 f 2-cyanobenzothiazole (CBT) with N-terminal cysteines (NCys) typically gives a luciferin product.

145 As there are no cysteines near the eIF4E cap binding site, we developed

146 Consequently, cysteine nitrile is not stable, and cysteine has been pr

147 le conformations in the regions flanking the cysteine noose.

148 tion of oxygen with the conserved N-terminal cysteine of ERF-VIIs to form cysteine sulfinic acid, tri

149 GT1 interact with the carboxyl oxygen of the cysteine of GSH.

150 an covalently bind to amino acids other than cysteine on target proteins such as glutathione S-transf

151 time, giving central stage to the amino acid cysteine, one of the least abundant amino acid residues

152 iferate in medium supplemented with cystine, cysteine, or N-acetyl cysteine as the sole sulfur source

153 by d-cysteine-bound FliY, and maximally by l-cysteine- or l-cystine-bound FliY.

154 t3 and Sirt5 were resistant to inhibition by cysteine oxidants.

155 ed three distinct spatiotemporal patterns of cysteine oxidation in functionally organized protein net

156 Our previously reported finding that protein cysteine oxidation is increased during mitosis relative

157 heomelanin synthesis made in melanosomes via cysteine oxidation(5,6).

158 rizes through disulfide bridges generated by cysteine oxidation.

159 omparative study of potential direct sirtuin cysteine oxidative modifications has been performed.

160 find that disulfide bonding between a native cysteine pair at the groove (C55) and C-terminal alpha9

161 We found that the introduction of a cysteine pair in the receptor-binding domain of sigma1 y

162 icate that the proximity and orientation for cysteine pairs at I409C/R410C, in close proximity to the

163 Cysteine palmitoylation (S-palmitoylation) is a reversib

164 Cysteine palmitoylation, a form of S-acylation, is a key

165 phorylation, while ROS reduction by N-acetyl cysteine partially reversed the phosphorylation.

166 effect of light exposure on the formation of cysteine-phenol adduct in meat added 4-methylcatechol (4

167 The burgeoning cysteine pool is itself hazardous, as cysteine promotes

168 However, this conversion of cystine to cysteine precludes product inhibition of the importer, s

169 ographic elution times, and superior in-cell cysteine profiling for in-depth proteome-wide analysis a

170 Competitive cysteine profiling has been performed to interrogate ita

171 eoning cysteine pool is itself hazardous, as cysteine promotes the formation of reactive oxygen speci

172 idis strains were observed to produce strong cysteine protease activity when grown at high density.

173 yclic peptides that irreversibly inhibited a cysteine protease and a serine hydrolase with nanomolar

174 Calpain 15 (CAPN15) is an intracellular cysteine protease belonging to the non-classical small o

175 hich unleashes the proteolytic activity of a cysteine protease caspase-1.

176 ermeability and/or cross-reactivity with the cysteine protease cathepsin B.

177 The current study found that a cysteine protease Cathepsin B3 (CathB3), and the associa

178 f a transacylating member of the papain-like cysteine protease family and an iteratively acting ATP-g

179 Metacaspases (MCs) belong to a cysteine protease family, structurally related to metazo

180 Here, we show that the human cysteine protease legumain exhibits a strict substrate s

181 The vacuolar cysteine protease legumain plays important functions in

182 Lgmn is a cysteine protease of late endosomes and lysosomes that c

183 ation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP

184 for this activity was identified as EcpA, a cysteine protease under quorum sensing control.

185 Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically inc

186 .5 minutes incubation using just 4 nM of the cysteine protease, papain.

187 lators such as terpene synthase, papain-like cysteine protease, serine carboxypeptidase, and lipoxyge

188 ureus and damage the skin by expression of a cysteine protease.

189 Amebic cysteine proteases (CPs) were inhibited using an irrever

190 ns L and host lysosomal cathepsin L, S and K cysteine proteases (inhibition constants < 10 nM).

191 For instance, cysteine proteases (PRO) frequently double up as ubiquit

192 lation of parasite-secreted cathepsin L-like cysteine proteases associated with virulence is importan

193 Caspases are a family of conserved cysteine proteases that play key roles in programmed cel

194 (caspase-4/5) belong to caspase-1 family of cysteine proteases, and play a role in inflammation.

195 Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptoti

196 o late endosomes where GP is cleaved by host cysteine proteases.

197 ve site, and we find that, of four conserved cysteines putatively critical for function, only three a

198 he data also demonstrate that compounds with cysteine reactivity have the potential to act as antivir

199 recent advances in proteomic strategies for cysteine redoxome profiling, compare the advantages and

200 rthologues is exploited to identify suitable cysteine replacements compatible with protein activity a

201 s in which modification of a highly reactive cysteine residue (C621) promotes reorientation of a cyto

202 ing site, which at this stage is occupied by cysteine residue 62.

203 situ, which reacts with nearby nucleophilic cysteine residue from the DUB active site.

204 variants having substitutions with a single cysteine residue in different secondary structures, enab

205 de reactive moiety, binds to the active-site cysteine residue of UCHL1 in an activity-dependent manne

206 xtracts and mammalian cells that a conserved cysteine residue within the Aurora A activation loop is

207 roteins share a variably acylated N-terminal cysteine residue.

208 discuss the idea that oxidation of conserved cysteine residues and partial unfolding of its structure

209 d through reversible modification of protein cysteine residues by reactive oxygen species (ROS).

210 ent exposure and redox regulation of cryptic cysteine residues contextually delineate redox signaling

211 investigation, including a discussion of how cysteine residues could contribute to envelope homeostas

212 me oxygenase-2 (HO2) contains two HRMs whose cysteine residues form a disulfide bond; when reduced, t

213 ation between CBT derivatives and N-terminal cysteine residues has been established as a biocompatibl

214 "S-sulfhydrome" consisted of 3446 individual cysteine residues in 1591 proteins.

215 These ROS then oxidize cysteine residues in proteins to potentiate downstream s

216 ng the covalent attachment of fatty acids to cysteine residues in proteins.

217 ytium formation, alteration of palmitoylated cysteine residues in the cytoplasmic tail decreased the

218 d subfamily that features two extra pairs of cysteine residues in the extracellular domain.

219 OACs), a process that converts nucleophilic cysteine residues into an electrophilic S-aryl-Pd-X unit

220 via covalent bond modifications of specific cysteine residues located in the cytoplasmic domains.

221 n of OGG1 is sensitive to oxidants, with the cysteine residues of OGG1 being the most likely site of

222 ntioxidant ingredients, are known to bind to cysteine residues on meat proteins.

223 Mutation of the individual cysteine residues produced stable Erv46 proteins that we

224 probe, we generated a data set of proteomic cysteine residues sensitive to the reduction in fumarate

225 d contains an Fe-S cluster and identify four cysteine residues that are likely to co-ordinate the clu

226 cated widespread redox regulation of cryptic cysteine residues that are solvent exposed only upon cha

227 nct modes by which EGF specified the cryptic cysteine residues that became solvent exposed and redox

228 ra A kinase domain delineate redox-sensitive cysteine residues that, upon covalent modification, can

229 reacts with gasdermin D (GSDMD) at critical cysteine residues to form S-(2-succinyl)-cysteine.

230 ron microscopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitr

231 nsfer (TR-FRET) detection method for PTMs of cysteine residues using a single-peptide approach perfor

232 ific conjugation of two proteins with unique cysteine residues yielding a nonhydrolyzable phosphonoth

233 fibrillar filaments by oxidation of its two cysteine residues, generating an intermolecular disulfid

234 otein binds a [2Fe-2S] cluster via conserved cysteine residues.

235 t proteins like OGG1 itself, specifically at cysteine residues.

236 dues in GSTP and cross-link them to adjacent cysteine residues.

237 conjugation of cytotoxic drugs to lysine and cysteine residues.

238 e-encoding leaderless short ORFs function as cysteine-responsive attenuators of operonic gene express

239 Val(*); mutation of Val172 to isoleucine or cysteine results in accumulation of an Ile(*) or Cys(*)

240 Metallothionein (MT), a cysteine rich protein is involved as a radical scavenger

241 me Medicago truncatula, ~700 nodule-specific cysteine-rich (NCR) peptides with conserved cysteine sig

242 pe lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at the cent

243 RNA-Seq analysis showed that both ID2 and Cysteine-rich angiogenic inducer 61 (CYR61) expression l

244 connective tissue growth factor (CTGF), and cysteine-rich angiogenic inducer 61 (CYR61).

245 In contrast, the accumulation of the cysteine-rich Bowman-Birk protease inhibitor was several

246 In Arabidopsis, pollen tubes are guided by cysteine-rich chemoattractants to target the female game

247 17)), which is downstream of its S-acylated, cysteine-rich domain ((85)CGLCVCPC(92)).

248 n binding interface to the RAS G domain, its cysteine-rich domain (CRD) is responsible for associatio

249 we observed binding of carbamazepine to the cysteine-rich domain (CRD) of the Wnt receptor FZD8 usin

250 removal of a membrane-tethering domain, the cysteine-rich domain, and a disintegrin domain, respecti

251 present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong com

252 inal domain, which contains highly conserved cysteine-rich motifs reminiscent of zinc finger motifs.

253 determined to be an unprecedented 42-residue cysteine-rich peptide named recifin A.

254 by extrapolation, our findings suggest that cysteine-rich peptides diversified for a variety of spec

255 ocation across the outer membrane and that a cysteine-rich region directs TraA to the T2SS.

256 Conserved hydrophobic amino acids within the cysteine-rich region of Erv46 were also required for ret

257 rgo binding to a hydrophobic site within the cysteine-rich region of Erv46.

258 bunit and define an approximately 60 residue cysteine-rich region that is unique to the Erv46 family

259 sirtuin Sirt2, are modified and inhibited by cysteine S-nitrosation in response to exposure to both f

260 n)), that exert their biological actions via cysteine S-sulfhydration of target proteins.

261 However, cysteine's aminothiol is incompatible with nitriles.

262 ure increased levels of oxidatively modified cysteine(s) of wt OGG1 without impairing its association

263 was previously proposed to oxidize S-allyl-l-cysteine (SAC) to alliin, an allicin precursor.

264 Cysteine scanning mutagenesis and EPR spectroscopy ident

265 noclonal antibody trastuzumab with excellent cysteine-selectivity, we applied our protocol for the si

266 cysteine-rich (NCR) peptides with conserved cysteine signature are expressed.

267 ation of the EGF-dependent oxidation of 4200 cysteine sites in A431 cells.

268 Point mutations in cysteine string protein-alpha (CSPalpha) cause dominantl

269 rons to show that the normally palmitoylated cysteine string region of CSPalpha loses palmitoylation

270 s exploited to chemically transform a single cysteine, such that the expression of said functionality

271 nt and use it to prepare a protected form of cysteine suitable for SPPS.

272 e the triplet-sensitized photodegradation of cysteine sulfinic acid, a (photo)degradation product of

273 rved N-terminal cysteine of ERF-VIIs to form cysteine sulfinic acid, triggering degradation via the C

274 anin metabolites (sulforaphane, sulforaphane cysteine, sulforaphane N-acetyl cysteine) and indole met

275 cavity where water can hydrogen bond to the cysteine sulfur atoms.

276 bining three distinct characteristics: (1) a cysteine sulfur layer for metal coordination, (2) a thio

277 olydisperse gold thiolate nanoplatelets with cysteine surface ligands.

278 serine sulfhydrylase (OASS), referred to as cysteine synthase (CS), synthesizes cysteine from O-acet

279 s critical to the design and optimization of cysteine-targeted covalent inhibitors.

280 o uncover additional mechanisms that specify cysteines that are redox regulated by EGF stimulation, w

281 ated posttranslational modification (PTM) of cysteine thiols (SNO), modulates the activity of protein

282 versibly covalent binding mechanisms towards cysteine thiols and other amino acids.

283 Oxidation of cysteine thiols by physiological reactive oxygen species

284 osthetics for bioconjugation more often with cysteine thiols or lysine amines.

285 chemical modification, the oxidation of two cysteine thiols to a disulfide bond, during the catalyti

286 which post-translationally oxidizes beta2AR cysteine thiols to Cys-S-sulfenic acids (Cys-S-OH).

287 mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory

288 lfinic acid, a (photo)degradation product of cysteine, to sulfate (SO(4)(2-)).

289 The cysteine trisulfide in SQOR is thus critical for activit

290 Lysine, methionine, and cysteine usage also contribute to ROS resistance of the

291 y p-aminobenzenesulfonic acid (p-ABSA) and l-cysteine using intensive oxidative conditions, and attri

292 Heteroaromatic sulfones react with cysteine via nucleophilic aromatic substitution, providi

293 These chromophores are ligated to specific cysteines via bilin lyases, and some of these enzymes, c

294 Cysteine was studied as an anti-greening strategy, given

295 ds to the increased level of extracellular l-cysteine, whereas induction of cydDC or tcyP causes the

296 ur-containing metabolites within the host is cysteine, which acts as the major redox buffer in the bl

297 owever, many proteins have multiple reactive cysteines, which must be mutated to other residues to en

298 or the protection and deprotection of native cysteine with a succinimide group in a peptide fragment

299 ic site involving three arsenic-coordinating cysteines within the DNA-binding domain, distal to the z

300 Our findings indicate that conserved cysteines within the MYXO-CTERM are posttranslationally