ライフサイエンスコーパス: cysteine residue

1 tion, geranylgeranylation, of the C-terminal cysteine residue.

2 PEB and PUB covalent attachment to the same cysteine residue.

3 roteins share a variably acylated N-terminal cysteine residue.

4 ulfhydryl substituents of its amino-terminal cysteine residue.

5 minal undecapeptide, which contains a single cysteine residue.

6 r transfer through sacrificing its catalytic cysteine residue.

7 in part through alkylation of a nonconserved cysteine residue.

8 ng-pong mechanism centered on an active site cysteine residue.

9 -bond between protonated D46 and a catalytic cysteine residue.

10 ovalent catalysis mediated by an active-site cysteine residue.

11 of OGG1 by mutating and characterizing each cysteine residue.

12 quaternized vinyl pyridinium reagent at the cysteine residues.

13 d to sequential oxidation of certain protein cysteine residues.

14 orm redox-sensitive dimers via two conserved cysteine residues.

15 ised of 91 amino acids, with eight conserved cysteine residues.

16 ns, which contain multiple zinc-coordinating cysteine residues.

17 ometric analysis of the oxidation of nuclear cysteine residues.

18 em, which functions to oxidize pairs of free-cysteine residues.

19 t proteins like OGG1 itself, specifically at cysteine residues.

20 thyltransferase requiring only two conserved cysteine residues.

21 ave ArsM orthologs with only three conserved cysteine residues.

22 the cell membrane through palmitoylation of cysteine residues.

23 d, activity was dependent on the presence of cysteine residues.

24 lmon nuclei despite salmon protamine lacking cysteine residues.

25 xidative post-translational modifications of cysteine residues.

26 ested disulfide bonds and motifs of adjacent cysteine residues.

27 haracterized ArsM to date has four conserved cysteine residues.

28 dues in GSTP and cross-link them to adjacent cysteine residues.

29 which is ligated by one histidine and three cysteine residues.

30 only the second, third and fourth conserved cysteine residues.

31 rticular, oxidation of mitochondrial protein cysteine residues.

32 e introduction of spin labels via engineered cysteine residues.

33 ed by S-palmitoylation at four juxtamembrane cysteine residues.

34 lic phosphatases by oxidation of active site cysteine residues.

35 um atoms bind at N- and C-terminal catalytic cysteine residues.

36 e in proteins containing multiple endogenous cysteine residues.

37 s function is identification of the targeted cysteine residues.

38 les have an unusual conserved cleft with two cysteine residues.

39 de bond that is formed by the second pair of cysteine residues.

40 rone activity that depended on its conserved cysteine residues.

41 ranslationally, via covalent modification of cysteine residues.

42 h the covalent modification of intracellular cysteine residues.

43 conjugation of cytotoxic drugs to lysine and cysteine residues.

44 talytic subunits are glutathionylated on two cysteine residues.

45 otein binds a [2Fe-2S] cluster via conserved cysteine residues.

46 e ZBTB24 ZF domain, which alter zinc-binding cysteine residues.

47 The mutation of cysteine residue 107 in NDUFB10 impaired oxidation and e

48 e formation of disulfide-linked polymers via cysteine residue 148.

49 nd binding mode for the K1-cluster involving cysteine residues 29 and 128 in addition to histidine 42

50 ing site, which at this stage is occupied by cysteine residue 62.

51 ddition of a thiol (-SH) group onto reactive cysteine residues: a process known as persulfidation.

52 h activity-based protein profiling to assess cysteine residues across the human proteome for both irr

53 ification in which palmitic acid is added to cysteine residues, allowing association with different c

54 fore, covalent molecules targeting conserved cysteine residues among RGS proteins have emerged as pot

55 Although these inhibitors bind to conserved cysteine residues among RGS proteins, we have previously

56 ed by maleimide coupling of NOTA to a unique cysteine residue and chelation of (18)F-AlF.

57 1Ser substitution affects a highly conserved cysteine residue and is predicted by molecular modeling

58 ied by S-glutathionylation at this conserved cysteine residue and that either endogenously synthesize

59 itor, 3-bromopyruvate, also targets the same cysteine residue and that our electrophilic quinazolines

60 ii) Fe(II) ions bind to the IscU active site cysteine residues and another lower affinity binding sit

61 cant reduction in HCN currents by binding to cysteine residues and forming S-nitrosothiol complexes.

62 al infectivity by >100-fold and included two cysteine residues and neighboring residues.

63 Three cysteine residues and one disulfide bond conserved withi

64 discuss the idea that oxidation of conserved cysteine residues and partial unfolding of its structure

65 brane protein 3 is S-fatty acylated on three cysteine residues and site-specific modification of high

66 Oxidative modifications of cysteine residues are an important component in signalin

67 As transmembrane domains followed by cysteine residues are common motifs for S-acylation to o

68 Disulfide bonds between cysteine residues are commonly involved in the stability

69 These cysteine residues are conserved in all four desmoglein f

70 st, MTSET has no effect on channels in which cysteine residues are engineered into intracellular regi

71 As some of these cysteine residues are highly conserved within the RGS fa

72 tures of Tau filaments revealed that the two cysteine residues are not structurally equivalent since

73 verexpression of mutant MTA3, in which the 2 cysteine residues are replaced by alanine residues, impa

74 Protein cysteine residues are susceptible to oxidative modificat

75 Vicinal disulfides between sequence-adjacent cysteine residues are very rare and rather startling str

76 anslocated into plant cells and two of its 8 cysteine-residues are required for its function.

77 ysteine redoxome, the repertoire of oxidized cysteine residues, are pivotal towards a better understa

78 ess of this strategy has centered on exposed cysteine residues as nucleophiles but the low abundance

79 and irreversible engagement of noncatalytic cysteine residues as well as other amino acids.

80 ps that are able to interact covalently with cysteine residues, as exemplified by its effect on NF-ka

81 Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin beta c

82 The OPH signal peptide contains an invariant cysteine residue at the junction of the signal peptidase

83 mic one another by substituting the variable cysteine residues at position III in the protein.

84 ron transfer was mediated by an array of six cysteine residues at the very C-terminal end, which also

85 We present a method for the ethynylation of cysteine residues based on the use of ethynylbenziodoxol

86 t facilitates site-specific conjugation to a cysteine residue-bearing antibody fragment, introduction

87 Lung Ndufs2 cysteine residues became reduced during acute hypoxia an

88 experiments produced similar results of many cysteine residues bound to N-acetylglucosamine (GlcNAc).

89 ation through covalent modification of KEAP1 cysteine residues, but such electrophilic compounds lack

90 a fatty acid chain is covalently linked to a cysteine residue by a thioester linkage, is the most pre

91 These inhibitors react with the mutant cysteine residue by binding covalently to the switch-II

92 olipids and modification of ENaC cytoplasmic cysteine residues by palmitoylation, which enhance chann

93 d through reversible modification of protein cysteine residues by reactive oxygen species (ROS).

94 and forms a covalent adduct with a conserved cysteine residue (C159) within the pocket and disrupts s

95 During topology mapping, we discovered two cysteine residues (C187 and C293) located on opposite si

96 nkage through reaction of X' with the target cysteine residue C32.

97 ed within its conserved N-terminal domain at cysteine residues C466 and C473 by the DHHC family palmi

98 ttaches a doubly linked phycourobilin to two cysteine residues (C50, C61) on the beta-subunit of both

99 R domain of FisR through the three conserved cysteine residues (C53, C64 and C71), FisR activates the

100 the alpha-helix with the former peroxidatic cysteine residue C61 by six residues.

101 s in which modification of a highly reactive cysteine residue (C621) promotes reorientation of a cyto

102 MOM)-OH, peptides containing a Bhc-protected cysteine residue can be easily prepared.

103 Furthermore, peptides containing two cysteine residues can be stapled or cyclized using homob

104 cies may generate adducts of tyrosine and/or cysteine residues, causing CYP2B6 downregulation, and se

105 F/TrkA interaction, we sought to eliminate a cysteine residue close to the C-terminal of both sequenc

106 requirement for both C328 and C343, the two cysteine residues closest to the C terminus of pejvakin,

107 mechanism involving covalent modification of cysteine residues clustered within an amino-terminal cyt

108 rreversible covalent bond with the catalytic cysteine residue, confirmed by crystal structure analysi

109 ent exposure and redox regulation of cryptic cysteine residues contextually delineate redox signaling

110 of a pair of hydrogen atoms from juxtaposed cysteine residues, contrasts with the substantial change

111 Each cysteine residue contributes differentially to Tau stabi

112 investigation, including a discussion of how cysteine residues could contribute to envelope homeostas

113 on electrode surfaces through an engineered cysteine residue coupled with impedimetric detection fac

114 The ten internal cysteine residues crucial to functional structure format

115 as inhibited by the oxidation of a conserved cysteine residue (Cys(290)) that lies adjacent to Thr(28

116 mology-based structural modeling predicted a cysteine residue (Cys-298) in position to form a disulfi

117 ergoes S-palmitoylation on two juxtamembrane cysteine residues, Cys-264 and Cys-265.

118 BlArsM has six cysteine residues (Cys10, Cys11, Cys145, Cys193, Cys195

119 SpArsR has two conserved cysteine residues, Cys101 and Cys102.

120 covalent bond between TTN and a PP1-specific cysteine residue, Cys127.

121 We show that one natural cysteine residue, Cys327, out of three, has an enhanced

122 nfluenzae response to formaldehyde, with two cysteine residues (Cys54 and Cys71) identified to be imp

123 a modification of a unique, highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

124 idopsis (Arabidopsis thaliana) revealed that cysteine residues, CysI and CysII, are both involved in

125 These cysteine residues did not form disulfide bonds in HBx ex

126 Palmitoylation at a membrane proximal cysteine residue enables Fas to localize to lipid raft m

127 one that oxidizes the thiolate side chain of cysteine residues; events that were enhanced in cells un

128 A cysteine residue, exclusively present in bacterial TGTs,

129 2) that disulfide bonds form between single cysteine residues experimentally introduced into an extr

130 lasso peptide microcin J25 (MccJ25) with two cysteine residues followed by cleavage of the peptide wi

131 C8-3 and TIL3 modules are required to expose cysteine residues for disulfide linkage.

132 me oxygenase-2 (HO2) contains two HRMs whose cysteine residues form a disulfide bond; when reduced, t

133 e antiparallel beta-sheet with six conserved cysteine residues forming a disulfide-bonded knottin sca

134 s10, Cys145 and Cys195) align with conserved cysteine residues found in most ArsMs.

135 situ, which reacts with nearby nucleophilic cysteine residue from the DUB active site.

136 Using this method, we identify numerous cysteine residues from diverse protein classes that are

137 II) binding stabilizes IscU and protects the cysteine residues from oxidation, weakens the interactio

138 fibrillar filaments by oxidation of its two cysteine residues, generating an intermolecular disulfid

139 ation between CBT derivatives and N-terminal cysteine residues has been established as a biocompatibl

140 Disulfide bonds formed by cysteine residues have been introduced into soluble form

141 ing chemical reagents specific for lysine or cysteine residues, identification of gas-phase fragmenta

142 rough site-directed mutagenesis of conserved cysteine residues impaired Delta3 FA production.

143 ized so far contain evolutionarily conserved cysteine residues implicated in protochlorophyllide (Pch

144 eat and contained an extra repetitive-domain cysteine residue in 1Dx5 that was important for understa

145 demonstrate the in situ labeling of a buried cysteine residue in BSA during extensional stress.

146 n and the absence of the essential catalytic cysteine residue in certain non-bacterial ALDH16 sequenc

147 variants having substitutions with a single cysteine residue in different secondary structures, enab

148 reductase, independently of H2O2 A conserved cysteine residue in OxyR2 is critical for this function.

149 the SSS mutant background, the presence of a cysteine residue in place of highly conserved tryptophan

150 results support key roles for this essential cysteine residue in substrate binding, as a general acid

151 ubstrate, which is coordinated by a peptidyl-cysteine residue in the bound state.

152 "S-sulfhydrome" consisted of 3446 individual cysteine residues in 1591 proteins.

153 opper atom is coordinated by two active-site cysteine residues in a nearly linear geometry, supportin

154 using CLH-3b channels engineered with single-cysteine residues in CBS2 indicate that V228L, Y529A, an

155 Mutational analysis of cysteine residues in CNPYb identified differential depen

156 structures, as XEEL lacks the corresponding cysteine residues in hIntL-1 that stabilize the disulfid

157 y bound to GlcNAc through the side chains of cysteine residues in human cells, and the current discov

158 ible covalency has mainly been evaluated for cysteine residues in individual kinases and the broader

159 rmolecular disulfide bonds between conserved cysteine residues in neurexins and CA10.

160 trate that the inability to produce reactive cysteine residues in pairs is a result of the disulfide

161 low molecular weight thiols are attached to cysteine residues in peptides via disulfide bonds.

162 Protein disulfide bonds link pairs of cysteine residues in polypeptide chains.

163 d by reacting an abasic site in DNA with the cysteine residues in protein was targeted in this study.

164 ve shown that iron-sulfur clusters hosted by cysteine residues in proteins are readily disrupted by n

165 s a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P-SSH

166 These ROS then oxidize cysteine residues in proteins to potentiate downstream s

167 ng the covalent attachment of fatty acids to cysteine residues in proteins.

168 Missense mutations that introduce or remove cysteine residues in receptor tyrosine kinases are belie

169 Alkylation of cysteine residues in TG2 or inhibition of endothelial NO

170 ytium formation, alteration of palmitoylated cysteine residues in the cytoplasmic tail decreased the

171 Cysteine residues in the double-stranded beta-helix fold

172 ctively, as measured by the accessibility of cysteine residues in the extracellular and cytoplasmic p

173 d subfamily that features two extra pairs of cysteine residues in the extracellular domain.

174 n this study, we investigate the role of the cysteine residues in the function of OGG1 by mutating an

175 y is related to the covalent modification of cysteine residues in the human proteome.

176 We identified two cysteine residues in the juxtamembrane (intracellular an

177 ein kinases, is regulated by redox-sensitive cysteine residues in the kinase domain.

178 f the redox regulation of Akt identified two cysteine residues in the pleckstrin homology domain (C60

179 till relies on maleimide chemistry involving cysteine residues in the protein of interest.

180 functional analysis of the role of reactive cysteine residues in the protein.

181 ity ligation assay with chemical labeling of cysteine residues in the sulfenic acid state, we visuali

182 erved region unusually rich in histidine and cysteine residues in the TMA-L1 region of eukaryotic chl

183 OACs), a process that converts nucleophilic cysteine residues into an electrophilic S-aryl-Pd-X unit

184 anslationally modified to convert serine and cysteine residues into oxazole and thiazole rings.

185 a) residues (in this instance, from a unique cysteine residue introduced by site-directed mutagenesis

186 d VKORL form disulfide-linked oligomers, the cysteine residues involved in the oligomerization appear

187 Chemical modification of a unique cysteine residue is among the most facile methods for si

188 Our analyses determined that the cysteine residue is not required for NGF binding, but is

189 We conclude that a cysteine residue is required within potential peptide-ba

190 oach utilizes conjugation to native antibody cysteine residues, it is widely applicable and enables h

191 -terminal region around the highly conserved cysteine residues known to be involved in regulation by

192 y, mass spectrometry reveals three potential cysteine residues labeled by this compound, and mutagene

193 ite of covalent modification was mapped to a cysteine residue located in a region of V-ATPase subunit

194 al interaction that requires three conserved cysteine residues located adjacent to the catalytic loop

195 region forms a three-helical bundle with two cysteine residues located at positions 191 and 192 in th

196 ide bond formation, depends on two conserved cysteine residues located in the C-terminal region.

197 via covalent bond modifications of specific cysteine residues located in the cytoplasmic domains.

198 the HBx:DDB1 complex identified several HBx cysteine residues (located between amino acids 61 and 13

199 hepatoma cells and stably modifies specific cysteine residues (namely, Cys-257, -273, -288, -434, -4

200 SETD8 (MS453), which specifically modifies a cysteine residue near the inhibitor binding site, has an

201 hat NS2 is palmitoylated at the position 113 cysteine residue (NS2/C113) when expressed by itself in

202 of the 1Ax1 gene corresponding to the extra cysteine residue of 1Dx5 was substituted by a cysteine c

203 It was concluded that the extra cysteine residue of mutant 1Ax1 subunit plays a positive

204 holipid to the amine group of the N-terminal cysteine residue of the apolipoprotein.

205 de reactive moiety, binds to the active-site cysteine residue of UCHL1 in an activity-dependent manne

206 ate is not due to irreversible reaction with cysteine residues of C/EBPbeta.

207 t in Cox4i2(-/-) PASMCs and was dependent on cysteine residues of Cox4i2.

208 Four conserved cysteine residues of DENR (C34, C37, C44, C53) form a cl

209 n of OGG1 is sensitive to oxidants, with the cysteine residues of OGG1 being the most likely site of

210 Oxidants react with cysteine residues of proteins to form glutathione (GSH)

211 ducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic t

212 lysis showed that ACR-adducts were formed on cysteine residues of some synaptic proteins.

213 H(2) O(2) oxidizes specific cysteine residues of target proteins to the sulfenic aci

214 Cysteine-291 and Cysteine-322, the only two cysteine residues of Tau present in only 4-Repeat or all

215 Furthermore, substitution of multiple cysteine residues of the NOTCH3 N terminus activated pro

216 nds on the conversion of selected serine and cysteine residues of the precursor peptide to oxazoles a

217 luorophores because the lysine, arginine and cysteine residues of viral proteins are labelled simulta

218 the loop sequence between the two conserved cysteine residues of VKORL affects its activity, support

219 In the context of a single conserved cysteine residue on the alpha (4) helix, RGS19 is the mo

220 d formation through attack of an active site cysteine residue on the benzo[d]isothiazol-3(2H)-one cor

221 of sigma receptors results in oxidation of a cysteine residue on VMAT2, which decreases transporter f

222 e irreversible and selective modification of cysteine residues on antibodies, using functionalized ca

223 Specifically, fumarate covalently modifies cysteine residues on iron regulatory protein 2 (IRP2), r

224 ntioxidant ingredients, are known to bind to cysteine residues on meat proteins.

225 ally derived from palmitoyl-CoA, to specific cysteine residues on target proteins, which affects thei

226 arise from the sequential cross-coupling of cysteine residues on two different proteins.

227 KDM5 covalent inhibitors designed to target cysteine residues only present in the KDM5 sub-family.

228 These differences raise the possibility that cysteine residues play a potential role in determining t

229 ubular protein nanoreactors, which contained cysteine residues positioned at different locations alon

230 Mutation of the only cysteine residue present in HLH-30 (C284) significantly

231 ins through site-selective bis-alkylation of cysteine residues present as disulfides under mild and b

232 y, our data support that the seven conserved cysteine residues, present within the SPASM domain, are

233 tide is post-translationally modified at the cysteine residue, preventing the subsequent thiol coupli

234 Mutation of the individual cysteine residues produced stable Erv46 proteins that we

235 s found to abstract the sulfur atom from the cysteine residue, providing an alternative way to transf

236 ation or geranylgeranylation at a C-terminal cysteine residue regulates the localization and function

237 , the role of this highly conserved reactive cysteine residue remains largely unknown.

238 The crystal structure of monomeric D'D3 with cysteine residues required for dimerization mutated to a

239 firming that the C-terminal, redox-sensitive cysteine residues reside within the intermembrane space

240 otein domain harboring three solvent-exposed cysteine residues, resulting in the in situ cyclization

241 Deletion of ccoG or mutation of the cysteine residues results in defective cbb (3)-Cox assem

242 idation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH).

243 strategy, we identified 1,276 S-nitrosylated cysteine residues [S-nitrosothiol (SNO)] on 491 proteins

244 probe, we generated a data set of proteomic cysteine residues sensitive to the reduction in fumarate

245 ABSTRACT: The modification of cysteine residues (substituted for D43 and T47) by 2-ami

246 H4-mimicking peptide, containing a lysine to cysteine residue substitution (K12C), resulted in acetyl

247 existence of ArsMs with only three conserved cysteine residues suggest that the ability to methylate

248 ost focus has been on targeting binding-site cysteine residues, targeting nucleophilic lysine residue

249 scriptional factor has a conserved catalytic cysteine residue that confers antibiotic tolerance to th

250 The KRAS(G12C) mutant has a cysteine residue that has been exploited to design coval

251 rc homology 2 (SH2) or SH3 domains or of the cysteine residue that undergoes LPS-induced palmitoylati

252 is regulated by palmitoylation of C-terminal cysteine residues that allows Golgi localization.

253 d contains an Fe-S cluster and identify four cysteine residues that are likely to co-ordinate the clu

254 cated widespread redox regulation of cryptic cysteine residues that are solvent exposed only upon cha

255 nct modes by which EGF specified the cryptic cysteine residues that became solvent exposed and redox

256 Conotoxins contain conserved cysteine residues that form disulfide bonds that stabili

257 ding bulls and humans, also contain multiple cysteine residues that form intra- and interprotamine su

258 amino acid motif and including six conserved cysteine residues that form intramolecular disulfide bon

259 by mouse macrophages, lacks three conserved cysteine residues that have been shown to form disulfide

260 ra A kinase domain delineate redox-sensitive cysteine residues that, upon covalent modification, can

261 y depends on one or two catalytically active cysteine residues, the peroxidatic Cys (CP) and, if pres

262 5-aminoacid peptide guanylin containing four cysteine residues; the net simulation time using Amber f

263 thionylation, glutathione adducts of protein cysteine residues, thus modulating redox signaling and g

264 e spontaneous oxidation of the Hha conserved cysteine residue to a -SOxH-containing species (sulfenic

265 pically have severe effects, mutation of the cysteine residue to alanine has minor effects on overall

266 ften use nucleophilic serine, threonine, and cysteine residues to achieve the same type of reaction;

267 , especially in eukaryotes, contain too many cysteine residues to be amenable to this strategy, and t

268 ichael-type addition of native or engineered cysteine residues to carbonylacrylic reagents equipped w

269 hlight the emerging role of enzymes that use cysteine residues to catalyze reactions that are necessa

270 reacts with gasdermin D (GSDMD) at critical cysteine residues to form S-(2-succinyl)-cysteine.

271 (TDZDs) are covalent inhibitors that act on cysteine residues to inhibit RGS4, RGS8, and RGS19.

272 donating the sulfur atom of their exclusive cysteine residues to the substrate.

273 oxic moiety covalently linked, via lysine or cysteine residues, to a monoclonal antibody (mAb) scaffo

274 conjugated with biotin via native lysine and cysteine residues, under native-MS and solution conditio

275 ron microscopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitr

276 ion is irreversible and enhanced if a nearby cysteine residue undergoes an initial reversible S-acyla

277 niques, which leave the sensitive network of cysteine residues undisturbed.

278 nsfer (TR-FRET) detection method for PTMs of cysteine residues using a single-peptide approach perfor

279 unsaturated aldehydes, which then react with cysteine residues via Michael addition.

280 ociated with dynamic reversible oxidation of cysteine residues via sequential sulfenylation and S-glu

281 work, unexpected protein S-GlcNAcylation on cysteine residues was observed to extensively exist in h

282 d histidine and intact histidine, lysine, or cysteine residues were discovered and characterized from

283 or stabilized oxidation of SHP-1's catalytic cysteine residue, which inhibited the tyrosine-phosphata

284 cation generates dehydroalanine at a single cysteine residue, which is easily identified by the odd-

285 ) methylation activities have four conserved cysteine residues, which are thought to be essential for

286 ) via covalent modification of extracellular cysteine residues, which leads to autophosphorylation of

287 ompromised by acquired mutation of C797, the cysteine residue with which they form a key covalent bon

288 d by an additional blockage of residual free cysteine residues with 2,2'-dithiodipyridine prior to th

289 Currently, targeting noncatalytic cysteine residues with acrylamides and other alpha,beta-

290 anslational modification of membrane protein cysteine residues with many regulatory roles.

291 is approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable s

292 risingly, although pertussis toxin targets a cysteine residue within the alpha subunit of inhibitory

293 xtracts and mammalian cells that a conserved cysteine residue within the Aurora A activation loop is

294 nce alignment highlighted a poorly conserved cysteine residue within the FGFR4 ATP-binding site at po

295 Ps) is achieved by the introduction of three cysteine residues within a conserved loop of the PTP dom

296 Our findings suggest that cysteine residues within p38alpha act as redox sensors t

297 stigated whether the conserved extracellular cysteine residues within the amino terminus of gK contri

298 Mutagenesis of individual cysteine residues within the non-amyloid cysteine-rich K

299 nteractions through covalent modification of cysteine residues within the RGS domain that are located

300 ific conjugation of two proteins with unique cysteine residues yielding a nonhydrolyzable phosphonoth