ライフサイエンスコーパス: cysteine protease

1 PrtS (IL-8 degrading proteinase), and SpeB (cysteine protease).

2 hese results strongly suggest that SpvD is a cysteine protease.

3 ic inhibitor of calpain, a calcium-dependent cysteine protease.

4 equently exposed the mice to ovalbumin and a cysteine protease.

5 inant Dpi showed inhibitory activity against cysteine protease.

6 ion as novel regulators of the secreted SpeB cysteine protease.

7 ragment was generated by a calcium-dependent cysteine protease.

8 y functioning both as a scaffold protein and cysteine protease.

9 of SERA6 by PfSUB1 converts it to an active cysteine protease.

10 es, including speB, which encodes a secreted cysteine protease.

11 perturbs the active site of this papain-like cysteine protease.

12 pping boundaries with the predicted putative cysteine protease.

13 ureus and damage the skin by expression of a cysteine protease.

14 tially with a region predicted as a putative cysteine protease.

15 ed to be cleaved by cathepsin B, a lysosomal cysteine protease.

16 rall protein fold reminiscent of other plant cysteine proteases.

17 is activation of calpains-calcium-dependent cysteine proteases.

18 ity of inhibition against calpain over other cysteine proteases.

19 e Y283 is highly conserved among papain-like cysteine proteases.

20 D is an inhibitor of lysosomal and secreted cysteine proteases.

21 elucidate novel inhibitors of the falcipain cysteine proteases.

22 ective for cathepsins B and Z, two lysosomal cysteine proteases.

23 yzed possible adjuvant function of exogenous cysteine proteases.

24 posure of cystatin domains for inhibition of cysteine proteases.

25 o late endosomes where GP is cleaved by host cysteine proteases.

26 us enhancing PMC's inhibitory ability toward cysteine proteases.

27 CLD is unable to function as an inhibitor of cysteine proteases.

28 repeating units, each capable of inhibiting cysteine proteases.

29 been exploited as inhibitors for serine and cysteine proteases.

30 hat are crucial to the enzymatic activity of cysteine proteases.

31 rotease (USP) family is the largest group of cysteine proteases.

32 blocks delta-secretase but not other related cysteine proteases.

33 e cytosol upon inhibition of serine, but not cysteine, proteases.

34 nfection, RIP3 is cleaved by the CVB-encoded cysteine protease 3C(pro), which serves to abrogate RIP3

35 h are cleaved at specific sites by a 3C-like cysteine protease (3CL(pro)) in a post-translational pro

36 ranscripts encoding Maize insect resistance1-Cysteine Protease, a key defensive protein against insec

37 wn to contain four domains: an N-terminal, a cysteine protease, a peptidoglycan-binding and an SH3 ba

38 and alters tight junction permeability as Eh cysteine protease A5 (EhCP-A5).

39 ine protease inhibitor but not inhibitors of cysteine proteases, acid proteases, metalloproteases, or

40 ein processes the viral polyprotein with its cysteine protease activity and helps EV71 replicate thro

41 d granularity, demonstrating that control of cysteine protease activity by CF is critical for normal

42 In vivo, EspL cysteine protease activity contributes to persistent col

43 with the mature form, demonstrating that the cysteine protease activity critically contributes to the

44 Here we found that HDMs with cysteine protease activity directly activated peptidergi

45 Thus, glucosyltransferase but not cysteine protease activity is critical for TcdB-mediated

46 Mutations specifically disrupting the cysteine protease activity of PEDV nsp5 abrogated NEMO c

47 Mechanistically, the cysteine protease activity of PEDV nsp5 mediates proteol

48 elatively small group of proteins, most with cysteine protease activity that target several key prote

49 idis strains were observed to produce strong cysteine protease activity when grown at high density.

50 We showed that Der p 1, which has cysteine protease activity, cleaves the ectodomain of pe

51 rgely dependent on T. foetus cell-associated cysteine protease activity.

52 This cleavage relies on 3C(pro)'s cysteine protease activity.

53 ella flexneri type III effector protein with cysteine protease activity.

54 Papain, a cysteine protease allergen with inherent adjuvant activi

55 We identified the cysteine protease Amb a 11 as a new major allergen from

56 yclic peptides that irreversibly inhibited a cysteine protease and a serine hydrolase with nanomolar

57 Cathepsin S is a lysosomal cysteine protease and controls HLA-DR-antigen complex pr

58 activities: cleavage of the precursor via a cysteine protease and cyclization via isopeptide bond fo

59 s, 7F and E3, that specifically inhibit TcdB cysteine protease and glucosyltransferase activities, re

60 time that toxin autoprocessing occurs after cysteine protease and glucosyltransferase domains transl

61 Der p1 is a cysteine protease and major allergen from the house dust

62 tosis-related pathway and requires endosomal cysteine proteases and an intact fusion peptide.

63 Furthermore, an imbalance between cysteine proteases and antiproteases could be seen, whic

64 in the gut with the primary proteases being cysteine proteases, and alkaline (8 to 9) in the saliva

65 (caspase-4/5) belong to caspase-1 family of cysteine proteases, and play a role in inflammation.

66 ts a new clade of previously uncharacterized cysteine proteases, and the dependence of S. aureus on L

67 a member of the papain/cathepsin L family of cysteine proteases, and the major cysteine protease of t

68 Cysteine proteases are an important class of enzymes imp

69 The caspase family of cysteine proteases are highly sought-after drug targets

70 efore, the activities of these two lysosomal cysteine proteases are important in host defense against

71 Cysteine proteases are important targets for the discove

72 Cysteine proteases are potent triggers of allergic infla

73 Calpains, a group of calcium-dependent cysteine proteases, are important mediators of ataxin-3

74 zation of limited enzymatic digestion with a cysteine protease as compared to the recently published

75 s strongly suggest that the use of endosomal cysteine proteases as host factors for entry is a genera

76 nd provide important insights for the use of cysteine proteases as immunomodulatory agents.

77 ium and support further investigation of the cysteine proteases as virulence factors in vivo and as p

78 mine a nonredundant subset of the serine and cysteine proteases as well as the barnase-barstar and Ra

79 lation of parasite-secreted cathepsin L-like cysteine proteases associated with virulence is importan

80 s the biogenesis of SpeB, the major secreted cysteine protease, at a post-translational level, suscep

81 om autophagosomes, both executed by the same cysteine protease ATG4.

82 ruzi encodes two copies of autophagy-related cysteine proteases, Atg4.1 and Atg4.2.

83 LC3 is a substrate of the cysteine protease ATG4B (Autophagin-1), where cleavage g

84 reasing LC3-II availability by silencing the cysteine protease ATG4B or acute trehalose exposure incr

85 Among the candidates, the host cysteine protease autophagy-related protein 4 homolog B

86 ial type III effector proteins including the cysteine protease AvrRpt2.

87 Cathepsin B (CTB) is a cysteine protease believed to be an important therapeuti

88 Calpain 15 (CAPN15) is an intracellular cysteine protease belonging to the non-classical small o

89 Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a pr

90 species (ROS) emission and activation of the cysteine protease calpain are required for DOX-induced m

91 t functions of a ubiquitous Ca(2+)-dependent cysteine protease, calpain-2, and of the calpain substra

92 Rs are also substrates for the intracellular cysteine proteases, calpain and caspase.

93 e CAPN1 gene, encoding the calcium dependent cysteine protease calpain1 (mu-calpain), was identified.

94 The catalytic activity of serine and cysteine proteases can be regulated after activation by

95 vation of an intracellular caspase-1/calpain cysteine protease cascade degraded filamin, thereby seve

96 tein complexes that regulate the cleavage of cysteine protease caspase-1, secretion of inflammatory c

97 flammasome assembly is the activation of the cysteine protease caspase-1, which activates the pro-inf

98 hich unleashes the proteolytic activity of a cysteine protease caspase-1.

99 The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell

100 grammed cell death is the aspartate-specific cysteine protease (caspase)-8.

101 The cysteine protease cathepsin B (CTSB) is frequently overe

102 The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involve

103 lly identified the inhibitor-binding site in cysteine protease cathepsin B, a potential drug target a

104 that Xenopus 2F3 cells apically express the cysteine protease cathepsin B, as indicated by two-dimen

105 ermeability and/or cross-reactivity with the cysteine protease cathepsin B.

106 The current study found that a cysteine protease Cathepsin B3 (CathB3), and the associa

107 The cysteine protease cathepsin C (CatC) activates granule-a

108 (PLS) results from mutations that inactivate cysteine protease cathepsin C (CTSC), which processes a

109 nflammatory factors and proteases, including cysteine protease cathepsin K (CTSK).

110 The cysteine protease cathepsin K has been implicated in pat

111 for cardiovascular disease and the lysosomal cysteine protease cathepsin K plays a critical role in c

112 The cysteine protease cathepsin L (CTSL) is often thought to

113 ive, and irreversible inhibitor of the human cysteine protease cathepsin L.

114 We show that the cysteine protease cathepsin S activates MrgprC11 and evo

115 timicrobial function and did not inhibit the cysteine protease, cathepsin L.

116 quired for optimal activity of the lysosomal cysteine protease, cathepsin S.

117 calpain with high selectivity versus related cysteine protease cathepsins, other proteases, and recep

118 ffector genes namely Eng-1, Cathepsin S-like cysteine protease, cellulase, and two unknown genes with

119 V. dahliae genes encoding a Ca(2+)-dependent cysteine protease (Clp-1) and an isotrichodermin C-15 hy

120 hages with the arginine- and lysine-specific cysteine protease complex (RgpA-Kgp complex), produced b

121 led a catalytic site typical for papain-like cysteine proteases, comprising a catalytic triad, oxyani

122 We found that disrupting a VAC-localized cysteine protease compromised VAC digestive function and

123 We have identified a cysteine protease, conserved among bacteria containing t

124 family while providing new insights into how cysteine proteases contribute to itch.

125 14 has classical calpain motifs, including a cysteine protease core.

126 el in which to study RIBEs, and identify the cysteine protease CPR-4, a homologue of human cathepsin

127 Amebic cysteine proteases (CPs) were inhibited using an irrever

128 almonella (S) carrying plasmids encoding the cysteine protease cruzipain (Cz) protects against Trypan

129 recombinant enzyme with characteristics of a cysteine protease, demonstrating that SERA5 can bind pep

130 shares structural homology also with non-C58-cysteine proteases, deubiquitinases, and deamidases.

131 of the Venus flytrap (Dionaea muscipula) are cysteine proteases (dionain-1 to -4).

132 suis, is a cysteine protease distinct from previous characterized s

133 Two domains, X and the papain-like cysteine protease domain (PCP), of HEV ORF1 were identif

134 main for inactivating host Rho GTPases and a cysteine protease domain for the delivery of the effecto

135 Fusion of the most stable cysteine protease domain to the adjacent effector domain

136 l hexakisphosphate (InsP(6)) by an intrinsic cysteine protease domain, located next to the glucosyltr

137 leader peptides that are cleaved off by the cysteine protease domain, referred to as the C39 domain,

138 ve mechanisms to fine-tune the activity of a cysteine protease dubbed RD21 (RESPONSIVE TO DESICCATION

139 he activity of EspL defines a family of T3SS cysteine protease effectors found in a range of bacteria

140 A cysteine protease encoded by enteroviruses cleaves FAK t

141 ity ligation (ADPL), to serine hydrolase and cysteine protease enzymes enables quantification of diff

142 rly demonstrate that Amb a 11 is a bona fide cysteine protease exhibiting a strong allergenicity.

143 y activity against the Plasmodium falciparum cysteine proteases falcipain 2 and falcipain 3 and again

144 f a transacylating member of the papain-like cysteine protease family and an iteratively acting ATP-g

145 ZmPCP belongs to the cysteine protease family but has no closely related para

146 Metacaspases (MCs) belong to a cysteine protease family, structurally related to metazo

147 a 11, a new major allergen belonging to the cysteine protease family.

148 eronyssinus, that belongs to the papain-like cysteine protease family.

149 al significance for these two members of the cysteine protease family.

150 of pro-Amb a 11 shows an overall typical C1A cysteine protease fold with a network of molecular inter

151 From parasitic diseases to cancer, cysteine proteases follow a common mechanism, the format

152 ivity against the major hemoglobin degrading cysteine protease FP-2.

153 This study provides the first analysis of a cysteine protease from the digestive fluid of a carnivor

154 lo t 1 is characteristic for the pro-form of cysteine proteases from the C1A class.

155 n system in rice by combining Brassica napus cysteine-protease gene (BnCysP1) with anther-specific P1

156 Calpains, calcium-activated cysteine proteases, have been shown to increase inflamma

157 present a middle-down approach employing the cysteine protease IdeS under reducing conditions to obta

158 l antifungal, while several others inhibit a cysteine protease implicated in cancer.

159 esiccation 21), a granulin domain-containing cysteine protease implicated in stress responses and def

160 rphyromonas gingivalis, secretes gingipains, cysteine proteases implicated as the main factors in the

161 ease in Alzheimer's disease), cathepsin B (a cysteine protease in cancer), and Alp2 (a serine proteas

162 tudy investigated the effect of actinidin, a cysteine protease in kiwifruit, on the hydrolysis of glu

163 s protein degradation by a calcium-dependent cysteine protease in response to unsaturated fatty acids

164 n underappreciated role of the SspB and ScpA cysteine proteases in modulating S. aureus biofilm archi

165 article describes a novel role for Giardia's cysteine proteases in pathogenesis and how Giardia's dis

166 cluding serine proteases and thioesterases), cysteine proteases (including caspases), and many compon

167 Zinc inhibits cysteine proteases, including the apoptotic caspases, le

168 vealed a high structural homology with known cysteine proteases, including the mite Der p 1 allergen.

169 )/Arg(15)) had modest adverse effects on the cysteine protease inhibition but conferred potent activi

170 asome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved.

171 ough proteasome inhibition and not serine or cysteine protease inhibition, likely through positive ch

172 ns L and host lysosomal cathepsin L, S and K cysteine proteases (inhibition constants < 10 nM).

173 The cysteine protease inhibitor cystatin C is internalized b

174 The cysteine protease inhibitor cystatin C is thought to be

175 In contrast, the cysteine protease inhibitor cystatin C was expressed onl

176 er cell internalization of the extracellular cysteine protease inhibitor cystatin C, 12 variants of t

177 s efficiently inhibited by both the covalent cysteine protease inhibitor E-64 and the reversible sele

178 DeltasigB mutant through the addition of the cysteine protease inhibitor E-64 or by using Staphostati

179 Importantly, the cysteine protease inhibitor E64 prevented mucous degrada

180 ile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at no

181 Collectively, these results indicate that a cysteine protease inhibitor from bacterial origin could

182 Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the

183 The serine/cysteine protease inhibitor SCCA1 (SERPINB3) is upregula

184 structural analysis between the hCLD and the cysteine protease inhibitor stefin A showed why the hCLD

185 lution as well as complexes with the general cysteine protease inhibitor trans-epoxysuccinyl-l-leucyl

186 le abnormalities similar to that seen with a cysteine protease inhibitor, E-64 (I-1).

187 t the helminth immunomodulator AvCystatin, a cysteine protease inhibitor, induces a novel regulatory

188 l-characterized apoplastic effector EPIC1, a cysteine protease inhibitor, was also secreted from haus

189 Serine and cysteine protease inhibitors also reduced Alternaria-ind

190 Kfyve kinase inhibitor apilimod(2-4) and the cysteine protease inhibitors MDL-28170, Z LVG CHN2, VBY-

191 In vitro, cysteine protease inhibitors restored granularity, demon

192 d tolerance of antiherbivory defenses (i.e., cysteine protease inhibitors) expressed in soybean folia

193 1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upre

194 In this study, the roles of rice bran cysteine protease inhibitors, oryzacystatins, were consi

195 one-based triazoles as potential nonpeptidic cysteine protease inhibitors.

196 ytes and belonging to the cystatin family of cysteine protease inhibitors.

197 ream of CTSB, a gene encoding cathepsin B, a cysteine protease involved in keratinocyte homeostasis.

198 a family of intracellular, calcium-dependent cysteine proteases involved in a variety of regulatory p

199 Thus, intracellular cysteine proteases involved in cancer-promoting processe

200 to identify specific members of papain-like cysteine proteases involved in the N-terminal cleavage o

201 NS2-encoded cysteine protease is responsible for autoprocessing of N

202 Expression of SpeB, a streptococcal cysteine protease, is critical for this process, as an i

203 ive, cruzain, an essential Trypanosoma cruzi cysteine protease, is highly homologous.

204 Activity of cathepsin S (CTSS), a cysteine protease, is significantly and specifically inc

205 A secreted cysteine protease known as streptococcal pyrogenic exoto

206 is required for cleavage by the periplasmic cysteine protease LapG and release of the adhesin from t

207 Here, we show that the human cysteine protease legumain exhibits a strict substrate s

208 The vacuolar cysteine protease legumain plays important functions in

209 The cysteine protease legumain plays important functions in

210 TecA and other bacterial homologs bear a cysteine protease-like catalytic triad, which inactivate

211 In this study, we identified a cysteine protease-like domain spanning PaTox residues 18

212 luding but not limited to serine hydrolases, cysteine proteases, matrix metalloproteases, nitrilases,

213 osome biogenesis requires Autophagy 4 (Atg4) cysteine protease-mediated processing of ubiquitin-like

214 We propose that PaTox(P) is a C58-like cysteine protease module that is essential for full PaTo

215 equires a previously unrecognized tripartite cysteine protease motif in EspL (Cys47, His131, Asp153)

216 Consistent with these in vitro results, a cysteine protease noncleavable mutant, TcdB-L543A, delay

217 Cathepsin S (Cat-S) is a lysosomal cysteine protease of antigen-presenting cells that is se

218 Lgmn is a cysteine protease of late endosomes and lysosomes that c

219 Rhodesain, a cathepsin L-like cysteine protease of T. brucei rhodesiense, is considere

220 ed the possibility that cruzipain, the major cysteine protease of T. cruzi, is responsible for trunca

221 Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosom

222 family of cysteine proteases, and the major cysteine protease of the protozoan Trypanosoma cruzi, th

223 inhibitor of the major secreted cathepsin L cysteine proteases of F. hepatica, FhCL1 and FhCL2, and

224 of transition state inhibitors of serine and cysteine proteases of medical relevance.

225 Calcium-dependent cysteine proteases of the calpain family are modulatory

226 varian tumor domain (OTU) deubiquitinylating cysteine proteases OTUB1 and OTUB2 (OTU ubiquitin aldehy

227 scovered three nonpeptidic inhibitors of the cysteine protease papain.

228 nical acquisition and internalization of the cysteine protease papain.

229 netic beads, we demonstrate retrieval of the cysteine protease papain.

230 comparing full length Cal1 with the general cysteine protease papain.

231 A cysteine protease, papain, is a prototypic protease alle

232 Finally, studies with the cysteine protease, papain, suggest that the reduction of

233 .5 minutes incubation using just 4 nM of the cysteine protease, papain.

234 In this study using calcium and cysteine protease pathway-specific siRNA libraries, we i

235 cloned, expressed and purified this putative cysteine protease (PCP), which presented autoproteolytic

236 Cysteine proteases play important roles in pathobiology.

237 E02 targets A. thaliana vacuolar papain-like cysteine protease (PLCP) 'Responsive to Dehydration 21A'

238 increasing body of evidence for papain-like cysteine proteases (PLCPs) being central hubs in plant i

239 protein Pit2 is an inhibitor of papain-like cysteine proteases (PLCPs) essential for virulence.

240 For instance, cysteine proteases (PRO) frequently double up as ubiquit

241 al extension also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage.

242 ation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP

243 Mutant analysis suggested the role of the cysteine protease RESPONSE TO DROUGHT21A-LIKE1 in beta-o

244 Vacuolar processing enzymes are cysteine proteases responsible for maturation of vacuola

245 c peptide sequence for the inhibition of the cysteine proteases rhodesain of Trypanosoma brucei rhode

246 We demonstrate further that different cysteine proteases selectively activate specific mouse a

247 Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of

248 lators such as terpene synthase, papain-like cysteine protease, serine carboxypeptidase, and lipoxyge

249 to investigate the substrate specificity of cysteine proteases, serine proteases and metalloproteina

250 hase, surface M1 protein cleavage by the GAS cysteine protease SpeB eliminated Fg binding and relieve

251 found that elimination of production of the cysteine protease SpeB was not necessary for emergence o

252 d necrotizing fasciitis, secretes the potent cysteine protease SpeB.

253 Streptococcal cysteine protease (SpeB), the major secreted protease pr

254 s that specifically target the extracellular cysteine proteases SspB and ScpA (called Staphopains).

255 obes that specifically target three distinct cysteine protease subfamilies: aleurain-like proteases,

256 sub-micromolar inhibition activities against cysteine proteases such as papain and calpain as well as

257 uickly in the lungs of naive mice exposed to cysteine proteases, such as bromelain and papain, as a m

258 han the other analogs, whereas intracellular cysteine proteases, such as cathepsin-L, might be involv

259 etected members of the transglutaminase-like cysteine protease superfamily, and all possess a non-can

260 omal activity via inhibition of trypanosomal cysteine proteases, TbCatB and rhodesain, through alkyla

261 Caspase-1 is a cysteine protease that can be activated by both endogeno

262 Cathepsin L (Cat L) is a cysteine protease that can proteolytically activate CCAA

263 opeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor pr

264 n of the gene encoding cathepsin S (Ctss), a cysteine protease that cleaves invariant chains and prod

265 mble and recruit and activate caspase-1, the cysteine protease that cleaves numerous downstream targe

266 n this dysfunction of cathepsin S (Cat-S), a cysteine protease that degrades elastic fibers and activ

267 ffector domain (MCFVv) is an autoproteolytic cysteine protease that induces rounding of various cell

268 Cathepsin S (Ctss) is a cysteine protease that is actively secreted in areas of

269 Rationale: CTSS (cathepsin S) is a cysteine protease that is observed at higher concentrati

270 AvrPphB is a cysteine protease that specifically targets a subfamily

271 mediated by activated cathepsin B (CatB), a cysteine protease that translocates to the cell surface

272 ic dyad that is characteristic of C11-family cysteine proteases that are conserved in multiple pathog

273 Because there are dozens of cysteine proteases that are posttranslationally regulate

274 Ovarian tumour deubiquitinases are cysteine proteases that cleave polyubiquitin chains in v

275 tein) and calpain 1 and 2 (calcium-dependent cysteine proteases that control the podocyte cytoskeleto

276 Caspases are aspartate-directed cysteine proteases that have numerous cellular targets.

277 Calpains are calcium-dependent neutral cysteine proteases that modulate cellular function and h

278 Caspases are cysteine proteases that play essential roles in apoptosi

279 Caspases are a family of conserved cysteine proteases that play key roles in programmed cel

280 Caspases are cysteine proteases that regulate embryonic development,

281 The MJD family of DUBs consists of four cysteine proteases that share a catalytic "Josephin" dom

282 d the hypothesis that activation of specific cysteine proteases, the caspases, during C. trachomatis

283 theses for the exclusive binding of FhKT1 to cysteine proteases, the importance of the Leu(15) in anc

284 emphasizing repurposing inhibitors from one cysteine protease to others.

285 Using selective inhibitors of either PKG or cysteine proteases to separately inhibit the sequential

286 for this activity was identified as EcpA, a cysteine protease under quorum sensing control.

287 rt a model in which GP cleavage by endosomal cysteine proteases unmasks the binding site for NPC1, an

288 prolines and that actin-related proteins and cysteine proteases were highly enriched in the group.

289 Finally, T. foetus cysteine proteases were identified as enabling cytopathi

290 ns, which are calcium-dependent nonlysosomal cysteine proteases, were activated upon ATP stimulation

291 y levels of these enzymes, in particular the cysteine proteases, were increased in a rot mutant.

292 Asparaginyl endopeptidases (AEPs) are cysteine proteases which break Asx (Asn/Asp)-Xaa bonds i

293 also activates calpain, a calcium-dependent cysteine protease, which has been shown to play a critic

294 Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptoti

295 iquitin-like conjugation system and the ATG4 cysteine proteases, which are implicated in the formatio

296 alpain-1 and calpain-2, are Ca(+2)-dependent cysteine proteases, which have been associated with nume

297 C-cleavage, is mediated by the activity of a cysteine protease whose activity is independent from tha

298 Legumain is a lysosomal cysteine protease whose biological function remains poor

299 Separase is a cysteine protease with a crucial role in the dissolution

300 ubstrate for cathepsin H (CtsH), a lysosomal cysteine protease with a strong aminopeptidase activity.